PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
10422637-7	1999	Alpha,beta-methyleneadenosine 5"-diphosphate (alpha,beta-meADP, 100 microM), an inhibitor of ecto-5"-nucleotidase, abolished the AMP-induced increase in dialysate adenosine.	alpha,beta-methyleneadenosine 5'-diphosphate	0-44	5' nucleotidase, ecto	Rattus norvegicus	93-113	
16029911-10	2005	Since extracellular ATP is rapidly metabolized to adenosine, we also assessed ATP outflow in the presence of the ecto-5"-nucleotidase inhibitor, alpha,beta-methylene-adenosine diphosphate (AOPCP, 1 mM) directly perfused into the striatum.	alpha,beta-methyleneadenosine 5'-diphosphate	189-194	5' nucleotidase, ecto	Rattus norvegicus	113-133	
14993098-11	2004	Although inhibition of ecto-5"-nucleotidase by alpha,beta-methylene ADP (200 microm) or by concanavalin A (0.1 mg ml(-1)) attenuated endogenous adenosine formation from AMP, analysed by HPLC, the corresponding reduction in [(3)H]ACh release only became evident when stimulation of the myenteric plexus was prolonged to over 250 s. 5.	alpha,beta-methyleneadenosine 5'-diphosphate	47-71	5' nucleotidase, ecto	Rattus norvegicus	23-43	
12670309-6	2003	The source for extracellular adenosine was likely to be intracellular adenosine as the ecto-5"-nucleotidase inhibitor alpha beta-methylene-ADP was unable to block the effect of NMDA.	alpha,beta-methyleneadenosine 5'-diphosphate	118-142	5' nucleotidase, ecto	Rattus norvegicus	87-107	
12356888-3	2002	This inosine signal was greatly reduced by addition of the ecto-5"-nucleotidase inhibitor alpha,beta-methylene ADP (200 microM), suggesting that the inosine arose from adenosine that was produced in the extracellular space by the prior release of ATP.	alpha,beta-methyleneadenosine 5'-diphosphate	90-114	5' nucleotidase, ecto	Rattus norvegicus	59-79	
12356889-6	2002	Addition of the ecto-5"-nucleotidase inhibitor alpha,beta-methylene ADP (200 microM) to the dorsal surface of the brainstem completely abolished the signal evoked by hypoxia, suggesting that the inosine arose from adenosine that was produced in the extracellular space by the prior release of ATP.	alpha,beta-methyleneadenosine 5'-diphosphate	47-71	5' nucleotidase, ecto	Rattus norvegicus	16-36	
10869532-10	2000	Administration of alpha,beta-methylene adenosine diphosphate (AMP-CP), an inhibitor of ecto-5"-nucleotidase, significantly diminished the tolerance to ischemia-reperfusion injury in H group (P<0.05).	alpha,beta-methyleneadenosine 5'-diphosphate	18-60	5' nucleotidase, ecto	Rattus norvegicus	87-107	
10869532-10	2000	Administration of alpha,beta-methylene adenosine diphosphate (AMP-CP), an inhibitor of ecto-5"-nucleotidase, significantly diminished the tolerance to ischemia-reperfusion injury in H group (P<0.05).	alpha,beta-methyleneadenosine 5'-diphosphate	62-68	5' nucleotidase, ecto	Rattus norvegicus	87-107	
10490889-5	1999	Further studies in rat cardiac fibroblasts revealed that the effects of A(1) receptor blockade on extracellular adenosine levels were concentration dependent and prevented by inhibition of G(i) proteins with pertussis toxin or blockade of ecto-5"-nucleotidase with alpha, beta-methyleneadenosine-5"-diphosphate.	alpha,beta-methyleneadenosine 5'-diphosphate	265-310	5' nucleotidase, ecto	Rattus norvegicus	239-259	
11145997-4	2001	This conversion is decreased by the ecto-5"-nucleotidase inhibitor, alpha,beta-methylene ADP.	alpha,beta-methyleneadenosine 5'-diphosphate	68-92	5' nucleotidase, ecto	Rattus norvegicus	36-56	
10978314-5	2000	The ecto-5"-nucleotidase inhibitor, alpha,beta-methylene ADP (100 microm), caused a larger inhibition (54%) of adenosine release in the presence of AA (30 microm) compared with control (37% inhibition) indicating that the AA-induced extracellular adenosine accumulation is mostly originated from an increased release and extracellular catabolism of ATP.	alpha,beta-methyleneadenosine 5'-diphosphate	36-60	5' nucleotidase, ecto	Rattus norvegicus	4-24	
