PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 1311859-4 1992 We report here that trans-UCA is biologically active in vitro in human dermal fibroblasts, inducing adenyl cyclase as measured by cAMP (adenosine 3",5"-cyclic monophosphate) formation in a dose-dependent manner similar to the action of histamine. Urocanic Acid 20-29 cathelicidin antimicrobial peptide Homo sapiens 130-134 1311859-6 1992 Cis-UCA does not increase cAMP in these human fibroblasts but actively down regulates the increase of cAMP induced by either histamine or trans-UCA. Urocanic Acid 138-147 cathelicidin antimicrobial peptide Homo sapiens 102-106 1311859-8 1992 The trans-UCA induction of cAMP can also be downregulated with an H2 histamine receptor antagonist cimetidine. Urocanic Acid 4-13 cathelicidin antimicrobial peptide Homo sapiens 27-31