PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34878641-8 2022 RESULTS: Significant correlations (r = 0.19-0.55, p < .05) with AMPK activity were found between end-exercise muscle glycogen, exercise intensity, and muscle metabolites phosphocreatine, creatine, and free ADP. Adenosine Diphosphate 206-209 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 64-68 34878641-1 2022 BACKGROUND: The 5" adenosine monophosphate (AMP)-activated protein kinase (AMPK) is a cellular energy sensor that is activated by increases in the cellular AMP/adenosine diphosphate:adenosine triphosphate (ADP:ATP) ratios and plays a key role in metabolic adaptations to endurance training. Adenosine Diphosphate 206-209 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 75-79 32434052-9 2020 Additionally, empagliflozin-mediated AMPK activation prevented LPS-induced ATP/ADP depletion. Adenosine Diphosphate 79-82 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 37-41 29623826-3 2019 AMPK is a heterotrimeric protein complex regulated by AMP, ADP, and ATP allosterically. Adenosine Diphosphate 59-62 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 0-4 32185076-9 2020 Usually, AMPK can be activated by ADP or AMP, upstream kinases or other cytokines, and pharmacological agents, and then it phosphorylates key molecules that are involved in energy metabolism, autophagy, anti-inflammation, oxidative stress, and aging process to keep cellular homeostasis and finally keeps cell normal activity and function. Adenosine Diphosphate 34-37 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 9-13 31000529-2 2019 At the cellular level, AMPK is activated by metabolic stresses that increase AMP or adenosine 5"-diphosphate (ADP) coupled with falling adenosine 5"-triphosphate (ATP) and acts to restore energy balance by choreographing a shift in metabolism in favour of energy-producing catabolic pathways while inhibiting non-essential anabolic processes. Adenosine Diphosphate 84-108 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 23-27 31000529-2 2019 At the cellular level, AMPK is activated by metabolic stresses that increase AMP or adenosine 5"-diphosphate (ADP) coupled with falling adenosine 5"-triphosphate (ATP) and acts to restore energy balance by choreographing a shift in metabolism in favour of energy-producing catabolic pathways while inhibiting non-essential anabolic processes. Adenosine Diphosphate 110-113 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 23-27 32181500-1 2020 AMPK (adenosine monophosphate-activated protein kinase) is phosphorylated (AMPK-P) in response to low energy through allosteric activation by Adenosine mono- or diphosphate (AMP/ADP). Adenosine Diphosphate 178-181 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 0-4 32181500-1 2020 AMPK (adenosine monophosphate-activated protein kinase) is phosphorylated (AMPK-P) in response to low energy through allosteric activation by Adenosine mono- or diphosphate (AMP/ADP). Adenosine Diphosphate 178-181 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 6-54 32181500-1 2020 AMPK (adenosine monophosphate-activated protein kinase) is phosphorylated (AMPK-P) in response to low energy through allosteric activation by Adenosine mono- or diphosphate (AMP/ADP). Adenosine Diphosphate 178-181 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 75-79 32007387-2 2020 AMP or adenosine diphosphate (ADP) levels rise during metabolic stress, such as during nutrient starvation, hypoxia and muscle contraction, and bind to AMPK to induce activity. Adenosine Diphosphate 7-28 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 152-156 32007387-2 2020 AMP or adenosine diphosphate (ADP) levels rise during metabolic stress, such as during nutrient starvation, hypoxia and muscle contraction, and bind to AMPK to induce activity. Adenosine Diphosphate 30-33 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 152-156 30836318-1 2019 AMP-activated protein kinase (AMPK) plays a major role in maintaining cellular energy homeostasis by sensing and responding to AMP/ADP concentrations relative to ATP. Adenosine Diphosphate 131-134 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 0-28 30836318-1 2019 AMP-activated protein kinase (AMPK) plays a major role in maintaining cellular energy homeostasis by sensing and responding to AMP/ADP concentrations relative to ATP. Adenosine Diphosphate 131-134 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 30-34 30423971-2 2018 Energy stress manifests as a drop in the ratio of