10700389-5	2000	The introduction of AMP (100 microM) through the probe increased markedly the dialysate adenosine to 8.95 +/- 0.86 microM, and this increase was inhibited by ecto-5"-nucleotidase inhibitor, alpha, beta-methyleneadenosine 5"-diphosphate (AOPCP, 100 microM), to 0.66 +/- 0.38 microM.	alpha,beta-methyleneadenosine 5'-diphosphate	237-242	5' nucleotidase, ecto	Rattus norvegicus	158-178	
10543721-6	1999	In the presence of AOPCP (alpha,beta-methyleneadenosine 5"-diphosphate), an ecto-5"-nucleotidase inhibitor, the ganglion-stimulated increase in interstitial ATP and adenosine reached levels similar to those in the absence of AOPCP, also suggesting that adenosine does not derive from extracellular ATP.	alpha,beta-methyleneadenosine 5'-diphosphate	19-24	5' nucleotidase, ecto	Rattus norvegicus	76-96	
10543721-6	1999	In the presence of AOPCP (alpha,beta-methyleneadenosine 5"-diphosphate), an ecto-5"-nucleotidase inhibitor, the ganglion-stimulated increase in interstitial ATP and adenosine reached levels similar to those in the absence of AOPCP, also suggesting that adenosine does not derive from extracellular ATP.	alpha,beta-methyleneadenosine 5'-diphosphate	26-70	5' nucleotidase, ecto	Rattus norvegicus	76-96	
9580599-6	1998	Inhibition of 5"-nucleotidase by alpha, beta-methylene ADP dose-dependently decreased adenosine levels under basal as well as NMDA-stimulated conditions.	alpha,beta-methyleneadenosine 5'-diphosphate	33-58	5' nucleotidase, ecto	Rattus norvegicus	14-29	
9288680-6	1997	alpha, beta-Methyleneadenosine 5"-diphosphate (AOPCP, 100 microM), an inhibitor of ecto-5"-nucleotidase, abolished the AMP-induced increase in dialysate adenosine, but did not affect the baseline level of adenosine.	alpha,beta-methyleneadenosine 5'-diphosphate	0-45	5' nucleotidase, ecto	Rattus norvegicus	83-103	
9288680-6	1997	alpha, beta-Methyleneadenosine 5"-diphosphate (AOPCP, 100 microM), an inhibitor of ecto-5"-nucleotidase, abolished the AMP-induced increase in dialysate adenosine, but did not affect the baseline level of adenosine.	alpha,beta-methyleneadenosine 5'-diphosphate	47-52	5' nucleotidase, ecto	Rattus norvegicus	83-103	
7697853-8	1995	The increase in adenosine release was blunted by GF109203X and alpha, beta-methyleneadenosine 5"-diphosphate, an inhibitor of ecto-5"-nucleotidase.	alpha,beta-methyleneadenosine 5'-diphosphate	63-108	5' nucleotidase, ecto	Rattus norvegicus	126-146	
9336768-6	1997	In contrast, the coapplication of a cAMP-phosphodiesterase inhibitor, 3-isobutyl-1-methylxanthine (IBMX), or a 5"-nucleotidase inhibitor, adenosine 5"-[alpha, beta-methylene] diphosphate (AMP-CP), enhanced the cAMP-induced suppressive effect.	alpha,beta-methyleneadenosine 5'-diphosphate	138-186	5' nucleotidase, ecto	Rattus norvegicus	111-126	
2537026-2	1989	Intramuscular injection of the ADP-analogue adenosine alpha, beta-methylene diphosphate (AMP-CP) achieved a 70% reduction in 5"-nucleotidase activity, as measured in crude extracts of rat kidney.	alpha,beta-methyleneadenosine 5'-diphosphate	44-87	5' nucleotidase, ecto	Rattus norvegicus	125-140	
8515275-10	1993	Inhibition of ecto-5"-nucleotidase by alpha,beta-methylene ADP and GMP did not affect basal adenosine outflow but potentiated "ischemia"-evoked adenosine outflow.	alpha,beta-methyleneadenosine 5'-diphosphate	38-62	5' nucleotidase, ecto	Rattus norvegicus	14-34	
1967143-4	1990	Inhibition of ecto-5"-nucleotidase by alpha,beta-methylene ADP and GMP decreased basal release of adenosine by 40%, indicating that part of the adenosine was derived from the extracellular metabolism of released nucleotide.	alpha,beta-methyleneadenosine 5'-diphosphate	38-62	5' nucleotidase, ecto	Rattus norvegicus	14-34	
2993513-5	1985	In the presence of alpha,beta-methylene ADP and GMP, which inhibit ecto-5"-nucleotidase, conversion of added ATP and AMP to adenosine was inhibited by 90% in synaptosomal suspensions.	alpha,beta-methyleneadenosine 5'-diphosphate	19-43	5' nucleotidase, ecto	Rattus norvegicus	67-87	
