PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
30431076-5	2019	The attenuation of the autophagic flux by applying the specific inhibitor of autophagy, chloroquine, significantly suppressed DR5 expression.	Chloroquine	88-99	TNF receptor superfamily member 10b	Homo sapiens	126-129	
34080659-8	2021	Blocking autophagy flux with the final stage autophagy inhibitor chloroquine (CQ) also upregulated DR4 and DR5 expression.	Chloroquine	65-76	TNF receptor superfamily member 10b	Homo sapiens	107-110	
34080659-8	2021	Blocking autophagy flux with the final stage autophagy inhibitor chloroquine (CQ) also upregulated DR4 and DR5 expression.	Chloroquine	78-80	TNF receptor superfamily member 10b	Homo sapiens	107-110	
32626921-6	2020	Inhibition of autophagy using autophagy inhibitors 3-methyladenine and chloroquine upregulated the expression of DR5 and enhanced TRAIL-induced apoptosis, as confirmed by the increase of pro-apoptotic proteins caspase-8 and caspase-3.	Chloroquine	71-82	TNF receptor superfamily member 10b	Homo sapiens	113-116	
29929000-7	2018	Furthermore, using chloroquine and siATG5 significantly enhances ROS production and application of the ROS scavenger N-acetyl-cysteine (NAC) rescues the cells undergoing apoptosis by abrogating the expression of DR5 and finally the caspase cascade.	Chloroquine	19-30	TNF receptor superfamily member 10b	Homo sapiens	212-215	
27506940-4	2016	DR5, which is essential for 5-FU-induced apoptosis, accumulated in lysosomes and autophagosomes upon chloroquine treatment.	Chloroquine	101-112	TNF receptor superfamily member 10b	Homo sapiens	0-3	
27506940-8	2016	We conclude that targeting of lysosomes by chloroquine deregulates DR5 trafficking and abrogates 5-FU- but not TRAIL-stimulated cell elimination, hence suggesting a novel mechanism for receptor activation.	Chloroquine	43-54	TNF receptor superfamily member 10b	Homo sapiens	67-70	
26964637-0	2016	Chloroquine enhances TRAIL-mediated apoptosis through up-regulation of DR5 by stabilization of mRNA and protein in cancer cells.	Chloroquine	0-11	TNF receptor superfamily member 10b	Homo sapiens	71-74	
26964637-4	2016	CQ up-regulates DR5 mRNA and protein expression in a dose- and time- dependent manner.	Chloroquine	0-2	TNF receptor superfamily member 10b	Homo sapiens	16-19	
26964637-6	2016	Moreover, we found that CQ decreased the expression of Cbl, an E3 ligase of DR5, and knock-down of Cbl markedly enhanced DR5 up-regulation.	Chloroquine	24-26	TNF receptor superfamily member 10b	Homo sapiens	76-79	
26964637-8	2016	Therefore, this study demonstrates that lysosomal inhibition by CQ may sensitize TRAIL-mediated apoptosis in human renal cancer Caki cells via DR5 up-regulation.	Chloroquine	64-66	TNF receptor superfamily member 10b	Homo sapiens	143-146