PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 3769242-3 1986 In all chloroquine-treated patients spontaneous and IFN-induced NK activities were decreased, as compared with healthy controls or RA patients, not treated with chloroquine. Chloroquine 7-18 interferon alpha 1 Homo sapiens 52-55 29772762-9 2018 In humans, chloroquine treatment did not affect viremia or clinical parameters during the acute stage of the disease (D1 to D14), but affected the levels of C-reactive Protein (CRP), IFNalpha, IL-6, and MCP1 over time (D1 to D16). Chloroquine 11-22 interferon alpha 1 Homo sapiens 183-191 33062720-3 2020 Also, CQ and HCQ inhibit the production of interferon- (IFN-) alpha and IFN-gamma and/or tumor necrotizing factor- (TNF-) alpha. Chloroquine 6-8 interferon alpha 1 Homo sapiens 43-67 32943718-6 2020 Rubicon overexpression or administration of bafilomycin A1 or chloroquine, an inhibitor of late-stage autophagy, suppressed autophagy and activated the type 1 IFN pathway. Chloroquine 62-73 interferon alpha 1 Homo sapiens 159-162 24680477-9 2014 On the other hand, the analysis of the antimalarial effect showed that chloroquine was able to inhibit in vitro the expression of TNFalpha and STAT4 enhanced by IFNalpha. Chloroquine 71-82 interferon alpha 1 Homo sapiens 161-169 26682054-4 2015 Bafilomycin and chloroquine, agents that inhibit the function of endosomal toll-like receptors (TLRs), significantly reduced the capacity of TLR3-, TLR7- and TLR-9-stimulated cells to produce IFN-alpha and the IFN-induced chemokine CXCL10 (IP-10). Chloroquine 16-27 interferon alpha 1 Homo sapiens 192-201 24680477-11 2014 CONCLUSIONS: IFNalpha treatment enhances the induction of TNFalpha and STAT4 in stimulated monocytes, an effect inhibited in vitro by chloroquine treatment. Chloroquine 134-145 interferon alpha 1 Homo sapiens 13-21 24194639-6 2013 Moreover, we report here, for the first time, that in combined therapy, IFNalpha induces a clear process of autophagosome formation, and prior treatment with chloroquine, an autophagy inhibitor, is able to significantly reduce IFNalpha/bozepinib-induced cell death. Chloroquine 158-169 interferon alpha 1 Homo sapiens 72-80 24229417-9 2014 Conversely, 6-DFQs and CQ had similar inhibitory effects on HIV-induced monocyte activation, consistent with the primary mechanism being associated with IFN-alpha signaling. Chloroquine 23-25 interferon alpha 1 Homo sapiens 153-162 24194639-6 2013 Moreover, we report here, for the first time, that in combined therapy, IFNalpha induces a clear process of autophagosome formation, and prior treatment with chloroquine, an autophagy inhibitor, is able to significantly reduce IFNalpha/bozepinib-induced cell death. Chloroquine 158-169 interferon alpha 1 Homo sapiens 227-235 22786771-8 2012 Inhibition of MMP-induced IFN-alpha secretion by cytochalasin D, chloroquine, and an inhibitory G-rich oligodeoxynucleotide identify TLR9 as the receptor for MMP-DNA. Chloroquine 65-76 interferon alpha 1 Homo sapiens 26-35 23755314-9 2013 Chloroquine treatment inhibited DENV-2-induced mTRAIL relocalization and IFN-alpha production by pDC. Chloroquine 0-11 interferon alpha 1 Homo sapiens 73-82 23658644-9 2013 dsRNA- but not dsRNA/LyoVec-induced IFN expression was partly inhibited by chloroquine that suppresses endosomal TLR3 activation. Chloroquine 75-86 interferon alpha 1 Homo sapiens 36-39 22606294-8 2012 Induction of IFN-alpha in pDCs by myxoma virus or Heat-VAC is blocked by chloroquine, which inhibits endosomal acidification required for TLR7/9 signaling, and by inhibitors of cellular kinases PI3K and Akt. Chloroquine 73-84 interferon alpha 1 Homo sapiens 13-16 20713890-7 2010 Although EBV does not establish