PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 25100739-3 2014 To devise a different strategy, we engineered and optimized the apyrase activity of human nucleoside triphosphate diphosphohydrolase-3 (CD39L3) to enhance scavenging of extracellular adenosine diphosphate, a predominant ligand of P2Y12 receptors. Adenosine Diphosphate 183-204 ectonucleoside triphosphate diphosphohydrolase 3 Homo sapiens 136-142 18404504-6 2005 In contrast, NTPDases 2, 3 and 8 are expected to promote the activation of ADP specific receptors, because in the presence of ATP they produce a sustained (NTPDase2) or transient (NTPDases 3 and 8) accumulation of ADP. Adenosine Diphosphate 75-78 ectonucleoside triphosphate diphosphohydrolase 3 Homo sapiens 180-196 25372046-5 2015 NTPDase3 and -8 yield AMP and ADP, while NTPDase2 results mainly in the formation of ADP. Adenosine Diphosphate 30-33 ectonucleoside triphosphate diphosphohydrolase 3 Homo sapiens 0-8 25372046-5 2015 NTPDase3 and -8 yield AMP and ADP, while NTPDase2 results mainly in the formation of ADP. Adenosine Diphosphate 85-88 ectonucleoside triphosphate diphosphohydrolase 3 Homo sapiens 0-8