PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
33497360-2	2021	The pentose phosphate pathway (PPP), a metabolic pathway parallel to glycolysis, generates NADPH as a reducing equivalent and ribose 5-phosphate for nucleotide synthesis.	Pentosephosphates	4-21	2,4-dienoyl CoA reductase 1, mitochondrial	Mus musculus	91-96	
32853822-3	2020	Macrophages activation under FBW7 deficiency decreases substrate flux through the pentose phosphate pathway (PPP) to produce less equivalents (NADPH and GSH) and aggravate the generation of intracellular reactive oxygen species (ROS) in macrophages, thereby over-activating proinflammatory reaction.	Pentosephosphates	82-99	2,4-dienoyl CoA reductase 1, mitochondrial	Mus musculus	143-148	
33222382-3	2020	NADPH is produced principally by the housekeeping enzyme glucose-6-phosphate dehydrogenase (G6PD), which catalyzes the rate-limiting step in the pentose phosphate pathway.	Pentosephosphates	145-162	2,4-dienoyl CoA reductase 1, mitochondrial	Mus musculus	0-5	
33142766-3	2020	Indeed, previous studies reported a close link between FDG uptake and activation of a specific pentose phosphate pathway (PPP), triggered by hexose-6P-dehydrogenase (H6PD) and contributing to fuel NADPH-dependent antioxidant responses in the endoplasmic reticulum (ER).	Pentosephosphates	95-112	2,4-dienoyl CoA reductase 1, mitochondrial	Mus musculus	197-202	
24872551-1	2014	TP53-induced glycolysis and apoptosis regulator (TIGAR) inhibits glycolysis and increases the flow of pentose phosphate pathway (PPP), which generates NADPH and pentose.	Pentosephosphates	102-119	2,4-dienoyl CoA reductase 1, mitochondrial	Mus musculus	151-156	
31328803-4	2019	PKM2 inhibition increases substrate flux through the pentose phosphate pathway to generate reducing equivalents (NADPH and GSH) and protect against oxidative stress.	Pentosephosphates	53-70	2,4-dienoyl CoA reductase 1, mitochondrial	Mus musculus	113-118	
28473643-1	2017	Glucose-6-phosphate dehydrogenase (G6PD) is the first and rate-limiting enzyme of the pentose phosphate pathway; it catalyzes the conversion of glucose-6-phosphate to 6-phosphogluconate and NADP+ to NADPH and is thought to be the principal source of NADPH for the cytosolic glutathione and thioredoxin antioxidant defense systems.	Pentosephosphates	86-103	2,4-dienoyl CoA reductase 1, mitochondrial	Mus musculus	199-204	
28473643-1	2017	Glucose-6-phosphate dehydrogenase (G6PD) is the first and rate-limiting enzyme of the pentose phosphate pathway; it catalyzes the conversion of glucose-6-phosphate to 6-phosphogluconate and NADP+ to NADPH and is thought to be the principal source of NADPH for the cytosolic glutathione and thioredoxin antioxidant defense systems.	Pentosephosphates	86-103	2,4-dienoyl CoA reductase 1, mitochondrial	Mus musculus	250-255	
28852166-5	2017	Model simulations also reveal that pentose phosphate pathway and oxidative phosphorylation activities were kept at minimal levels to ensure NADPH production and anabolic precursors synthesis.	Pentosephosphates	35-52	2,4-dienoyl CoA reductase 1, mitochondrial	Mus musculus	140-145	
26710800-6	2016	In addition, pharmacologic inhibition of the pentose phosphate pathway decreased rates of disulfide reduction and proteolysis in the phagosome, implicating NADPH as a source of phagosomal reductive energy.	Pentosephosphates	45-62	2,4-dienoyl CoA reductase 1, mitochondrial	Mus musculus	156-161	
19822207-3	2010	Conflicting data exist regarding the effect of pO(2) on NADPH production via the oxidative pentose phosphate cycle (OPPC).	Pentosephosphates	91-108	2,4-dienoyl CoA reductase 1, mitochondrial	Mus musculus	56-61	
34662447-8	2022	Bioinformatic integration revealed a significant shunting of glucose away from glycolysis-citrate cycle and glycerol-lipid genesis to pentose phosphate cycle for NADPH/GSH/GSSG redox and pentose moieties for purine and pyrimidine nucleotides, and glycosylation/glucuronidation.	Pentosephosphates	134-151	2,4-dienoyl CoA reductase 1, mitochondrial	Mus musculus	162-167	
16213215-5	2005	We show that pentose-phosphate-pathway generation of NADPH is critical for oocyte survival and that the target of this regulation is caspase-2, previously shown to be required for oocyte death in mice.	Pentosephosphates	13-30	2,4-dienoyl CoA reductase 1, mitochondrial	Mus musculus	53-58	
15896329-1	2005	6-Phosphogluconate dehydrogenase (6PGDH) constitutes the pentose phosphate pathway and produces NADPH.	Pentosephosphates	57-74	2,4-dienoyl CoA reductase 1, mitochondrial	Mus musculus	96-101	
34522704-2	2021	Recent studies showed that, to prevent toxic buildup of highly insoluble cystine inside cells, cancer cells with high expression of SLC7A11 (SLC7A11high) are forced to quickly reduce cystine to more soluble cysteine, which requires substantial NADPH supply from the glucose-pentose phosphate pathway (PPP) route, thereby inducing glucose- and PPP-dependency in SLC7A11high cancer cells.	Pentosephosphates	274-291	2,4-dienoyl CoA reductase 1, mitochondrial	Mus musculus	244-249	
34845393-4	2021	Here we show using stable isotope tracing in mice that de novo lipogenesis in adipose is supported by glucose and its catabolism via the pentose phosphate pathway to make NADPH.	Pentosephosphates	137-154	2,4-dienoyl CoA reductase 1, mitochondrial	Mus musculus	171-176	
33964586-8	2021	Hyperglycosylation activated glucose-6-phosphate dehydrogenase (G6PDH), the rate-limiting enzyme in the pentose phosphate pathway, resulting in an upregulation of NADPH/NADP+ and GSH/GSSG couples and enhancement of redox homeostasis in the heart.	Pentosephosphates	104-121	2,4-dienoyl CoA reductase 1, mitochondrial	Mus musculus	163-168