PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 19729987-6 2009 A pronounced inhibition of 5"-AMP-induced adenosine formation by the CD73 inhibitor AMP-CP confirmed the involvement of CD73. alpha,beta-methyleneadenosine 5'-diphosphate 84-90 5'-nucleotidase ecto Homo sapiens 69-73 17487388-3 2007 In this study, alpha,beta-methylene adenosine-5"-diphosphate (APCP), a specific CD73 inhibitor was used to block the hydrolase"s activity. alpha,beta-methyleneadenosine 5'-diphosphate 15-60 5'-nucleotidase ecto Homo sapiens 80-84 18825744-5 2008 Importantly, this reduction can be reversed using alpha,beta-methyleneadenosine-5"-diphosphate, a specific inhibitor of ecto-5"-nucleotidase. alpha,beta-methyleneadenosine 5'-diphosphate 50-94 5'-nucleotidase ecto Homo sapiens 120-140 17878054-2 2007 alpha,beta-methylene-ADP, an ecto-5"-nucleotidase inhibitor, suppressed the hydrolysis of AMP and reversed the inhibition of cell growth induced by AMP but not by adenosine. alpha,beta-methyleneadenosine 5'-diphosphate 0-24 5'-nucleotidase ecto Homo sapiens 29-49 17643826-8 2007 In addition, the cell treatment with APCP (alpha,beta-methyleneadenosine-5"-diphosphate), an ecto-5"-NT/CD73 inhibitor, led to a significant reduction in glioma cell proliferation. alpha,beta-methyleneadenosine 5'-diphosphate 43-87 5'-nucleotidase ecto Homo sapiens 104-108 18404437-7 2007 Ecto-5"-nucleotidase was susceptible to inhibition by zinc acetate and by alpha,beta-methylene-adenosine diphosphate (alpha,beta-methylene-ADP). alpha,beta-methyleneadenosine 5'-diphosphate 74-116 5'-nucleotidase ecto Homo sapiens 0-20 18404437-7 2007 Ecto-5"-nucleotidase was susceptible to inhibition by zinc acetate and by alpha,beta-methylene-adenosine diphosphate (alpha,beta-methylene-ADP). alpha,beta-methyleneadenosine 5'-diphosphate 118-142 5'-nucleotidase ecto Homo sapiens 0-20 18404437-10 2007 Ecto-5"-nucleotidase appears to be the major enzyme responsible for generation of adenosine from adenine nucleotides in the T84 cell line, and inhibitors of ecto-5"-nucleotidase, such as alpha,beta-methylene-ADP and zinc, might be useful for treatment of the watery diarrhea produced by EPEC infection. alpha,beta-methyleneadenosine 5'-diphosphate 187-211 5'-nucleotidase ecto Homo sapiens 157-177 14578500-7 2003 The 5"-AMP-induced increase in intracellular cAMP level was inhibited markedly by xanthine amine congener, an adenosine receptor antagonist, and partially by alpha,beta-methylene adenosine 5"-diphosphate, an ecto-5"-nucleotidase inhibitor. alpha,beta-methyleneadenosine 5'-diphosphate 158-203 5'-nucleotidase ecto Homo sapiens 208-228 15893296-7 2005 Inhibition of the enzymatic conversion of ATP to adenosine using a combination of a potent ecto-5"-nucleotidase inhibitor, alpha,beta-methylene adenosine 5"-diphosphate (AMP-CP), and a competitive substrate for ecto-5"-nucleotidase (guanosine monophosphate, GMP) did not affect basal VP release. alpha,beta-methyleneadenosine 5'-diphosphate 170-176 5'-nucleotidase ecto Homo sapiens 211-231 15044076-8 2004 Intracerebroventricular treatment with 960 nmol GMP prevented 80% of seizures and the 5"-nucleotidase inhibitor alpha-beta-methyleneadenosine 5"-diphosphate (AOPCP), when injected 3 min before, reduced this anticonvulsant effect to 30% protection as well as significantly decreased the conversion of GMP into guanosine measured in the CSF. alpha,beta-methyleneadenosine 5'-diphosphate 112-156 5'-nucleotidase ecto Homo sapiens 86-101 15044076-8 2004 Intracerebroventricular treatment with 960 nmol GMP prevented 80% of seizures and the 5"-nucleotidase inhibitor alpha-beta-methyleneadenosine 5"-diphosphate (AOPCP), when injected 3 min before, reduced this anticonvulsant effect to 30% protection as well as