PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 7964269-6 1994 In contrast, at micromolar concentrations pGlu-Glu-ProNH2 exhibited intrinsic TRH-like activity causing stimulation of both GH and prolactin release from GH3 cells. Pyrrolidonecarboxylic Acid 42-46 thyrotropin releasing hormone Rattus norvegicus 78-81 7832488-0 1994 Predominance of pGlu-His-Pro-Gly among all TRH precursor peptides in rat limbic forebrain after electroconvulsive seizures. Pyrrolidonecarboxylic Acid 16-20 thyrotropin releasing hormone Rattus norvegicus 43-46 7798029-1 1995 TRH-like peptides share the N- and C-terminal amino acids with TRH (pGlu-His-Pro-NH2) but differ in the middle amino acid residue. Pyrrolidonecarboxylic Acid 68-72 thyrotropin releasing hormone Rattus norvegicus 0-3 7798029-1 1995 TRH-like peptides share the N- and C-terminal amino acids with TRH (pGlu-His-Pro-NH2) but differ in the middle amino acid residue. Pyrrolidonecarboxylic Acid 68-72 thyrotropin releasing hormone Rattus norvegicus 63-66 7798029-4 1995 To distinguish between TRH and EEP two antisera were used for RIA: specificity of antiserum 4319 for the TRH-like peptides pGlu-Phe-Pro-NH2 and EEP was equal to or greater than that for TRH, whereas antiserum 8880 is TRH-specific. Pyrrolidonecarboxylic Acid 123-127 thyrotropin releasing hormone Rattus norvegicus 105-108 7798029-4 1995 To distinguish between TRH and EEP two antisera were used for RIA: specificity of antiserum 4319 for the TRH-like peptides pGlu-Phe-Pro-NH2 and EEP was equal to or greater than that for TRH, whereas antiserum 8880 is TRH-specific. Pyrrolidonecarboxylic Acid 123-127 thyrotropin releasing hormone Rattus norvegicus 105-108 7798029-4 1995 To distinguish between TRH and EEP two antisera were used for RIA: specificity of antiserum 4319 for the TRH-like peptides pGlu-Phe-Pro-NH2 and EEP was equal to or greater than that for TRH, whereas antiserum 8880 is TRH-specific. Pyrrolidonecarboxylic Acid 123-127 thyrotropin releasing hormone Rattus norvegicus 105-108 2121465-1 1990 TRH (pGlu-His-Pro-NH2) arises from the post-translational processing of a larger precursor peptide containing multiple copies of the TRH progenitor sequence, Gln-His-Pro-Gly. Pyrrolidonecarboxylic Acid 5-9 thyrotropin releasing hormone Rattus norvegicus 0-3 1310004-1 1992 An analogue of thyrotropin-releasing hormone (TRH, pGlu-His-ProNH2), i.e. pGlu-His-ProNH-(CH2)6-(4-azidosalicylamide) (TRH-ASA), has been synthesized and, in a radioiodinated form (TRH-IASA), characterized and used as a photoaffinity reagent to label the TRH receptor on rat pituitary GH4C1 cells. Pyrrolidonecarboxylic Acid 51-55 thyrotropin releasing hormone Rattus norvegicus 15-44 1639022-2 1992 In the present study, designed to determine the role of endogenous TRH, we first characterized chromatographically the identity of immunoreactive TRH with synthetic pGlu-His-Pro-NH2. Pyrrolidonecarboxylic Acid 165-169 thyrotropin releasing hormone Rattus norvegicus 146-149 1314591-1 1992 Analogs of thyrotropin-releasing hormone (Glp-His-Pro-NH2, TRH) have been prepared which contain thioamide moieties in the pyroglutamic acid ring, the carboxyamide proline terminus, and in both positions (dithio). Pyrrolidonecarboxylic Acid 123-140 thyrotropin releasing hormone Rattus norvegicus 11-40 1314325-1 1992 Thyroliberin E-H-P-NH2 (TRH) is a small neuropeptide pGlu-His-Pro-NH2 widely distributed in neural sites. Pyrrolidonecarboxylic Acid 53-57 thyrotropin releasing hormone Rattus norvegicus 24-27 2121465-1 1990 TRH (pGlu-His-Pro-NH2) arises from the post-translational processing of a larger precursor peptide containing multiple copies of the TRH progenitor sequence, Gln-His-Pro-Gly. Pyrrolidonecarboxylic Acid 5-9 thyrotropin releasing hormone Rattus norvegicus 133-136 2500333-1 1989 In the present study