PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 33748286-6 2021 Furthermore, rapamycin reduced urinary protein-induced NGAL and KIM-1 secretion and cell growth inhibition, while chloroquine played the opposite effect, indicating that autophagy activation by ERK pathway was an adaptive response in the exposure to urinary proteins. Chloroquine 114-125 mitogen-activated protein kinase 1 Homo sapiens 194-197 32753885-0 2020 Chloroquine Combined with Imatinib Overcomes Imatinib Resistance in Gastrointestinal Stromal Tumors by Inhibiting Autophagy via the MAPK/ERK Pathway. Chloroquine 0-11 mitogen-activated protein kinase 1 Homo sapiens 137-140 33062720-6 2020 Additionally, CQ is capable of blocking lipopolysaccharide- (LPS-) triggered stimulation of extracellular signal-modulated extracellular signal-regulated kinases 1/2 in human PBMCs. Chloroquine 14-16 mitogen-activated protein kinase 1 Homo sapiens 123-165 31208693-4 2019 Importantly, they demonstrated that autophagy blockade via chloroquine (CQ) or hydroxychloroquine (HCQ) enhanced the efficacy of MEK-ERK inhibition in various preclinical models of KRAS-driven cancers, providing a rational basis for future clinical evaluation of this combination therapy. Chloroquine 59-70 mitogen-activated protein kinase 1 Homo sapiens 133-136 32104716-0 2020 Chloroquine and Rapamycin Augment Interleukin-37 Expression via the LC3, ERK, and AP-1 Axis in the Presence of Lipopolysaccharides. Chloroquine 0-11 mitogen-activated protein kinase 1 Homo sapiens 73-76 31208693-4 2019 Importantly, they demonstrated that autophagy blockade via chloroquine (CQ) or hydroxychloroquine (HCQ) enhanced the efficacy of MEK-ERK inhibition in various preclinical models of KRAS-driven cancers, providing a rational basis for future clinical evaluation of this combination therapy. Chloroquine 72-74 mitogen-activated protein kinase 1 Homo sapiens 133-136 19088425-4 2008 The chloroquine-mediated cell cycle arrest was associated with a decrease in protein levels/activity of polo-like kinase 1 (Plk1), phosphorylated cell division cycle 25C (Cdc25C), phosphorylated extracellular signal-regulated kinase 1/2 (ERK1/2), phosphorylated Akt. Chloroquine 4-15 mitogen-activated protein kinase 1 Homo sapiens 195-236 30833752-5 2019 Accordingly, we found that the autophagy inhibitor chloroquine and genetic or pharmacologic inhibition of specific autophagy regulators synergistically enhanced the ability of ERK inhibitors to mediate antitumor activity in KRAS-driven PDAC. Chloroquine 51-62 mitogen-activated protein kinase 1 Homo sapiens 176-179 26572581-11 2016 Moreover, orexin A upregulated ERK phosphorylation; however, U0126 or chloroquine abrogated ERK phosphorylation and decreased autophagy, compared to treatment with orexin A alone. Chloroquine 70-81 mitogen-activated protein kinase 1 Homo sapiens 92-95 26690546-10 2015 Chloroquine alleviated CDK2 and ERK, but not Chk2, activation and thus inhibited centrosome amplification in either ETO- or hydroxyurea-treated ACT cells. Chloroquine 0-11 mitogen-activated protein kinase 1 Homo sapiens 32-35 26690546-12 2015 In summary, we have demonstrated that chloroquine inhibited ACT cell growth and alleviated DNA damage-induced centrosome amplification by inhibiting CDK2 and ERK activity, thus preventing genomic instability and recurrence of ACT. Chloroquine 38-49 mitogen-activated protein kinase 1 Homo sapiens 158-161 24785258-6 2014 The inhibitory effect of chloroquine was not related to inhibition of autophagy, but was due to inhibition of CXCL12/CXCR4 signaling, resulting in reduced phosphorylation of ERK and STAT3. Chloroquine 25-36 mitogen-activated protein kinase 1 Homo sapiens 174-177 18379071-3 2008 Chloroquine effectively suppressed U937 cell-cell adhesion mediated by CD29 and CD98, in a protein kinase (PK) C, PKA, protein tyrosine kinase (PTK), extracellular signal-regulated kinase (ERK) and actin cytoskeleton-independent manner. Chloroquine 0-11 mitogen-activated protein kinase 1 Homo sapiens 150-187 18379071-3 2008 Chloroquine effectively suppressed U937 cell-cell adhesion mediated by CD29 and CD98, in a protein kinase (PK) C, PKA, protein tyrosine kinase (PTK), extracellular signal-regulated kinase (ERK) and actin cytoskeleton-independent manner. Chloroquine 0-11 mitogen-activated protein kinase 1 Homo sapiens 189-192 18055026-3 2008 We demonstrated that CQ affects the activation of p38 mitogen-activated protein kinase (MAPK) and extracellular signal-regulated kinase (ERK). Chloroquine 21-23 mitogen-activated protein kinase 1 Homo sapiens 88-92 18055026-3 2008 We demonstrated that CQ affects the activation of p38 mitogen-activated protein kinase (MAPK) and extracellular signal-regulated kinase (ERK). Chloroquine 21-23 mitogen-activated protein kinase 1 Homo sapiens 98-135 18055026-3 2008 We demonstrated that CQ affects the activation of p38 mitogen-activated protein kinase (MAPK) and extracellular signal-regulated kinase (ERK). Chloroquine 21-23 mitogen-activated protein kinase 1 Homo sapiens 137-140 35201948-7 2022 In summary, IGF1R and MAPK/ERK signaling promotes resistance to CQ/HCQ in PDAC, and their dual inhibition increases sensitivity to autophagy inhibitors. Chloroquine 64-67 mitogen-activated protein kinase 1 Homo sapiens 27-30 11994488-9 2002 Taken together, these data argue that therapeutic concentrations of CQ interfere with ERK activation by a novel mechanism, an effect that could be responsible, at least in part, for the potent anti-inflammatory effects of this drug. Chloroquine 68-70 mitogen-activated protein kinase 1 Homo sapiens 86-89 34852220-3 2021 CHK1 inhibition also activates ERK and AMPK and increases autophagy, providing a mechanistic basis for increased efficacy of concurrent CHK1 and ERK inhibition and/or autophagy inhibition with chloroquine. Chloroquine 193-204 mitogen-activated protein kinase 1 Homo sapiens 31-34