PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 27129170-2 2016 In this study, we identified a novel C21 steroidal glycoside, asclepiasterol, capable of reversing P-gp-mediated MDR. Glycosides 51-60 ATP binding cassette subfamily B member 1 Homo sapiens 99-103 19647009-4 2009 The mechanism by which cardioactive glycosides increase Pgp is not known and in this work we investigated whether digoxin and ouabain elicited the expression of Pgp with a calcium-driven mechanism. Glycosides 36-46 ATP binding cassette subfamily B member 1 Homo sapiens 56-59 26823559-3 2016 The calcium channel antagonist, verapamil and the cardiac glycoside, digoxin, exhibit DDIs with Pgp through non-competitive inhibition of digoxin transport, which leads to elevated digoxin plasma concentrations and digoxin toxicity. Glycosides 58-67 ATP binding cassette subfamily B member 1 Homo sapiens 96-99 23602050-5 2013 Furthermore, we showed that P-gp located at the nuclear envelope might have a different glycoside chain when compared to the form located in the cytoplasm. Glycosides 88-97 ATP binding cassette subfamily B member 1 Homo sapiens 28-32 23602050-6 2013 It suggests that the glycoside chain plays a role in the intracellular trafficking of P-gp and may decide about the destination place in the cell. Glycosides 21-30 ATP binding cassette subfamily B member 1 Homo sapiens 86-90 19647009-9 2009 This work clarified the molecular mechanisms by which digoxin and oubain induce Pgp and pointed out that the administration of cardioactive glycosides may widely affect the absorption of drugs in colon epithelia. Glycosides 140-150 ATP binding cassette subfamily B member 1 Homo sapiens 80-83 18317988-1 2008 Digoxin, a commonly prescribed cardiac glycoside with a narrow therapeutic window, is routinely used in pharmacokinetic studies to assess the in vivo activity of the drug efflux pump P-glycoprotein. Glycosides 39-48 ATP binding cassette subfamily B member 1 Homo sapiens 183-197 1360207-0 1992 The MDR1 gene product, P-glycoprotein, mediates the transport of the cardiac glycoside, digoxin. Glycosides 77-86 ATP binding cassette subfamily B member 1 Homo sapiens 4-8 1360207-0 1992 The MDR1 gene product, P-glycoprotein, mediates the transport of the cardiac glycoside, digoxin. Glycosides 77-86 ATP binding cassette subfamily B member 1 Homo sapiens 23-37 12364568-3 2002 Expression of transport proteins in the heart could be an important factor modifying cardiac concentrations of drugs known to be transported by P-gp (e.g., beta-blockers, cardiac glycosides, doxorubicin). Glycosides 179-189 ATP binding cassette subfamily B member 1 Homo sapiens 144-148