PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 25308733-1 2014 It is known that phosphoinositide-specific phospholipases gamma1(PLCgamma1) can trigger several signalling pathways to regulate cell proliferation, differentiation, and metastasis. Phosphatidylinositols 17-33 phospholipase C gamma 1 Homo sapiens 58-74 18922242-12 2008 A higher frequency of phospholipase C isoenzyme gamma1 (PLCG1)-5 repeat allele genes has also been associated with a good response to lithium, PLCG1 being a major enzyme of the phosphatidylinositol second messenger system. Phosphatidylinositols 177-197 phospholipase C gamma 1 Homo sapiens 22-54 22454520-7 2012 This is likely to have profound consequences for our understanding of several cellular functions that are dependent on phosphoinositides and controlled by PDK1 and PLCgamma1. Phosphatidylinositols 119-136 phospholipase C gamma 1 Homo sapiens 164-173 18922242-12 2008 A higher frequency of phospholipase C isoenzyme gamma1 (PLCG1)-5 repeat allele genes has also been associated with a good response to lithium, PLCG1 being a major enzyme of the phosphatidylinositol second messenger system. Phosphatidylinositols 177-197 phospholipase C gamma 1 Homo sapiens 56-61 18922242-12 2008 A higher frequency of phospholipase C isoenzyme gamma1 (PLCG1)-5 repeat allele genes has also been associated with a good response to lithium, PLCG1 being a major enzyme of the phosphatidylinositol second messenger system. Phosphatidylinositols 177-197 phospholipase C gamma 1 Homo sapiens 143-148 9826521-5 1998 The results suggest that Tor2p, as a PtdIns kinase, produces phosphorylated PtdIns, which is then hydrolyzed by the associated Plc1p. Phosphatidylinositols 37-43 phospholipase C gamma 1 Homo sapiens 127-132 15607032-0 2004 Point mutations in the split PLC-gamma1 PH domain modulate phosphoinositide binding. Phosphatidylinositols 59-75 phospholipase C gamma 1 Homo sapiens 29-39 15607032-6 2004 We found that two PLC-gamma1 nPH2 domain mutants, P500A and H503A, showed reduced affinities for phosphoinositide binding. Phosphatidylinositols 97-113 phospholipase C gamma 1 Homo sapiens 18-28 11226408-0 2001 Localization of phospholipase C-gamma1 signaling in caveolae: importance in EGF-induced phosphoinositide hydrolysis but not in tyrosine phosphorylation. Phosphatidylinositols 88-104 phospholipase C gamma 1 Homo sapiens 16-38 11226408-4 2001 Pretreatment of cells with methyl-beta-cyclodextrin (MbetaCD), a chemical disrupting caveolae structure, inhibits the translocation of PLC-gamma1 to CM as well as phosphatidylinositol (PtdIns) turnover. Phosphatidylinositols 185-191 phospholipase C gamma 1 Homo sapiens 135-145 11018473-0 2000 Phosphatidylinositol-specific phospholipase C-gamma1 undergoes pH-induced activation and conformational change. Phosphatidylinositols 0-20 phospholipase C gamma 1 Homo sapiens 30-52 9915811-2 1999 The kinetics of PI-PLCgamma1 toward a water-soluble substrate (inositol 1,2-cyclic phosphate, cIP) and phosphatidylinositol (PI) in detergent mixed micelles were monitored by 31P NMR spectroscopy. Phosphatidylinositols 103-123 phospholipase C gamma 1 Homo sapiens 19-28 9915811-6 1999 The effect of Ca2+ on PI-PLCgamma1 activity is unique compared with other isozymes enzymes: Ca2+ is necessary for the activity and low Ca2+ activates the enzyme; however, high Ca2+ inhibits PI-PLCgamma1 hydrolysis of phosphoinositides (but not cIP) with the extent of inhibition dependent on pH, substrate identity (cIP or PI), substrate presentation (e.g. detergent matrix), and substrate surface concentration. Phosphatidylinositols 217-234 phospholipase C gamma 1 Homo sapiens 25-34 16445858-3 2006 We recently found that phosphatidylinositol-specific phospholipase C-gamma1 (PLC-gamma1) directly binds to extracellular signal-regulated kinase 2 (ERK2), a MAPK, via a D-domain-dependent mechanism. Phosphatidylinositols 23-43 phospholipase C gamma 1 Homo sapiens 77-87 14989173-1 2003 Phospholipase C gamma 1 (PLC gamma 1), an enzyme participating in phosphoinositide turnover, is one of the key elements in cell signaling. Phosphatidylinositols 66-82 phospholipase C gamma 1 Homo sapiens 0-23 14989173-1 2003 Phospholipase C gamma 1 (PLC gamma 1), an enzyme participating in phosphoinositide turnover, is one of the key elements in cell signaling. Phosphatidylinositols 66-82 phospholipase C gamma 1 Homo sapiens 25-36 9826521-6 1998 The proximity of Tor2p to Plc1p may therefore result in a regulated spatial and temporal coupling of synthesis and hydrolysis of phosphorylated forms of PtdIns. Phosphatidylinositols 153-159 phospholipase C gamma 1 Homo sapiens 26-31 9793178-3 1998 Here we show that