PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 31660152-1 2019 Isocitrate dehydrogenase (IDH) is a key enzyme involved in the conversion of isocitrate to alpha-ketoglutarate (alpha-KG) in the tricarboxylic acid (TCA) cycle. 2-oxoglutarate 91-110 isocitrate dehydrogenase (NADP(+)) 1 Homo sapiens 0-24 31888244-2 2019 IDH1wt converts isocitrate to alpha-ketoglutarate while reducing nicotinamide adenine dinucleotide phosphate (NADP+), whereas IDH1R132H uses alpha-ketoglutarate and NADPH to generate the oncometabolite 2-hydroxyglutarate (2-HG). 2-oxoglutarate 30-49 isocitrate dehydrogenase (NADP(+)) 1 Homo sapiens 0-4 31888244-2 2019 IDH1wt converts isocitrate to alpha-ketoglutarate while reducing nicotinamide adenine dinucleotide phosphate (NADP+), whereas IDH1R132H uses alpha-ketoglutarate and NADPH to generate the oncometabolite 2-hydroxyglutarate (2-HG). 2-oxoglutarate 141-160 isocitrate dehydrogenase (NADP(+)) 1 Homo sapiens 0-4 31727689-6 2020 Mutant IDH catalyzes the conversion of alpha-ketoglutarate (alpha-KG) to the oncometabolite 2-hydroxyglutarate (2-HG), which induces aberrant epigenetic status and contributes to malignant progression, and is therefore a potential therapeutic target for IDH mutant tumors. 2-oxoglutarate 39-58 isocitrate dehydrogenase (NADP(+)) 1 Homo sapiens 7-10 31727689-6 2020 Mutant IDH catalyzes the conversion of alpha-ketoglutarate (alpha-KG) to the oncometabolite 2-hydroxyglutarate (2-HG), which induces aberrant epigenetic status and contributes to malignant progression, and is therefore a potential therapeutic target for IDH mutant tumors. 2-oxoglutarate 39-58 isocitrate dehydrogenase (NADP(+)) 1 Homo sapiens 254-257 31727689-6 2020 Mutant IDH catalyzes the conversion of alpha-ketoglutarate (alpha-KG) to the oncometabolite 2-hydroxyglutarate (2-HG), which induces aberrant epigenetic status and contributes to malignant progression, and is therefore a potential therapeutic target for IDH mutant tumors. 2-oxoglutarate 60-68 isocitrate dehydrogenase (NADP(+)) 1 Homo sapiens 7-10 31727689-6 2020 Mutant IDH catalyzes the conversion of alpha-ketoglutarate (alpha-KG) to the oncometabolite 2-hydroxyglutarate (2-HG), which induces aberrant epigenetic status and contributes to malignant progression, and is therefore a potential therapeutic target for IDH mutant tumors. 2-oxoglutarate 60-68 isocitrate dehydrogenase (NADP(+)) 1 Homo sapiens 254-257 31935911-5 2020 IDH mutations and D-2HG are thought to contribute to tumorigenesis due to the role of D-2HG as a competitive inhibitor of alpha-KG-dependent dioxygenases. 2-oxoglutarate 122-130 isocitrate dehydrogenase (NADP(+)) 1 Homo sapiens 0-3 32055803-1 2020 Isocitrate dehydrogenase 1 and 2 (IDH1 and IDH2) are key metabolic enzymes that convert isocitrate to alpha-ketoglutarate (alphaKG). 2-oxoglutarate 102-121 isocitrate dehydrogenase (NADP(+)) 1 Homo sapiens 34-38 32055803-1 2020 Isocitrate dehydrogenase 1 and 2 (IDH1 and IDH2) are key metabolic enzymes that convert isocitrate to alpha-ketoglutarate (alphaKG). 2-oxoglutarate 123-130 isocitrate dehydrogenase (NADP(+)) 1 Homo sapiens 34-38 31660152-1 2019 Isocitrate dehydrogenase (IDH) is a key enzyme involved in the conversion of isocitrate to alpha-ketoglutarate (alpha-KG) in the tricarboxylic acid (TCA) cycle. 2-oxoglutarate 91-110 isocitrate dehydrogenase (NADP(+)) 1 Homo sapiens 26-29 31660152-1 2019 Isocitrate dehydrogenase (IDH) is a key enzyme involved in the conversion of isocitrate to alpha-ketoglutarate (alpha-KG) in the tricarboxylic acid (TCA) cycle. 2-oxoglutarate 112-120 isocitrate dehydrogenase (NADP(+)) 1 Homo sapiens 0-24 31660152-1 2019 Isocitrate dehydrogenase (IDH) is a key enzyme involved in the conversion of isocitrate to alpha-ketoglutarate (alpha-KG) in the tricarboxylic acid (TCA) cycle. 2-oxoglutarate 112-120 isocitrate dehydrogenase (NADP(+)) 1 Homo sapiens 26-29