PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
12429455-5	2002	Furthermore, oral ACZ is reported to be more physiologically effective than 2% dorzolamide hydrochloride administered topically, even though in isolated tissues dorzolamide appears to be the most active as it shows the lowest IC(50) values for CA-II and CA-IV [M.F.	Acetazolamide	18-21	carbonic anhydrase 4	Homo sapiens	254-259	
10768298-2	2000	METHODS: The inhibition constants (Ki) of TPM and acetazolamide (AZM) for CA I, CA II, CA III, CA IV, CA V, and CA VI were determined for human (HCA), rat (RCA), or mouse (MCA).	Acetazolamide	50-63	carbonic anhydrase 4	Homo sapiens	95-100	
10768298-2	2000	METHODS: The inhibition constants (Ki) of TPM and acetazolamide (AZM) for CA I, CA II, CA III, CA IV, CA V, and CA VI were determined for human (HCA), rat (RCA), or mouse (MCA).	Acetazolamide	65-68	carbonic anhydrase 4	Homo sapiens	95-100	
33085484-4	2020	Very potent pan-inhibitors with nanomolar potency against CA IX and sub-nanomolar potency against CA II and CA IV, and with potency against CA I one order of magnitude better than the parent acetazolamide 1 were also identified in this study, together with compounds that displayed selectivity against membrane-bound CA IV.	Acetazolamide	191-204	carbonic anhydrase 4	Homo sapiens	108-113	
8056514-3	1994	Given the solubility coefficient of acetazolamide, the drug is most likely to act by direct inhibition of membrane-bound CA (CA IV).	Acetazolamide	36-49	carbonic anhydrase 4	Homo sapiens	125-130	
33085484-4	2020	Very potent pan-inhibitors with nanomolar potency against CA IX and sub-nanomolar potency against CA II and CA IV, and with potency against CA I one order of magnitude better than the parent acetazolamide 1 were also identified in this study, together with compounds that displayed selectivity against membrane-bound CA IV.	Acetazolamide	191-204	carbonic anhydrase 4	Homo sapiens	317-322	
29571155-4	2018	The membrane bound isoform hCA IV, involved in glaucoma and retinitis pigmentosa among others, was effectively inhibited by some of these compounds with Ki < 60 nM, better than the reference drug acetazolamide (AAZ).	Acetazolamide	199-212	carbonic anhydrase 4	Homo sapiens	27-33	
29571155-4	2018	The membrane bound isoform hCA IV, involved in glaucoma and retinitis pigmentosa among others, was effectively inhibited by some of these compounds with Ki < 60 nM, better than the reference drug acetazolamide (AAZ).	Acetazolamide	214-217	carbonic anhydrase 4	Homo sapiens	27-33	
25704766-8	2015	CA-IV inhibition by acetazolamide or carbon dioxide results in the accumulation of extracellular protons, causing AQP-4 inhibition and a secondary increase in rCBF.	Acetazolamide	20-33	carbonic anhydrase 4	Homo sapiens	0-5	
15686931-5	2005	The hCA IV/bCA IV inhibition ratios for all the investigated compounds ranged between 1.05 (for acetazolamide) and 198.37 (for dorzolamide).	Acetazolamide	96-109	carbonic anhydrase 4	Homo sapiens	4-10