PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 29475177-13 2018 These data further support the role of periprocedural Gp IIb-IIIa inhibitors in order to overcome any suboptimal inhibition of platelet aggregation at the time of the procedure due to drug-resistance or delayed (downstream) administration of ADP antagonists, especially in complex high-risk procedures. Adenosine Diphosphate 242-245 integrin subunit alpha 2b Homo sapiens 54-60 29126301-3 2017 Platelet-derived ADP and thromboxane activate non-adhered platelets via their GPIIb/IIIa receptors, allowing these platelets to participate in platelet aggregation. Adenosine Diphosphate 17-20 integrin subunit alpha 2b Homo sapiens 78-83 26160282-7 2015 The reduction of GPIIb/IIIa on the platelet surface was further proved by the reduction of further activated platelet GPIIb/IIIa surface expression induced by ADP and the increase in GPIIb/IIIa concentration in microparticle-free plasma with increasing the applied shear stress and exposure time. Adenosine Diphosphate 159-162 integrin subunit alpha 2b Homo sapiens 17-22 28092426-8 2017 Methods Whole blood was treated in vitro with ~ 50% inhibitory concentrations of ticagrelor, T-AM, cangrelor, P-AM and assessed for ADP-stimulated activated GPIIb-IIIa and P-selectin and vasodilator-stimulated phosphoprotein (VASP) platelet reactivity index (PRI) before and after 100-fold dilution. Adenosine Diphosphate 132-135 integrin subunit alpha 2b Homo sapiens 157-162 26282717-9 2015 In washed human platelets, 100 nM riociguat reduced ADP-induced GPIIb/IIIa activation, while a 10-fold higher concentration was required to reduce convulxin-stimulated GPIIb/IIIa activation. Adenosine Diphosphate 52-55 integrin subunit alpha 2b Homo sapiens 64-69 27028818-8 2016 According to the data obtained by Western blot, upon the cell activation with ADP, the number of GP IIb-IIIa and P2Y12 receptors increases, which may serve as evidence of these proteins being synthesized in the activated platelets. Adenosine Diphosphate 78-81 integrin subunit alpha 2b Homo sapiens 97-103 26160282-7 2015 The reduction of GPIIb/IIIa on the platelet surface was further proved by the reduction of further activated platelet GPIIb/IIIa surface expression induced by ADP and the increase in GPIIb/IIIa concentration in microparticle-free plasma with increasing the applied shear stress and exposure time. Adenosine Diphosphate 159-162 integrin subunit alpha 2b Homo sapiens 118-123 26160282-7 2015 The reduction of GPIIb/IIIa on the platelet surface was further proved by the reduction of further activated platelet GPIIb/IIIa surface expression induced by ADP and the increase in GPIIb/IIIa concentration in microparticle-free plasma with increasing the applied shear stress and exposure time. Adenosine Diphosphate 159-162 integrin subunit alpha 2b Homo sapiens 118-123 26058047-6 2015 ADP-induced platelet reactivity by all aggregation tests correlated significantly with ADP-induced P-selectin expression and activated GPIIb/IIIa (all p<0.001). Adenosine Diphosphate 0-3 integrin subunit alpha 2b Homo sapiens 135-140 26014752-6 2015 Patients with concomitant CCB therapy showed significantly higher platelet surface expressions of P-selectin and activated GPIIb/IIIa in response to ADP than patients without CCBs (both P <= 0.03). Adenosine Diphosphate 149-152 integrin subunit alpha 2b Homo sapiens 123-128 26014752-7 2015 Moreover, the fold increase of P-selectin and activated GPIIb/IIIa in response to ADP was significantly more pronounced in patients taking CCBs (both P <= 0.03). Adenosine Diphosphate 82-85 integrin subunit alpha 2b Homo sapiens 56-61 26014752-8 2015 The associations of ADP-inducible activated GPIIb/IIIa and fold increase of activated GPIIb/IIIa after the addition of ADP with CCB therapy remained significant after adjustment for differences in patient characteristics and factors that were previously associated with clopidogrel response by multivariate regression analyses (both P < 0.05). Adenosine Diphosphate 20-23 integrin subunit alpha 2b Homo sapiens 44-49 26014752-8 2015 The associations of ADP-inducible activated GPIIb/IIIa and fold increase of activated GPIIb/IIIa after the addition of ADP with CCB therapy remained significant after adjustment for differences in patient characteristics and factors that were previously associated with clopidogrel response by multivariate regression analyses (both P < 0.05). Adenosine Diphosphate 20-23 integrin subunit alpha 2b Homo sapiens 86-91 26014752-8 2015 The associations of ADP-inducible activated GPIIb/IIIa and fold increase of activated GPIIb/IIIa after the addition of ADP with CCB therapy remained significant after adjustment for differences in patient characteristics and factors that were previously associated with clopidogrel response by multivariate regression analyses (both P < 0.05). Adenosine Diphosphate 119-122 integrin subunit alpha 2b Homo sapiens 44-49 26014752-8 2015 The associations of ADP-inducible activated GPIIb/IIIa and fold increase of activated GPIIb/IIIa after the addition of ADP with CCB therapy remained significant after adjustment for differences in patient characteristics and factors that were previously associated with clopidogrel response by multivariate regression analyses (both P < 0.05). Adenosine Diphosphate 119-122 integrin subunit alpha 2b Homo sapiens 86-91 26058047-8 2015 The platelet surface expressions of P-selectin and activated GPIIb/IIIa in response to ADP were significantly higher in patients with high on-treatment residual platelet reactivity (HRPR) to ADP by all test systems (all p<0.001). Adenosine Diphosphate 87-90 integrin subunit alpha 2b Homo sapiens 61-66 26058047-8 2015 The platelet surface expressions of P-selectin and activated GPIIb/IIIa in response to ADP were significantly higher in patients with high on-treatment residual platelet reactivity (HRPR) to ADP by all test systems (all p<0.001). Adenosine Diphosphate 191-194 integrin subunit alpha 2b Homo sapiens 61-66 22372532-9 2013 We demonstrated that diminished expression of active GPIIb/IIIa in the ADP-activated platelets is associated with increased carotid IMT, independently of stroke. Adenosine Diphosphate 71-74 integrin subunit alpha 2b Homo sapiens 53-58 24642865-4 2014 The P-selectin and activated gpIIb/IIIa expression on platelet membranes in response to ADP, collagen and thrombin stimulation was measured at various hematocrit and oxygen levels. Adenosine Diphosphate 88-91 integrin subunit alpha 2b Homo sapiens 29-34 24401225-5 2014 Platelet surface expression of P-selectin and activated glycoprotein IIb/IIIa (GPIIb/IIIa) in response to ADP, AA, and TRAP-6, and the formation of monocyte-platelet aggregates (MPA) in response to ADP and TRAP-6 were assessed by flow cytometry. Adenosine Diphosphate 106-109 integrin subunit alpha 2b Homo sapiens 79-84 23676293-5 2013 R-138727 and the GPIIb-IIIa antagonists had additive inhibitory effects on collagen-stimulated platelet aggregation and on the collagen plus ADP-stimulated level of activated platelet surface GPIIb-IIIa. Adenosine Diphosphate 141-144 integrin subunit alpha 2b Homo sapiens 17-22 23676293-5 2013 R-138727 and the GPIIb-IIIa antagonists had additive inhibitory effects on collagen-stimulated platelet aggregation and on the collagen plus ADP-stimulated level of activated platelet surface GPIIb-IIIa. Adenosine Diphosphate 141-144 integrin subunit alpha 2b Homo sapiens 192-197 24019084-6 2014 CD41-platelet expression, however, was significantly increased in patients with KD compared with controls, both at rest (14.3 +- 1.9 vs 12.4 +- 1.9 mean fluorescence intensity [mfi], P = .01) and after adenosine diphosphate stimulation (19.3 +- 1.3 vs 17 +- 1.7 mfi, P < .001). Adenosine Diphosphate 202-223 integrin subunit alpha 2b Homo sapiens 0-4 24401225-5 2014 Platelet surface expression of P-selectin and activated glycoprotein IIb/IIIa (GPIIb/IIIa) in response to ADP, AA, and TRAP-6, and the formation of monocyte-platelet aggregates (MPA) in response to ADP and TRAP-6 were assessed by flow cytometry. Adenosine Diphosphate 198-201 integrin subunit alpha 2b Homo sapiens 79-84 24401225-7 2014 Likewise, the expression of P-selectin and GPIIb/IIIa following stimulation with ADP and AA, and MPA formation in response to ADP were significantly higher in PAD patients than in CAD patients. Adenosine Diphosphate 81-84 integrin subunit alpha 2b Homo sapiens 43-48 23729489-8 2013 Moreover, patients with CKD exhibited a more pronounced expression of GPIIb/IIIa in response to ADP (13 versus 9.6 MFI) and AA (6 versus 5.1 MFI; both P<= 0.02) than patients without CKD. Adenosine Diphosphate 96-99 integrin subunit alpha 2b Homo sapiens 70-75 22197119-6 2013 RESULTS: MPAs and expression of platelet receptors CD41 and PAC-1 were significantly lower in patients with than patients without PIA, both with and without ADP stimulation. Adenosine Diphosphate 157-160 integrin subunit alpha 2b Homo sapiens 51-55 23340049-6 2013 Obesity was independently associated with higher residual platelet reactivity by the VASP assay and MEA ADP, and with platelet surface expressions of P-selectin and activated GPIIb/IIIa in response to ADP (all P <= 0.04). Adenosine Diphosphate 201-204 integrin subunit alpha 2b Homo sapiens 175-180 28348696-3 2013 The purpose of this review is to define the roles that GP IIb/IIIa inhibitors may still have in acute ischemic settings by explaining why in high risk patients they might be preferable and/or whether they might be added to ADP inhibitors also emphasizing the underlying mechanistic actions. Adenosine Diphosphate 223-226 integrin subunit alpha 2b Homo sapiens 55-61 23558828-7 2013 At rest, MPAs and CD41 platelet expression increased more with ADP in MVA patients (+71+-11.0% and +37+-7.5%, respectively), than in CAD patients (+37+-8.6% and +19+-4.5%, respectively) and controls (+29+-3.5% and +21+-3.1%, respectively; P<0.001 for both). Adenosine Diphosphate 63-66 integrin subunit alpha 2b Homo sapiens 18-22 22294727-6 2012 Expression of P-selectin and activated GPIIb/IIIa in response to high-dose ADP was lower during eltrombopag treatment than at baseline. Adenosine Diphosphate 75-78 integrin subunit alpha 2b Homo sapiens 39-44 21470666-11 2011 ADP induced a higher increase in CD41 platelet expression in STEMI patients compared to controls both at 1 and 6 months (P < 0.001). Adenosine Diphosphate 0-3 integrin subunit alpha 2b Homo sapiens 33-37 21642242-10 2011 While no differences in the increase in MPA and CD41 expression were observed after EST-1 and EST-2, ADP stimulation after EST-2 induced a lower increase in MPA (+18.3+-8.1% vs +27.9+-9.7%, p<0.001) and CD41 (+18.3+-9.2% vs +27.2+-12.4%, p<0.001) than after EST-1. Adenosine Diphosphate 101-104 integrin subunit alpha 2b Homo sapiens 206-210 21329420-8 2011 Positive correlation of the level of ADP-induced aggregation and GP IIb-IIIa content was detected in patients with ACS within the first hour upon admission to the hospital when they had already received aspirin, but not clopidogrel. Adenosine Diphosphate 37-40 integrin subunit alpha 2b Homo sapiens 65-71 21329420-5 2011 In healthy volunteers positive associations were observed between GP IIb-IIIa number and the level of ADP-induced aggregation when this relationship was analysed in untreated platelet-rich plasma (PRP) as well as upon in vitro addition of aspirin or non-saturating concentrations of GP IIb-IIIa blockers. Adenosine Diphosphate 102-105 integrin subunit alpha 2b Homo sapiens 66-72 21329420-5 2011 In healthy volunteers positive associations were observed between GP IIb-IIIa number and the level of ADP-induced aggregation when this relationship was analysed in untreated platelet-rich plasma (PRP) as well as upon in vitro