PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
19088425-5	2008	The chloroquine-treated Bcap-37 cells exhibited a marked decrease in the level of mitochondrial transmembrane potential (DeltaPsim), which was accompanied by the activation of caspase-3 and cleaved poly(ADP-ribose) polymerase (PARP).	Chloroquine	4-15	poly(ADP-ribose) polymerase 1	Homo sapiens	198-225	
32214849-11	2020	Chloroquine treatment enhanced autophagosome accumulation and cell death but with reduced c-PARP level suggests that mechanism of caspase-independent cell death also contributes to Verapamil/chemotherapy-induced anticancer effects.	Chloroquine	0-11	poly(ADP-ribose) polymerase 1	Homo sapiens	92-96	
31653348-7	2020	In the combined treatment of MTX and CQ, where autophagy was inhibited by CQ, the elevations of cleaved Caspase-3 and PARP were observed, indicating the enhanced apoptosis in HepG2 cells.	Chloroquine	37-39	poly(ADP-ribose) polymerase 1	Homo sapiens	118-122	
29382424-5	2017	The apoptotic protease caspase-3 and substrate PARP were obviously degraded, which could be enhanced by 3-MA but inhibited by CQ.	Chloroquine	126-128	poly(ADP-ribose) polymerase 1	Homo sapiens	47-51	
28433067-6	2017	Moreover, bladder cancer cells treated with CQ and HCQ underwent apoptosis, resulting in increased caspase 3/7 activities, increased level of cleaved poly(ADP-ribose) polymerase (PARP), caspase 3, and DNA fragmentation.	Chloroquine	44-46	poly(ADP-ribose) polymerase 1	Homo sapiens	150-177	
28433067-6	2017	Moreover, bladder cancer cells treated with CQ and HCQ underwent apoptosis, resulting in increased caspase 3/7 activities, increased level of cleaved poly(ADP-ribose) polymerase (PARP), caspase 3, and DNA fragmentation.	Chloroquine	44-46	poly(ADP-ribose) polymerase 1	Homo sapiens	179-183	
19088425-5	2008	The chloroquine-treated Bcap-37 cells exhibited a marked decrease in the level of mitochondrial transmembrane potential (DeltaPsim), which was accompanied by the activation of caspase-3 and cleaved poly(ADP-ribose) polymerase (PARP).	Chloroquine	4-15	poly(ADP-ribose) polymerase 1	Homo sapiens	227-231	
32766148-0	2020	Chloroquine Triggers Cell Death and Inhibits PARPs in Cell Models of Aggressive Hepatoblastoma.	Chloroquine	0-11	poly(ADP-ribose) polymerase 1	Homo sapiens	45-50	
32766148-15	2020	Conclusions: CQ treatment inhibits cell survival in cell models of aggressive HB, presumably by perturbing NAD+ levels, impairing aspartate bioavailability, and inhibiting PARP expression.	Chloroquine	13-15	poly(ADP-ribose) polymerase 1	Homo sapiens	172-176	
30337735-9	2018	While 3-MA, an early autophagy inhibitor, reduced the ST-induced cleavage of poly (ADP-ribose) polymerase-1 (PARP-1), a substrate of caspase 3/7 and often used marker of caspase-dependent apoptosis, CQ promoted the ST-dependent PARP-1 cleavage, indicating that the early and late autophagy functioned differentially on the ST-activated apoptotic process.	Chloroquine	199-201	poly(ADP-ribose) polymerase 1	Homo sapiens	109-115	
26043797-8	2015	Pretreatment with the autophagy inhibitors LY294002, 3-methyladenine, chloroquine, and bafilomycin A1 enhanced the induction of apoptosis by MHY218, and this was accompanied by an increase in PARP cleavage.	Chloroquine	70-81	poly(ADP-ribose) polymerase 1	Homo sapiens	192-196	
23695424-12	2013	Chloroquine, NAC and bafilomycin A1 also decreased tetrandrine-induced cleaved caspase-3 and cleaved PARP in SAS cells.	Chloroquine	0-11	poly(ADP-ribose) polymerase 1	Homo sapiens	101-105	
22824846-5	2012	Moreover, we demonstrate that the collapse of the mitochondrial membrane potential contributes to chloroquine and IBC-induced cell death, which is accompanied by the activation of caspase-9, and -3, the cleavage of poly (ADP-ribose) polymerase (PARP) and the proteolytic activation of protein kinase Cdelta (PKCdelta).	Chloroquine	98-109	poly(ADP-ribose) polymerase 1	Homo sapiens	215-243	
22824846-5	2012	Moreover, we demonstrate that the collapse of the mitochondrial membrane potential contributes to chloroquine and IBC-induced cell death, which is accompanied by the activation of caspase-9, and -3, the cleavage of poly (ADP-ribose) polymerase (PARP) and the proteolytic activation of protein kinase Cdelta (PKCdelta).	Chloroquine	98-109	poly(ADP-ribose) polymerase 1	Homo sapiens	245-249	
34356312-8	2021	Interestingly, using autophagy inhibitors such as 3-methyladenine (3-MA) and chloroquine (CQ) both showed an increase in cleaved-PARP protein level, indicating apoptosis induction.	Chloroquine	77-88	poly(ADP-ribose) polymerase 1	Homo sapiens	129-133	
34356312-8	2021	Interestingly, using autophagy inhibitors such as 3-methyladenine (3-MA) and chloroquine (CQ) both showed an increase in cleaved-PARP protein level, indicating apoptosis induction.	Chloroquine	90-92	poly(ADP-ribose) polymerase 1	Homo sapiens	129-133