adenosine triphosphate (ATP) to AMP/ADP, which activates AMPK"s kinase activity, allowing it to upregulate ATP-generating catabolic pathways and to reduce energy-consuming catabolic pathways and cellular programs. Adenosine Diphosphate 86-89 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 107-111 30423971-3 2018 AMPK senses the cellular energy state by competitive binding of the three adenine nucleotides AMP, ADP, and ATP to three sites in its gamma subunit, each, which in turn modulates the activity of AMPK"s kinase domain in its alpha subunit. Adenosine Diphosphate 99-102 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 0-4 30423971-3 2018 AMPK senses the cellular energy state by competitive binding of the three adenine nucleotides AMP, ADP, and ATP to three sites in its gamma subunit, each, which in turn modulates the activity of AMPK"s kinase domain in its alpha subunit. Adenosine Diphosphate 99-102 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 195-199 29480469-1 2018 AMP-activated protein kinase (AMPK) is an energy sensor that is activated by increases in the cellular AMP/ATP and ADP/ATP ratios by three mechanisms: (1) allosteric activation, (2) promotion of phosphorylation at Thr172 on the alpha subunit by upstream kinases, and (3) inhibition of dephosphorylation of Thr172 by protein phosphatases. Adenosine Diphosphate 115-118 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 0-28 29205673-1 2018 AMP-activated protein kinase (AMPK) is a conserved sensor of cellular energy change and is activated by increased AMP/ATP and/or ADP/ATP ratios. Adenosine Diphosphate 129-132 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 0-28 29205673-1 2018 AMP-activated protein kinase (AMPK) is a conserved sensor of cellular energy change and is activated by increased AMP/ATP and/or ADP/ATP ratios. Adenosine Diphosphate 129-132 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 30-34 29343628-6 2018 AMPK is activated by increasing AMP or ADP (AMP being generated from ADP whenever ADP rises) coupled with falling ATP. Adenosine Diphosphate 39-42 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 0-4 29343628-6 2018 AMPK is activated by increasing AMP or ADP (AMP being generated from ADP whenever ADP rises) coupled with falling ATP. Adenosine Diphosphate 69-72 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 0-4 29343628-6 2018 AMPK is activated by increasing AMP or ADP (AMP being generated from ADP whenever ADP rises) coupled with falling ATP. Adenosine Diphosphate 69-72 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 0-4 29343628-8 2018 Structural studies have illuminated how AMPK achieves the task of detecting small changes in AMP and ADP, despite the presence of much higher concentrations of ATP. Adenosine Diphosphate 101-104 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 40-44 29480469-1 2018 AMP-activated protein kinase (AMPK) is an energy sensor that is activated by increases in the cellular AMP/ATP and ADP/ATP ratios by three mechanisms: (1) allosteric activation, (2) promotion of phosphorylation at Thr172 on the alpha subunit by upstream kinases, and (3) inhibition of dephosphorylation of Thr172 by protein phosphatases. Adenosine Diphosphate 115-118 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 30-34 28232179-2 2017 AMPK responds to changes in intracellular adenine nucleotide levels, being activated by an increase in AMP/ADP relative to ATP. Adenosine Diphosphate 107-110 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 0-4 28146060-1 2017 Adenosine monophosphate-activated protein kinase (AMPK) is an important energy sensor which is activated by increases in adenosine monophosphate (AMP)/adenosine triphosphate (ATP) ratio and/or adenosine diphosphate (ADP)/ATP ratio, and increases different metabolic pathways such as fatty acid oxidation, glucose transport and mitochondrial biogenesis. Adenosine Diphosphate 216-219 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 0-48 28146060-1 2017 Adenosine monophosphate-activated protein kinase (AMPK) is an important energy sensor which is activated by increases in adenosine monophosphate (AMP)/adenosine triphosphate (ATP) ratio and/or adenosine diphosphate (ADP)/ATP ratio, and increases different metabolic pathways such as fatty acid oxidation, glucose transport and mitochondrial biogenesis. Adenosine Diphosphate 216-219 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 50-54 25556665-8 2015 Adenosine monophosphate (AMP) and adenosine diphosphate (ADP) accumulation