addition of aspirin or non-saturating concentrations of GP IIb-IIIa blockers. Adenosine Diphosphate 102-105 integrin subunit alpha 2b Homo sapiens 283-289 19126390-7 2009 2 positive phage antibodies with high specific for GP IIb/IIIa were verified, and the purified antibody can inhibited ADP induced platelet aggregation. Adenosine Diphosphate 118-121 integrin subunit alpha 2b Homo sapiens 51-57 20823666-7 2010 Adenosine diphosphate (ADP)-induced or non-ADP-induced expression of P-selectin and GPIIb/IIIa was significantly higher in AMI, ICH or DM than that in controls (P < 0.01 for each). Adenosine Diphosphate 0-21 integrin subunit alpha 2b Homo sapiens 84-89 20823666-7 2010 Adenosine diphosphate (ADP)-induced or non-ADP-induced expression of P-selectin and GPIIb/IIIa was significantly higher in AMI, ICH or DM than that in controls (P < 0.01 for each). Adenosine Diphosphate 23-26 integrin subunit alpha 2b Homo sapiens 84-89 20823666-7 2010 Adenosine diphosphate (ADP)-induced or non-ADP-induced expression of P-selectin and GPIIb/IIIa was significantly higher in AMI, ICH or DM than that in controls (P < 0.01 for each). Adenosine Diphosphate 43-46 integrin subunit alpha 2b Homo sapiens 84-89 20823666-8 2010 Either SZ-21 or aspirin can inhibit the ADP-induced expression of P-selectin and GPIIb/IIIa. Adenosine Diphosphate 40-43 integrin subunit alpha 2b Homo sapiens 81-86 18282622-4 2009 Platelet reactivity was assessed by ADP-induced aggregation and activation was measured by p-selectin, total and active GPIIb/IIIa expression, and platelet-leukocyte aggregates in. Adenosine Diphosphate 36-39 integrin subunit alpha 2b Homo sapiens 120-125 20076852-6 2010 In the stroke patients the increased expressions of P-selectin and active GP IIb/IIIa in TRAP- or ADP-activated cells were less pronounced (p<0.01), while the increments in PMP fraction remained higher (p<0.05). Adenosine Diphosphate 98-101 integrin subunit alpha 2b Homo sapiens 74-80 18712091-5 2008 The level and rate of platelet aggregation induced by ADP (1.25-20 M) correlated with GP IIb-IIIa number (r from 0.315 to 0.591) and were higher in a group of donors with high in comparison with low GP IIb-IIIa content (> 60 and (40-50) x 10(3) per platelet respectively). Adenosine Diphosphate 54-57 integrin subunit alpha 2b Homo sapiens 86-92 18841285-4 2008 After stimulation with 20 muM ADP, 2 hours after LD, significantly lower expression of activated GPIIb/IIIa (4.3 vs. 21.8 [mean fluorescent intensity (MFI)], p < 0.001) and P-selectin (2.0 vs. 11.7 MFI, p < 0.001) along with decreased formation of platelet-monocyte aggregates (16.4% vs. 29.6% positive cells, p < 0.001) was observed with prasugrel versus clopidogrel. Adenosine Diphosphate 30-33 integrin subunit alpha 2b Homo sapiens 97-102 18718422-6 2008 Patients in the upper tertile displayed greater platelet aggregation to 5-mumol/l adenosine diphosphate (ADP) (50.7 +/- 16.4% vs. 34.2 +/- 17.3%, p < 0.001), 1.5-mmol/l arachidonic acid (AA) (27.3 +/- 16.9% vs. 11.7 +/- 9.3%, p < 0.001), and 1-mug/ml collagen (18 +/- 11.6% vs. 12.1 +/- 8.7%, p < 0.05) and greater expression of GP IIb/IIIa (4.7 +/- 1.8% vs. 3.1 +/- 2.2%, p < 0.001). Adenosine Diphosphate 105-108 integrin subunit alpha 2b Homo sapiens 338-344 18687246-10 2008 RESULTS: Current smokers on chronic clopidogrel therapy displayed significantly lower PA and ADP-stimulated active GP IIb/IIIa expression compared with NS (p < or = 0.0008 for both). Adenosine Diphosphate 93-96 integrin subunit alpha 2b Homo sapiens 115-121 18712091-5 2008 The level and rate of platelet aggregation induced by ADP (1.25-20 M) correlated with GP IIb-IIIa number (r from 0.315 to 0.591) and were higher in a group of donors with high in comparison with low GP IIb-IIIa content (> 60 and (40-50) x 10(3) per platelet respectively). Adenosine Diphosphate 54-57 integrin subunit alpha 2b Homo sapiens 199-205 17957566-7 2007 Consistent correlations were revealed between GP IIb-IIIa quantity and the level and rate of ADP-induced aggregation (r from 0.353 to 0.583, p from <0.001 to 0.037) as well as resistance (level of residual aggregation) to both GP IIb-IIIa antagonists (r from 0.345 to 0.602, p from <0.001 to 0.042). Adenosine Diphosphate 93-96 integrin subunit alpha 2b Homo sapiens 46-52 17957566-7 2007 Consistent correlations were revealed between GP IIb-IIIa quantity and the level and rate of ADP-induced aggregation (r from 0.353 to 0.583, p from <0.001 to 0.037) as well as resistance (level of residual aggregation) to both GP IIb-IIIa antagonists (r from 0.345 to 0.602, p from <0.001 to 0.042). Adenosine Diphosphate 93-96 integrin subunit alpha 2b Homo sapiens 230-236 16987338-9 2006 HES200/0.5 and HES130/0.4 reduced the CD42b, CD41/61 and CD62p expression of ADP-agonist-activated platelets at 15 min after intravenous infusion. Adenosine Diphosphate 77-80 integrin subunit alpha 2b Homo sapiens 45-52 17683357-8 2007 At 20% and 40% dilutions, ADP and TRAP-induced expression of activated platelet surface GP IIb/IIIa was significantly increased by B-HES compared to NB-HES and RL. Adenosine Diphosphate 26-29 integrin subunit alpha 2b Homo sapiens 88-94 17683357-13 2007 B-HES but not NB-HES increases the expression of activated platelet GP IIb/IIIa induced by ADP or TRAP. Adenosine Diphosphate 91-94 integrin subunit alpha 2b Homo sapiens 68-74 17602871-7 2007 Flow cytometric analysis revealed minor changes in CD41 expression after ADP on the 3rd day compared to 1st day and on the 5th day compared to 3rd day. Adenosine Diphosphate 73-76 integrin subunit alpha 2b Homo sapiens 51-55 17239165-7 2007 ADP-induced GPIIb/IIIa activation showed the same pattern as LTA (r = 0.74). Adenosine Diphosphate 0-3 integrin subunit alpha 2b Homo sapiens 12-17 17393024-10 2007 On ADP-stimulated platelets the thresholds for P-selectin expression and GP IIb/IIa activation are 34.0 degrees C and 36.4 degrees