we have examined the in vivo effects of thyroid hormone and TRH on secretory tissue concentrations of TRH and TRH-Gly (pGlu-His-Pro-Gly), a TRH precursor. Pyrrolidonecarboxylic Acid 140-144 thyrotropin releasing hormone Rattus norvegicus 81-84 2113484-2 1990 TRH-extended peptides have been detected in the rat olfactory lobe: these peptides accounted for approximately 11% of the total TRH immunoreactivity present in the tissue and contained the sequence pGlu-His-Pro-Gly-Arg exclusively at their N-termini. Pyrrolidonecarboxylic Acid 198-202 thyrotropin releasing hormone Rattus norvegicus 0-3 2493964-2 1989 In the present study, microinjection of 10 ng to 5 micrograms of TRH into the anterior hypothalamus (AHy) dose-dependently suppressed heat production in interscapular brown adipose tissue (BAT) in chloral hydrate-anaesthetized rats tested at a room temperature of 23 +/- 2 degrees C. This effect of TRH was mimicked by the structurally related peptides acid-TRH and luteinizing hormone releasing hormone (LH-RH), and by the TRH analog CG 3509, but not by the TRH fragments pGlu-His and His-Pro. Pyrrolidonecarboxylic Acid 473-477 thyrotropin releasing hormone Rattus norvegicus 65-68 2566131-2 1989 Following the fractionation of liver homogenate in 0.25 M sucrose, solubilization of the particulate fraction with papain and gel filtration on ACA34, an enzyme activity was detected which converts TRH into pyroglutamic acid and histidyl-proline diketopiperazine (cyclo[His-Pro]; cHP). Pyrrolidonecarboxylic Acid 207-224 thyrotropin releasing hormone Rattus norvegicus 198-201 3141237-1 1988 Brain and spinal sites of action of the stable thyrotropin-releasing hormone (TRH) analogue, RX 77368 [pGlu-His-(3,3"-dimethyl)-Pro-NH2], for stimulation of gastric acid secretion have been investigated in urethane-anesthetized rats with gastric fistula. Pyrrolidonecarboxylic Acid 103-107 thyrotropin releasing hormone Rattus norvegicus 47-76 2501768-1 1989 In the present study we have examined the in vivo effects of thyroid hormones and TRH on tissue and blood levels of TRH and TRH-Gly (pGlu-His-Pro-Gly), a TRH precursor. Pyrrolidonecarboxylic Acid 133-137 thyrotropin releasing hormone Rattus norvegicus 82-85 3141237-1 1988 Brain and spinal sites of action of the stable thyrotropin-releasing hormone (TRH) analogue, RX 77368 [pGlu-His-(3,3"-dimethyl)-Pro-NH2], for stimulation of gastric acid secretion have been investigated in urethane-anesthetized rats with gastric fistula. Pyrrolidonecarboxylic Acid 103-107 thyrotropin releasing hormone Rattus norvegicus 78-81 3099113-4 1986 Because this last step in the biosynthesis of TRH is rate limiting for pGlu-His-Pro-Gly, we have combined several chromatographic and radioimmunoassay techniques to identify this TRH precursor in rat prostate. Pyrrolidonecarboxylic Acid 71-75 thyrotropin releasing hormone Rattus norvegicus 46-49 3120012-2 1987 This hypothesis is strengthened by the observation that TRH is hydrolysed at the pyroGlu-His bond by a particulate enzyme located in the synaptosomal and adenohypophyseal plasma membrane. Pyrrolidonecarboxylic Acid 81-88 thyrotropin releasing hormone Rattus norvegicus 56-59 2869108-3 1986 Reports of a thyrotropin-releasing hormone-degrading enzyme with narrow specificity that cleaves the pGlu-His bond of this tripeptide led us to develop a coupled assay using pGlu-His-Pro-2NA as the substrate to measure this activity. Pyrrolidonecarboxylic Acid 101-105 thyrotropin releasing hormone Rattus norvegicus 13-42 3089346-1 1986 To define the role of different fragments of TRF molecule in its neurotropic activity a number of newly synthesized dipeptides of pyroglutamic acid with beta-alanine residue, GABA or GABA ester have been studied. Pyrrolidonecarboxylic Acid 130-147 thyrotropin releasing hormone Rattus norvegicus 