significantly decreased the conversion of GMP into guanosine measured in the CSF. alpha,beta-methyleneadenosine 5'-diphosphate 158-163 5'-nucleotidase ecto Homo sapiens 86-101 11509639-8 2001 Because ecto 5" nucleotidase inhibitor (alpha,beta-methylene adenosine-5"-diphosphate) blocked the effect of MTX, adenosine mimicked the effect of MTX, and adenosine A2b receptor antagonist (3,7-dimethyl-1-propargylxanthine) reversed the inhibitory effect of MTX, we suggest that MTX suppresses NF-kappaB activation by releasing adenosine. alpha,beta-methyleneadenosine 5'-diphosphate 40-85 5'-nucleotidase ecto Homo sapiens 8-28 9169488-10 1997 An inhibitor of the ecto-5"-nucleotidase CD73, alpha, beta-methylene ADP (AOPCP), inhibited epithelial Cl- secretory responses to 5"-AMP, but not to authentic adenosine. alpha,beta-methyleneadenosine 5'-diphosphate 47-72 5'-nucleotidase ecto Homo sapiens 20-40 9435300-3 1998 First, pretreatment of a human microvascular endothelial cell line (HMEC-1) with methotrexate increases extracellular adenosine after exposure of the pretreated cells to activated neutrophils; the ecto-5"-nucleotidase inhibitor alpha, beta-methylene adenosine-5"-diphosphate (APCP) abrogates completely the increase in extracellular adenosine. alpha,beta-methyleneadenosine 5'-diphosphate 228-274 5'-nucleotidase ecto Homo sapiens 197-217 9315551-4 1997 The intracoronary administration of alpha,beta-methyleneadenosine 5"-diphosphate, an inhibitor of ecto-5"-nucleotidase, or GF109203X or calphostin C, both of which are PKC inhibitors, attenuated the L-NAME-induced increases in adenosine levels and ecto-5"-nucleotidase activity. alpha,beta-methyleneadenosine 5'-diphosphate 36-80 5'-nucleotidase ecto Homo sapiens 98-118 9315551-4 1997 The intracoronary administration of alpha,beta-methyleneadenosine 5"-diphosphate, an inhibitor of ecto-5"-nucleotidase, or GF109203X or calphostin C, both of which are PKC inhibitors, attenuated the L-NAME-induced increases in adenosine levels and ecto-5"-nucleotidase activity. alpha,beta-methyleneadenosine 5'-diphosphate 36-80 5'-nucleotidase ecto Homo sapiens 248-268 9169488-10 1997 An inhibitor of the ecto-5"-nucleotidase CD73, alpha, beta-methylene ADP (AOPCP), inhibited epithelial Cl- secretory responses to 5"-AMP, but not to authentic adenosine. alpha,beta-methyleneadenosine 5'-diphosphate 47-72 5'-nucleotidase ecto Homo sapiens 41-45 9169488-10 1997 An inhibitor of the ecto-5"-nucleotidase CD73, alpha, beta-methylene ADP (AOPCP), inhibited epithelial Cl- secretory responses to 5"-AMP, but not to authentic adenosine. alpha,beta-methyleneadenosine 5'-diphosphate 74-79 5'-nucleotidase ecto Homo sapiens 20-40 9169488-10 1997 An inhibitor of the ecto-5"-nucleotidase CD73, alpha, beta-methylene ADP (AOPCP), inhibited epithelial Cl- secretory responses to 5"-AMP, but not to authentic adenosine. alpha,beta-methyleneadenosine 5'-diphosphate 74-79 5'-nucleotidase ecto Homo sapiens 41-45 8901821-5 1996 The conversion of cAMP to adenosine and inosine was inhibited by blockade of phosphodiesterase with IBMX, of ecto-phosphodiesterase with DPSPX, and of ecto-5"-nucleotidase with AMP-CP. alpha,beta-methyleneadenosine 5'-diphosphate 177-183 5'-nucleotidase ecto Homo sapiens 151-171 8645720-9 1996 50 microM, alpha,beta-methylene adenosine 5"-diphosphate (AOPCP), a selective inhibitor of ecto 5"-nucleotidase, elevated interstitial AMP concentration tenfold, did not attenuate basal nucleoside release, but completely inhibited Mg2+-stimulated coronary venous purine nucleoside release and blunted Mg2+-stimulated interstitial purine nucleoside formation by 69%. alpha,beta-methyleneadenosine 5'-diphosphate 11-56 5'-nucleotidase ecto Homo sapiens 91-111 8645720-9 1996 50 microM, alpha,beta-methylene