C, respectively, and lie in the temperature range routinely applied in cardiac surgery. Adenosine Diphosphate 3-6 integrin subunit alpha 2b Homo sapiens 73-79 17337041-13 2007 CONCLUSIONS: Our data show that, in patients with stable CAD, an increased platelet reactivity to C/ADP stimulation after exercise, as assessed by the PFA-100 method, is specifically associated with an increased expression of platelet GP IIb/IIIa receptor. Adenosine Diphosphate 100-103 integrin subunit alpha 2b Homo sapiens 235-241 16792915-5 2006 RESULTS: (1) Anti-platelet GPIIb/IIIa and/or GPIb/IX autoantibodies were detected in 34 of 68 (53.6%) ITP patients" plasmas and that from 5 patients significantly inhibited the platelet aggregation induced by ADP or ristocetin. Adenosine Diphosphate 209-212 integrin subunit alpha 2b Homo sapiens 27-32 16634757-5 2006 Conversely, the platelet shape change promoted by ADP in the presence of the GPIIb/IIIa antagonist eptifibatide was similar to that promoted by MRS2365. Adenosine Diphosphate 50-53 integrin subunit alpha 2b Homo sapiens 77-82 15955470-5 2005 While the platelet count was similar in both groups, platelet sensitivity to stimulators was reduced in group 1 (P-selectin and activated GP IIb/IIIa on ADP-stimulated platelets, p < or = 0.01). Adenosine Diphosphate 153-156 integrin subunit alpha 2b Homo sapiens 138-144 16405437-7 2006 Among the 34 positive plasmas, four with positive anti-GPIIb/IIIa autoantibody showed significant inhibition of platelet aggregation induced by adenosine diphosphate (ADP), whereas one with GPIb/IX-specific antibody inhibited ristocetin-induced platelet aggregation. Adenosine Diphosphate 144-165 integrin subunit alpha 2b Homo sapiens 55-60 16405437-7 2006 Among the 34 positive plasmas, four with positive anti-GPIIb/IIIa autoantibody showed significant inhibition of platelet aggregation induced by adenosine diphosphate (ADP), whereas one with GPIb/IX-specific antibody inhibited ristocetin-induced platelet aggregation. Adenosine Diphosphate 167-170 integrin subunit alpha 2b Homo sapiens 55-60 16044034-9 2005 However, spermine inhibits the ADP- or thrombin-induced activation of GP IIb/IIIa. Adenosine Diphosphate 31-34 integrin subunit alpha 2b Homo sapiens 70-76 15668185-7 2005 Atorvastatin therapy normalized platelet hyperfunction in the patients studied and reduced GPIIb/IIIa response to ADP (from 82.65+/-6.43% to 75.84+/-4.89%, p<0.01). Adenosine Diphosphate 114-117 integrin subunit alpha 2b Homo sapiens 91-96 15786005-7 2005 GPIIb/IIIa function was evaluated with the activation-specific antibody PAC-1 after stimulation with 10 microM ADP. Adenosine Diphosphate 111-114 integrin subunit alpha 2b Homo sapiens 0-5 15792682-9 2005 The defined peptide interferes with the formation of the GP IIb/IIIa complex by inhibiting the binding of FITC-PAC-1 onto ADP-, type I collagen-, and type III collagen-activated platelets. Adenosine Diphosphate 122-125 integrin subunit alpha 2b Homo sapiens 57-63 12714504-7 2003 Further, anti-CIB- or GPIIb peptide-induced inhibition of platelet spreading can be overcome by the addition of exogenous adenosine diphosphate (ADP). Adenosine Diphosphate 122-143 integrin subunit alpha 2b Homo sapiens 22-27 15461628-3 2004 This is caused by an autoantibody with specificity for platelet GP IIb/IIIa or an epitope close to that of the GP, resulting in partial or complete refractoriness of the patient"s platelets to ADP, collagen and arachidonic acid. Adenosine Diphosphate 193-196 integrin subunit alpha 2b Homo sapiens 64-70 15487851-6 2004 Clopidogrel has additional effects on the ADP-induced expression of adhesion molecules (P-selectin, GPIIb/IIIa) and inflammatory mediators (CD40L). Adenosine Diphosphate 42-45 integrin subunit alpha 2b Homo sapiens 100-105 15476209-3 2004 Pairs of monoclonal antibodies that induced a high-fluorescence resonance energy transfer (FRET) efficiency served as tools to detect activation-dependent changes of GP IIb after addition of adenosine diphosphate and several fibans. Adenosine Diphosphate 191-212 integrin subunit alpha 2b Homo sapiens 166-172 14736431-5 2004 RESULTS: After platelet activation with adenosine diphosphate, thrombin receptor-activating peptide, or U46-619, relative reductions in conformationally activated GP IIb/IIIa receptor expression (evaluated with PAC-1) of 48%, 43%, and 33%, respectively (all p < 0.0001), were seen with clopidogrel, but further 80%, 78%, and 72% (all p < 0.0001) reductions were seen with eptifibatide. Adenosine Diphosphate 40-61 integrin subunit alpha 2b Homo sapiens 163-169 12714504-7 2003 Further, anti-CIB- or GPIIb peptide-induced inhibition of platelet spreading can be overcome by the addition of exogenous adenosine diphosphate (ADP). Adenosine Diphosphate 145-148 integrin subunit alpha 2b Homo sapiens 22-27 12714504-8 2003 These data suggest that formation of the CIB-GPIIb/IIIa complex may be necessary for initiation of downstream signaling events, such as ADP secretion, that lead to platelet spreading. Adenosine Diphosphate 136-139 integrin subunit alpha 2b Homo sapiens 45-50 11447083-6 2001 Patients were classified into high and low platelet reactivity groups on the basis of extent of activation of GP IIb/IIIa in response to 0.2 micromol/L ADP. Adenosine Diphosphate 152-155 integrin subunit alpha 2b Homo sapiens 110-116 12911597-5 2003 GPIIb/IIIa blockade enhanced ADP- or TRAP-induced leukocyte CD11b expression, but not the response to PAF. Adenosine Diphosphate 29-32 integrin subunit alpha 2b Homo sapiens 0-5 12911597-6 2003 GPIIb/IIIa blockade attenuated PAF-induced, but enhanced ADP- or TRAP-induced platelet-leukocyte aggregation. Adenosine Diphosphate 57-60 integrin subunit alpha 2b Homo sapiens 0-5 12911597-11 2003 GPIIb/IIIa blockade enhances thrombin-induced platelet MEK 1/2 and ERK 1/2 activation, and augments ADP- and TRAP-induced leukocyte activation