PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
22001377-1	2012	gamma-Glutamylcyclotransferase (GGCT) is a component of the gamma-glutamyl cycle and specifically cleaves gamma-glutamyl-amino acid dipeptides to release the free amino acid and 5-oxoproline.	Pyrrolidonecarboxylic Acid	178-190	gamma-glutamylcyclotransferase	Homo sapiens	0-30	
6106548-2	1980	It is known that gamma-glutamylcyclotransferase is present in many cells and may convert gamma-glutamylcysteine to 5-oxoproline and cysteine, but until now there has not been a credible explanation for the apparent suppression of the gamma-glutamylcyclotransferase reaction during glutathione synthesis.	Pyrrolidonecarboxylic Acid	115-127	gamma-glutamylcyclotransferase	Homo sapiens	17-47	
1261042-5	1976	The conversion of glutamate to 5-oxoproline occurred in two steps, catalyzed by gamma-glutamyl-cysteine synthetase and gamma-glutamyl cyclotransferase, respectively.	Pyrrolidonecarboxylic Acid	31-43	gamma-glutamylcyclotransferase	Homo sapiens	119-150	
1261042-9	1976	Therefore gamma-glutamyl-cysteine is produced in excessive amounts and it is subsequently converted to 5-oxoproline (and cysteine) by gamma-glutamyl cyclotransferase.	Pyrrolidonecarboxylic Acid	103-115	gamma-glutamylcyclotransferase	Homo sapiens	134-165	
29601-12	1978	gamma-Glutamylcyclotransferase catalyses the formation of 5-oxoproline from gamma-glutamyl dipeptides.	Pyrrolidonecarboxylic Acid	58-70	gamma-glutamylcyclotransferase	Homo sapiens	0-30	
12077-2	1976	Since this enzyme is not specific for cysteine, different gamma-glutamylamino acids may be formed in vivo which represent potential substrates for the enzymes gamma-glutamylcyclotransferase; in this way 5-oxo-L-proline and free amino acid are formed.	Pyrrolidonecarboxylic Acid	203-218	gamma-glutamylcyclotransferase	Homo sapiens	159-189	
1112810-4	1975	These patients produce greater than normal amounts of gamma-glutamyl-cysteine, which is converted by the action of gamma-glutamyl cyclotransferase to 5-oxoproline; production of the latter compound exceeds the capacity of 5-oxoprolinase to convert it to glutamate.	Pyrrolidonecarboxylic Acid	150-162	gamma-glutamylcyclotransferase	Homo sapiens	115-146	
31217077-4	2019	The expression of a 5-oxoproline-catalyzing enzyme, gamma-glutamylcyclotransferase (GGCT), was also upregulated by IGF-1 treatment and further enhanced by the addition of EP2/EP4 inhibitors.	Pyrrolidonecarboxylic Acid	20-32	gamma-glutamylcyclotransferase	Homo sapiens	52-82	
31217077-4	2019	The expression of a 5-oxoproline-catalyzing enzyme, gamma-glutamylcyclotransferase (GGCT), was also upregulated by IGF-1 treatment and further enhanced by the addition of EP2/EP4 inhibitors.	Pyrrolidonecarboxylic Acid	20-32	gamma-glutamylcyclotransferase	Homo sapiens	84-88	
30952730-1	2019	BACKGROUND/AIM: gamma-Glutamylcyclotransferase (GGCT), a key enzyme involved in glutathione metabolism, catalyzes a specific reaction that generates 5-oxoproline and free amino acids from the gamma-glutamyl peptide.	Pyrrolidonecarboxylic Acid	149-161	gamma-glutamylcyclotransferase	Homo sapiens	16-46	
30952730-1	2019	BACKGROUND/AIM: gamma-Glutamylcyclotransferase (GGCT), a key enzyme involved in glutathione metabolism, catalyzes a specific reaction that generates 5-oxoproline and free amino acids from the gamma-glutamyl peptide.	Pyrrolidonecarboxylic Acid	149-161	gamma-glutamylcyclotransferase	Homo sapiens	48-52	
27373633-1	2016	gamma-Glutamylcyclotransferase (GGCT) is an important enzyme that cleaves gamma-glutamyl-amino acid in the gamma-glutamyl cycle to release 5-oxoproline and amino acid.	Pyrrolidonecarboxylic Acid	139-151	gamma-glutamylcyclotransferase	Homo sapiens	0-30	
27373633-1	2016	gamma-Glutamylcyclotransferase (GGCT) is an important enzyme that cleaves gamma-glutamyl-amino acid in the gamma-glutamyl cycle to release 5-oxoproline and amino acid.	Pyrrolidonecarboxylic Acid	139-151	gamma-glutamylcyclotransferase	Homo sapiens	32-36	
25651484-1	2015	Cancer-related gamma-glutamyl cyclotransferase (GGCT) specifically converts gamma-glutamyl amino acids (gamma-Glu-Xaa) into pyroglutamate and the corresponding amino acids (Xaa).	Pyrrolidonecarboxylic Acid	124-137	gamma-glutamylcyclotransferase	Homo sapiens	15-46	
25651484-1	2015	Cancer-related gamma-glutamyl cyclotransferase (GGCT) specifically converts gamma-glutamyl amino acids (gamma-Glu-Xaa) into pyroglutamate and the corresponding amino acids (Xaa).	Pyrrolidonecarboxylic Acid	124-137	gamma-glutamylcyclotransferase	Homo sapiens	48-52	
22001377-1	2012	gamma-Glutamylcyclotransferase (GGCT) is a component of the gamma-glutamyl cycle and specifically cleaves gamma-glutamyl-amino acid dipeptides to release the free amino acid and 5-oxoproline.	Pyrrolidonecarboxylic Acid	178-190	gamma-glutamylcyclotransferase	Homo sapiens	32-36	
22001377-2	2012	The action of GGCT in glutathione synthetase-deficient patients results in the accumulation of high levels of 5-oxoproline.	Pyrrolidonecarboxylic Acid	110-122	gamma-glutamylcyclotransferase	Homo sapiens	14-18