PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
1181279-4	1975	A complete initial rate kinetic analysis of the forward reaction catalyzed by 5-oxoprolinase was carried out using 5-oxo-L-proline and MgATP2theta as substrates.	Pyrrolidonecarboxylic Acid	115-130	5-oxoprolinase (ATP-hydrolysing)	Rattus norvegicus	78-92	
3611103-2	1987	5-Oxoprolinase catalyzes a reaction in which the cleavage of ATP to ADP and Pi and the decyclization of 5-oxoproline to form glutamate are coupled.	Pyrrolidonecarboxylic Acid	104-116	5-oxoprolinase (ATP-hydrolysing)	Rattus norvegicus	0-14	
3611103-3	1987	When the reaction catalyzed by 5-oxoprolinase of Pseudomonas putida was carried out to 90% completion in H2(18)O, the residual 5-oxoproline was found to contain 18O in the amide carbonyl oxygen atom.	Pyrrolidonecarboxylic Acid	127-139	5-oxoprolinase (ATP-hydrolysing)	Rattus norvegicus	31-45	
6115861-2	1981	Rat kidney 5-oxo-L-prolinase catalyzes the endergonic hydrolysis of 5-oxo-L-proline (L-pyroglutamate, L-2-pyrrolidone-5-carboxylate) to form L-glutamate; the reaction is driven by and dependent on the stoichiometric concomitant hydrolysis of ATP to ADP and inorganic phosphate.	Pyrrolidonecarboxylic Acid	68-83	5-oxoprolinase (ATP-hydrolysing)	Rattus norvegicus	11-28	
6115861-2	1981	Rat kidney 5-oxo-L-prolinase catalyzes the endergonic hydrolysis of 5-oxo-L-proline (L-pyroglutamate, L-2-pyrrolidone-5-carboxylate) to form L-glutamate; the reaction is driven by and dependent on the stoichiometric concomitant hydrolysis of ATP to ADP and inorganic phosphate.	Pyrrolidonecarboxylic Acid	85-100	5-oxoprolinase (ATP-hydrolysing)	Rattus norvegicus	11-28	
6115861-2	1981	Rat kidney 5-oxo-L-prolinase catalyzes the endergonic hydrolysis of 5-oxo-L-proline (L-pyroglutamate, L-2-pyrrolidone-5-carboxylate) to form L-glutamate; the reaction is driven by and dependent on the stoichiometric concomitant hydrolysis of ATP to ADP and inorganic phosphate.	Pyrrolidonecarboxylic Acid	102-131	5-oxoprolinase (ATP-hydrolysing)	Rattus norvegicus	11-28	
2563377-1	1989	5-Oxoprolinase catalyzes the ATP-dependent decyclization of 5-oxo-L-proline to L-glutamate.	Pyrrolidonecarboxylic Acid	60-75	5-oxoprolinase (ATP-hydrolysing)	Rattus norvegicus	0-14	
239948-2	1975	5-Oxo-L-prolinase, an enzyme that catalyzes the conversion of 5-oxo-L-proline (L-pyroglutamate; L-2-pyrrolidone-5-carboxylate) to L-glutamate coupled with the cleavage of ATP to ADP and Pi, has been purified about 1600-fold from rat kidney.	Pyrrolidonecarboxylic Acid	62-77	5-oxoprolinase (ATP-hydrolysing)	Rattus norvegicus	0-17	
239948-2	1975	5-Oxo-L-prolinase, an enzyme that catalyzes the conversion of 5-oxo-L-proline (L-pyroglutamate; L-2-pyrrolidone-5-carboxylate) to L-glutamate coupled with the cleavage of ATP to ADP and Pi, has been purified about 1600-fold from rat kidney.	Pyrrolidonecarboxylic Acid	79-94	5-oxoprolinase (ATP-hydrolysing)	Rattus norvegicus	0-17	