by enhancing platelet-leukocyte aggregation. Adenosine Diphosphate 100-103 integrin subunit alpha 2b Homo sapiens 0-5 11904526-7 2002 ADP-induced platelet degranulation, activation of GPIIb/IIIa receptor, and aggregation in vivo are effectively inhibited by clopidogrel. Adenosine Diphosphate 0-3 integrin subunit alpha 2b Homo sapiens 50-55 12626998-10 2003 MEASUREMENTS AND MAIN RESULTS: Expression of GP IIb-IIIa and P-selectin on adenosine diphosphate-activated platelets and platelet-leukocyte aggregation were significantly lower after the passage of blood through the hemofilter in patients receiving an extracorporeal infusion of prostacyclin plus heparin when compared with control patients receiving heparin only. Adenosine Diphosphate 75-96 integrin subunit alpha 2b Homo sapiens 45-51 12693968-3 2003 Suppression of GP IIb-IIIa receptor activity by both preparations led to 100% inhibition of [(14)C]serotonin secretion from dense granules upon platelet activation with ADP, to partial inhibition upon activation with thromboxane A(2) analog U46619 (by 60-70%) and thrombin at 0.1 U/ml (by 40-50%), but did not decrease serotonin secretion induced by thrombin at 1 U/ml. Adenosine Diphosphate 169-172 integrin subunit alpha 2b Homo sapiens 15-21 12428106-4 2002 Analysis of integrin alpha(2)beta(1)-dependent platelet adhesion to collagen indicated that ADP-induced suppression of platelet adhesion is the result of trans-dominant inhibition of integrin alpha(2)beta(1) caused by fibrinogen binding to integrin GPIIb-IIIa. Adenosine Diphosphate 92-95 integrin subunit alpha 2b Homo sapiens 249-254 12413588-4 2002 Platelet function was measured by the PFA-100(R) analyser; platelet GP IIb-IIIa activation by ADP 10 micro M was assessed by flow cytometry using PAC-1 MoAb. Adenosine Diphosphate 94-97 integrin subunit alpha 2b Homo sapiens 68-74 11944027-7 2002 Antibodies known to inhibit fibrinogen binding to GPIIb/IIIa after adenosine diphosphate- and collagen- induced aggregation had very little effect on initial platelet adhesion. Adenosine Diphosphate 67-88 integrin subunit alpha 2b Homo sapiens 50-55 11520817-2 2001 However, a marked and rapid externalization of GPIIb/IIIa was also observed upon stimulation with 30 microM adenosine diphosphate (ADP). Adenosine Diphosphate 108-129 integrin subunit alpha 2b Homo sapiens 47-52 11520817-2 2001 However, a marked and rapid externalization of GPIIb/IIIa was also observed upon stimulation with 30 microM adenosine diphosphate (ADP). Adenosine Diphosphate 131-134 integrin subunit alpha 2b Homo sapiens 47-52 11323013-4 2001 RESULTS: For citrated blood, aggregation induced by 20 microM ADP was blocked up to 100% by both GPIIb/IIIa-antagonists, IC50 values varied between 0.11-0.22 microg/ml for eptifibatide and 1.25-2.3 microg/ml for abciximab. Adenosine Diphosphate 62-65 integrin subunit alpha 2b Homo sapiens 97-102 11122160-6 2000 Activation of GPIIb-IIIa, monitored with mAb PAC-1, was markedly decreased (< 20% of normal) in response to ADP, thrombin and platelet-activating factor (PAF); expression of ligand-induced binding sites (LIBS) was < or = 30% of normal. Adenosine Diphosphate 111-114 integrin subunit alpha 2b Homo sapiens 14-19 11239710-0 2001 Adhesion of adenosine diphosphate-activated platelets to human brain microvascular endothelial cells under flow in vitro is mediated via GPIIb/IIIa. Adenosine Diphosphate 12-33 integrin subunit alpha 2b Homo sapiens 137-142 11342206-6 2001 All tested GPIIb-IIIa antagonists completely inhibit concentration-dependent ADP (20 micromol/l)-induced aggregation. Adenosine Diphosphate 77-80 integrin subunit alpha 2b Homo sapiens 11-16 11001901-4 2000 Clot retraction inhibition by D3 was not due to altered platelet-fibrin interaction; however, combination treatments of D3 and adenosine diphosphate (ADP) inhibited full-scale aggregation and decreased the amounts of GPIIb-IIIa and talin incorporated into the core cytoskeletons. Adenosine Diphosphate 127-148 integrin subunit alpha 2b Homo sapiens 217-222 11001901-6 2000 ADP addition to platelets caused an increase in the number of D3 binding sites indicating that ligand had bound to the GPIIb-IIIa receptor. Adenosine Diphosphate 0-3 integrin subunit alpha 2b Homo sapiens 119-124 11001901-4 2000 Clot retraction inhibition by D3 was not due to altered platelet-fibrin interaction; however, combination treatments of D3 and adenosine diphosphate (ADP) inhibited full-scale aggregation and decreased the amounts of GPIIb-IIIa and talin incorporated into the core cytoskeletons. Adenosine Diphosphate 150-153 integrin subunit alpha 2b Homo sapiens 217-222 10741635-11 2000 Aspirin and clopidogrel reinforced effects of the GPIIb/IIIa inhibitors on adenosine diphosphate (5 micromol/L)-induced aggregation in an additive manner, a supra-additive effect was observed with collagen (2 microg x mL(-1))-induced aggregation. Adenosine Diphosphate 75-96 integrin subunit alpha 2b Homo sapiens 50-55 10735780-4 2000 Unfractionated heparin increased adenosine diphosphate-induced expression of P-selectin and GP IIb-IIIa in a dose-dependent manner. Adenosine Diphosphate 33-54 integrin subunit alpha 2b Homo sapiens 92-98 10896249-5 2000 We found that inhibition of aggregation and GPIIb-IIIa blockade of ADP-stimulated platelets was almost complete during abciximab administration. Adenosine Diphosphate 67-70 integrin subunit alpha 2b Homo sapiens 44-49 10704169-6 2000 Surface expression of GP IIb/IIIa was similar in resting platelets of all 3 genotypes but was significantly greater on Pl(A2,A2) platelets after ADP stimulation (P=0.003 versus Pl(A1,A1); P=0.03 versus Pl(A1,A2)). Adenosine Diphosphate 145-148 integrin subunit alpha 2b Homo sapiens 22-28 10021912-2 1999 They were found to bind GPIIb/IIIa with high affinity and were potent antagonists of ADP mediated platelet aggregation. Adenosine Diphosphate 85-88 integrin