PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 31517637-13 2019 Moreover, inhibition of autophagy with molecules such as hydroxychloroquine (20 muMu) and 3-methyladenine (5 mM) was identified by the accumulation of p62 and LC3B. 3-methyladenine 90-105 nucleoporin 62 Homo sapiens 151-154 30317896-7 2018 3-MA administration reduced the accumulation of autophagic vacuoles, the expression of LC3B-II and p62, followed by a significant attenuation of histopathological changes, inflammation, and oxidative stress. 3-methyladenine 0-4 nucleoporin 62 Homo sapiens 99-102 31524953-6 2019 After autophagy was blocked by 3-MA or CQ, the expression of LC3II was significantly increased in 3-MA+ARs group and p62 was significantly decreased in CQ+ARs group. 3-methyladenine 31-35 nucleoporin 62 Homo sapiens 117-120 31024806-10 2019 The expressions of Beclin-1 and Atg5 were significantly reduced by 3-MA or CQ treatment, while expression of p62 was increased in the 3-MA or CQ treated cells. 3-methyladenine 134-138 nucleoporin 62 Homo sapiens 109-112 30897708-7 2019 CLE-10 that was pretreated with 3-methyladenine (3-MA) or chloroquine (CQ) weakened the upregulation of the protein expression of p-ULK1, or the downregulation of p62, p-mTOR, and decreased the level of cytotoxicity against MDA-MB-231 cells. 3-methyladenine 32-47 nucleoporin 62 Homo sapiens 163-166 30897708-7 2019 CLE-10 that was pretreated with 3-methyladenine (3-MA) or chloroquine (CQ) weakened the upregulation of the protein expression of p-ULK1, or the downregulation of p62, p-mTOR, and decreased the level of cytotoxicity against MDA-MB-231 cells. 3-methyladenine 49-53 nucleoporin 62 Homo sapiens 163-166 34951247-9 2021 The addition of 3-MA had no effect on the expression of SIRT1 protein, but the expression of SIRT1 and LC3-II proteins decreased and the expression of p62 increased after the addition of EX-527. 3-methyladenine 16-20 nucleoporin 62 Homo sapiens 151-154 28779993-4 2017 The results showed that S14161 induced autophagy as demonstrated by increased LC3-II and decreased p62, which were prevented by autophagy inhibitors including 3-methyladenine and bafilomycin A1. 3-methyladenine 159-174 nucleoporin 62 Homo sapiens 99-102 29049987-10 2017 In addition, ATR inhibited autophagy, whereas isoflavones induced autophagy through the accumulation of LC3-II and decreased expression of p62; this effect was abolished by 3-methyladenine (3-MA). 3-methyladenine 173-188 nucleoporin 62 Homo sapiens 139-142 29049987-10 2017 In addition, ATR inhibited autophagy, whereas isoflavones induced autophagy through the accumulation of LC3-II and decreased expression of p62; this effect was abolished by 3-methyladenine (3-MA). 3-methyladenine 190-194 nucleoporin 62 Homo sapiens 139-142 23302200-8 2012 The expression of p62 in cells treated with 3-MA showed a dose-dependent increase, while cyclinB1 showed a dose-dependent decrease. 3-methyladenine 44-48 nucleoporin 62 Homo sapiens 18-21 26534988-7 2016 Autophagy inhibitor 3-methyladenine accumulated YFP-hPXR T408D mutant more efficiently than the WT in the presence of proteasome inhibitor lactacystin, and the T408D mutant colocalized with the autophagy markers, microtubule-associated protein 1 light chain 3 and p62, which were contained in the autophagic cargo. 3-methyladenine 20-35 nucleoporin 62 Homo sapiens 264-267 25295079-4 2014 In addition, western blot analysis was performed to determine the effect of 3-methyl adenine (3-MA) activity on the inhibition of autophagy, SB203580 inhibition of the p38-mitogen-activated protein kinase (MAPK) pathway, and Beclin 1, LC3, p62, p38 and phosphorylated (p)-p38 protein expression. 