adenosine 5"-diphosphate (AOPCP), a selective inhibitor of ecto 5"-nucleotidase, elevated interstitial AMP concentration tenfold, did not attenuate basal nucleoside release, but completely inhibited Mg2+-stimulated coronary venous purine nucleoside release and blunted Mg2+-stimulated interstitial purine nucleoside formation by 69%. alpha,beta-methyleneadenosine 5'-diphosphate 58-63 5'-nucleotidase ecto Homo sapiens 91-111 7532359-5 1995 An inhibitor of 5"-nucleotidase, alpha,beta-methyleneadenosine 5"-diphosphate, blocked most of the response to luminal ATP. alpha,beta-methyleneadenosine 5'-diphosphate 33-77 5'-nucleotidase ecto Homo sapiens 16-31 8779965-6 1996 Addition of alpha, beta-methyleneadenosine 5"-diphosphate (50 microM) to inhibit 5"-nucleotidase activity increased AMP concentrations two- to threefold. alpha,beta-methyleneadenosine 5'-diphosphate 12-57 5'-nucleotidase ecto Homo sapiens 81-96 8417143-3 1993 The ecto-5"-nucleotidase (EC 3.1.3.5) had a Km of 21 microM, was inhibited by AMPPNP and alpha,beta-methylene ADP, and by a specific antiserum. alpha,beta-methyleneadenosine 5'-diphosphate 89-113 5'-nucleotidase ecto Homo sapiens 4-24 8456972-8 1993 Inhibition of ecto-5"-nucleotidase by alpha,beta-methylene-ADP (5 x 10(-5) M) enhanced AN release from 2.6 to 8.2 pmol.min-1 x ml CV-1 and reduced ADO release by an equivalent extent. alpha,beta-methyleneadenosine 5'-diphosphate 38-62 5'-nucleotidase ecto Homo sapiens 14-34 8417143-6 1993 The intraterminal 5"-nucleotidase enzyme, which amounted to 40% of the total 5"-nucleotidase activity, was inhibited by AMPPNP, alpha,beta-methylene ADP, and the antiserum, and also had the same kinetic properties as the ectoenzyme. alpha,beta-methyleneadenosine 5'-diphosphate 128-152 5'-nucleotidase ecto Homo sapiens 18-33 8417143-6 1993 The intraterminal 5"-nucleotidase enzyme, which amounted to 40% of the total 5"-nucleotidase activity, was inhibited by AMPPNP, alpha,beta-methylene ADP, and the antiserum, and also had the same kinetic properties as the ectoenzyme. alpha,beta-methyleneadenosine 5'-diphosphate 128-152 5'-nucleotidase ecto Homo sapiens 77-92 1898656-8 1991 alpha, beta-Methyleneadenosine 5"-diphosphate (AMPCP, 2.5 mM), an inhibitor of membranous ecto-5"-nucleotidase, profoundly inhibited endogenous adenosine accumulation under all conditions. alpha,beta-methyleneadenosine 5'-diphosphate 0-45 5'-nucleotidase ecto Homo sapiens 90-110 1832463-7 1991 In the presence of BWA1433U and a continuous intralobar infusion of the selective 5"-nucleotidase inhibitor, alpha,beta-methyleneadenosine-5"-diphosphate, ATP VC responses are significantly enhanced compared to those after BWA1433U. alpha,beta-methyleneadenosine 5'-diphosphate 109-153 5'-nucleotidase ecto Homo sapiens 82-97 1998727-6 1991 Adenosine 5"-[alpha,beta-methylene]diphosphate is a competitive inhibitor of 5"-nucleotidase, whereas concanavalin A inhibits the enzymatic activity in a non-competitive manner. alpha,beta-methyleneadenosine 5'-diphosphate 0-46 5'-nucleotidase ecto Homo sapiens 77-92 1898656-8 1991 alpha, beta-Methyleneadenosine 5"-diphosphate (AMPCP, 2.5 mM), an inhibitor of membranous ecto-5"-nucleotidase, profoundly inhibited endogenous adenosine accumulation under all conditions. alpha,beta-methyleneadenosine 5'-diphosphate 47-52 5'-nucleotidase ecto Homo sapiens 90-110 33909515-6 2021 EXPERT OPINION: : Considerable advances have been reported in the design of nucleotide/nucleoside-based CD73 inhibitors, after the X-ray crystal structure of the enzyme in complex with the non-hydrolyzable ADP analog, adenosine (alpha,beta)-methylene diphosphate (AMPCP), was reported. alpha,beta-methyleneadenosine 5'-diphosphate 264-269 5'-nucleotidase ecto Homo sapiens 104-108 2539728-4 