PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 30958073-0 2019 Emerging drug profile: Krebs cycle and cancer: IDH mutations and therapeutic implications. krebs 23-28 isocitrate dehydrogenase (NADP(+)) 1 Homo sapiens 47-50 34344935-2 2021 Aerobic life forms generate ATP through the oxidation of organic molecules in a process known as Krebs" Cycle, where the enzyme isocitrate dehydrogenase (IDH) regulates the cycle"s turnover rate. krebs 97-102 isocitrate dehydrogenase (NADP(+)) 1 Homo sapiens 128-152 34344935-2 2021 Aerobic life forms generate ATP through the oxidation of organic molecules in a process known as Krebs" Cycle, where the enzyme isocitrate dehydrogenase (IDH) regulates the cycle"s turnover rate. krebs 97-102 isocitrate dehydrogenase (NADP(+)) 1 Homo sapiens 154-157 32291392-1 2020 Isocitrate dehydrogenase (IDH) enzymes catalyse the oxidative decarboxylation of isocitrate and therefore play key roles in the Krebs cycle and cellular homoeostasis. krebs 128-133 isocitrate dehydrogenase (NADP(+)) 1 Homo sapiens 0-24 32291392-1 2020 Isocitrate dehydrogenase (IDH) enzymes catalyse the oxidative decarboxylation of isocitrate and therefore play key roles in the Krebs cycle and cellular homoeostasis. krebs 128-133 isocitrate dehydrogenase (NADP(+)) 1 Homo sapiens 26-29 30194083-1 2018 Isocitrate dehydrogenases 1 and 2 (IDH1/2) are enzymes that play a major role in the Krebs cycle. krebs 85-90 isocitrate dehydrogenase (NADP(+)) 1 Homo sapiens 35-41 31263678-1 2019 Isocitrate dehydrogenase (IDH) is a key rate-limiting enzyme in the Krebs cycle that plays an important role in energy metabolism. krebs 68-73 isocitrate dehydrogenase (NADP(+)) 1 Homo sapiens 0-24 31263678-1 2019 Isocitrate dehydrogenase (IDH) is a key rate-limiting enzyme in the Krebs cycle that plays an important role in energy metabolism. krebs 68-73 isocitrate dehydrogenase (NADP(+)) 1 Homo sapiens 26-29 30050099-1 2019 PURPOSE: Metabolic aberrations have been described in neoplasms with pathogenic variants (PV) in the Krebs cycle genes encoding succinate dehydrogenase (SDH), fumarate hydratase (FH) and isocitrate dehydrogenase (IDH). krebs 101-106 isocitrate dehydrogenase (NADP(+)) 1 Homo sapiens 213-216 31086759-9 2019 Almost unique amongst intracellular bacteria, MAP"s variant isocitrate dehydrogenase 1 (IDH1) enzyme, a type 2-oxoglutarate ferredoxin oxidoreductase, can use a host cell"s cytosolic alpha-ketoglutarate in its own Krebs or tricarboxylic acid cycle. krebs 214-219 isocitrate dehydrogenase (NADP(+)) 1 Homo sapiens 88-92 29661250-1 2018 BACKGROUND: The isocitrate dehydrogenase (IDH) gene family expresses key functional metabolic enzymes in the Krebs cycle and mediates the epigenetic reprogramming, which serves as an important biomarker of breast cancer. krebs 109-114 isocitrate dehydrogenase (NADP(+)) 1 Homo sapiens 16-40 29775073-3 2018 Of the recently discovered gene alterations, mutations in the Krebs cycle enzymes isocitrate dehydrogenases (IDHs) 1 and 2 have fundamentally changed the way the gliomas are understood and classified. krebs 62-67 isocitrate dehydrogenase (NADP(+)) 1 Homo sapiens 82-122 29661250-1 2018 BACKGROUND: The isocitrate dehydrogenase (IDH) gene family expresses key functional metabolic enzymes in the Krebs cycle and mediates the epigenetic reprogramming, which serves as an important biomarker of breast cancer. krebs 109-114 isocitrate dehydrogenase (NADP(+)) 1 Homo sapiens 42-45 29547090-3 2018 Mutant IDH produces 2-hydroxyglutarate from alpha-ketoglutarate, a key metabolite of the Krebs cycle. krebs 89-94 isocitrate dehydrogenase (NADP(+)) 1 Homo sapiens 7-10 29439493-1 2018 Isocitrate dehydrogenases 1 and 2 (IDH1,2), the key Krebs cycle enzymes that generate NADPH reducing equivalents, undergo heterozygous mutations in >70% of low- to mid-grade gliomas and ~20% of acute myeloid leukemias (AMLs) and gain an unusual new activity of reducing the alpha-ketoglutarate (alpha-KG) to D-2 hydroxyglutarate (D-2HG) in a NADPH-consuming reaction. krebs 52-57 isocitrate dehydrogenase (NADP(+)) 1 Homo sapiens 35-41 24989313-6 2014 IDH contains IDH1 and IDH2, which are related with the Krebs cycle. krebs 55-60 isocitrate dehydrogenase (NADP(+)) 1 Homo sapiens 0-3 24989313-6 2014 IDH contains IDH1 and IDH2, which are related with the Krebs cycle. krebs 55-60 isocitrate dehydrogenase (NADP(+)) 1 Homo sapiens 13-17 23288593-1 2013 The Krebs cycle dictates oxidative and reductive conditions in Staphylococcus aureus and is mainly regulated by isocitrate dehydrogenase (IDH) which plays pivotal role in the growth and pathogenesis of the bacteria. krebs 4-9 isocitrate dehydrogenase (NADP(+)) 1 Homo sapiens 138-141 27466503-1 2016 The isocitrate dehydrogenase (IDH) family of enzymes comprises of the key functional metabolic enzymes in the Krebs cycle that catalyze the conversion of isocitrate to alpha-ketoglutarate (alpha-KG). krebs 110-115 isocitrate dehydrogenase (NADP(+)) 1 Homo sapiens 4-28 27466503-1 2016 The isocitrate dehydrogenase (IDH) family of enzymes comprises of the key functional metabolic enzymes in the Krebs cycle that catalyze the conversion of isocitrate to alpha-ketoglutarate (alpha-KG). krebs 110-115 isocitrate dehydrogenase (NADP(+)) 1 Homo sapiens 30-33 27097804-1 2016 PURPOSE: Inactivating mutations of isocitrate dehydrogenase (IDH) 1 and 2, mitochondrial enzymes participating in the Krebs tricarboxylic acid cycle play a role in the tumorigenesis of gliomas and also less frequently in acute myeloid leukemia and other malignancies. krebs 118-123 isocitrate dehydrogenase (NADP(+)) 1 Homo sapiens 35-73