PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 7556412-8 1995 In addition, cyclosporin A blocked substance P induced phosphatidylinositol (PI) turnover in U-373 MG cells without blocking the corresponding response to histamine. Phosphatidylinositols 55-75 tachykinin precursor 1 Homo sapiens 35-46 8812299-7 1996 ET-induced activation of the phosphoinositide/Ca(2+)- mobilizing pathway in neuronal and endocrine cells is associated with rapid stimulation of secretory responses, including release of gonadotropin-releasing hormone, oxytocin, vasopressin, substance P, atrial natriuretic peptides, gonadotropins, thyrotropin, growth hormone, parathyroid hormone, aldosterone, and catecholamines. Phosphatidylinositols 29-45 tachykinin precursor 1 Homo sapiens 242-253 7531648-4 1994 In Chinese hamster ovary cells permanently expressing the human NK1 receptor, FK888 inhibited the substance P-induced phosphatidylinositol hydrolysis and produced a parallel shift in the dose-response curve for substance P. Phosphatidylinositols 118-138 tachykinin precursor 1 Homo sapiens 98-109 7531657-0 1995 Nerve extracts and substance P activate the phosphatidylinositol signaling pathway and mitogenesis in newt forelimb regenerates. Phosphatidylinositols 44-64 tachykinin precursor 1 Homo sapiens 19-30 7511982-1 1993 Substance P (SP) has been shown to stimulate the hydrolysis of inositol phospholipids in peripheral tissues and in the brain. Phosphatidylinositols 63-85 tachykinin precursor 1 Homo sapiens 0-11 7511982-1 1993 Substance P (SP) has been shown to stimulate the hydrolysis of inositol phospholipids in peripheral tissues and in the brain. Phosphatidylinositols 63-85 tachykinin precursor 1 Homo sapiens 13-15 7511982-4 1993 SP, previously described as a NK1 agonist, and Neurokinin A (NKA), previously described as a NK2 agonist, stimulated phosphoinositide breakdown in the hypothalamus in a dose-dependent fashion, with SP being more potent than NKA. Phosphatidylinositols 117-133 tachykinin precursor 1 Homo sapiens 0-2 7511982-4 1993 SP, previously described as a NK1 agonist, and Neurokinin A (NKA), previously described as a NK2 agonist, stimulated phosphoinositide breakdown in the hypothalamus in a dose-dependent fashion, with SP being more potent than NKA. Phosphatidylinositols 117-133 tachykinin precursor 1 Homo sapiens 47-59 7511982-4 1993 SP, previously described as a NK1 agonist, and Neurokinin A (NKA), previously described as a NK2 agonist, stimulated phosphoinositide breakdown in the hypothalamus in a dose-dependent fashion, with SP being more potent than NKA. Phosphatidylinositols 117-133 tachykinin precursor 1 Homo sapiens 61-64 7511982-4 1993 SP, previously described as a NK1 agonist, and Neurokinin A (NKA), previously described as a NK2 agonist, stimulated phosphoinositide breakdown in the hypothalamus in a dose-dependent fashion, with SP being more potent than NKA. Phosphatidylinositols 117-133 tachykinin precursor 1 Homo sapiens 93-96 7511982-4 1993 SP, previously described as a NK1 agonist, and Neurokinin A (NKA), previously described as a NK2 agonist, stimulated phosphoinositide breakdown in the hypothalamus in a dose-dependent fashion, with SP being more potent than NKA. Phosphatidylinositols 117-133 tachykinin precursor 1 Homo sapiens 198-200 7682962-7 1993 Substance P stimulated the hydrolysis of phosphoinositide in a time- and concentration-dependent manner and this effect was mimicked by selective agonists of the NK1 receptor ([Pro9]SP and septide). Phosphatidylinositols 41-57 tachykinin precursor 1 Homo sapiens 0-11 7689642-1 1993 Bradykinin- and substance P (SP)-stimulated second messenger studies in isolated subsets of neuroglia showed bradykinin-stimulated synthesis of phosphoinositides (PI) in type-1 astrocytes and oligodendrocytes. Phosphatidylinositols 144-161 tachykinin precursor 1 Homo sapiens 16-27 1378486-0 1992 Preincubation with substance P induces substance P-stimulated phosphatidylinositol turnover in cultured cerebellar astrocytes. Phosphatidylinositols 62-82 tachykinin precursor 1 Homo sapiens 19-30 1378486-0 1992 Preincubation with substance P induces substance P-stimulated phosphatidylinositol turnover in cultured cerebellar astrocytes. Phosphatidylinositols 62-82 tachykinin precursor 1 Homo sapiens 39-50 1696081-6 1990 Cellular responses subsequent to the binding of substance P to its receptor that have been identified in various cell populations include phosphatidyl inositol turnover, arachidonic acid metabolism, immunoglobulin synthesis, and enzyme production and secretion. Phosphatidylinositols 138-159 tachykinin precursor 1 Homo sapiens 48-59 1657150-5 1991 When transfected into COS-7 cells, the NK-1 receptor binds 125I-BHSP with a Kd of 0.35 +/- 0.07 nM and mediates substance P induced phosphatidylinositol metabolism. Phosphatidylinositols 132-152 tachykinin precursor 1 Homo sapiens 112-123 2459200-4 1988 The respiratory and secretory response to SP are associated with an activation of phosphoinositide turnover, of Ca2+ influx and release from intracellular stores. Phosphatidylinositols 82-98 tachykinin precursor 1 Homo sapiens 42-44 2579657-1 1985 The mammalian tachykinins substance K, neuromedin K and substance P stimulated inositol phospholipid hydrolysis in paired coronal sections through the rat brain. Phosphatidylinositols 79-100 tachykinin precursor 1 Homo sapiens 26-37 2450745-0 1988 Dual mechanism of phosphatidylinositol hydrolysis by substance P in brain. Phosphatidylinositols 18-38 tachykinin precursor 1 Homo sapiens 53-64 2450745-7 1988 These results are consistent with the phosphatidylinositol breakdown caused by substance P in some tissues. Phosphatidylinositols 38-58 tachykinin precursor 1 Homo sapiens 79-90 2450745-9 1988 Thus, in the presence of very low doses of substance P (65 pM) a preferential degradation of 1-acyl(predominantly stearoyl)-2-arachidonoylglycerophosphoinositol molecular species occurs, whereas high doses of the peptide (0.65 microM) induce a generalized hydrolysis of phosphatidylinositol without showing any preference towards molecular species rich in arachidonic acid. Phosphatidylinositols 270-290 tachykinin precursor 1 Homo sapiens 43-54 2450745-10 1988 Hence we describe for the first time a dual, dose-dependent mechanism for phosphatidylinositol hydrolysis by substance P, suggesting the possibility that either phospholipase A2 or phospholipase C activation is involved. Phosphatidylinositols 74-94 tachykinin precursor 1 Homo sapiens 109-120 2579657-1 1985 The mammalian tachykinins substance K, neuromedin K and substance P stimulated inositol phospholipid hydrolysis in paired coronal sections through the rat brain. Phosphatidylinositols 79-100 tachykinin precursor 1 Homo sapiens 56-67 2579657-3 1985 The present results therefore implicate inositol phospholipid hydrolysis as a possible second messenger system mediating the effects of substance K and neuromedin K in addition to substance P. Phosphatidylinositols 40-61 tachykinin precursor 1 Homo sapiens 136-147 24065247-6 2013 DA receptor-mediated regulation of NKA mediates a diverse range of cellular responses and includes endocytosis/exocytosis, phosphorylation/dephosphorylation of the alpha subunit of NKA and multiple signaling pathways, including phosphatidylinositol (PI)-phospholipase C/protein kinase (PK) C, cAMP/PKA, PI3K, adaptor protein 2, tyrosine phosphatase and mitogen-activated protein kinase/extracellular signal-regulated protein kinase. Phosphatidylinositols 