PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
25261792-4	2014	Deposited ABri exhibits abundant post-translational pyroglutamate (pE) formation at the N-terminus, a feature seen in truncated forms of Abeta found in AD deposits, and co-exists with neurofibrillary tangles almost identical to those found in AD.	Pyrrolidonecarboxylic Acid	52-65	integral membrane protein 2B	Homo sapiens	10-14	
25261792-4	2014	Deposited ABri exhibits abundant post-translational pyroglutamate (pE) formation at the N-terminus, a feature seen in truncated forms of Abeta found in AD deposits, and co-exists with neurofibrillary tangles almost identical to those found in AD.	Pyrrolidonecarboxylic Acid	67-69	integral membrane protein 2B	Homo sapiens	10-14	
25261792-6	2014	The presence of pE conferred to the ABri molecule enhanced hydrophobicity and accelerated aggregation/fibrillization properties.	Pyrrolidonecarboxylic Acid	16-18	integral membrane protein 2B	Homo sapiens	36-40	
23261769-8	2013	These similarities of ABri and ADan to Abeta in Alzheimer"s disease suggest that the posttranslational pGlu-modification of amyloid peptides might represent a general pathological mechanism leading to increased aggregation and toxicity in these forms of degenerative dementias.	Pyrrolidonecarboxylic Acid	103-107	integral membrane protein 2B	Homo sapiens	22-26	
21037969-0	2010	PYROGLUTAMATE FORMATION AT THE N-TERMINI OF ABRI MOLECULES IN FAMILIAL BRITISH DEMENTIA IS NOT RESTRICTED TO THE CENTRAL NERVOUS SYSTEM.	Pyrrolidonecarboxylic Acid	0-13	integral membrane protein 2B	Homo sapiens	44-48	
21037969-4	2010	Soluble ABri molecules present in the circulation of carriers of the BRI2 mutation are 34 amino acids long exclusively harboring Glu residue at the N-termini (ABri1-34E), whereas water- and formic acid-soluble ABri molecules extracted from FBD brains have abundant ABri species bearing pGlu residue (ABri1-34pE), suggesting that pyroglutamate formation occurs at the site of deposition.	Pyrrolidonecarboxylic Acid	329-342	integral membrane protein 2B	Homo sapiens	8-12	
21037969-7	2010	The data indicate that pyroglutamate formation at the N-termini of ABri molecules is an early step in the process of FBD amyloid deposition, and its formation is not restricted to the central nervous system.	Pyrrolidonecarboxylic Acid	23-36	integral membrane protein 2B	Homo sapiens	67-71	
19518051-3	2009	Similarly, the deposited amyloid peptides ABri and ADan, which cause a very similar histopathology in familial British dementia (FBD) and familial Danish dementia (FDD), are N-terminally blocked by pGlu.	Pyrrolidonecarboxylic Acid	198-202	integral membrane protein 2B	Homo sapiens	42-46	
19518051-9	2009	The effect of pGlu on the morphology is virtually indistinguishable between ABri, ADan, and Abeta.	Pyrrolidonecarboxylic Acid	14-18	integral membrane protein 2B	Homo sapiens	76-80