phosphoinositide-specific phospholipase C gamma 1, one of the key elements in phosphoinositide pathway of signal transduction, is physically associated with members of the STAT pathway. Phosphatidylinositols 18-34 phospholipase C gamma 1 Homo sapiens 44-67 9610484-1 1998 It is shown that phosphoinositide-specific phospholipase C gamma 1 (PLC gamma 1), a substrate of growth factor receptors, is associated with cytoskeleton in A-431 cells. Phosphatidylinositols 17-33 phospholipase C gamma 1 Homo sapiens 43-66 9610484-1 1998 It is shown that phosphoinositide-specific phospholipase C gamma 1 (PLC gamma 1), a substrate of growth factor receptors, is associated with cytoskeleton in A-431 cells. Phosphatidylinositols 17-33 phospholipase C gamma 1 Homo sapiens 68-79 9857980-3 1998 We have investigated a polymorphism located in the gene (PLCG1) that codes for a gamma-1 isozyme of phospholipase (PLC), an enzyme that plays an important role in the phosphoinositide second messenger system. Phosphatidylinositols 167-183 phospholipase C gamma 1 Homo sapiens 57-62 9793178-3 1998 Here we show that phosphoinositide-specific phospholipase C gamma 1, one of the key elements in phosphoinositide pathway of signal transduction, is physically associated with members of the STAT pathway. Phosphatidylinositols 96-112 phospholipase C gamma 1 Homo sapiens 44-67 8755506-1 1996 The X and Y domains of phospholipase C (PLC)-gamma1, which are conserved in all mammalian phosphoinositide-specific PLC isoforms and are proposed to interact to form the catalytic site, have been expressed as individual hexahistidine-tagged fusion proteins in the baculovirus system. Phosphatidylinositols 90-106 phospholipase C gamma 1 Homo sapiens 23-51 8909300-11 1996 This D-3 phosphoinositide-mediated regulation may represent a new mechanism for controlling PtdIns(4,5)P2 turnover by PLC-gamma 1. Phosphatidylinositols 9-25 phospholipase C gamma 1 Homo sapiens 118-129 8641669-7 1996 His321 inhibited phosphatidylinositol 4,5-bisphosphate (PIP2) hydrolysis by phospholipase C gamma 1 more strongly in vitro than did wild-type gelsolin because of its higher binding capacity to phosphoinositide. Phosphatidylinositols 193-209 phospholipase C gamma 1 Homo sapiens 76-99 8649391-6 1996 These data demonstrate that tyrosine phosphorylation of a protein(s) which binds the SH2 domain of Grb2 correlates with phospholipase C gamma 1 activation and suggest that such a phosphoprotein(s) plays a critical role in coupling the TCR with the phosphatidylinositol second-messenger pathway. Phosphatidylinositols 248-268 phospholipase C gamma 1 Homo sapiens 120-143 8630067-1 1996 Previously, we demonstrated that microinjection of phosphoinositide-specific phospholipase C gamma 1 (PLC gamma 1) and lipase-defective mutants of PLC gamma 1 induced G(0) growth arrested NIH 3T3 fibroblasts to enter S phase of the cell cycle. Phosphatidylinositols 51-67 phospholipase C gamma 1 Homo sapiens 77-100 8630067-1 1996 Previously, we demonstrated that microinjection of phosphoinositide-specific phospholipase C gamma 1 (PLC gamma 1) and lipase-defective mutants of PLC gamma 1 induced G(0) growth arrested NIH 3T3 fibroblasts to enter S phase of the cell cycle. Phosphatidylinositols 51-67 phospholipase C gamma 1 Homo sapiens 102-113 8630067-1 1996 Previously, we demonstrated that microinjection of phosphoinositide-specific phospholipase C gamma 1 (PLC gamma 1) and lipase-defective mutants of PLC gamma 1 induced G(0) growth arrested NIH 3T3 fibroblasts to enter S phase of the cell cycle. Phosphatidylinositols 51-67 phospholipase C gamma 1 Homo sapiens 147-158 8525617-6 1995 These results suggest that tyrosine phosphorylation of PLC-gamma 1, mediated by VGF, leads to activation of PLC-gamma 1 and a concomitant increase in phosphatidylinositol turnover. Phosphatidylinositols 150-170 phospholipase C gamma 1 Homo sapiens 55-66 34454048-0 2021 Recent advances in understanding the molecular role of phosphoinositide-specific phospholipase C gamma 1 as an emerging onco-driver and novel therapeutic target in human carcinogenesis. Phosphatidylinositols 55-71 phospholipase C gamma 1 Homo sapiens 81-104 7831290-10 1995 Thus, pp120 may serve as a link between Syk and PLC gamma 1, coupling the B-cell antigen receptor to the phosphatidylinositol pathway. Phosphatidylinositols 105-125 phospholipase C gamma 1 Homo sapiens 48-59 1313007-1 1992 The effective resolution of human platelet cytosolic phosphoinositide-phospholipase C (PLC) revealed five distinct activity peaks by Q-Sepharose and heparin-Sepharose column chromatographies when assayed using phosphatidylinositol (PI) and phosphatidylinositol 