subunit alpha 2b Homo sapiens 24-29 10544919-2 1999 In vitro effects of the GPIIb/IIIa antagonist fradafiban on ADP-induced platelet aggregation were determined using WBSPC and PRP turbidimetry, comparing citrate and hirudin anticoagulation. Adenosine Diphosphate 60-63 integrin subunit alpha 2b Homo sapiens 24-29 10411706-7 1999 These fragments also reduced the binding of PAC-1, an activation-dependent anti-GP IIb-IIIa monoclonal antibody, to adenosine diphosphate (ADP)-activated normal platelets. Adenosine Diphosphate 116-137 integrin subunit alpha 2b Homo sapiens 80-86 10411706-7 1999 These fragments also reduced the binding of PAC-1, an activation-dependent anti-GP IIb-IIIa monoclonal antibody, to adenosine diphosphate (ADP)-activated normal platelets. Adenosine Diphosphate 139-142 integrin subunit alpha 2b Homo sapiens 80-86 8051492-1 1994 Platelet membrane glycoproteins Ib (GPIb) and IIb/IIIa (GPIIb/IIIa) bind soluble von Willebrand factor (vWf) after stimulation with ristocetin (GPIb) or with thrombin or ADP (GPIIb/IIIa). Adenosine Diphosphate 170-173 integrin subunit alpha 2b Homo sapiens 56-61 8977459-9 1996 Flow cytometry confirmed that the number of ligand-occupied GP IIb/IIIa complexes was much lower on platelets stimulated with ADP or 2-MeS-ADP after clopidogrel treatment. Adenosine Diphosphate 126-129 integrin subunit alpha 2b Homo sapiens 60-66 8608226-7 1996 Binding of MoAb PAC1, which binds to only activated GPIIb-IIIa, was diminished upon activation with PAF, adenosine diphosphate (ADP), thrombin receptor agonist peptide (SFLLRN), A23187, and 1,2-dioctonylglycerol (DiC8). Adenosine Diphosphate 105-126 integrin subunit alpha 2b Homo sapiens 52-57 8608226-7 1996 Binding of MoAb PAC1, which binds to only activated GPIIb-IIIa, was diminished upon activation with PAF, adenosine diphosphate (ADP), thrombin receptor agonist peptide (SFLLRN), A23187, and 1,2-dioctonylglycerol (DiC8). Adenosine Diphosphate 128-131 integrin subunit alpha 2b Homo sapiens 52-57 8772236-1 1995 We examined interspecies differences in the function of the platelet fibrinogen receptor, GPIIb-IIIa, by comparing platelet aggregation responses to adenosine diphosphate (ADP) added alone or in combination with a GPIIIa specific monoclonal antibody (mAb), D3. Adenosine Diphosphate 149-170 integrin subunit alpha 2b Homo sapiens 90-95 7794942-11 1995 These results show that ADP binding and photoincorporation are occurring at different sites on the platelet surface but suggest that the ADP binding site may be located in proximity to GPIIb alpha. Adenosine Diphosphate 137-140 integrin subunit alpha 2b Homo sapiens 185-190 7843648-2 1994 An ELISA was developed for directly measuring the expression of glycoprotein IIb/IIIa (GPIIb/IIIa) on platelets in the presence and absence of ADP and under the influence of various heparins. Adenosine Diphosphate 143-146 integrin subunit alpha 2b Homo sapiens 87-97 7993797-3 1994 Out of 30 monoclonal antibodies reacting with GPIIb/IIIa, one, MA-16N7C2, potently inhibited platelet aggregation induced by ADP, thrombin, arachidonic acid, collagen, U46619, adrenaline and platelet-activating factor, whereas ristocetin-induced aggregation was unaffected. Adenosine Diphosphate 125-128 integrin subunit alpha 2b Homo sapiens 46-51 9432026-8 1997 PLA formation by the platelet agonist ADP was inhibited by P-selectin blockade, but enhanced by GPIIb/IIIa blockade (which inhibits platelet-platelet interactions). Adenosine Diphosphate 38-41 integrin subunit alpha 2b Homo sapiens 96-101 9134653-9 1997 Plasmin cleaves GPIIb/IIIa so that it becomes a competent fibrinogen receptor, and binding of 125I-fibrinogen during ADP-induced aggregation was greatly potentiated within 10 s. Potentiation of aggregation by other agonists may be due to increased binding of released fibrinogen. Adenosine Diphosphate 117-120 integrin subunit alpha 2b Homo sapiens 16-21 9134654-7 1997 1.6 x 10(-7)M), however, the number of GPIIb-IIIa receptors per platelet capable of binding fibrinogen was significantly greater in women than men in response to 2 microM ADP (16,319 +/- 1871 vs 9669 +/- 1994, p = 0.02), 20 microM ADP (39,951 +/- 4711 vs 25,948 +/- 4953, p = 0.05) and 50 microM TRAP (39,236 +/- 3965 vs 21,848 +/- 4159, p = 0.007). Adenosine Diphosphate 171-174 integrin subunit alpha 2b Homo sapiens 39-44 9134654-8 1997 Similarly, the number of GPIIb-IIIa receptors capable of binding PAC-1 in response to ADP and TRAP was 50% to 80% greater in women than men. Adenosine Diphosphate 86-89 integrin subunit alpha 2b Homo sapiens 25-30 8998163-5 1997 The binding of P748 peptide and [ReO]P748 to GPIIb/IIIa receptors on activated platelets was assessed by their inhibition of ADP stimulated human platelet aggregation in platelet rich plasma (PRP). Adenosine Diphosphate 125-128 integrin subunit alpha 2b Homo sapiens 45-50 8965144-2 1996 METHODS: The affinity and specificity of P280 peptide for the GPIIb/IIIa receptor was assessed by the inhibition of ADP-stimulated human platelet aggregation, the inhibition of the binding of fibrinogen to the GPIIb/IIIa receptor and the inhibition of the binding of vitronectin to the vitronectin receptor. Adenosine Diphosphate 116-119 integrin subunit alpha 2b Homo sapiens 62-67 9363587-13 1995 Activation of intact platelets with ADP resulted in an increased binding of HAG to the platelets, indicating that an augmented Fc gamma R activity is associated with the activation of GPIIb/IIIa. Adenosine Diphosphate 36-39 integrin subunit alpha 2b Homo sapiens 184-189 8281661-5 1994 METHODS AND RESULTS: DMP 728 demonstrated antiplatelet efficacy in vitro in inhibiting ADP-induced human platelet aggregation (IC50, 46 +/- 2 nmol/L) and fibrinogen binding to human platelets (IC50, 2.3 +/- 0.8 nmol/L) or purified human GPIIb/IIIa receptors (IC50, 0.6 +/- 0.1 nmol/L). Adenosine Diphosphate 87-90 integrin subunit alpha 2b Homo