PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 28261841-2 2017 Propafenone (PPF) exhibits extensive saturable presystemic biotransformation (first-pass effect) resulting in two active metabolites: 5-hydroxypropafenone (5-OH PPF) formed by CYP2D6 and N-depropylpropafenone (NDP) formed by both CYP3A4 and CYP1A2 enzymes. 5-hydroxypropafenone 134-154 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 230-236