239948-2	1975	5-Oxo-L-prolinase, an enzyme that catalyzes the conversion of 5-oxo-L-proline (L-pyroglutamate; L-2-pyrrolidone-5-carboxylate) to L-glutamate coupled with the cleavage of ATP to ADP and Pi, has been purified about 1600-fold from rat kidney.	Pyrrolidonecarboxylic Acid	96-125	5-oxoprolinase (ATP-hydrolysing)	Rattus norvegicus	0-17	
5289242-1	1971	A new enzyme, 5-oxoprolinase, was found in rat kidney and in several other tissues; it catalyzes the conversion of 5-oxo-L-proline (L-5-oxo-pyrrolidine-2-carboxylic acid, L-2-pyrrolidone-5-carboxylic acid, L-pyroglutamic acid) to L-glutamic acid, with concomitant stoichiometric cleavage of ATP to ADP and orthophosphate.	Pyrrolidonecarboxylic Acid	115-130	5-oxoprolinase (ATP-hydrolysing)	Rattus norvegicus	14-28	
5289242-1	1971	A new enzyme, 5-oxoprolinase, was found in rat kidney and in several other tissues; it catalyzes the conversion of 5-oxo-L-proline (L-5-oxo-pyrrolidine-2-carboxylic acid, L-2-pyrrolidone-5-carboxylic acid, L-pyroglutamic acid) to L-glutamic acid, with concomitant stoichiometric cleavage of ATP to ADP and orthophosphate.	Pyrrolidonecarboxylic Acid	171-204	5-oxoprolinase (ATP-hydrolysing)	Rattus norvegicus	14-28	
5289242-1	1971	A new enzyme, 5-oxoprolinase, was found in rat kidney and in several other tissues; it catalyzes the conversion of 5-oxo-L-proline (L-5-oxo-pyrrolidine-2-carboxylic acid, L-2-pyrrolidone-5-carboxylic acid, L-pyroglutamic acid) to L-glutamic acid, with concomitant stoichiometric cleavage of ATP to ADP and orthophosphate.	Pyrrolidonecarboxylic Acid	206-225	5-oxoprolinase (ATP-hydrolysing)	Rattus norvegicus	14-28	
5289242-2	1971	The reaction catalyzed by 5-oxoprolinase, in which 5-oxoproline formed from gamma-glutamyl amino acids by the action of gamma-glutamylcyclotransferase is converted to glutamate, appears to function in the gamma-glutamyl cycle.	Pyrrolidonecarboxylic Acid	51-63	5-oxoprolinase (ATP-hydrolysing)	Rattus norvegicus	26-40	
9516961-2	1998	Previous studies on rats have shown that administration of the cysteine prodrug L-2-oxothiazolidine-4-carboxylate, a 5-oxo-L-proline analogue that is metabolized by 5-OPase, preferentially increases the GSH content of normal tissues while paradoxically decreasing it in the tumor and results in an enhanced in vivo tumor response to the anticancer drug melphalan.	Pyrrolidonecarboxylic Acid	117-132	5-oxoprolinase (ATP-hydrolysing)	Rattus norvegicus	165-172	
9751079-2	1998	Previous studies showed that L-2-oxothiazolidine-4-carboxylate (OTZ), a 5-oxo-L-proline analog that is metabolized by 5-OPase, can preferentially decrease the cellular GSH levels in vivo in rat mammary tumors and sensitizes the tumors to the alkylating agent melphalan.	Pyrrolidonecarboxylic Acid	72-87	5-oxoprolinase (ATP-hydrolysing)	Rattus norvegicus	118-125	
8943290-1	1996	5-Oxoprolinase (EC 3.5.2) catalyzes a reaction in which the endergonic cleavage of 5-oxo-L-proline to form L-glutamate is coupled to the exergonic hydrolysis of ATP to ADP and inorganic phosphate.	Pyrrolidonecarboxylic Acid	83-98	5-oxoprolinase (ATP-hydrolysing)	Rattus norvegicus	0-14