sapiens 237-242 1737752-8 1992 Ultraviolet irradiation of platelets in the presence of either [35S]GTP alpha S or [35S]UTP alpha S resulted in their specific incorporation into the alpha chain of GPIIb as previously shown with [35S]ATP alpha S. These results show that the structure of the nucleotide base has little influence on its ability to occupy the ADP-binding site on platelets, to function as an inhibitor of ADP-induced activation or to be photoincorporated into GPIIb alpha. Adenosine Diphosphate 325-328 integrin subunit alpha 2b Homo sapiens 165-170 21043608-5 1994 The results show that GpIIb/IIIa is involved in mediating the second phase or sustained actin polymerization that occurs after activating platelets with ADP and confirm the requirement for platelet aggregation. Adenosine Diphosphate 153-156 integrin subunit alpha 2b Homo sapiens 22-27 8238012-5 1993 Activation-dependent receptor function of the GP IIb-IIIa complex was studied with 125I-fibrinogen and 125I-vWF binding to washed platelets stimulated with adenosine diphosphate plus epinephrine (10 mumol/L each). Adenosine Diphosphate 156-177 integrin subunit alpha 2b Homo sapiens 46-52 7515044-6 1994 In addition, the percent expression of P-selectin and activated GpIIb/IIIa in response to ADP was reproducible in each individual studied on five separate occasions (CV < or = 8%). Adenosine Diphosphate 90-93 integrin subunit alpha 2b Homo sapiens 64-69 8241506-5 1993 Platelet exposure to adenosine diphosphate or thrombin, but not A23187 or chymotrypsin, markedly enhanced GPIIb and GPIIIa recovery relative to that observed with unstimulated platelets, or prostaglandin E1-treated platelets. Adenosine Diphosphate 21-42 integrin subunit alpha 2b Homo sapiens 106-111 8325838-4 1993 Time- and calcium-dependent vesiculation of platelets in response to ADP, collagen, thrombin, phorbol myristate acetate, and the thrombin peptide SFLLRN were dramatically inhibited, in a concentration-dependent manner, by monoclonal antibodies to GPIIb-IIIa (A2A9, 7E3, PAC1) and RGDS. Adenosine Diphosphate 69-72 integrin subunit alpha 2b Homo sapiens 247-252 1518177-6 1992 The anti-GPIIb/IIIa antibody completely inhibited ADP-and collagen-induced platelet aggregation, but no or only mild prolongation of bleeding time was observed. Adenosine Diphosphate 50-53 integrin subunit alpha 2b Homo sapiens 9-14 1467434-6 1992 The increase of PBIgG produced by ADP was significantly greater when ITP plasma positive for anti-GPIIb/IIIa antibody was used compared with that obtained using antibody-negative ITP plasma. Adenosine Diphosphate 34-37 integrin subunit alpha 2b Homo sapiens 98-103 1737752-8 1992 Ultraviolet irradiation of platelets in the presence of either [35S]GTP alpha S or [35S]UTP alpha S resulted in their specific incorporation into the alpha chain of GPIIb as previously shown with [35S]ATP alpha S. These results show that the structure of the nucleotide base has little influence on its ability to occupy the ADP-binding site on platelets, to function as an inhibitor of ADP-induced activation or to be photoincorporated into GPIIb alpha. Adenosine Diphosphate 387-390 integrin subunit alpha 2b Homo sapiens 165-170 2529923-8 1989 Using monoclonal antibodies (MoAbs) against the platelet glycoproteins (GP) IIb/IIIa and Ib (MoAbs 10E5 and 6D1, respectively), we demonstrated that the ADP-induced increase in platelet-vWF expression on control platelets primarily involved the binding of secreted platelet-vWF to the platelet GPIIb/IIIa. Adenosine Diphosphate 153-156 integrin subunit alpha 2b Homo sapiens 294-299 1902217-7 1991 Cell stimulation by thrombin, ADP plus epinephrine or phorbol-ester caused up to a 2-fold increase in RET between chromophore-labeled, platelet-bound B1B5, SSA6, and A2A9 (p less than or equal to 0.05), suggesting a change in the separation or orientation of these epitopes within the GP IIb-IIIa complex. Adenosine Diphosphate 30-33 integrin subunit alpha 2b Homo sapiens 285-291 1995321-4 1991 Western blotting revealed that 10 of these 15 patients had either anti-GPIIb or anti-GPIIIa and 2 had anti-GPIb autoantibodies, ADP-induced aggregation of normal platelets was inhibited by autoantibodies in 12 of 60 patients, and 11 of these had anti-GPIIb/IIIa antibodies. Adenosine Diphosphate 128-131 integrin subunit alpha 2b Homo sapiens 71-76 1995321-4 1991 Western blotting revealed that 10 of these 15 patients had either anti-GPIIb or anti-GPIIIa and 2 had anti-GPIb autoantibodies, ADP-induced aggregation of normal platelets was inhibited by autoantibodies in 12 of 60 patients, and 11 of these had anti-GPIIb/IIIa antibodies. Adenosine Diphosphate 128-131 integrin subunit alpha 2b Homo sapiens 251-256 34934451-6 2022 Denuded, but not native, platelets underwent slow spontaneous aggregation and rapid ADP-mediated GPIIb/IIIa-dependent aggregation according to spectrophotometric assay. Adenosine Diphosphate 84-87 integrin subunit alpha 2b Homo sapiens 97-102 1905716-10 1991 As an alternative assay for these interactions, we have examined pertussis toxin-catalyzed ADP-ribosylation of the Gt alpha subunit which is markedly enhanced in rate by beta gamma subunits. Adenosine Diphosphate 91-94 integrin subunit alpha 2b Homo sapiens 115-123 2175608-3 1990 Ticlopidine inhibits ADP-induced binding of fibrinogen to platelet glycoprotein GP IIb-IIIa but not shape change and increases deaggregation. Adenosine Diphosphate 21-24 integrin subunit alpha 2b Homo sapiens 80-86 2274928-4 1990 Such proteolytic modification of the GPIIb/IIIa complex was accompanied by a slight increase in the binding of fibrinogen to blood platelets in the absence of ADP. Adenosine Diphosphate 159-162 integrin subunit alpha 2b Homo sapiens 37-42 2773809-5 1989 To ascertain whether the receptors clustered prior to ligand binding or as a consequence thereof, we studied the surface distribution of