PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
27129170-2	2016	In this study, we identified a novel C21 steroidal glycoside, asclepiasterol, capable of reversing P-gp-mediated MDR.	Glycosides	51-60	ATP binding cassette subfamily B member 1	Homo sapiens	99-103	
19647009-4	2009	The mechanism by which cardioactive glycosides increase Pgp is not known and in this work we investigated whether digoxin and ouabain elicited the expression of Pgp with a calcium-driven mechanism.	Glycosides	36-46	ATP binding cassette subfamily B member 1	Homo sapiens	56-59	
26823559-3	2016	The calcium channel antagonist, verapamil and the cardiac glycoside, digoxin, exhibit DDIs with Pgp through non-competitive inhibition of digoxin transport, which leads to elevated digoxin plasma concentrations and digoxin toxicity.	Glycosides	58-67	ATP binding cassette subfamily B member 1	Homo sapiens	96-99	
23602050-5	2013	Furthermore, we showed that P-gp located at the nuclear envelope might have a different glycoside chain when compared to the form located in the cytoplasm.	Glycosides	88-97	ATP binding cassette subfamily B member 1	Homo sapiens	28-32	
23602050-6	2013	It suggests that the glycoside chain plays a role in the intracellular trafficking of P-gp and may decide about the destination place in the cell.	Glycosides	21-30	ATP binding cassette subfamily B member 1	Homo sapiens	86-90	
19647009-9	2009	This work clarified the molecular mechanisms by which digoxin and oubain induce Pgp and pointed out that the administration of cardioactive glycosides may widely affect the absorption of drugs in colon epithelia.	Glycosides	140-150	ATP binding cassette subfamily B member 1	Homo sapiens	80-83	
18317988-1	2008	Digoxin, a commonly prescribed cardiac glycoside with a narrow therapeutic window, is routinely used in pharmacokinetic studies to assess the in vivo activity of the drug efflux pump P-glycoprotein.	Glycosides	39-48	ATP binding cassette subfamily B member 1	Homo sapiens	183-197	
1360207-0	1992	The MDR1 gene product, P-glycoprotein, mediates the transport of the cardiac glycoside, digoxin.	Glycosides	77-86	ATP binding cassette subfamily B member 1	Homo sapiens	4-8	
1360207-0	1992	The MDR1 gene product, P-glycoprotein, mediates the transport of the cardiac glycoside, digoxin.	Glycosides	77-86	ATP binding cassette subfamily B member 1	Homo sapiens	23-37	
12364568-3	2002	Expression of transport proteins in the heart could be an important factor modifying cardiac concentrations of drugs known to be transported by P-gp (e.g., beta-blockers, cardiac glycosides, doxorubicin).	Glycosides	179-189	ATP binding cassette subfamily B member 1	Homo sapiens	144-148