activates AMP protein kinase (AMPK) and increases entry of glucose into glycolysis. Adenosine Diphosphate 34-55 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 105-109 26876938-2 2016 When intracellular ATP levels decrease during energy stress, AMPK is initially activated through AMP or ADP binding and phosphorylation of a threonine residue (Thr-172) within the activation loop of its kinase domain. Adenosine Diphosphate 104-107 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 61-65 27812974-3 2016 AMPK complexes are regulated by changes in cellular AMP:ATP or ADP:ATP ratios and by a number of neutraceuticals and some of the widely-used diabetes medications such as metformin and thiazolinonediones. Adenosine Diphosphate 63-66 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 0-4 27063142-1 2016 Mammalian AMP-activated protein kinase (AMPK) acts as an important sensor of cellular energy homeostasis related with AMP/ADP to ATP ratio. Adenosine Diphosphate 122-125 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 10-38 27063142-1 2016 Mammalian AMP-activated protein kinase (AMPK) acts as an important sensor of cellular energy homeostasis related with AMP/ADP to ATP ratio. Adenosine Diphosphate 122-125 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 40-44 25556665-8 2015 Adenosine monophosphate (AMP) and adenosine diphosphate (ADP) accumulation activates AMP protein kinase (AMPK) and increases entry of glucose into glycolysis. Adenosine Diphosphate 57-60 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 105-109 25084564-0 2014 Oxidative stress activates AMPK in cultured cells primarily by increasing cellular AMP and/or ADP. Adenosine Diphosphate 94-97 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 27-31 25122135-3 2015 AMPK exists as alphabetagamma trimeric complexes that are allosterically regulated by AMP, ADP, and ATP. Adenosine Diphosphate 91-94 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 0-4 24450630-1 2014 AMPK (AMP-activated protein kinase) is a cellular energy sensor that monitors the ratio of AMP/ATP, and possibly also ADP/ATP, inside cells. Adenosine Diphosphate 118-121 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 0-4 24583089-3 2014 The current understanding of AMPK structure and regulation, however, has propelled a paradigm shift in which many researchers now consider ADP to be an additional regulatory nucleotide of AMPK. Adenosine Diphosphate 139-142 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 29-33 24583089-3 2014 The current understanding of AMPK structure and regulation, however, has propelled a paradigm shift in which many researchers now consider ADP to be an additional regulatory nucleotide of AMPK. Adenosine Diphosphate 139-142 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 188-192 24450630-1 2014 AMPK (AMP-activated protein kinase) is a cellular energy sensor that monitors the ratio of AMP/ATP, and possibly also ADP/ATP, inside cells. Adenosine Diphosphate 118-121 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 6-34 24396733-4 2013 To identify drugs that modulate AMPK activity independent of the canonical ATP-binding pocket found throughout the kinome, we designed a robust fluorescence-based high throughput screening assay biased toward the identification of molecules that bind the regulatory region of AMPK through displacement of MANT-ADP, a fluorescent ADP analog. Adenosine Diphosphate 310-313 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 276-280 24850385-3 2014 Nevertheless, the AMPK system has been preserved in mammals where, by monitoring cellular AMP:adenosine triphosphate (ATP) and adenosine diphosphate (ADP):ATP ratios and balancing the rates of catabolism and ATP consumption, it maintains energy homeostasis at a cell-autonomous level. Adenosine Diphosphate 127-148 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 18-22 24850385-3 2014 Nevertheless, the AMPK system has been preserved in mammals where, by monitoring cellular AMP:adenosine triphosphate (ATP) and adenosine diphosphate (ADP):ATP ratios and balancing the rates of catabolism and ATP consumption, it maintains energy homeostasis at a cell-autonomous level. Adenosine Diphosphate 150-153 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 18-22 23716691-3 2013 AMPK is activated by the rising ADP/ATP and AMP/ATP ratios during conditions of energy depletion and also by increasing intracellular Ca(2+). Adenosine Diphosphate 32-35 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 