PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34306988-4 2021 Since Chloroquine has been looked as potential therapy against COVID-19, we also compared the binding of chloroquine and artemisinin for its interaction with spike proteins (6VXX, 6VYB) and its variant 7NXA, respectively. Chloroquine 105-116 surface glycoprotein Severe acute respiratory syndrome coronavirus 2 158-163 33979123-4 2021 Among promising candidates identified, several dyes (Congo red, direct violet 1, Evans blue) and novel druglike compounds (DRI-C23041, DRI-C91005) inhibited the interaction of hACE2 with the spike proteins of SARS-CoV-2 as well as SARS-CoV with low micromolar activity in our cell-free ELISA-type assays (IC50"s of 0.2-3.0 muM), whereas control compounds, such as sunset yellow FCF, chloroquine, and suramin, showed no activity. Chloroquine 383-394 surface glycoprotein Severe acute respiratory syndrome coronavirus 2 191-196 33535144-5 2021 In this study, we focused on identifying a more potent analogue of HCQ and CQ against the spike protein of SAR-CoV-2 that can act as an effective antiviral agent for COVID-19 treatment. Chloroquine 68-70 surface glycoprotein Severe acute respiratory syndrome coronavirus 2 90-95 33977847-0 2021 Computational and experimental insights on the interaction of artemisinin, dihydroartemisinin and chloroquine with SARS-CoV-2 spike protein receptor-binding domain (RBD). Chloroquine 98-109 surface glycoprotein Severe acute respiratory syndrome coronavirus 2 126-131 33750821-3 2021 The endosomal acidification inhibitors (8P9R and chloroquine) can synergistically enhance the activity of arbidol, a spike-ACE2 fusion inhibitor, against SARS-CoV-2 and SARS-CoV in cells. Chloroquine 49-60 surface glycoprotein Severe acute respiratory syndrome coronavirus 2 117-122 32920291-0 2020 Chloroquine and hydroxychloroquine as ACE2 blockers to inhibit viropexis of 2019-nCoV Spike pseudotyped virus. Chloroquine 0-11 surface glycoprotein Severe acute respiratory syndrome coronavirus 2 86-91 32562764-3 2020 Furthermore, it is emphasized that the viral spike protein is prevented from binding gangliosides, which are composed of a glycosphingolipid with one or more sialic acids, in the presence of chloroquine or hydroxychloroquine. Chloroquine 191-202 surface glycoprotein Severe acute respiratory syndrome coronavirus 2 45-50