45-48 2869108-3 1986 Reports of a thyrotropin-releasing hormone-degrading enzyme with narrow specificity that cleaves the pGlu-His bond of this tripeptide led us to develop a coupled assay using pGlu-His-Pro-2NA as the substrate to measure this activity. Pyrrolidonecarboxylic Acid 174-178 thyrotropin releasing hormone Rattus norvegicus 13-42 2869108-8 1986 The data suggest that degradation of thyrotropin-releasing hormone by the particulate fraction of a brain homogenate is catalyzed mainly by an enzyme that cleaves the pGlu-His bond of thyrotropin-releasing hormone but is distinct from pyroglutamyl peptide hydrolase. Pyrrolidonecarboxylic Acid 167-171 thyrotropin releasing hormone Rattus norvegicus 37-66 2869108-8 1986 The data suggest that degradation of thyrotropin-releasing hormone by the particulate fraction of a brain homogenate is catalyzed mainly by an enzyme that cleaves the pGlu-His bond of thyrotropin-releasing hormone but is distinct from pyroglutamyl peptide hydrolase. Pyrrolidonecarboxylic Acid 167-171 thyrotropin releasing hormone Rattus norvegicus 184-213 18069127-0 2008 A novel TRH analog, Glp-Asn-Pro-D-Tyr-D-TrpNH2, binds to [3H][3-Me-His2]TRH-labelled sites in rat hippocampus and cortex but not pituitary or heterologous cells expressing TRHR1 or TRHR2. Pyrrolidonecarboxylic Acid 20-23 thyrotropin releasing hormone Rattus norvegicus 8-11 6820171-3 1982 Of the TRH analogues studied, RX77368 (pGlu-His-3,3"-dimethyl-ProNH2) was the most potent in this behavioural test system. Pyrrolidonecarboxylic Acid 39-43 thyrotropin releasing hormone Rattus norvegicus 7-10 6796786-1 1981 The histidine residue of thyrotropin releasing factor (TRF, pGlu-His-Pro-NH2) offers the possibility of conjugating TRF to a macromolecule to produce TRF antibodies. Pyrrolidonecarboxylic Acid 60-64 thyrotropin releasing hormone Rattus norvegicus 25-53 6796786-1 1981 The histidine residue of thyrotropin releasing factor (TRF, pGlu-His-Pro-NH2) offers the possibility of conjugating TRF to a macromolecule to produce TRF antibodies. Pyrrolidonecarboxylic Acid 60-64 thyrotropin releasing hormone Rattus norvegicus 55-58 6796786-1 1981 The histidine residue of thyrotropin releasing factor (TRF, pGlu-His-Pro-NH2) offers the possibility of conjugating TRF to a macromolecule to produce TRF antibodies. Pyrrolidonecarboxylic Acid 60-64 thyrotropin releasing hormone Rattus norvegicus 116-119 6796786-1 1981 The histidine residue of thyrotropin releasing factor (TRF, pGlu-His-Pro-NH2) offers the possibility of conjugating TRF to a macromolecule to produce TRF antibodies. Pyrrolidonecarboxylic Acid 60-64 thyrotropin releasing hormone Rattus norvegicus 116-119 24145076-5 2013 TRH analogue 8, metabolically stabilized by the replacement of pyroglutamate with the pyrohomocysteic acid (pHcs), was found to be inactive. Pyrrolidonecarboxylic Acid 63-76 thyrotropin releasing hormone Rattus norvegicus 0-3 19526311-5 2010 Furthermore, the MS/MS fragmentation pattern of TRH has been investigated to develop a selected reaction monitoring (SRM) method that allows the detection of a specific b2 product ion at m/z 249.1, corresponding to the N-terminus dipeptide pyroglutamic acid-histidine. Pyrrolidonecarboxylic Acid 240-257 thyrotropin releasing hormone Rattus norvegicus 48-51 27434852-4 2017 The present study is an extension of our previous work showing that brain levels of TRH (pGlu-His-Pro-NH2) and TRH-like peptides (X-TRH: pGlu-X-Pro-NH2, where "X" can be any amino acid residue) fluctuate throughout the day-night cycle. Pyrrolidonecarboxylic Acid 89-93 thyrotropin releasing hormone Rattus norvegicus 84-87 18069127-0 2008 A novel TRH analog, Glp-Asn-Pro-D-Tyr-D-TrpNH2, binds to [3H][3-Me-His2]TRH-labelled sites in rat hippocampus and cortex but not pituitary or heterologous cells expressing