PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 10078874-1 1999 5-Oxo-L-prolinase (5-OPase) catalyses the hydrolysis of 5-oxo-L-proline to glutamate with concomitant stoichiometric cleavage of ATP to ADP, a reaction which is known to be part of the gamma-glutamyl cycle-an interrelated series of reactions involved in the synthesis and metabolism of glutathione. Pyrrolidonecarboxylic Acid 56-71 5-oxoprolinase, ATP-hydrolysing Homo sapiens 0-17 11302195-3 2001 We developed a simultaneous assay method for L-glutamate and L-pyroglutamate by using 5-oxoprolinase (without ATP hydrolyzing activity) and glutamate oxidase. Pyrrolidonecarboxylic Acid 61-76 5-oxoprolinase, ATP-hydrolysing Homo sapiens 86-100 10644552-1 2000 L-2-oxothiazolidine-4-carboxylic acid (OTZ), a 5-oxoproline analog, is metabolized by 5-oxoprolinase and converted to cysteine, the rate-limiting amino acid for GSH synthesis, with the release of CO(2). Pyrrolidonecarboxylic Acid 47-59 5-oxoprolinase, ATP-hydrolysing Homo sapiens 86-100 10460889-6 1999 The enzyme also cleaved 5-oxo-L-proline to L-glutamic acid and is considered to be 5-oxo-L-prolinase. Pyrrolidonecarboxylic Acid 24-39 5-oxoprolinase, ATP-hydrolysing Homo sapiens 83-100 12362798-6 2002 Within the gamma glutamyl cycle, 5-oxoproline (L-pyroglutamic acid) is a metabolite generated during GSH catabolism, and is metabolized to glutamic acid by 5-oxoprolinase. Pyrrolidonecarboxylic Acid 33-45 5-oxoprolinase, ATP-hydrolysing Homo sapiens 156-170 12362798-6 2002 Within the gamma glutamyl cycle, 5-oxoproline (L-pyroglutamic acid) is a metabolite generated during GSH catabolism, and is metabolized to glutamic acid by 5-oxoprolinase. Pyrrolidonecarboxylic Acid 47-66 5-oxoprolinase, ATP-hydrolysing Homo sapiens 156-170 10078874-1 1999 5-Oxo-L-prolinase (5-OPase) catalyses the hydrolysis of 5-oxo-L-proline to glutamate with concomitant stoichiometric cleavage of ATP to ADP, a reaction which is known to be part of the gamma-glutamyl cycle-an interrelated series of reactions involved in the synthesis and metabolism of glutathione. Pyrrolidonecarboxylic Acid 56-71 5-oxoprolinase, ATP-hydrolysing Homo sapiens 19-26 10078874-4 1999 Thus, the degradation of 5-oxo-L-proline by 5-OPase leads to the downregulation of this stimulus. Pyrrolidonecarboxylic Acid 25-40 5-oxoprolinase, ATP-hydrolysing Homo sapiens 44-51 32886767-7 2020 The end product of Chac1 action is 5-oxoproline, and studies with 5-oxoprolinase (OPLAH), an enzyme of the glutathione cycle has revealed that down-regulation of OPLAH can lead to the accumulation of 5-oxproline which is an important factor in heart failure. Pyrrolidonecarboxylic Acid 35-47 5-oxoprolinase, ATP-hydrolysing Homo sapiens 162-167 9474033-5 1998 We suggest that this patient developed a transient disturbance in the gamma-glutamyl cycle involving the 5-oxoprolinase step, which resulted in accumulation of 5-oxoproline that caused a severe high anion gap metabolic acidosis. Pyrrolidonecarboxylic Acid 160-172 5-oxoprolinase, ATP-hydrolysing Homo sapiens 105-119 4152248-3 1974 Thus, 5-oxoproline is produced in amounts that exceed the normal capacity of 5-oxoprolinase to convert it to glutamate. Pyrrolidonecarboxylic Acid 6-18 5-oxoprolinase, ATP-hydrolysing Homo sapiens 77-91 3745154-1 1986 Bacterial 5-oxoprolinase is composed of two protein components: Component A, which catalyzes 5-oxoproline-dependent ATP-hydrolysis and Component B, which couples the hydrolysis of ATP with the decyclization of 5-oxoproline to form glutamate (Seddon, A. P., Li, L., and Meister, A. Pyrrolidonecarboxylic Acid 93-105 5-oxoprolinase, ATP-hydrolysing Homo sapiens 10-24 3745154-1 1986 Bacterial 5-oxoprolinase is composed of two protein components: Component A, which catalyzes 5-oxoproline-dependent ATP-hydrolysis and Component B, which couples the hydrolysis of ATP with the decyclization of 5-oxoproline to form glutamate (Seddon, A. P., Li, L., and Meister, A. Pyrrolidonecarboxylic Acid 210-222 5-oxoprolinase, ATP-hydrolysing Homo sapiens 10-24 6121802-2 1982 5-Oxoprolinase catalyzes the coupled hydrolysis of ATP and 5-oxoproline to yield glutamate, ADP, and Pi; the reaction may be partially or completely uncoupled by structural modification of either substrate. Pyrrolidonecarboxylic Acid 59-71 5-oxoprolinase, ATP-hydrolysing Homo sapiens 0-14 6121802-8 1982 The findings indicate that 5-oxoprolinase is a hysteretic enzyme, and are consistent with the hypothesis that in the normal catalytic reaction, the binding of both ATP and 5-oxo-proline to the enzyme induces a conformational change that brings the substrates into a juxtaposition that facilitates the reaction. Pyrrolidonecarboxylic Acid 172-185 5-oxoprolinase, ATP-hydrolysing Homo sapiens 27-41 31520514-4 2019 PxpA associates with the PxpBC complex to form a functional 5-oxoprolinase enzyme for conversion of 5-oxoproline to L-glutamate. Pyrrolidonecarboxylic Acid 100-112 5-oxoprolinase, ATP-hydrolysing Homo sapiens 60-74 26654818-3 2015 The etiology seems to be a drug-induced reversible inhibition of glutathione synthetase or 5-oxoprolinase leading to elevated serum and urine levels of 5-oxoproline. Pyrrolidonecarboxylic Acid 152-164 5-oxoprolinase, ATP-hydrolysing Homo sapiens 91-105 20413906-4 2010 The enzyme gamma-glutamyl cysteine synthetase (gamma-GCS), in the absence of cysteine, forms 5-oxoproline (instead of the normal substrate, gamma-glutamyl cysteine) and the 5-oxoproline is converted into glutamate by the ATP-dependant enzyme, 5-oxoprolinase. Pyrrolidonecarboxylic Acid 93-105 5-oxoprolinase, ATP-hydrolysing Homo sapiens 243-257