PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
33416933-8	2021	Studies indicate that one of the possible anti-inflammatory mechanisms of chloroquine and hydroxychloroquine is inhibition of the activity of NLRP3 inflammasome.	Chloroquine	74-85	NLR family pyrin domain containing 3	Homo sapiens	142-147	
35633614-8	2022	Furthermore, we found that the autophagy inhibitor chloroquine, not the proteasome inhibitor MG132, could counteract the promoting effect of tCQA on NLRP3 degradation and the inhibitory effect on cell death.	Chloroquine	51-62	NLR family pyrin domain containing 3	Homo sapiens	149-154	
34492927-5	2021	Besides, both 3-MA and CQ addition increased NLRP3, Caspase-1, NEK7, ASC, GSDMA, GSDME, IL-1beta, IL-18 mRNA levels, NLRP3, Caspase-1 p20, ASC, GSDMD protein and ROS levels, and NO, LDH, IL-1beta, IL-18 releases.	Chloroquine	23-25	NLR family pyrin domain containing 3	Homo sapiens	45-50	
34492927-5	2021	Besides, both 3-MA and CQ addition increased NLRP3, Caspase-1, NEK7, ASC, GSDMA, GSDME, IL-1beta, IL-18 mRNA levels, NLRP3, Caspase-1 p20, ASC, GSDMD protein and ROS levels, and NO, LDH, IL-1beta, IL-18 releases.	Chloroquine	23-25	NLR family pyrin domain containing 3	Homo sapiens	117-122	
33254688-10	2020	Conversely, chloroquine, an autophagic flux inhibitor, exacerbated PFOA-induced lipid accumulation and NLRP3 inflammasome activation.	Chloroquine	12-23	NLR family pyrin domain containing 3	Homo sapiens	103-108	
32088265-4	2020	Chloroquine and hydroxychloroquine increased IL-1beta-induced CXCL8 secretion in macrophages which was critically dependent on the lysosomotropic character and inhibition of macroautophagy but independent from the NLRP3 inflammasome.	Chloroquine	0-11	NLR family pyrin domain containing 3	Homo sapiens	214-219	
19001869-6	2008	Unexpectedly, microarray analysis of PBMC from patients treated with chloroquine reveals a reversal of disease-linked KPNA1-, NLRP1- and NLRP3-gene expression phenotypes, implying that chloroquine could serve as a readily clinically available drug for targeted correction of identified aberrations.	Chloroquine	69-80	NLR family pyrin domain containing 3	Homo sapiens	137-142	
19001869-6	2008	Unexpectedly, microarray analysis of PBMC from patients treated with chloroquine reveals a reversal of disease-linked KPNA1-, NLRP1- and NLRP3-gene expression phenotypes, implying that chloroquine could serve as a readily clinically available drug for targeted correction of identified aberrations.	Chloroquine	185-196	NLR family pyrin domain containing 3	Homo sapiens	137-142