PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
15900513-5	2005	The aim of this study, therefore, was to investigate the P-glycoprotein-mediated transport and inhibition properties of propafenone and its major metabolites 5-hydroxypropafenone and N-desalkylpropafenone in Caco-2 cell monolayers.	5-hydroxypropafenone	158-178	ATP binding cassette subfamily B member 1	Homo sapiens	57-71	
15900513-9	2005	Moreover, propafenone, 5-hydroxypropafenone and N-desalkylpropafenone inhibited P-glycoprotein-mediated digoxin transport with IC(50) values of 6.8, 19.9, and 21.3 microM, respectively.	5-hydroxypropafenone	23-43	ATP binding cassette subfamily B member 1	Homo sapiens	80-94	
15900513-10	2005	In summary, whereas propafenone and N-desalkylpropafenone are not substrates of P-glycoprotein, 5-hydroxypropafenone is translocated by human P-glycoprotein across cell monolayers.	5-hydroxypropafenone	96-116	ATP binding cassette subfamily B member 1	Homo sapiens	142-156	
15900513-11	2005	In addition, propafenone and its two major metabolites 5-hydroxypropafenone and N-desalkylpropafenone are inhibitors of human P-glycoprotein and therefore contribute to the digoxin-propafenone interaction observed in humans.	5-hydroxypropafenone	55-75	ATP binding cassette subfamily B member 1	Homo sapiens	126-140