PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 31479873-6 2020 Besides, inhibition of autophagy by chloroquine or 3-methyladenin and its activation by rapamycin were associated with elevated mRNA and protein levels of IL-6 and TNF-alpha inflammatory cytokines in C2C12 cells. Chloroquine 36-47 interleukin 6 Mus musculus 155-159 33612800-10 2020 B. pseudomallei-infected mice subjected to adjunct treatment with chloroquine and doxycycline significantly (P<0.05) reduced serum levels of pro-inflammatory cytokines (TNF-alpha, IFN-gamma and IL-6) but increased levels of antiinflammatory cytokines (IL-4 and IL-10). Chloroquine 66-77 interleukin 6 Mus musculus 194-198 17456179-4 2007 Peritoneal macrophages from chloroquine-treated infected mice showed higher H(2)O(2) production and TfR expression, and decreased levels of NO, endogenous and stimulated-TNF-alpha, IL-6 and IL-10 during the three evaluated periods. Chloroquine 28-39 interleukin 6 Mus musculus 181-185 30572800-14 2019 The cfDNA-stimulated IL6 release by macrophage cells was suppressed by chloroquine, a Toll-like receptor 9 (TLR9) inhibitor. Chloroquine 71-82 interleukin 6 Mus musculus 21-24 28884630-7 2018 The IL6 response was significantly inhibited by chloroquine (10 mug/mL), thereby confirming the important role for TLR9 in the response by macrophage cells. Chloroquine 48-59 interleukin 6 Mus musculus 4-7 28249220-7 2017 In addition, the inflammatory responses induced by paraquat were inhibited after treatment with chloroquine, as indicated by the decreased number of leukocytes, the reduced levels of TNF-alpha, IL-1beta and IL-6 in the bronchoalveolar lavage fluid, the reduced NO content, and downregulation of iNOS expression in lung tissues. Chloroquine 96-107 interleukin 6 Mus musculus 207-211 27282478-12 2016 This protective effect of CQ was associated with a reduced expression of the inflammatory mediators interleukin-1beta, interleukin-6, and cyclooxygenase-2, while the levels of matrix metalloproteinases-2 and -9 were not modified. Chloroquine 26-28 interleukin 6 Mus musculus 119-132 25613602-6 2015 Chloroquine combined with low-dose dexamethasone significantly lessened inflammations around the bronchioles (P<0.05) and blood vessels (P<0.01) in the lung tissue, and obviously lowered IL-6 (P<0.05) and PGF2alpha (P<0.001) in the BALF in the asthmatic mice. Chloroquine 0-11 interleukin 6 Mus musculus 193-197 22660171-7 2012 Limiting autophagy in mice with coadministration of chloroquine (CQ) diminishes serum levels of HMGB1, cytokines (IFNG and IL6 but not IL18), and autophagic flux, attenuating weight gain, enhancing DC, T-cell and NK cell numbers, and promoting long-term tumor control in a murine hepatic metastases model. Chloroquine 52-63 interleukin 6 Mus musculus 123-126 22660171-7 2012 Limiting autophagy in mice with coadministration of chloroquine (CQ) diminishes serum levels of HMGB1, cytokines (IFNG and IL6 but not IL18), and autophagic flux, attenuating weight gain, enhancing DC, T-cell and NK cell numbers, and promoting long-term tumor control in a murine hepatic metastases model. Chloroquine 65-67 interleukin 6 Mus musculus 123-126 29926670-10 2018 Compared with ethanol group, addition of CQ increased furtherthe level of LC3-IIexpression, and TG amount, serum AST and ALT activities, and the expression of NF-kappaB p65, TNF-alphaand IL-6. Chloroquine 41-43 interleukin 6 Mus musculus 187-191 28986232-5 2017 Here, we demonstrate that rifampicin pretreatment alleviated rotenone induced release of IL-1beta and IL-6, and its effects were suppressed when autophagy was inhibited by chloroquine. Chloroquine 172-183 interleukin 6 Mus musculus 102-106 14996414-5 2004 We found that 30 mg/kg of CQ could protect mice from lethal challenge by CpG ODN and LPS, and 25 mg/kg of CQ could decrease serum TNF-alpha and IL-6 in rats injected with sublethal doses of CpG ODN and LPS. Chloroquine 106-108 interleukin 6 Mus musculus 144-148 14996414-6 2004 In addition, treatment of murine macrophage ANA-1 cells with 2 mM CQ potently inhibited the release of TNF-alpha, IL-6 and IL-12 induced by CpG ODN and LPS. Chloroquine 66-68 interleukin 6 Mus musculus 114-118 34303829-8 2021 IL-6 and IL-1beta secretions induced by heme in the presence of PRRs agonists were inhibited by chloroquine, but not by calcium chelator BAPTA or inhibitor of endosomal acidification concamycin B. Chloroquine 96-107 interleukin 6 Mus musculus 0-4 10577734-6 1999 CQ treatment of infected mice resulted in parasite clearance that was associated with an earlier production of IL-4, IL-6, and IL-10 when compared with nontreated infected mice. Chloroquine 0-2 interleukin 6 Mus musculus 117-121 1912565-10 1991 Our data indicate that CQ selectively inhibits the release of TNF, IL-6, and PGE2 by KC, while IL-1 secretion was unaffected. Chloroquine 23-25 interleukin 6 Mus musculus 67-71 12523576-7 2002 Chloroquine significantly suppressed CpG ODN-induced splenic proliferation and interleukin 6 (IL-6) production associated with GVHD. Chloroquine 0-11 interleukin 6 Mus musculus 79-92 12523576-7 2002 Chloroquine significantly suppressed CpG ODN-induced splenic proliferation and interleukin 6 (IL-6) production associated with GVHD. Chloroquine 0-11 interleukin 6 Mus musculus 94-98 9570525-2 1998 We report that quinacrine, chloroquine, and structurally related compounds completely inhibit the antiapoptotic effect of CpG-ODN on WEHI 231 murine B lymphoma cells and inhibit CpG-ODN-induced secretion of IL-6 by WEHI 231. Chloroquine 27-38 interleukin 6 Mus musculus 207-211 1912565-6 1991 The administration of CQ led to a significant reduction in the hemorrhage-induced elevation of TNF, IL-6, and PGE2 release by KC; however, IL-1 secretion was not affected by CQ. Chloroquine 22-24 interleukin 6 Mus musculus 100-104 1912565-7 1991 In addition, CQ treatment abolished the hemorrhage-induced increase in circulating TNF and IL-6. Chloroquine 13-15 interleukin 6 Mus musculus 91-95