PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 7019446-1 1981 Metabolic breakdown of the luteinizing hormone-releasing hormone (LH-RH) could lead to the following fragments containing pyroglutamic acid: pyroglutamic acid (1), pGlu-His (2), pGLu-His-Trp (3), pGlu-His-Trp-Ser (4), etc., and finally pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly (10). Pyrrolidonecarboxylic Acid 122-139 gonadotropin releasing hormone 1 Rattus norvegicus 27-64 8175672-1 1994 The metalloendopeptidase EC 3.4.24.15 is believed to degrade gonadotropin-releasing hormone (GnRH) (pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2) by cleavage at the Tyr5-Gly6 bond. Pyrrolidonecarboxylic Acid 100-104 gonadotropin releasing hormone 1 Rattus norvegicus 61-91 8175672-1 1994 The metalloendopeptidase EC 3.4.24.15 is believed to degrade gonadotropin-releasing hormone (GnRH) (pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2) by cleavage at the Tyr5-Gly6 bond. Pyrrolidonecarboxylic Acid 100-104 gonadotropin releasing hormone 1 Rattus norvegicus 93-97 6377112-5 1984 Determination of GnRH cleavage sites was performed by amino acid analysis of the fragments obtained after incubation of the peptidase with (3H)-GnRH labelled on the pyroglutamic acid residue, in presence of carboxypeptidase and peptidyldipeptidase inhibitors. Pyrrolidonecarboxylic Acid 165-182 gonadotropin releasing hormone 1 Rattus norvegicus 17-21 6377112-5 1984 Determination of GnRH cleavage sites was performed by amino acid analysis of the fragments obtained after incubation of the peptidase with (3H)-GnRH labelled on the pyroglutamic acid residue, in presence of carboxypeptidase and peptidyldipeptidase inhibitors. Pyrrolidonecarboxylic Acid 165-182 gonadotropin releasing hormone 1 Rattus norvegicus 144-148 6344654-11 1983 These metabolites and possibly LHRH are partially reabsorbed and undergo further intracellular degradation to produce pGlu. Pyrrolidonecarboxylic Acid 118-122 gonadotropin releasing hormone 1 Rattus norvegicus 31-35 7019446-1 1981 Metabolic breakdown of the luteinizing hormone-releasing hormone (LH-RH) could lead to the following fragments containing pyroglutamic acid: pyroglutamic acid (1), pGlu-His (2), pGLu-His-Trp (3), pGlu-His-Trp-Ser (4), etc., and finally pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly (10). Pyrrolidonecarboxylic Acid 196-200 gonadotropin releasing hormone 1 Rattus norvegicus 27-64 7019446-1 1981 Metabolic breakdown of the luteinizing hormone-releasing hormone (LH-RH) could lead to the following fragments containing pyroglutamic acid: pyroglutamic acid (1), pGlu-His (2), pGLu-His-Trp (3), pGlu-His-Trp-Ser (4), etc., and finally pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly (10). Pyrrolidonecarboxylic Acid 196-200 gonadotropin releasing hormone 1 Rattus norvegicus 66-71 7019446-1 1981 Metabolic breakdown of the luteinizing hormone-releasing hormone (LH-RH) could lead to the following fragments containing pyroglutamic acid: pyroglutamic acid (1), pGlu-His (2), pGLu-His-Trp (3), pGlu-His-Trp-Ser (4), etc., and finally pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly (10). Pyrrolidonecarboxylic Acid 122-139 gonadotropin releasing hormone 1 Rattus norvegicus 66-71 7019446-1 1981 Metabolic breakdown of the luteinizing hormone-releasing hormone (LH-RH) could lead to the following fragments containing pyroglutamic acid: pyroglutamic acid (1), pGlu-His (2), pGLu-His-Trp (3), pGlu-His-Trp-Ser (4), etc., and finally pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly (10). Pyrrolidonecarboxylic Acid 141-158 gonadotropin releasing hormone 1 Rattus norvegicus 27-64 7019446-1 1981 Metabolic breakdown of the luteinizing hormone-releasing hormone (LH-RH) could lead to the following fragments containing pyroglutamic acid: pyroglutamic acid (1), pGlu-His (2), pGLu-His-Trp (3), pGlu-His-Trp-Ser (4), etc., and finally pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly (10). Pyrrolidonecarboxylic Acid 141-158 gonadotropin releasing hormone 1 Rattus norvegicus 66-71 7019446-1 1981 Metabolic breakdown of the luteinizing hormone-releasing hormone (LH-RH) could lead to the following fragments containing pyroglutamic acid: pyroglutamic acid (1), pGlu-His (2), pGLu-His-Trp (3), pGlu-His-Trp-Ser (4), etc., and finally pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly (10). Pyrrolidonecarboxylic Acid 164-168 gonadotropin releasing hormone 1 Rattus norvegicus 27-64 7019446-1 1981 Metabolic breakdown of the luteinizing hormone-releasing hormone (LH-RH) could lead to the following fragments containing pyroglutamic acid: pyroglutamic acid (1), pGlu-His (2), pGLu-His-Trp (3), pGlu-His-Trp-Ser (4), etc., and finally pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly (10). Pyrrolidonecarboxylic Acid 164-168 gonadotropin releasing hormone 1 Rattus norvegicus 66-71 7019446-1 1981 Metabolic breakdown of the luteinizing hormone-releasing hormone (LH-RH) could lead to the following fragments containing pyroglutamic acid: pyroglutamic acid (1), pGlu-His (2), pGLu-His-Trp (3), pGlu-His-Trp-Ser (4), etc., and finally pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly (10). Pyrrolidonecarboxylic Acid 178-182 gonadotropin releasing hormone 1 Rattus norvegicus 27-64 7019446-1 1981 Metabolic breakdown of the luteinizing hormone-releasing hormone (LH-RH) could lead to the following fragments containing pyroglutamic acid: pyroglutamic acid (1), pGlu-His (2), pGLu-His-Trp (3), pGlu-His-Trp-Ser (4), etc., and finally pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly (10). Pyrrolidonecarboxylic Acid 178-182 gonadotropin releasing hormone 1 Rattus norvegicus 66-71 7019446-1 1981 Metabolic breakdown of the luteinizing hormone-releasing hormone (LH-RH) could lead to the following fragments containing pyroglutamic acid: pyroglutamic acid (1), pGlu-His (2), pGLu-His-Trp (3), pGlu-His-Trp-Ser (4), etc., and finally pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly (10). Pyrrolidonecarboxylic Acid 196-200 gonadotropin releasing hormone 1 Rattus norvegicus 27-64 7019446-1 1981 Metabolic breakdown of the luteinizing hormone-releasing hormone (LH-RH) could lead to the following fragments containing pyroglutamic acid: pyroglutamic acid (1), pGlu-His (2), pGLu-His-Trp (3), pGlu-His-Trp-Ser (4), etc., and finally pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly (10). Pyrrolidonecarboxylic Acid 196-200 gonadotropin releasing hormone 1 Rattus norvegicus 66-71 364062-4 1978 These results support the concept of an important interaction between the ends of the LH-RH molecule possibly involving hydrogen-bond formation between the pyrrolidone carbonyl group of pyroglutamic acid and the glycinamide group. Pyrrolidonecarboxylic Acid 186-203 gonadotropin releasing hormone 1 Rattus norvegicus 86-91