PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 9011641-7 1996 Perfusion with either 10 PM ET-1 at constant coronary artery flow for 5 min in lieu of ischemia or 50 PM ET-1 with 10 nM nicardipine to block the former"s coronary constructive effect was quite protective and equipotent with preconditioning. Nicardipine 121-132 endothelin-1 Oryctolagus cuniculus 105-109 15258766-3 2004 In whole-cell patch clamp recordings, ET-1 (10(-7) M) induced a long-lasting inwards current (94.7+/-7.2 pA) that was inhibited by 8 mM [Mg(2+)](o) (45.3+/-4.4%) and NSC channel blockers (10(-3) M streptomycin and 10(-3) M La(3+)), but not by the voltage-dependent Ca(2+) channel blocker nicardipine. Nicardipine 288-299 endothelin-1 Oryctolagus cuniculus 38-42 9147187-0 1997 Nicardipine modification of endothelin-1 effects on visual evoked potential. Nicardipine 0-11 endothelin-1 Oryctolagus cuniculus 28-40 9147187-3 1997 We examined the antagonistic effect of a calcium-ion channel blocker, nicardipine, on ET-1 effects on visual evoked potential (VEP). Nicardipine 70-81 endothelin-1 Oryctolagus cuniculus 86-90 9147187-8 1997 Nicardipine suppressed the ET-1-induced reduction of VEP amplitude (P < 0.05, Scheffe). Nicardipine 0-11 endothelin-1 Oryctolagus cuniculus 27-31 9147187-10 1997 Since nicardipine interferes with the activity of ET-1, we believe that Ca2+ channel blockers can be useful in the treatment of ischemic retinal and optic nerve disorders that are related to abnormal ET-1 production. Nicardipine 6-17 endothelin-1 Oryctolagus cuniculus 50-54 9147187-10 1997 Since nicardipine interferes with the activity of ET-1, we believe that Ca2+ channel blockers can be useful in the treatment of ischemic retinal and optic nerve disorders that are related to abnormal ET-1 production. Nicardipine 6-17 endothelin-1 Oryctolagus cuniculus 200-204 2473330-4 1989 The calcium antagonists nitrendipine and nicardipine partially antagonize the vasoconstrictive effects of ET-1 in a dose-dependent manner, but this antagonism is only functional and noncompetitive. Nicardipine 41-52 endothelin-1 Oryctolagus cuniculus 106-110 20504726-3 1991 The vasoconstrictor action of endothelin-1 and its enhancing effect on stimulation-induced responses were significantly decreased by the presence of the dihydropyridine-type calcium channel antagonist nicardipine (10 nM). Nicardipine 201-212 endothelin-1 Oryctolagus cuniculus 30-42 1725343-2 1991 In low concentrations with no vasoconstrictor action (0.1 and 0.3 nM), and in a concentration that increased the perfusion pressure by 70 mm Hg (1 nM), ET-1 significantly enhanced responses to the agonists studied; this enhancement was apparently mediated by an increased influx of extracellular calcium through voltage-operated channels, as it was abolished by the calcium channel antagonist nicardipine (10 nM). Nicardipine 393-404 endothelin-1 Oryctolagus cuniculus 152-156 1725343-3 1991 In contrast, higher concentrations of ET-1 (3 and 10 nM) inhibited responses to VP and 5-HT and this inhibitory effect was accentuated in the presence of nicardipine. Nicardipine 154-165 endothelin-1 Oryctolagus cuniculus 38-42 7932217-6 1994 Nicardipine completely blocked the ET-1-induced increase in [Ca2+]i. Nicardipine 0-11 endothelin-1 Oryctolagus cuniculus 35-39 8300340-9 1994 Intracellular mobilization was linked to increases in IP3 turnover because 1 microM ET-1 increased IP3 content by 48% from its control value (EC50 = 23 nM), whereas Ca2+ influx occurred through a non-L-type Ca2+ channel because preexposure to 1 microM nicardipine did not affect either the height or the duration of a [Ca2+]i transient. Nicardipine 252-263 endothelin-1 Oryctolagus cuniculus 84-88 2201203-7 1990 Nicardipine (0.01-1 microM) produced concentration-dependent shifts in the ET-1 concentration-response curve in afferent arterioles. Nicardipine 0-11 endothelin-1 Oryctolagus cuniculus 75-79 2201203-9 1990 The contractile response to ET-1 was significantly more sensitive to nicardipine than was the response to norepinephrine. Nicardipine 69-80 endothelin-1 Oryctolagus cuniculus 28-32