228-248 tachykinin precursor 1 Homo sapiens 35-38 38406-4 1979 The binding of SP to phosphatidyl serine, phosphatidyl ethanolamine and phosphatidyl inositol was lowest at pH 2 and increased with pH. Phosphatidylinositols 72-93 tachykinin precursor 1 Homo sapiens 15-17 38406-9 1979 The high affinity (KD = 0.1 microM) and capacity of 44 pmol SP/microgram phosphatidyl serine and 48 pmol SP/microgram phosphatidyl ethanolamine at pH 7.2 under conditions of saturation contrasted with the very low binding of SP to phosphatidyl inositol or phosphatidyl choline. Phosphatidylinositols 231-252 tachykinin precursor 1 Homo sapiens 60-62 38406-9 1979 The high affinity (KD = 0.1 microM) and capacity of 44 pmol SP/microgram phosphatidyl serine and 48 pmol SP/microgram phosphatidyl ethanolamine at pH 7.2 under conditions of saturation contrasted with the very low binding of SP to phosphatidyl inositol or phosphatidyl choline. Phosphatidylinositols 231-252 tachykinin precursor 1 Homo sapiens 105-107 38406-9 1979 The high affinity (KD = 0.1 microM) and capacity of 44 pmol SP/microgram phosphatidyl serine and 48 pmol SP/microgram phosphatidyl ethanolamine at pH 7.2 under conditions of saturation contrasted with the very low binding of SP to phosphatidyl inositol or phosphatidyl choline. Phosphatidylinositols 231-252 tachykinin precursor 1 Homo sapiens 105-107 6204206-0 1984 Correlation between inositol phospholipid hydrolysis and substance P receptors in rat CNS. Phosphatidylinositols 20-41 tachykinin precursor 1 Homo sapiens 57-68 6204206-3 1984 Previous studies have shown that substance P stimulates the hydrolysis of inositol phospholipids in peripheral tissues and in the hypothalamus, probably through stimulation of a polyphosphoinositide-specific phospholipase C (refs 9-11). Phosphatidylinositols 74-96 tachykinin precursor 1 Homo sapiens 33-44 6204206-5 1984 We have therefore investigated the distribution of 3H-labelled substance P binding sites within various rat brain regions and correlated this with the rate of substance P-induced hydrolysis of inositol phospholipids in the same areas of the CNS. Phosphatidylinositols 193-215 tachykinin precursor 1 Homo sapiens 159-170 6204206-6 1984 We found that the rate of inositol phospholipid hydrolysis was proportional to the number of binding sites specific for 3H-substance P, suggesting that binding sites revealed by 3H-substance P autoradiography correspond to functional substance P receptors. Phosphatidylinositols 26-47 tachykinin precursor 1 Homo sapiens 123-134 6204206-6 1984 We found that the rate of inositol phospholipid hydrolysis was proportional to the number of binding sites specific for 3H-substance P, suggesting that binding sites revealed by 3H-substance P autoradiography correspond to functional substance P receptors. Phosphatidylinositols 26-47 tachykinin precursor 1 Homo sapiens 181-192 6204206-6 1984 We found that the rate of inositol phospholipid hydrolysis was proportional to the number of binding sites specific for 3H-substance P, suggesting that binding sites revealed by 3H-substance P autoradiography correspond to functional substance P receptors. Phosphatidylinositols 26-47 tachykinin precursor 1 Homo sapiens 181-192 20435073-11 2010 These results suggest AGEs modulate arachidonic acid and phosphoinositide metabolism to inhibit NKA via clathrin-mediated endocytosis. Phosphatidylinositols 57-73 tachykinin precursor 1 Homo sapiens 96-99 17409218-7 2007 Tac1 expression at high SDF-1alpha involves an intracellular signaling pathway that incorporates the activation of phosphatidylinositol 3-kinase-phosphoinositide-dependent kinase-1-AKT-nuclear factor-kappaB (NF-kappaB). Phosphatidylinositols 115-135 tachykinin precursor 1 Homo sapiens 0-4