PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 31191307-0 2019 Reciprocal Relationship Between HDAC2 and P-Glycoprotein/MRP-1 and Their Role in Steroid Resistance in Childhood Nephrotic Syndrome. Steroids 81-88 ATP binding cassette subfamily B member 1 Homo sapiens 42-56 31191307-13 2019 Conclusion: Reduced HDAC2 and increased P-gp/MRP-1 activity may play a role in response to steroids in childhood NS. Steroids 91-99 ATP binding cassette subfamily B member 1 Homo sapiens 40-44 31191307-2 2019 P-glycoprotein (P-gp) over expression in peripheral blood mononuclear cells (PBMCs) has been reported in patients with steroid resistant nephrotic syndrome (NS). Steroids 119-126 ATP binding cassette subfamily B member 1 Homo sapiens 0-14 31191307-2 2019 P-glycoprotein (P-gp) over expression in peripheral blood mononuclear cells (PBMCs) has been reported in patients with steroid resistant nephrotic syndrome (NS). Steroids 119-126 ATP binding cassette subfamily B member 1 Homo sapiens 16-20 31191307-4 2019 Aim: To evaluate mRNA expression of P-gp/MRP-1 and HDAC2 in PBMCs of steroid sensitive (SSNS) and steroid resistant nephrotic syndrome (SRNS) patients, and determine the relationship between expression of HDAC2 and P-gp/ MRP-1in NS patients. Steroids 69-76 ATP binding cassette subfamily B member 1 Homo sapiens 36-40 28792718-0 2017 MDR-1 and CYP3A5 Polymorphisms in Pediatric Idiopathic Nephrotic Syndrome: Impact on Susceptibility and Response to Steroids (Preliminary Results). Steroids 116-124 ATP binding cassette subfamily B member 1 Homo sapiens 0-5 29352737-2 2018 We have shown loss of GC receptor (GCR) from the CD8+ cells, and we hypothesized that the drug membrane efflux pump, p-glycoprotein-1 (Pgp), may also be involved in lymphocyte steroid resistance following lung transplant. Steroids 176-183 ATP binding cassette subfamily B member 1 Homo sapiens 117-133 29352737-2 2018 We have shown loss of GC receptor (GCR) from the CD8+ cells, and we hypothesized that the drug membrane efflux pump, p-glycoprotein-1 (Pgp), may also be involved in lymphocyte steroid resistance following lung transplant. Steroids 176-183 ATP binding cassette subfamily B member 1 Homo sapiens 135-138 29289977-8 2018 Expression of MDR1 has been implicated in steroid resistance and may have contributed to the severity and lack of a sustained steroid response in this patient. Steroids 42-49 ATP binding cassette subfamily B member 1 Homo sapiens 14-18 29289977-8 2018 Expression of MDR1 has been implicated in steroid resistance and may have contributed to the severity and lack of a sustained steroid response in this patient. Steroids 126-133 ATP binding cassette subfamily B member 1 Homo sapiens 14-18 28614261-1 2017 BACKGROUND: Studies have investigated rs1128503, rs1045642, and rs2032582 in multidrug resistance protein 1 (MDR1) for association with susceptibility to idiopathic nephrotic syndrome (INS) and steroid resistance. Steroids 194-201 ATP binding cassette subfamily B member 1 Homo sapiens 77-107 31305689-0 2017 Erratum: A PRISMA-compliant meta-analysis of MDR1 polymorphisms and idiopathic nephrotic syndrome: Susceptibility and steroid responsiveness: Erratum. Steroids 118-125 ATP binding cassette subfamily B member 1 Homo sapiens 45-49 28614261-1 2017 BACKGROUND: Studies have investigated rs1128503, rs1045642, and rs2032582 in multidrug resistance protein 1 (MDR1) for association with susceptibility to idiopathic nephrotic syndrome (INS) and steroid resistance. Steroids 194-201 ATP binding cassette subfamily B member 1 Homo sapiens 109-113 28614261-3 2017 METHODS: The PubMed, Embase, and Web of Science databases were systematically searched to identify studies that examined MDR1 polymorphisms with susceptibility to INS and/or to steroid resistance. Steroids 177-184 ATP binding cassette subfamily B member 1 Homo sapiens 121-125 27719329-3 2017 The current study was conducted to evaluate the influence of two single nucleotide polymorphisms (SNPs) in ABCB1 (C3435T and C1236T) on the steroid treatment response in INS children. Steroids 140-147 ATP binding cassette subfamily B member 1 Homo sapiens 107-112 27719329-9 2017 CONCLUSION: Our results suggested that C1236T polymorphism in ABCB1 gene was associated with steroid resistance. Steroids 93-100 ATP binding cassette subfamily B member 1 Homo sapiens 62-67 27193461-0 2016 P-Glycoprotein Activity in Steroid-Responsive vs. Steroid-Resistant Nephrotic Syndrome. Steroids 27-34 ATP binding cassette subfamily B member 1 Homo sapiens 0-14 27193461-0 2016 P-Glycoprotein Activity in Steroid-Responsive vs. Steroid-Resistant Nephrotic Syndrome. Steroids 50-57 ATP binding cassette subfamily B member 1 Homo sapiens 0-14 27193461-5 2016 RESULTS: