PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
22147564-5	2012	Interestingly, the inhibition of the final molecules was found in the low micromolar range (IC(50) =7-45 muM), whereas the corresponding monomeric glycosides displayed high micromolar to low millimolar inhibition levels (IC(50) always above 400 muM).	Glycosides	147-157	latexin	Homo sapiens	105-108	
16346994-2	1986	The formation of highly fluorescent MUF on hydrolysis of the various glycosides was determined at low substrate concentrations (<1 muM) and with short incubation periods (>5 min).	Glycosides	69-79	latexin	Homo sapiens	134-137	
30097766-6	2019	Among them, macrolactone-type resin glycosides (jalapins), 1, 2, and 9, specifically demonstrated clear cytotoxic activity with IC50 values of 3.46, 14.7, and 10.9 muM, respectively.	Glycosides	36-46	latexin	Homo sapiens	164-167	
31527358-4	2019	In various in vitro studies, cardiac glycosides at sub-muM concentrations, which have no significant effect on enzymatic and ion-transporting activities of Na+,K+-ATPase, show anti-cancer effects.	Glycosides	37-47	latexin	Homo sapiens	55-58	
31527358-6	2019	Recently, we found that the receptor-type Na+,K+-ATPase, which has no pumping activity, is associated with leucine-rich repeat-containing 8 family, member A(LRRC8A), one of the components of volume-regulated anion channel (VRAC), in the membrane microdomains of plasma membrane of cancer cells, and that this crosstalk contributes to the inhibition of the cancer cell growth by sub-muM cardiac glycosides.	Glycosides	394-404	latexin	Homo sapiens	382-385	
22147564-5	2012	Interestingly, the inhibition of the final molecules was found in the low micromolar range (IC(50) =7-45 muM), whereas the corresponding monomeric glycosides displayed high micromolar to low millimolar inhibition levels (IC(50) always above 400 muM).	Glycosides	147-157	latexin	Homo sapiens	245-248	
21421322-8	2011	For the cancer cell viability assay the shortest mimics were found to have highest efficacy, with the best ligand having a monoethylene glycol unit (IC(50) 0.24 muM), which was slightly better than digitoxigenin (IC(50) 0.64 muM), while none of the novel cardiac glycoside mimics display an in vitro effect as high as digitoxin (IC(50) 0.02 muM).	Glycosides	263-272	latexin	Homo sapiens	161-164	
21221670-8	2011	Western blotting confirmed that Posiphen and the cardiac glycoside, strophanthidine, selectively blocked SNCA expression (~1 muM IC(50)) in neural cells.	Glycosides	57-66	latexin	Homo sapiens	125-128