35416841-6	2022	Chronic constriction injury rat models were intraperitoneally injected with alpha,beta-methyleneadenosine 5"-diphosphate, an ecto-5"-nucleotidase inhibitor, 30 min before electroacupuncture.	alpha,beta-methyleneadenosine 5'-diphosphate	76-120	5' nucleotidase, ecto	Rattus norvegicus	125-145	
8450475-9	1993	Moreover, reduction of extracellular adenosine formation by a focal injection of an ecto-5"-nucleotidase inhibitor, alpha, beta-methyleneadenosine diphosphate, produced generalized seizures (ED50 = 37.3 +/- 22.7 nmol).	alpha,beta-methyleneadenosine 5'-diphosphate	116-158	5' nucleotidase, ecto	Rattus norvegicus	84-104	
12106218-5	1991	Inhibition of ecto-5"-nucleotidase by alpha,beta-methylene ADP and GMP decreased basal and stimulated efflux of adenosine in the cerebellum by 50 - 60%, indicating that a significant proportion of adenosine was derived from the extracellular metabolism of released nucleotides.	alpha,beta-methyleneadenosine 5'-diphosphate	38-62	5' nucleotidase, ecto	Rattus norvegicus	14-34	
2352651-9	1990	Decreasing the levels of endogenous adenosine by increasing the concentration of adenosine deaminase and adding the 5"-nucleotidase inhibitor alpha-beta-methylene adenosine-5"-diphosphate gave an increase in [3H]8-cyclopentyl-1,3-dipropylxanthine binding and diminished the response to GTP.	alpha,beta-methyleneadenosine 5'-diphosphate	142-187	5' nucleotidase, ecto	Rattus norvegicus	116-131	
2537026-2	1989	Intramuscular injection of the ADP-analogue adenosine alpha, beta-methylene diphosphate (AMP-CP) achieved a 70% reduction in 5"-nucleotidase activity, as measured in crude extracts of rat kidney.	alpha,beta-methyleneadenosine 5'-diphosphate	89-95	5' nucleotidase, ecto	Rattus norvegicus	125-140	
32595514-5	2020	Furthermore, to interfere with the endogenous adenosine release, the ecto-5"-nucleotidase (CD73) inhibitor was applied [5"-(alpha,beta-methylene) diphosphate sodium salt (AMPCP), 500 muM].	alpha,beta-methyleneadenosine 5'-diphosphate	171-176	5' nucleotidase, ecto	Rattus norvegicus	69-89	
6303317-2	1983	This activity is inhibited by the alpha, beta-methyleneadenosine 5"-diphosphate, a specific inhibitor of 5"-nucleotidase.	alpha,beta-methyleneadenosine 5'-diphosphate	34-79	5' nucleotidase, ecto	Rattus norvegicus	105-120	
6123548-3	1982	AMP was somewhat less effective than adenosine, and its effect could be partially, but not completely, abolished by alpha, beta-methylene-ADP and GMP, which inhibited its metabolism by 5"-nucleotidase.	alpha,beta-methyleneadenosine 5'-diphosphate	116-141	5' nucleotidase, ecto	Rattus norvegicus	185-200	
3593790-3	1987	The inhibitor of 5"-nucleotidase (alpha,beta-methylene)-ADP, did not affect PIMOI cleavage and moderately inhibited AMP hydrolysis (by ADP, did not affect PIMOI cleavage and moderately inhibited AMP hydrolysis (by 30-50%), thus suggesting that acidic phosphatases are responsible for PIMOI and AMP hydrolysis under these conditions (pH 6.3).	alpha,beta-methyleneadenosine 5'-diphosphate	34-59	5' nucleotidase, ecto	Rattus norvegicus	17-32	
3003346-3	1986	A competitive inhibitor of 5"-nucleotidase, alpha,beta-methyleneadenosine diphosphate (120 microM), inhibited the production of adenosine during hypoxia (perfusate, 0.26 +/- 0.05 microM and renal cortex, 3.1 nmol/g) but did not prevent the decline in cortical tissue ATP and ADP.	alpha,beta-methyleneadenosine 5'-diphosphate	44-85	5' nucleotidase, ecto	Rattus norvegicus	27-42	
6098264-1	1984	Serum 5"-nucleotidase in rat and man is derived from the plasma membrane rather than the cytosol by the criteria of inhibition with [alpha beta-methylene]ADP and antisera.	alpha,beta-methyleneadenosine 5'-diphosphate	132-157	5' nucleotidase, ecto	Rattus norvegicus	6-21	
32595514-5	2020	Furthermore, to interfere with the endogenous adenosine release, the ecto-5"-nucleotidase (CD73) inhibitor was applied [5"-(alpha,beta-methylene) diphosphate sodium salt (AMPCP), 500 muM].	alpha,beta-methyleneadenosine 5'-diphosphate	171-176	5' nucleotidase, ecto	Rattus norvegicus	91-95	