GPIIb-IIIa after stimulation with ADP, which causes activation of the fibrinogen receptor function of GPIIb-IIIa without inducing the secretion of fibrinogen. Adenosine Diphosphate 171-174 integrin subunit alpha 2b Homo sapiens 137-142 2773809-5 1989 To ascertain whether the receptors clustered prior to ligand binding or as a consequence thereof, we studied the surface distribution of GPIIb-IIIa after stimulation with ADP, which causes activation of the fibrinogen receptor function of GPIIb-IIIa without inducing the secretion of fibrinogen. Adenosine Diphosphate 171-174 integrin subunit alpha 2b Homo sapiens 239-244 3607284-6 1987 When the pool of GP IIb/IIIa molecules exposed on the surface of unstimulated platelets was reacted with the monoclonal antibody LJ-CP3 to block ADP-induced fibrinogen binding and platelet aggregation, stimulation with thrombin or PMA still induced substantial binding of antibody and fibrinogen, and aggregation ensued. Adenosine Diphosphate 145-148 integrin subunit alpha 2b Homo sapiens 17-23 3049815-7 1988 Because 7E3 also recognizes a qualitative, ADP-mediated activated state of the platelet adhesion receptor GP IIb/IIIa, it is suggested that transients in cytosolic Ca2+ might represent early secondary events for a general pathway of rapid activation of integrin receptors and, as such, represent important signals for cellular interactions in the immune response. Adenosine Diphosphate 43-46 integrin subunit alpha 2b Homo sapiens 106-112 3155488-4 1985 A previously described monoclonal antibody specific for the GPIIb/IIIa complex (AP-2) inhibited platelet aggregation induced by ADP, thrombin, collagen, or arachidonic acid (Pidard et al, J Biol Chem 258:12582-12586, 1983). Adenosine Diphosphate 128-131 integrin subunit alpha 2b Homo sapiens 60-65 3584243-7 1987 To determine whether the receptors clustered before ligand binding, or as a consequence thereof, we studied the surface distribution of GPIIb-IIIa after stimulation with ADP, which causes activation of the fibrinogen receptor function of GPIIb-IIIa without inducing the release of fibrinogen. Adenosine Diphosphate 170-173 integrin subunit alpha 2b Homo sapiens 136-141 3584243-7 1987 To determine whether the receptors clustered before ligand binding, or as a consequence thereof, we studied the surface distribution of GPIIb-IIIa after stimulation with ADP, which causes activation of the fibrinogen receptor function of GPIIb-IIIa without inducing the release of fibrinogen. Adenosine Diphosphate 170-173 integrin subunit alpha 2b Homo sapiens 238-243 2944344-5 1986 Of the four anti-GPIIb-IIIa antibodies, three completely inhibited platelet aggregation induced with ADP or collagen, while the other caused only partial inhibition. Adenosine Diphosphate 101-104 integrin subunit alpha 2b Homo sapiens 17-22 2984300-6 1985 The number of antigenic sites for monoclonal antibody reacting with GPIIb/GPIIIa complex of adenosine diphosphate-stimulated platelets decreased from 34,200 +/- 5,940 to 19,500 +/- 9,680/platelet after recirculation (P less than or equal to 0.025). Adenosine Diphosphate 92-113 integrin subunit alpha 2b Homo sapiens 68-73 31418386-6 2019 RESULTS: After the ADP activation, the expression level of GPIb significantly decreased, while the expression levels of GPIb, GPIIb/III a and P-selectin significantly increased in control group, nothing bleeding symptom group and mild bleeding symptom group; but the expression level of GPIb significantly increased, while the expression level of GPIIb/III a significantly decreased in moderate and severe bleeding symptom group, the both differences were statistically significant (P<0.05). Adenosine Diphosphate 19-22 integrin subunit alpha 2b Homo sapiens 347-352 6230229-9 1984 Omission of photoactivation, platelets, or ADP from the reaction or use of unmodified 125I-Fg resulted in less than 5% immunoprecipitation by the anti-GP IIb/III. Adenosine Diphosphate 43-46 integrin subunit alpha 2b Homo sapiens 151-157 34029503-11 2022 Expression of GP IIb-IIIa activated form correlated with RP percentage and platelet size indexes when platelets were activated by TRAP and ADP at both applied concentrations (r from 0.309 to 0.560, p from 0.014 to < 0.001, n = 50-62). Adenosine Diphosphate 139-142 integrin subunit alpha 2b Homo sapiens 14-20 31418386-9 2019 After ADP activation, the expression levels of GPIb and P-selectin in ITP subgroups both were lower than those in control group, the expression level of GPIIb/IIIa in ITP subgroups was higher than that in control group (P<0.05). Adenosine Diphosphate 6-9 integrin subunit alpha 2b Homo sapiens 153-158 30052109-9 2019 The expression of platelet glycoproteins, such as GP IIb/IIIa and P-selectin, native or after stimulation with ADP, were markedly impaired by the conventional system, but not by the TCSS. Adenosine Diphosphate 111-114 integrin subunit alpha 2b Homo sapiens 50-56 30188609-6 2018 We proved the elevated expression of the active form of integrin receptor GPIIb/IIIa, responsible for platelet aggregation, and in the kinetic test we confirmed the increased aggregation of platelets in different intracellular signal pathways (dependent on ADP, collagen, arachidonic acid). Adenosine Diphosphate 257-260 integrin subunit alpha 2b Homo sapiens 74-79 29799301-3 2018 Upon platelet activation by adenosine diphosphate (ADP), thrombin, or other platelet agonists, GPIIb-IIIa undergoes conformational changes from a "resting" bent conformation to an "activated" extended conformation. Adenosine Diphosphate 28-49 integrin subunit alpha 2b Homo sapiens 95-100 29799301-3 2018 Upon platelet activation by adenosine diphosphate (ADP), thrombin, or other platelet agonists, GPIIb-IIIa undergoes conformational changes from a "resting" bent conformation to an "activated" extended conformation. Adenosine Diphosphate 51-54 integrin subunit alpha 2b Homo sapiens 95-100