0-4 21782450-4 2011 We review recent findings showing that AMPK is activated by ADP as well as AMP, and discuss the mechanism by which binding of these nucleotides prevent its dephosphorylation and inactivation. Adenosine Diphosphate 60-63 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 39-43 22702974-4 2012 AMPK is activated in response to a fall in ATP, and recent studies have suggested that ADP plays an important role in regulating AMPK. Adenosine Diphosphate 87-90 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 0-4 22702974-4 2012 AMPK is activated in response to a fall in ATP, and recent studies have suggested that ADP plays an important role in regulating AMPK. Adenosine Diphosphate 87-90 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 129-133 22284532-2 2012 Recent discoveries demonstrate that AMPK is activated primarily by rising ADP levels and not, as previously thought, by AMP. Adenosine Diphosphate 74-77 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 36-40 22284532-3 2012 AMPK activation is dependent on ADP-controlled phosphorylation of Thr172 on its activation loop, a mechanism of protein regulation that represents an example of an allosterically regulated modification (ARM). Adenosine Diphosphate 32-35 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 0-4 24352254-1 2013 AMP-activated protein kinase (AMPK) plays a major role in regulating cellular energy balance by sensing and responding to increases in AMP/ADP concentration relative to ATP. Adenosine Diphosphate 139-142 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 0-28 24352254-1 2013 AMP-activated protein kinase (AMPK) plays a major role in regulating cellular energy balance by sensing and responding to increases in AMP/ADP concentration relative to ATP. Adenosine Diphosphate 139-142 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 30-34 21399626-0 2011 Structure of mammalian AMPK and its regulation by ADP. Adenosine Diphosphate 50-53 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 23-27 21769098-4 2011 AMPK is activated by a fall in ATP (concomitant with a rise in ADP and AMP), which leads to the activation of catabolic pathways and the inhibition of anabolic pathways. Adenosine Diphosphate 63-66 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 0-4 21769098-5 2011 Here we review the role of AMPK as an energy sensor and consider the recent finding that ADP, as well as AMP, causes activation of mammalian AMPK. Adenosine Diphosphate 89-92 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 141-145 21769098-6 2011 We also review recent progress in structural studies on phosphorylated AMPK that provides a mechanism for the regulation of AMPK in which AMP and ADP protect it against dephosphorylation. Adenosine Diphosphate 146-149 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 71-75 21769098-6 2011 We also review recent progress in structural studies on phosphorylated AMPK that provides a mechanism for the regulation of AMPK in which AMP and ADP protect it against dephosphorylation. Adenosine Diphosphate 146-149 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 124-128 21399626-5 2011 Our studies show that active mammalian AMPK displays significantly tighter binding to ADP than to Mg-ATP, explaining how the enzyme is regulated under physiological conditions where the concentration of Mg-ATP is higher than that of ADP and much higher than that of AMP. Adenosine Diphosphate 86-89 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 39-43 21399626-5 2011 Our studies show that active mammalian AMPK displays significantly tighter binding to ADP than to Mg-ATP, explaining how the enzyme is regulated under physiological conditions where the concentration of Mg-ATP is higher than that of ADP and much higher than that of AMP. Adenosine Diphosphate 233-236 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 39-43 17651460-6 2007 Deletions caused a defect in the adenosine diphosphate (ADP)-ribosylation factor-like 2 (ARL2) transcript, which is known to be important in secretion and interacts with protein phosphatase 2A (PP2A) and thus AMPK. Adenosine Diphosphate 33-54 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 209-213 17651460-6 2007 Deletions caused a defect in the adenosine diphosphate (ADP)-ribosylation factor-like 2 (ARL2) transcript, which is known to be important in secretion and interacts with protein phosphatase 2A (PP2A) and thus AMPK. Adenosine Diphosphate 56-59 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 209-213