PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 24626522-9 2014 Treatment with the autophagy inhibitor 3-methyladenine (3-MA) significantly enhanced the apoptosis induced by apigenin, which was accompanied by an increase in the levels of PARP cleavage. 3-methyladenine 39-54 poly(ADP-ribose) polymerase 1 Homo sapiens 174-178 26043797-8 2015 Pretreatment with the autophagy inhibitors LY294002, 3-methyladenine, chloroquine, and bafilomycin A1 enhanced the induction of apoptosis by MHY218, and this was accompanied by an increase in PARP cleavage. 3-methyladenine 53-68 poly(ADP-ribose) polymerase 1 Homo sapiens 192-196 24626522-9 2014 Treatment with the autophagy inhibitor 3-methyladenine (3-MA) significantly enhanced the apoptosis induced by apigenin, which was accompanied by an increase in the levels of PARP cleavage. 3-methyladenine 56-60 poly(ADP-ribose) polymerase 1 Homo sapiens 174-178 17897837-20 2007 Therefore, triazene compounds can also kill tumour cells by a N(3)-methyladenine-mediated mechanism if BER activity is inhibited by chemical agents (i.e. PARP inhibitors). 3-methyladenine 62-80 poly(ADP-ribose) polymerase 1 Homo sapiens 154-158 32323792-6 2020 PARP-1 expression was not altered when treated with ERS inhibitor 4PBA and autophagy inhibitor 3MA, whereas 4PBA or 3MA in combination with 2 mM melatonin (or the three together) significantly increased PARP-1 expression. 3-methyladenine 116-119 poly(ADP-ribose) polymerase 1 Homo sapiens 203-209 34356312-8 2021 Interestingly, using autophagy inhibitors such as 3-methyladenine (3-MA) and chloroquine (CQ) both showed an increase in cleaved-PARP protein level, indicating apoptosis induction. 3-methyladenine 50-65 poly(ADP-ribose) polymerase 1 Homo sapiens 129-133 34356312-8 2021 Interestingly, using autophagy inhibitors such as 3-methyladenine (3-MA) and chloroquine (CQ) both showed an increase in cleaved-PARP protein level, indicating apoptosis induction. 3-methyladenine 67-71 poly(ADP-ribose) polymerase 1 Homo sapiens 129-133 14871963-11 2004 The underlying mechanism is probably a shift of the cytotoxic locus of temozolomide to N(7)-methylguanine and N(3)-methyladenine, which are repaired by the base excision repair pathway in which PARP-1 actively participates. 3-methyladenine 110-128 poly(ADP-ribose) polymerase 1 Homo sapiens 194-200 34873651-5 2021 The cell apoptosis rate and poly ADP-ribose polymerase (PARP) and caspase-3 activities were increased in GES-1 cells pretreated with 3-methyladenine (3-MA ) after H. pylori infection. 3-methyladenine 133-148 poly(ADP-ribose) polymerase 1 Homo sapiens 28-54 34873651-5 2021 The cell apoptosis rate and poly ADP-ribose polymerase (PARP) and caspase-3 activities were increased in GES-1 cells pretreated with 3-methyladenine (3-MA ) after H. pylori infection. 3-methyladenine 133-148 poly(ADP-ribose) polymerase 1 Homo sapiens 56-60 34873651-5 2021 The cell apoptosis rate and poly ADP-ribose polymerase (PARP) and caspase-3 activities were increased in GES-1 cells pretreated with 3-methyladenine (3-MA ) after H. pylori infection. 3-methyladenine 150-154 poly(ADP-ribose) polymerase 1 Homo sapiens 28-54 34873651-5 2021 The cell apoptosis rate and poly ADP-ribose polymerase (PARP) and caspase-3 activities were increased in GES-1 cells pretreated with 3-methyladenine (3-MA ) after H. pylori infection. 3-methyladenine 150-154 poly(ADP-ribose) polymerase 1 Homo sapiens 56-60 31968231-7 2020 Blocking autophagy using 3-methyladenine led to cell death via activation of enhanced ROS, PARP-1 and caspase 3 cleavage. 3-methyladenine 25-40 poly(ADP-ribose) polymerase 1 Homo sapiens 91-97 29382424-5 2017 The apoptotic protease caspase-3 and substrate PARP were obviously degraded, which could be enhanced by 3-MA but inhibited by CQ. 3-methyladenine 104-108 poly(ADP-ribose) polymerase 1 Homo sapiens 47-51 30337735-9 2018 While 3-MA, an early autophagy inhibitor, reduced the ST-induced cleavage of poly (ADP-ribose) polymerase-1 (PARP-1), a substrate of caspase 3/7 and often used marker of caspase-dependent apoptosis, CQ promoted the ST-dependent PARP-1 cleavage, indicating that the early and late autophagy functioned differentially on the ST-activated apoptotic process. 3-methyladenine 6-10 poly(ADP-ribose) polymerase 1 Homo sapiens 77-107 30337735-9 2018 While 3-MA, an early autophagy inhibitor, reduced the ST-induced cleavage of poly (ADP-ribose) polymerase-1 (PARP-1), a substrate of caspase 3/7 and often used marker of caspase-dependent apoptosis, CQ promoted the ST-dependent PARP-1 cleavage, indicating that the early and late autophagy functioned differentially on the ST-activated apoptotic process. 3-methyladenine 6-10 poly(ADP-ribose) polymerase 1 Homo sapiens 109-115 30337735-9 2018 While 3-MA, an early autophagy inhibitor, reduced the ST-induced cleavage of poly (ADP-ribose) polymerase-1 (PARP-1), a substrate of caspase 3/7 and often used marker of caspase-dependent apoptosis, CQ promoted the ST-dependent PARP-1 cleavage, indicating that the early and late autophagy functioned differentially on the ST-activated apoptotic process. 3-methyladenine 6-10 poly(ADP-ribose) polymerase 1 Homo sapiens 228-234