PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
25302046-5	2014	The patient had a successful trial of carglumic acid (a synthetic analog of the product of nags), which suggests that, at least in some cases, he can be treated by overcoming proximal inhibition of the urea cycle.	carglumic acid	38-52	N-acetylglutamate synthase	Homo sapiens	91-95	
30780843-3	2012	Carglumic acid (Carbaglu , Orphan Europe SARL, Paris, France) is approved for the acute and long-term treatment of primary defects of NAGS in Europe and the USA.	carglumic acid	0-14	N-acetylglutamate synthase	Homo sapiens	134-138	
30780843-1	2012	Carglumic acid is a structural analog and the first registered synthetic form of the naturally occurring allosteric activator of the urea cycle, N-acetylglutamate (NAG), which is the product of the enzyme NAG synthase (NAGS).	carglumic acid	0-14	N-acetylglutamate synthase	Homo sapiens	205-217	
30780843-1	2012	Carglumic acid is a structural analog and the first registered synthetic form of the naturally occurring allosteric activator of the urea cycle, N-acetylglutamate (NAG), which is the product of the enzyme NAG synthase (NAGS).	carglumic acid	0-14	N-acetylglutamate synthase	Homo sapiens	219-223	
30780843-3	2012	Carglumic acid (Carbaglu , Orphan Europe SARL, Paris, France) is approved for the acute and long-term treatment of primary defects of NAGS in Europe and the USA.	carglumic acid	16-24	N-acetylglutamate synthase	Homo sapiens	134-138	
33763330-6	2021	We then suspected n-acetylglutamate synthase or carbamoyl-phosphate synthase I deficiency due to marked hyperammonemia, elevated glutamine level, normal orotic acid, and normalization of ammonia at 2 h of carglumic acid (200 mg/kg/d).	carglumic acid	205-219	N-acetylglutamate synthase	Homo sapiens	18-44	
30443462-4	2018	For these subtypes of patients, the United States Food and Drug Administration (US FDA) has recently approved carglumic acid, a medication that can act as a scavenger by effectively increasing the levels of NAGS, ultimately enhancing the conversion of ammonia to urea.	carglumic acid	110-124	N-acetylglutamate synthase	Homo sapiens	207-211