TRHR1 or TRHR2. Pyrrolidonecarboxylic Acid 20-23 thyrotropin releasing hormone Rattus norvegicus 72-75 18354249-2 2008 We, and others, have previously reported that thyrotropin-releasing hormone (TRH, pGlu-His-Pro-NH(2)) and TRH-like peptides with the general structure pGlu-X-Pro-NH(2), where "X" can be any amino acid residue, have neuroprotective, antidepressant, analeptic, arousal, and anti-epileptic effects that could mediate the neuropsychiatric and therapeutic effects of a variety of neurotropic agents. Pyrrolidonecarboxylic Acid 82-86 thyrotropin releasing hormone Rattus norvegicus 46-75 10395408-0 1999 Identification of the TRH-like peptides pGlu-Glu-Pro amide and pGlu-Phe-Pro amide in rat thyroid: regulation by thyroid status. Pyrrolidonecarboxylic Acid 40-44 thyrotropin releasing hormone Rattus norvegicus 22-25 15305021-2 2004 Recently we cloned pyroglutamyl aminopeptidase I (PAP-I) which is known for specifically removing a L-pyroglutamate (L-pGlu) residue from the amino terminus of proteins and peptides including TRH. Pyrrolidonecarboxylic Acid 100-115 thyrotropin releasing hormone Rattus norvegicus 192-195 11881332-7 2002 In the experiment that follows compared effects of TRH (pyroGlu-His-Pro-NH2) and its metabolite dipeptide cHis-Pro-NH2 (10(-10) M, 10(-5) M). Pyrrolidonecarboxylic Acid 56-63 thyrotropin releasing hormone Rattus norvegicus 51-54 17234338-1 2007 Local perfusion of pGlu-Glu-Pro-NH2, an endogenous peptide structurally related to thyrotropine-releasing hormone (TRH), via in vivo microdialysis into the rat hippocampus did not change the basal level of extracellular acetylcholine. Pyrrolidonecarboxylic Acid 19-23 thyrotropin releasing hormone Rattus norvegicus 115-118 17726229-1 2007 Lipopolysaccharide (LPS) is a proinflammatory and depressogenic agent whereas thyrotropin-releasing hormone (TRH; pGlu-His-Pro-NH2) is an endogenous antidepressant and neuroprotective peptide. Pyrrolidonecarboxylic Acid 114-118 thyrotropin releasing hormone Rattus norvegicus 78-107 17726229-1 2007 Lipopolysaccharide (LPS) is a proinflammatory and depressogenic agent whereas thyrotropin-releasing hormone (TRH; pGlu-His-Pro-NH2) is an endogenous antidepressant and neuroprotective peptide. Pyrrolidonecarboxylic Acid 114-118 thyrotropin releasing hormone Rattus norvegicus 109-112 21153109-0 1996 Effects of TRH and TRH-like peptide pGLU-HIS-GLY-NH(2) on adrenocortical cell proliferation in rats. Pyrrolidonecarboxylic Acid 36-40 thyrotropin releasing hormone Rattus norvegicus 19-22 7577928-1 1995 To test the hypothesis that pGlu of the thyrotropin-releasing hormone (TRH, pGlu-His-ProNH2) binds to Asn289 in the third extracellular loop (EL3) of its receptor through a hydrogen bonding interaction, we converted Asn289 to Asp (N289D mutant) and measured the potencies of TRH and Pro1TRH for the wild-type and mutant receptors. Pyrrolidonecarboxylic Acid 28-32 thyrotropin releasing hormone Rattus norvegicus 275-278 7577928-1 1995 To test the hypothesis that pGlu of the thyrotropin-releasing hormone (TRH, pGlu-His-ProNH2) binds to Asn289 in the third extracellular loop (EL3) of its receptor through a hydrogen bonding interaction, we converted Asn289 to Asp (N289D mutant) and measured the potencies of TRH and Pro1TRH for the wild-type and mutant receptors. Pyrrolidonecarboxylic Acid 28-32 thyrotropin releasing hormone Rattus norvegicus 40-69 7577928-1 1995 To test the hypothesis that pGlu of the thyrotropin-releasing hormone (TRH, pGlu-His-ProNH2) binds to Asn289 in the third extracellular loop (EL3) of its receptor through a hydrogen bonding interaction, we converted Asn289 to Asp (N289D mutant) and measured the potencies of TRH and Pro1TRH for the wild-type and mutant receptors. Pyrrolidonecarboxylic Acid 28-32 thyrotropin releasing hormone Rattus norvegicus 71-74