PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
21261659-1	2011	BACKGROUND: Filaggrin, coded by FLG, is the main source of several major components of natural moisturizing factor (NMF) in the stratum corneum (SC), including pyrrolidone carboxylic acid (PCA) and urocanic acid (UCA).	Pyrrolidonecarboxylic Acid	160-187	filaggrin	Homo sapiens	32-35	
21812836-10	2012	The concomittant presence of low concentrations of histidine, alanine and either glycine or pyrrolidone-5-carboxylic acid (PCA) in the SC was associated with FLG mutations with 92% specificity.	Pyrrolidonecarboxylic Acid	92-121	filaggrin	Homo sapiens	158-161	
21812836-10	2012	The concomittant presence of low concentrations of histidine, alanine and either glycine or pyrrolidone-5-carboxylic acid (PCA) in the SC was associated with FLG mutations with 92% specificity.	Pyrrolidonecarboxylic Acid	123-126	filaggrin	Homo sapiens	158-161	
21261659-1	2011	BACKGROUND: Filaggrin, coded by FLG, is the main source of several major components of natural moisturizing factor (NMF) in the stratum corneum (SC), including pyrrolidone carboxylic acid (PCA) and urocanic acid (UCA).	Pyrrolidonecarboxylic Acid	189-192	filaggrin	Homo sapiens	32-35	
28936777-8	2017	The effect of PHS on FLG metabolism was manifested as the increase of pyrrolidone carboxylic acid and skin hydration in vivo human skin.	Pyrrolidonecarboxylic Acid	70-97	filaggrin	Homo sapiens	21-24	
33462753-5	2021	Filaggrin is degraded by caspase-14, calpain 1, and bleomycin hydrolases into amino acids and amino acid metabolites such as trans-urocanic acid and pyrrolidone carboxylic acid, which are pivotal natural moisturizing factors in the SC.	Pyrrolidonecarboxylic Acid	149-176	filaggrin	Homo sapiens	0-9	
24061166-5	2014	At day 7, the FLG degradation products urocanic (UCA) and pyrrolidone-5-carboxylic acid (PCA) were significantly decreased in FLG- constructs, but the skin surface pH was still physiological owing to an upregulation of NHE-1.	Pyrrolidonecarboxylic Acid	58-87	filaggrin	Homo sapiens	126-129	
24061166-5	2014	At day 7, the FLG degradation products urocanic (UCA) and pyrrolidone-5-carboxylic acid (PCA) were significantly decreased in FLG- constructs, but the skin surface pH was still physiological owing to an upregulation of NHE-1.	Pyrrolidonecarboxylic Acid	89-92	filaggrin	Homo sapiens	126-129