PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
33159802-3	2021	The N-terminal glutamine on immature CCL2 is replaced with pyroglutamate (pE) by glutaminyl cyclase (QC) and isoQC.	Pyrrolidonecarboxylic Acid	59-72	C-C motif chemokine ligand 2	Homo sapiens	37-41	
2648385-3	1989	By a combination of Edman degradation and mass spectrometry, it was established that GDCF-2 comprises 76 amino acid residues, commencing at the N terminus with pyroglutamic acid.	Pyrrolidonecarboxylic Acid	160-177	C-C motif chemokine ligand 2	Homo sapiens	85-91	
33159802-3	2021	The N-terminal glutamine on immature CCL2 is replaced with pyroglutamate (pE) by glutaminyl cyclase (QC) and isoQC.	Pyrrolidonecarboxylic Acid	74-76	C-C motif chemokine ligand 2	Homo sapiens	37-41	
33159802-4	2021	pE-CCL2 is stable and resistant to peptidases.	Pyrrolidonecarboxylic Acid	0-2	C-C motif chemokine ligand 2	Homo sapiens	3-7	
29076753-3	2017	Research shows that the more neurotoxic factor, pyroglutamate-Abetas, and the more important inflammatory mediators, pyroglutamate-CCL2, both contribute to the initiation of AD specifically and the generation of N-terminal intramolecular cyclization catalyzed by glutaminyl cyclase quality control, the over-expression of which correlates positively with the severity of AD.	Pyrrolidonecarboxylic Acid	117-130	C-C motif chemokine ligand 2	Homo sapiens	131-135	
29076753-4	2017	Subsequently, lowering pyroglutamate-Abetas and pyroglutamate-CCL2 levels by quality control inhibition using small molecule inhibitors could be expected as an amazing strategy for the prevention and treatment of AD.	Pyrrolidonecarboxylic Acid	48-61	C-C motif chemokine ligand 2	Homo sapiens	62-66	
28739588-2	2017	Frequently, the activity of chemokines depends on a modified N-terminus as described for the N-terminus of CCL2 modified to a pGlu- (pyroglutamate) residue by QC (glutaminyl cyclase) activity.	Pyrrolidonecarboxylic Acid	126-130	C-C motif chemokine ligand 2	Homo sapiens	107-111	
28739588-2	2017	Frequently, the activity of chemokines depends on a modified N-terminus as described for the N-terminus of CCL2 modified to a pGlu- (pyroglutamate) residue by QC (glutaminyl cyclase) activity.	Pyrrolidonecarboxylic Acid	133-146	C-C motif chemokine ligand 2	Homo sapiens	107-111	
25666182-3	2015	Two putative substrates of isoQC, N-truncated Abeta peptides and the monocyte chemoattractant chemokine CCL2, undergo isoQC-catalyzed pyroglutamate (pGlu) modification.	Pyrrolidonecarboxylic Acid	134-147	C-C motif chemokine ligand 2	Homo sapiens	104-108	
23183267-3	2013	Recently, we showed that the N-terminus of CCL2 is modified to a pyroglutamate (pE)-residue by both glutaminyl cyclases (QC (QPCT)) and its isoenzyme (isoQC (QPCTL)).	Pyrrolidonecarboxylic Acid	65-78	C-C motif chemokine ligand 2	Homo sapiens	43-47	
23183267-3	2013	Recently, we showed that the N-terminus of CCL2 is modified to a pyroglutamate (pE)-residue by both glutaminyl cyclases (QC (QPCT)) and its isoenzyme (isoQC (QPCTL)).	Pyrrolidonecarboxylic Acid	80-82	C-C motif chemokine ligand 2	Homo sapiens	43-47