PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 19001869-6 2008 Unexpectedly, microarray analysis of PBMC from patients treated with chloroquine reveals a reversal of disease-linked KPNA1-, NLRP1- and NLRP3-gene expression phenotypes, implying that chloroquine could serve as a readily clinically available drug for targeted correction of identified aberrations. Chloroquine 69-80 NLR family pyrin domain containing 3 Homo sapiens 137-142 19001869-6 2008 Unexpectedly, microarray analysis of PBMC from patients treated with chloroquine reveals a reversal of disease-linked KPNA1-, NLRP1- and NLRP3-gene expression phenotypes, implying that chloroquine could serve as a readily clinically available drug for targeted correction of identified aberrations. Chloroquine 185-196 NLR family pyrin domain containing 3 Homo sapiens 137-142 34492927-5 2021 Besides, both 3-MA and CQ addition increased NLRP3, Caspase-1, NEK7, ASC, GSDMA, GSDME, IL-1beta, IL-18 mRNA levels, NLRP3, Caspase-1 p20, ASC, GSDMD protein and ROS levels, and NO, LDH, IL-1beta, IL-18 releases. Chloroquine 23-25 NLR family pyrin domain containing 3 Homo sapiens 45-50 34492927-5 2021 Besides, both 3-MA and CQ addition increased NLRP3, Caspase-1, NEK7, ASC, GSDMA, GSDME, IL-1beta, IL-18 mRNA levels, NLRP3, Caspase-1 p20, ASC, GSDMD protein and ROS levels, and NO, LDH, IL-1beta, IL-18 releases. Chloroquine 23-25 NLR family pyrin domain containing 3 Homo sapiens 117-122 33416933-8 2021 Studies indicate that one of the possible anti-inflammatory mechanisms of chloroquine and hydroxychloroquine is inhibition of the activity of NLRP3 inflammasome. Chloroquine 74-85 NLR family pyrin domain containing 3 Homo sapiens 142-147 33254688-10 2020 Conversely, chloroquine, an autophagic flux inhibitor, exacerbated PFOA-induced lipid accumulation and NLRP3 inflammasome activation. Chloroquine 12-23 NLR family pyrin domain containing 3 Homo sapiens 103-108 32088265-4 2020 Chloroquine and hydroxychloroquine increased IL-1beta-induced CXCL8 secretion in macrophages which was critically dependent on the lysosomotropic character and inhibition of macroautophagy but independent from the NLRP3 inflammasome. Chloroquine 0-11 NLR family pyrin domain containing 3 Homo sapiens 214-219 35633614-8 2022 Furthermore, we found that the autophagy inhibitor chloroquine, not the proteasome inhibitor MG132, could counteract the promoting effect of tCQA on NLRP3 degradation and the inhibitory effect on cell death. Chloroquine 51-62 NLR family pyrin domain containing 3 Homo sapiens 149-154