4,5-bisphosphate (PIP2). Phosphatidylinositols 210-230 phospholipase C gamma 1 Homo sapiens 53-85 1313007-1 1992 The effective resolution of human platelet cytosolic phosphoinositide-phospholipase C (PLC) revealed five distinct activity peaks by Q-Sepharose and heparin-Sepharose column chromatographies when assayed using phosphatidylinositol (PI) and phosphatidylinositol 4,5-bisphosphate (PIP2). Phosphatidylinositols 210-230 phospholipase C gamma 1 Homo sapiens 87-90 1372020-2 1992 Stimulation of the T cell surface receptor CD2 similarly propagates early signals through phosphatidylinositol-PLC activation. Phosphatidylinositols 90-110 phospholipase C gamma 1 Homo sapiens 111-114 1647037-2 1991 Receptors trigger the hydrolysis of inositol phospholipids by activating phosphoinositidase C (PIC) enzymes. Phosphatidylinositols 36-58 phospholipase C gamma 1 Homo sapiens 73-93 1647037-2 1991 Receptors trigger the hydrolysis of inositol phospholipids by activating phosphoinositidase C (PIC) enzymes. Phosphatidylinositols 36-58 phospholipase C gamma 1 Homo sapiens 95-98 1644792-7 1992 Like other mammalian PLC isoforms, including PLC-beta 1, the catalytic activity of PLC-beta 2 was entirely dependent on Ca2+, and PLC-beta 2 preferred phosphatidyl-inositol 4,5-bisphosphate to phosphatidylinositol as substrate. Phosphatidylinositols 193-213 phospholipase C gamma 1 Homo sapiens 21-24 1376928-1 1992 The triggering of T- or B-cell antigen-specific receptors is accompanied by rapid tyrosine phosphorylation of distinct cellular substrates, one of which is the gamma 1 isoform of inositol phospholipid-specific phospholipase C (PLC-gamma 1). Phosphatidylinositols 179-200 phospholipase C gamma 1 Homo sapiens 227-238 1376928-2 1992 This phosphorylation event, mediated by a putative protein tyrosine kinase coupled to the antigen receptor, probably stimulates the enzymatic activity of PLC-gamma 1, thereby promoting inositol phospholipid hydrolysis and other downstream signal transduction events. Phosphatidylinositols 185-206 phospholipase C gamma 1 Homo sapiens 154-165 2061301-8 1991 These results strongly suggest that the TCR complex expressed by Jurkat cells is functionally coupled to the phosphoinositide-dependent signaling pathway through the tyrosine phosphorylation of PLC-gamma 1. Phosphatidylinositols 109-125 phospholipase C gamma 1 Homo sapiens 194-205 1828897-1 1991 The human T-cell line Jurkat was found to contain at least two immunologically distinct isoforms of inositol phospholipid-specific phospholipase C (PLC), PLC-beta 1 and PLC-gamma 1. Phosphatidylinositols 100-121 phospholipase C gamma 1 Homo sapiens 169-180 1828897-6 1991 Thus, the current data suggest that inositol phospholipid hydrolysis triggered by the T-cell antigen receptor-CD3 complex is due, at least in part, to activation of PLC-gamma 1 and that the mechanism by which this activation is achieved involves phosphorylation of multiple tyrosine residues on PLC-gamma 1 by a nonreceptor tyrosine kinase coupled to the T-cell antigen receptor-CD3 complex. Phosphatidylinositols 36-57 phospholipase C gamma 1 Homo sapiens 165-176 1828897-6 1991 Thus, the current data suggest that inositol phospholipid hydrolysis triggered by the T-cell antigen receptor-CD3 complex is due, at least in part, to activation of PLC-gamma 1 and that the mechanism by which this activation is achieved involves phosphorylation of multiple tyrosine residues on PLC-gamma 1 by a nonreceptor tyrosine kinase coupled to the T-cell antigen receptor-CD3 complex. Phosphatidylinositols 36-57 phospholipase C gamma 1 Homo sapiens 295-306 30510001-3 2018 One such enzyme, phospholipase-Cgamma1, is responsible for cleavage of a plasma membrane lipid substrate, a phosphoinositide, into two second messengers, diacylglycerol, which activates several enzymes including protein kinase C, and an inositol phosphate, which induces intracellular calcium elevation. Phosphatidylinositols 108-124 phospholipase C gamma 1 Homo sapiens 17-38 35124007-6 2022 We propose the multiple cooperative steps that we observed likely lead to conformational alterations in the regulatory domains of PLC-gamma1, enabling contact with its membrane substrate, disinhibition of PLC-gamma1 enzymatic activity, and production of the phosphoinositide cleavage products necessary for T cell activation. Phosphatidylinositols 258-274 phospholipase C gamma 1 Homo sapiens 130-140 32210730-1 2020 Our previous studies indicated that phosphoinositide specific phospholipase Cgamma1 (PLCgamma1) was involved in autophagy induction in colon and hepatic carcinoma cells. Phosphatidylinositols 36-52 phospholipase C gamma 1 Homo sapiens 85-94