1989 Inhibition of ecto-5"-nucleotidase with 100 microM alpha, beta-methyleneadenosine 5"-diphosphate (AOPCP) reduced plasma adenosine to 22 +/- 6 nM. alpha,beta-methyleneadenosine 5'-diphosphate 98-103 5'-nucleotidase ecto Homo sapiens 14-34 34445661-5 2021 The CD73 inhibitor AMPCP significantly increased IL-6 and decreased IL-10 in both cell types, while TNF only increased in RA cells. alpha,beta-methyleneadenosine 5'-diphosphate 19-24 5'-nucleotidase ecto Homo sapiens 4-8 6094404-4 1984 Kinetic values of 5"-nucleotidase for 5"-AMP (Km = 3-4 microM; Amax = 3-4 mumol/min) were substantially lower than those reported in vitro but also responded predictably to the competitive inhibitor of 5"-nucleotidase, adenosine 5"-[alpha, beta-methylene]diphosphate. alpha,beta-methyleneadenosine 5'-diphosphate 219-266 5'-nucleotidase ecto Homo sapiens 18-33 6086190-3 1984 alpha-beta-Methylene adenosine diphosphate competitively inhibited 5" nucleotidase in lymphocytes from both healthy subjects and patients with CVH: the inhibitor constant (Ki) was higher for lymphocytes from patients with CVH than from control subjects. alpha,beta-methyleneadenosine 5'-diphosphate 0-42 5'-nucleotidase ecto Homo sapiens 67-82 6099286-2 1984 These activity differences were due to true 5"-nucleotidase as shown by its inactivation through specific inhibitors such as concanavalin A and alpha, beta-methylene adenosine diphosphate. alpha,beta-methyleneadenosine 5'-diphosphate 144-187 5'-nucleotidase ecto Homo sapiens 44-59 6291401-5 1982 Specific inhibition of plasma membrane 5"-nucleotidase with 50 microM alpha, beta-methylene adenosine diphosphate (AMPCP) did not decrease purine release during deoxyglucose-induced nucleotide degradation. alpha,beta-methyleneadenosine 5'-diphosphate 115-120 5'-nucleotidase ecto Homo sapiens 39-54 26147331-0 2015 alpha,beta-Methylene-ADP (AOPCP) Derivatives and Analogues: Development of Potent and Selective ecto-5"-Nucleotidase (CD73) Inhibitors. alpha,beta-methyleneadenosine 5'-diphosphate 0-24 5'-nucleotidase ecto Homo sapiens 96-116 33399453-7 2021 Key binding interactions of the known inhibitor adenosine-5"-(alpha,beta-methylene)diphosphate (AMPCP) with hCD73 provided the foundation for our early designs. alpha,beta-methyleneadenosine 5'-diphosphate 96-101 5'-nucleotidase ecto Homo sapiens 108-113 32045236-2 2020 Here, we present the synthesis, structure-activity relationships, and cocrystal structures of novel derivatives of the competitive CD73 inhibitor alpha,beta-methylene-ADP (AOPCP) substituted in the 2-position. alpha,beta-methyleneadenosine 5'-diphosphate 146-170 5'-nucleotidase ecto Homo sapiens 131-135 32045236-2 2020 Here, we present the synthesis, structure-activity relationships, and cocrystal structures of novel derivatives of the competitive CD73 inhibitor alpha,beta-methylene-ADP (AOPCP) substituted in the 2-position. alpha,beta-methyleneadenosine 5'-diphosphate 172-177 5'-nucleotidase ecto Homo sapiens 131-135 31237169-9 2019 This effect was blocked by adenosine 5"-(alpha, beta-methylene) diphosphate, a specific inhibitor of CD 73 and ZM 241385, an A2 adenosine receptor antagonist. alpha,beta-methyleneadenosine 5'-diphosphate 27-75 5'-nucleotidase ecto Homo sapiens 101-106 28560821-9 2018 Inhibition of CD73 by alpha,beta-methylene ADP (AOPCP) in the whole CB preparation in vitro reduced basal discharge frequency by 76 +- 5% and reduced sensory activity throughout graded hypoxia. alpha,beta-methyleneadenosine 5'-diphosphate 22-46 5'-nucleotidase ecto Homo sapiens 14-18 28560821-9 2018 Inhibition of CD73 by alpha,beta-methylene ADP (AOPCP) in the whole CB preparation in vitro reduced basal discharge frequency by 76 +- 5% and reduced sensory activity throughout graded