infection in pDCs, challenge with either live EBV particles or isolated EBV DNA was found to induce the release of IFN-alpha through TLR9, as supported by blockage of TLR9 activity with iODN or chloroquine. Chloroquine 226-237 interferon alpha 1 Homo sapiens 147-156 18844109-13 2008 Chloroquine and inhibitory ODN dose-dependently inhibited the IFN-alpha levels in the supernatant. Chloroquine 0-11 interferon alpha 1 Homo sapiens 62-71 19949061-4 2010 Blocking of IFN-alpha production using chloroquine, an endosomal inhibitor, was tested in a novel in vitro model system with the aim of characterizing the effects of chloroquine on HIV-1-mediated TLR signaling, IFN-alpha production, and T-cell activation. Chloroquine 39-50 interferon alpha 1 Homo sapiens 12-21 19949061-5 2010 Our results indicate that chloroquine blocks TLR-mediated activation of pDC and MyD88 signaling, as shown by decreases in the levels of the downstream signaling molecules IRAK-4 and IRF-7 and by inhibition of IFN-alpha synthesis. Chloroquine 26-37 interferon alpha 1 Homo sapiens 209-218 19949061-8 2010 Our results indicate that TLR stimulation and production of IFN-alpha by pDC contribute to immune activation and that blocking of these pathways using chloroquine may interfere with events contributing to HIV pathogenesis. Chloroquine 151-162 interferon alpha 1 Homo sapiens 60-69 19760134-11 2010 Furthermore, combination treatment of chloroquine to IFNalpha enhanced the antiviral effect of IFNalpha and prevented re-propagation of HCV replicon. Chloroquine 38-49 interferon alpha 1 Homo sapiens 53-61 19760134-11 2010 Furthermore, combination treatment of chloroquine to IFNalpha enhanced the antiviral effect of IFNalpha and prevented re-propagation of HCV replicon. Chloroquine 38-49 interferon alpha 1 Homo sapiens 95-103 16278001-6 2005 IFN induction by HIV-infected cells was also prevented by low-dose chloroquine, which inhibits endosomal acidification. Chloroquine 67-78 interferon alpha 1 Homo sapiens 0-3 15854645-5 2005 The induction of TNF-alpha, IL-6 and interferon alpha (IFN-alpha) was chloroquine-sensitive and dependent more likely on endosomal Toll-like receptor signaling in particular TLR8. Chloroquine 70-81 interferon alpha 1 Homo sapiens 55-64 34813288-7 2021 Our results showed that 50 mug CQ/mg FM decreased MX1 expression and IFN-alpha production after TLR activation with either synthetic nucleic acid agonists or immune complex-rich sera from SLE patients. Chloroquine 31-33 interferon alpha 1 Homo sapiens 69-78 17913823-4 2007 The ability of WNV(Vero) to induce IFN-alpha in pDCs did not require viral replication and was prevented by the treatment of cells with bafilomycin A1 and chloroquine, suggesting that it was dependent on endosomal Toll-like receptor recognition. Chloroquine 155-166 interferon alpha 1 Homo sapiens 35-44 8091644-7 1994 IPC were also tested for sensitivity to the lysosomotropic drug chloroquine, which diminishes IFN-alpha produced in response to HSV but not Sendai virus. Chloroquine 64-75 interferon alpha 1 Homo sapiens 94-103 8091644-8 1994 With the exception of Sendai virus, chloroquine treatment abrogated the majority of IFN-alpha produced and IPC against each of the viruses. Chloroquine 36-47 interferon alpha 1 Homo sapiens 84-93 2126528-3 1990 No effect of rHuIFN-gamma was seen against experimental relapsing stage compared with controls; however, it appears that chloroquine (CHL) may have interfered with the antimalarial effect of IFN, since treatment with CHL inhibits the antiviral activity of mouse alpha/beta IFN and polyinosinic-polycytidylic acid (poly I:C) against Semliki forest virus (SFV) in mice. Chloroquine 121-132 interferon alpha 1 Homo sapiens 191-194