31354490-0	2019	The Ecto-5"-Nucleotidase/CD73 Inhibitor, alpha,beta-Methylene Adenosine 5"-Diphosphate, Exacerbates Carrageenan-Induced Pleurisy in Rat.	alpha,beta-methyleneadenosine 5'-diphosphate	41-86	5' nucleotidase, ecto	Rattus norvegicus	4-24	
31220343-4	2019	EXPERIMENTAL APPROACH: Effects of blocking CD73 with alpha,beta-methylene ADP (AOPCP) were assayed in 6-OHDA-treated rats and dopamine-differentiated neuroblastoma SH-SY5Y cells.	alpha,beta-methyleneadenosine 5'-diphosphate	53-77	5' nucleotidase, ecto	Rattus norvegicus	43-47	
31220343-4	2019	EXPERIMENTAL APPROACH: Effects of blocking CD73 with alpha,beta-methylene ADP (AOPCP) were assayed in 6-OHDA-treated rats and dopamine-differentiated neuroblastoma SH-SY5Y cells.	alpha,beta-methyleneadenosine 5'-diphosphate	79-84	5' nucleotidase, ecto	Rattus norvegicus	43-47	
31354490-0	2019	The Ecto-5"-Nucleotidase/CD73 Inhibitor, alpha,beta-Methylene Adenosine 5"-Diphosphate, Exacerbates Carrageenan-Induced Pleurisy in Rat.	alpha,beta-methyleneadenosine 5'-diphosphate	41-86	5' nucleotidase, ecto	Rattus norvegicus	25-29	
31354490-3	2019	Adenosine 5"-(alpha,beta-methylene)diphosphate (APCP) is a CD73 inhibitor, widely used as pharmacological tool to investigate the role of CD73/adenosine pathway in several in vitro and in vivo models, although it has been also shown to inhibit other ectoenzymes involved in adenosinergic pathway.	alpha,beta-methyleneadenosine 5'-diphosphate	0-46	5' nucleotidase, ecto	Rattus norvegicus	59-63	
31354490-3	2019	Adenosine 5"-(alpha,beta-methylene)diphosphate (APCP) is a CD73 inhibitor, widely used as pharmacological tool to investigate the role of CD73/adenosine pathway in several in vitro and in vivo models, although it has been also shown to inhibit other ectoenzymes involved in adenosinergic pathway.	alpha,beta-methyleneadenosine 5'-diphosphate	0-46	5' nucleotidase, ecto	Rattus norvegicus	138-142	
30913879-2	2019	Here we report that in an asthma model of male Sprague-Dawley rats, the expression and activity of ecto-5"-nucleotidase (CD73) were decreased in airway vagal centers, ATP concentration in cerebral spinal fluid was increased, and the inhibitory and excitatory airway vagal responses to intracisternally injected ATP (5 mumol) and CD73 inhibitor AMPCP (5 mumol), respectively, were attenuated.	alpha,beta-methyleneadenosine 5'-diphosphate	344-349	5' nucleotidase, ecto	Rattus norvegicus	99-119	
30913879-2	2019	Here we report that in an asthma model of male Sprague-Dawley rats, the expression and activity of ecto-5"-nucleotidase (CD73) were decreased in airway vagal centers, ATP concentration in cerebral spinal fluid was increased, and the inhibitory and excitatory airway vagal responses to intracisternally injected ATP (5 mumol) and CD73 inhibitor AMPCP (5 mumol), respectively, were attenuated.	alpha,beta-methyleneadenosine 5'-diphosphate	344-349	5' nucleotidase, ecto	Rattus norvegicus	121-125	
29331956-9	2018	A subset of MSCs were pretreated with the CD73 inhibitor, alpha,beta-methylene adenosine diphosphate, before implantation.	alpha,beta-methyleneadenosine 5'-diphosphate	58-100	5' nucleotidase, ecto	Rattus norvegicus	42-46	
19966059-6	2010	The upregulation of adenosine receptors by phenylephrine was also abrogated by adenosine 5"-(alpha,beta-methylene)diphosphate, an inhibitor of ectosolic 5"-nucleotidase.	alpha,beta-methyleneadenosine 5'-diphosphate	79-125	5' nucleotidase, ecto	Rattus norvegicus	153-168	
18223197-4	2008	In 17 control kidneys pretreated with alpha,beta-methylene-adenosine-5"-diphosphate (inhibitor of ecto-5"-nucleotidase to prevent AMP metabolism; 100 microM), addition of cAMP (10 microM) to the perfusate increased renal venous AMP from 0.6 +/- 0.2 to 3.5 +/- 0.5 nmol/min/g.	alpha,beta-methyleneadenosine 5'-diphosphate	38-83	5' nucleotidase, ecto	Rattus norvegicus	98-118