3-methyladenine 94-98 nucleoporin 62 Homo sapiens 240-243 19074260-5 2008 This targeting requires the ubiquitin-binding protein, p62, and is blocked by the Class III phosphatidylinositol 3-kinase (PI3K) inhibitor, 3-methyladenine (3-MA), or by depletion of the autophagy-related-12 (Atg12) protein homolog. 3-methyladenine 140-155 nucleoporin 62 Homo sapiens 55-58 19074260-5 2008 This targeting requires the ubiquitin-binding protein, p62, and is blocked by the Class III phosphatidylinositol 3-kinase (PI3K) inhibitor, 3-methyladenine (3-MA), or by depletion of the autophagy-related-12 (Atg12) protein homolog. 3-methyladenine 157-161 nucleoporin 62 Homo sapiens 55-58 33349212-20 2021 Furthermore, Western blot showed that expression of Beclin1, lc3-I, lc3-II, atg-5 protein decreased significantly after 3-MA intervention, while the expression of p62 up-regulated, which also confirmed autophagy flow was blocked. 3-methyladenine 120-124 nucleoporin 62 Homo sapiens 163-166 34734026-6 2021 Results: Autophagy inhibitor 3-MA suppressed the Beclin-1 and ATG5 protein levels and the ratio of LC3-II to LC3-I, as well as autophagosome formation in RAW264.7 transfected with the MUT plasmid and enhanced p62 protein expression. 3-methyladenine 29-33 nucleoporin 62 Homo sapiens 209-212 34045875-6 2021 Results: EGF treatment significantly increased the protein expression level of LC3 and decreased the protein level of P62 in HG-stimulated podocytes, which was attenuated by autophagy inhibitor, 3-methyladenine. 3-methyladenine 195-210 nucleoporin 62 Homo sapiens 118-121 34565256-7 2021 Mechanism study revealed that LPS triggered the expression of LC3 II, p62, and cleaved caspase-3 at the early stage exposed to silica, which could be restored by 3-MA, while there was no difference in the expression of LAMP1 either at the early or late stage of silicosis in different groups. 3-methyladenine 162-166 nucleoporin 62 Homo sapiens 70-73 35365454-5 2022 The effects of melatonin treatment alone or in combination with 3-methyladenine (3-MA) on the expressions of the proteins associated with autophagy (LC3, P62 and Beclin1), apoptosis (Bcl2 and Bax) and epithelial-mesenchymal transition (E-cadherin and Snail) were examined with Western blotting. 3-methyladenine 64-79 nucleoporin 62 Homo sapiens 154-157 35365454-5 2022 The effects of melatonin treatment alone or in combination with 3-methyladenine (3-MA) on the expressions of the proteins associated with autophagy (LC3, P62 and Beclin1), apoptosis (Bcl2 and Bax) and epithelial-mesenchymal transition (E-cadherin and Snail) were examined with Western blotting. 3-methyladenine 81-85 nucleoporin 62 Homo sapiens 154-157 31715238-7 2020 Furthermore, it showed that NRF2 expression is restored in the presence of 3-methyladenine and Baficomycin-A1 establishing role of autophagy in modulation of NRF2 through p62. 3-methyladenine 75-90 nucleoporin 62 Homo sapiens 171-174 32836151-5 2020 Additionally, autophagy inhibitor 3-MA decreased Beclin-1, LC3II/LC3I protein levels and increased p62 protein level. 3-methyladenine 34-38 nucleoporin 62 Homo sapiens 99-102 32424110-13 2020 After inhibiting autophagy with 3-MA or CQ, compared with OA alone, cell mitochondrial membrane potential and ATP concentration were significantly reduced, cell p62 expression was reduced, and LC3-II expression was increased, apoptosis-related protein Bax protein was increased, and Bcl-2 protein was decreased, which suggested that 3-MA or CQ treatment increased OA-induced apoptosis of SMMC-7721 cells. 3-methyladenine 32-36 nucleoporin 62 Homo sapiens 161-164 32895198-12 2020 3-MA significantly inhibited the EV71-induced autophagy of THP-1 macrophages and reduced LC3 conversion (LC3-II/LC3-I) and p62 protein expression at 8 h after EV71 infection (P < 0.01). 3-methyladenine 0-4 nucleoporin 62 Homo sapiens 123-126