PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 30685842-0 2019 Impaired Pentose Phosphate Pathway in the Spinal Cord of the hSOD1G93A Mouse Model of Amyotrophic Lateral Sclerosis. Pentosephosphates 9-26 superoxide dismutase 1 Homo sapiens 61-66 30685842-6 2019 In the spinal cord, the levels of pentose phosphate pathway (PPP) intermediate ribose 5-phosphate (p = 0.037) were reduced by 37% in hSOD1G93A mice, while the % 13C enrichments in glucose 6-phosphate were increased threefold. Pentosephosphates 34-51 superoxide dismutase 1 Homo sapiens 133-138 34969852-3 2022 The mechanism involves Sod1-derived H2O2 oxidatively inactivating the glycolytic enzyme, GAPDH, which in turn reroutes carbohydrate flux to the oxidative phase of the pentose phosphate pathway (oxPPP) to generate NADPH. Pentosephosphates 167-184 superoxide dismutase 1 Homo sapiens 23-27 27020289-6 2016 In a previous study, we have demonstrated that overexpression of single genes of the oxidative pentose phosphate pathway (PPP) had a positive influence on recombinant production of cytosolic human superoxide dismutase (hSOD). Pentosephosphates 95-112 superoxide dismutase 1 Homo sapiens 219-223 15872021-7 2005 We provide evidence that dysregulation of Nrf2 and the ARE, coupled with reduced pentose phosphate pathway activity and decreased generation of NADPH, represent significant and hitherto unrecognized components of the toxic gain of function of mutant SOD1. Pentosephosphates 81-98 superoxide dismutase 1 Homo sapiens 250-254