PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 33727332-4 2021 Calcium imaging studies demonstrated MrgprA3 and MrgprC11 agonists (chloroquine, BAM8-22 and neuropeptide FF) activated sub-populations of bladder-innervating DRG neurons, showing functional evidence of co-expression between MrgprA3, MrgprC11 and TRPV1. Chloroquine 68-79 MAS-related GPR, member A3 Mus musculus 37-44 33010342-3 2020 Chloroquine, BAM-822, and SLIGRL respectively bind to Mas-related G-protein-coupled receptors MrgprA3, MrgprC11, and MrgprC11/PAR2 that in turn activate TRPA1. Chloroquine 0-11 MAS-related GPR, member A3 Mus musculus 94-101 34986325-6 2022 Moreover, Nmb in MRGPRA3+ afferents and NMBR+ DH neurons are required for chloroquine-induced scratching. Chloroquine 74-85 MAS-related GPR, member A3 Mus musculus 17-24 30337807-0 2018 Korean Red Ginseng extract and ginsenoside Rg3 have anti-pruritic effects on chloroquine-induced itch by inhibition of MrgprA3/TRPA1-mediated pathway. Chloroquine 77-88 MAS-related GPR, member A3 Mus musculus 119-126 30337807-5 2018 Results: CQ-induced Ca2+ influx was strongly inhibited by KRGE (10 mug/mL) in MrgprA3/TRPA1, and notably ginsenoside Rg3 dose-dependently suppressed CQ-induced Ca2+ influx in MrgprA3/TRPA1. Chloroquine 9-11 MAS-related GPR, member A3 Mus musculus 78-85 30337807-5 2018 Results: CQ-induced Ca2+ influx was strongly inhibited by KRGE (10 mug/mL) in MrgprA3/TRPA1, and notably ginsenoside Rg3 dose-dependently suppressed CQ-induced Ca2+ influx in MrgprA3/TRPA1. Chloroquine 9-11 MAS-related GPR, member A3 Mus musculus 175-182 30337807-5 2018 Results: CQ-induced Ca2+ influx was strongly inhibited by KRGE (10 mug/mL) in MrgprA3/TRPA1, and notably ginsenoside Rg3 dose-dependently suppressed CQ-induced Ca2+ influx in MrgprA3/TRPA1. Chloroquine 149-151 MAS-related GPR, member A3 Mus musculus 175-182 28217875-1 2017 KEY POINTS: Chloroquine (CQ) stimulates itch nerves and causes intense scratching in mice by activating the G-protein coupled receptor (GPCR) MrgprA3; it is not known how stimulation of MrgprA3 (or other GPCRs) leads to activation of the itch nerve terminals in the skin, but previous studies have found that transient receptor potential A1 (TRPA1) gene deletion blocks CQ-induced scratching. Chloroquine 12-23 MAS-related GPR, member A3 Mus musculus 142-149 28217875-1 2017 KEY POINTS: Chloroquine (CQ) stimulates itch nerves and causes intense scratching in mice by activating the G-protein coupled receptor (GPCR) MrgprA3; it is not known how stimulation of MrgprA3 (or other GPCRs) leads to activation of the itch nerve terminals in the skin, but previous studies have found that transient receptor potential A1 (TRPA1) gene deletion blocks CQ-induced scratching. Chloroquine 25-27 MAS-related GPR, member A3 Mus musculus 142-149 28217875-1 2017 KEY POINTS: Chloroquine (CQ) stimulates itch nerves and causes intense scratching in mice by activating the G-protein coupled receptor (GPCR) MrgprA3; it is not known how stimulation of MrgprA3 (or other GPCRs) leads to activation of the itch nerve terminals in the skin, but previous studies have found that transient receptor potential A1 (TRPA1) gene deletion blocks CQ-induced scratching. Chloroquine 25-27 MAS-related GPR, member A3 Mus musculus 186-193 28217875-9 2017 The response to CQ, but not histamine, was largely absent in mrgpr-cluster Delta-/- mice, supporting the hypothesis that CQ evokes itch largely via stimulation of MrgprA3 receptors. Chloroquine 121-123 MAS-related GPR, member A3 Mus musculus 163-170 21460831-4 2011 MrgprA3 and MrgprC11 act as receptors for the pruritogens chloroquine and BAM8-22, respectively. Chloroquine 58-69 MAS-related GPR, member A3 Mus musculus 0-7 20004959-6 2009 CQ specifically activates mouse MrgprA3 and human MrgprX1. Chloroquine 0-2 MAS-related GPR, member A3 Mus musculus 32-39 20004959-7 2009 Loss- and gain-of-function studies demonstrate that MrgprA3 is required for CQ responsiveness in mice. Chloroquine 76-78 MAS-related GPR, member A3 Mus musculus 52-59 32298640-2 2020 Here, we tested the multimodal capacity of peripheral first-order neurons, focusing on the genetically defined subpopulation of mouse C-fibers that express the chloroquine receptor MrgprA3. Chloroquine 160-171 MAS-related GPR, member A3 Mus musculus 181-188 31003539-5 2019 For example, mouse MrgprA3 responds to chloroquine (an anti-malarial drug), and are responsible for relaying chloroquine-induced scratching in mice. Chloroquine 39-50 MAS-related GPR, member A3 Mus musculus 19-26 31003539-5 2019 For example, mouse MrgprA3 responds to chloroquine (an anti-malarial drug), and are responsible for relaying chloroquine-induced scratching in mice. Chloroquine 109-120 MAS-related GPR, member A3 Mus musculus 19-26 29064954-0 2017 MrgprA3 shows sensitization to chloroquine in an acetone-ether-water mice model. Chloroquine 31-42 MAS-related GPR, member A3 Mus musculus 0-7 29064954-7 2017 The results showed that the scratching bouts induced by chloroquine increased significantly under the AEW condition; the density of MrgprA3 sensory fibers in the AEW-treated skin area and the number of MrgprA3 neurons in dorsal root ganglia from the AEW model mice also increased significantly. Chloroquine 56-67 MAS-related GPR, member A3 Mus musculus 202-209 23000623-4 2012 The MrgprA3 agonist chloroquine unidirectionally cross-sensitized BAM8-22-evoked scratching. Chloroquine 20-31 MAS-related GPR, member A3 Mus musculus 4-11 35066892-5 2022 Among 12 Mrgprs deleted in Mrgpr-clusterDelta-/- mice, the expression of MrgprC11 and MrgprA3 are significantly increased in ACD model, which also innervate the skin and spinal cord at higher-than-normal densities, the proportions of dorsal root ganglia neurons responding to bovine adrenal medulla peptide 8-22 and chloroquine are also remarkably increased in ACD model and result in enhancing itch behavior. Chloroquine 316-327 MAS-related GPR, member A3 Mus musculus 86-93