PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
34051623-1	2021	"Don"t eat me" signal of CD47 is activated via its interaction with SIRPalpha protein on myeloid cells, especially phagocytic cells, and prevents malignant cells from anti-tumor immunity in which pyroglutamate modification of CD47 by glutaminyl-peptide cyclotransferase-like protein (isoQC) takes an important part evidenced by our previous report that isoQC is an essential regulator for CD47-SIRPalpha axis with a strong inhibition on macrophage-mediated phagoctyosis.	Pyrrolidonecarboxylic Acid	196-209	signal regulatory protein alpha	Homo sapiens	68-77	
34058788-6	2021	However, binding of a human soluble SIRPalpha -Fc fusion protein to SEN177 treated cancer cells was significantly reduced in a dose-dependent manner, suggesting that pyro-glutamate formation of CD47 was affected.	Pyrrolidonecarboxylic Acid	166-180	signal regulatory protein alpha	Homo sapiens	36-45	
34051623-1	2021	"Don"t eat me" signal of CD47 is activated via its interaction with SIRPalpha protein on myeloid cells, especially phagocytic cells, and prevents malignant cells from anti-tumor immunity in which pyroglutamate modification of CD47 by glutaminyl-peptide cyclotransferase-like protein (isoQC) takes an important part evidenced by our previous report that isoQC is an essential regulator for CD47-SIRPalpha axis with a strong inhibition on macrophage-mediated phagoctyosis.	Pyrrolidonecarboxylic Acid	196-209	signal regulatory protein alpha	Homo sapiens	394-403	
32240171-8	2020	We also utilized the LSC assay to confirm published studies showing that the inhibition of amino-terminal pyroglutamate formation on CD47 using the glutaminyl cyclase inhibitor SEN177 disrupts SIRPalpha binding.	Pyrrolidonecarboxylic Acid	106-119	signal regulatory protein alpha	Homo sapiens	193-202