hypoxia. alpha,beta-methyleneadenosine 5'-diphosphate 48-53 5'-nucleotidase ecto Homo sapiens 14-18 27417582-8 2016 However, the CD73 inhibitor alpha-beta-methylene-ADP nullified the prolongation in the time to thrombosis in human CD39 transgenic (hC39-Tg)/CD73-null mice. alpha,beta-methyleneadenosine 5'-diphosphate 28-52 5'-nucleotidase ecto Homo sapiens 13-17 27417582-8 2016 However, the CD73 inhibitor alpha-beta-methylene-ADP nullified the prolongation in the time to thrombosis in human CD39 transgenic (hC39-Tg)/CD73-null mice. alpha,beta-methyleneadenosine 5'-diphosphate 28-52 5'-nucleotidase ecto Homo sapiens 141-145 32865411-5 2020 Based on the binding mode of adenosine 5"-( , -methylene)diphosphate (AOPCP) with human CD73, we designed a series of novel monophosphonate small molecule CD73 inhibitors. alpha,beta-methyleneadenosine 5'-diphosphate 70-75 5'-nucleotidase ecto Homo sapiens 88-92 32865411-5 2020 Based on the binding mode of adenosine 5"-( , -methylene)diphosphate (AOPCP) with human CD73, we designed a series of novel monophosphonate small molecule CD73 inhibitors. alpha,beta-methyleneadenosine 5'-diphosphate 70-75 5'-nucleotidase ecto Homo sapiens 155-159 32313990-7 2020 By contrast, the ecto-phosphodiesterase inhibitor DPSPX (1,3-dipropyl-8-sulfophenylxanthine) and the CD73 ecto-5"-nucleotidase inhibitor AMP-CP (adenosine 5"-(alpha,beta-methylene)diphosphate) were not protective. alpha,beta-methyleneadenosine 5'-diphosphate 137-143 5'-nucleotidase ecto Homo sapiens 101-105 32313990-7 2020 By contrast, the ecto-phosphodiesterase inhibitor DPSPX (1,3-dipropyl-8-sulfophenylxanthine) and the CD73 ecto-5"-nucleotidase inhibitor AMP-CP (adenosine 5"-(alpha,beta-methylene)diphosphate) were not protective. alpha,beta-methyleneadenosine 5'-diphosphate 137-143 5'-nucleotidase ecto Homo sapiens 106-126 26147331-0 2015 alpha,beta-Methylene-ADP (AOPCP) Derivatives and Analogues: Development of Potent and Selective ecto-5"-Nucleotidase (CD73) Inhibitors. alpha,beta-methyleneadenosine 5'-diphosphate 0-24 5'-nucleotidase ecto Homo sapiens 118-122 26147331-0 2015 alpha,beta-Methylene-ADP (AOPCP) Derivatives and Analogues: Development of Potent and Selective ecto-5"-Nucleotidase (CD73) Inhibitors. alpha,beta-methyleneadenosine 5'-diphosphate 26-31 5'-nucleotidase ecto Homo sapiens 96-116 26147331-0 2015 alpha,beta-Methylene-ADP (AOPCP) Derivatives and Analogues: Development of Potent and Selective ecto-5"-Nucleotidase (CD73) Inhibitors. alpha,beta-methyleneadenosine 5'-diphosphate 26-31 5'-nucleotidase ecto Homo sapiens 118-122 26147331-3 2015 The eN inhibitor alpha,beta-methylene-ADP (AOPCP, adenosine-5"-O-[(phosphonomethyl)phosphonic acid]) was used as a lead structure, and derivatives modified in various positions were prepared. alpha,beta-methyleneadenosine 5'-diphosphate 17-41 5'-nucleotidase ecto Homo sapiens 4-6 26147331-3 2015 The eN inhibitor alpha,beta-methylene-ADP (AOPCP, adenosine-5"-O-[(phosphonomethyl)phosphonic acid]) was used as a lead structure, and derivatives modified in various positions were prepared. alpha,beta-methyleneadenosine 5'-diphosphate 43-48 5'-nucleotidase ecto Homo sapiens 4-6 23300031-7 2013 Through treatment with the CD73 inhibitor adenosine 5"-(alpha, beta-methylene) diphosphate, chondrogenic matrix deposition was further increased; in contrast, mineral matrix deposition and expression of osteogenic markers was reduced. alpha,beta-methyleneadenosine 5'-diphosphate 42-90 5'-nucleotidase ecto Homo sapiens 27-31 22137869-6 2013 The treatment with APCP (alpha,beta-methyleneadenosine-5"-diphosphate), another ecto-5"-NT/CD73 inhibitor, led to a significant reduction in cell proliferation. alpha,beta-methyleneadenosine 5'-diphosphate 25-69 5'-nucleotidase ecto Homo sapiens 91-95