PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
31916058-10	2020	Further immunohistochemistry staining and Western blot showed that 3-MA-treated IRI group presented down-regulated Caspase-3 and up-regulated Bcl-2 protein expression with comparison of IRI group (P < 0.05).	3-methyladenine	67-71	caspase 3	Rattus norvegicus	115-124	
33106949-9	2021	We then linked these events with hypothyroidism-induced apoptosis and loss of hippocampal neurons, where we observed that like thyroxine, IL-1Ra and autophagy inhibitor, 3-methyladenine, reduced the cleaved caspase-3 and TUNEL-stained apoptotic neurons and enhanced Nissl-stained neuronal count in methimazole-treated rats.	3-methyladenine	170-185	caspase 3	Rattus norvegicus	207-216	
33312358-12	2020	PI3K, p-AKT1, p-mTOR, p-p70S6K and caspase-3 were down-regulated by rapamycin and beta-ecdysterone, and up-regulated by 3-methyladenine in both the chondrocytes and the cartilage tissues.	3-methyladenine	120-135	caspase 3	Rattus norvegicus	35-44	
26983718-9	2017	After short-term OGD (1, 4 h), cells treated with 3-MA showed higher level of cleaved caspase 3 compared with control cells.	3-methyladenine	50-54	caspase 3	Rattus norvegicus	86-95	
30737648-9	2019	An inhibitor of autophagy, 3-methyladenine or bafilomycin A1 significantly augmented GD-induced cleavage of caspase-3.	3-methyladenine	27-42	caspase 3	Rattus norvegicus	108-117	
30315711-13	2018	The pretreatment of 3-methyladenine (3-MA) reversed the reduction of Caspase-3 caused by ADMSCs, showing that the antiapoptotic effect was associated with autophagy inducing.	3-methyladenine	20-35	caspase 3	Rattus norvegicus	69-78	
30315711-13	2018	The pretreatment of 3-methyladenine (3-MA) reversed the reduction of Caspase-3 caused by ADMSCs, showing that the antiapoptotic effect was associated with autophagy inducing.	3-methyladenine	37-41	caspase 3	Rattus norvegicus	69-78	
30154458-8	2018	Co-injection of the pharmacological autophagy inhibitor 3-methyladenine prevented not only autophagy induction but also CASPASE-3 activation and calpain-dependent cleavage of SPECTRIN 24 h after the insult, thus providing a strong reduction of the long term brain injury (16 days after ibotenate injection) including lateral ventricle dilatation, decreases in cerebral tissue volume and in subcortical white matter thickness.	3-methyladenine	56-71	caspase 3	Rattus norvegicus	120-129	
29532851-5	2018	The inhibition of autophagy following treatment with 3-methyladenine significantly reversed the effect of si-miRNA-30e on apoptosis, Bax, caspase-3, iNOS and oxidative stress in H9C2 cells.	3-methyladenine	53-68	caspase 3	Rattus norvegicus	138-147	
31661991-7	2020	Additionally, MEHP induced the collapse of mitochondrial transmembrane potential and release of cytochrome c. Addition of autophagy inhibitor 3-methyladenine relieved MEHP-induced apoptosis as assessed by the expression of cleaved caspase 3, cleaved caspase 9, and terminal deoxynucleotidyl transferase dUTP nick end labeling assay, indicating that MEHP-induced apoptosis was autophagy dependent.	3-methyladenine	142-157	caspase 3	Rattus norvegicus	231-240	
28206988-6	2017	Immunofluorescence analysis showed that 3-MA or Wort treatment reversed OGD-induced release of cathepsin B and L from the lysosome to the cytoplasm and activation of caspase-3 in the astrocytes.	3-methyladenine	40-44	caspase 3	Rattus norvegicus	166-175	
25639566-4	2015	Incubation of 3-methyladenine (an autophagy inhibitor) prevented arsenite-induced LC3-II elevation, autolysosome formation, reduction in GAP 43 (a biomarker of neurite outgrowth), caspase 3 activation and neuronal cell loss.	3-methyladenine	14-29	caspase 3	Rattus norvegicus	180-189	
22361585-7	2012	3-MA, at the dose blocking autophagy, significantly inhibited IPC-induced HSP70, HSP60 and GRP78 upregulation; meanwhile, it also aggregated the ER stress and increased activated caspase-12, caspase-3 and CHOP protein levels both in vitro and in vivo models.	3-methyladenine	0-4	caspase 3	Rattus norvegicus	191-200