P-gp activity was significantly higher in steroid-resistant than steroid-sensitive cases. Steroids 51-58 ATP binding cassette subfamily B member 1 Homo sapiens 9-13 27193461-5 2016 RESULTS: P-gp activity was significantly higher in steroid-resistant than steroid-sensitive cases. Steroids 74-81 ATP binding cassette subfamily B member 1 Homo sapiens 9-13 27193461-6 2016 CONCLUSIONS: P-gp can be used as a predictor of outcome, as a part of laboratory evaluation of the cases before starting steroid therapy, so as to determine whether to use alternative line of therapy or use one of the P-gp inhibitors with steroid therapy. Steroids 121-128 ATP binding cassette subfamily B member 1 Homo sapiens 13-17 27193461-6 2016 CONCLUSIONS: P-gp can be used as a predictor of outcome, as a part of laboratory evaluation of the cases before starting steroid therapy, so as to determine whether to use alternative line of therapy or use one of the P-gp inhibitors with steroid therapy. Steroids 239-246 ATP binding cassette subfamily B member 1 Homo sapiens 13-17 27319155-4 2016 Here we abridge several examples of plant compounds from distinct classes, polyketides, lignans, anthraquinones, coumarins, alkaloids, mono- and sesqui-terpenes, steroids and limonoids, which have shown the ability to modulate in vitro or in vivo the P-gp activity. Steroids 162-170 ATP binding cassette subfamily B member 1 Homo sapiens 251-255 25862866-6 2015 RESULTS: Both the activity of steroid derivatives on inhibition of the ABCB1 pump and their interaction with doxorubicin are dependent on the substituent groups of the investigated steroidal structures. Steroids 30-37 ATP binding cassette subfamily B member 1 Homo sapiens 71-76 29083397-1 2015 This study examined how the 1199G > A polymorphism in the ABCB1 gene encoding P-glycoprotein (P-gp) affects the protein"s expression, ATPase activity, and ability to pump female steroid sex hormones out of LLC-PK1 cells. Steroids 181-188 ATP binding cassette subfamily B member 1 Homo sapiens 81-95 26154535-0 2015 Association of ACE and MDR1 Gene Polymorphisms with Steroid Resistance in Children with Idiopathic Nephrotic Syndrome. Steroids 52-59 ATP binding cassette subfamily B member 1 Homo sapiens 23-27 25862866-4 2015 MATERIALS AND METHODS: Steroid derivatives were studied for their growth-inhibitory effect, cytotoxicity, reversal of multidrug resistance, apoptosis induction, and interaction with doxorubicin on multidrug resistant human ATP-binding cassette, sub-family B, member 1 (ABCB1) gene-transfected mouse T-lymphoma cell line, and human PC-3 and LNCaP prostate cancer cell lines in vitro. Steroids 23-30 ATP binding cassette subfamily B member 1 Homo sapiens 223-267 25862866-4 2015 MATERIALS AND METHODS: Steroid derivatives were studied for their growth-inhibitory effect, cytotoxicity, reversal of multidrug resistance, apoptosis induction, and interaction with doxorubicin on multidrug resistant human ATP-binding cassette, sub-family B, member 1 (ABCB1) gene-transfected mouse T-lymphoma cell line, and human PC-3 and LNCaP prostate cancer cell lines in vitro. Steroids 23-30 ATP binding cassette subfamily B member 1 Homo sapiens 269-274 25112719-0 2015 Icariin may benefit the mesenchymal stem cells of patients with steroid-associated osteonecrosis by ABCB1-promoter demethylation: a preliminary study. Steroids 64-71 ATP binding cassette subfamily B member 1 Homo sapiens 100-105 25112719-6 2015 RESULTS: We observed that MSCs from the steroid-associated ONFH group showed reduced proliferation ability, elevated ROS level, depressed MMP, weakened osteogenesis, and enhanced adipogenesis while low P-gp activity, transcription level of ABCB1, and oxidative stress-related genes as well as aberrant CpG islands hypermethylation of ABCB1 were also noted in steroid-associated ONFH group. Steroids 40-47 ATP binding cassette subfamily B member 1 Homo sapiens 202-206 25112719-6 2015 RESULTS: We observed that MSCs from the steroid-associated ONFH group showed reduced proliferation ability, elevated ROS level, depressed MMP, weakened osteogenesis, and enhanced adipogenesis while low P-gp activity, transcription level of ABCB1, and oxidative stress-related genes as well as aberrant CpG islands hypermethylation of ABCB1 were also noted in steroid-associated ONFH group. Steroids 40-47 ATP binding cassette subfamily B member 1 Homo sapiens 240-245 25112719-6 2015 RESULTS: We observed that MSCs from the steroid-associated ONFH group showed reduced proliferation ability, elevated ROS level, depressed MMP, weakened osteogenesis, and enhanced adipogenesis while low P-gp activity, transcription level of ABCB1, and oxidative stress-related genes as well as aberrant CpG islands hypermethylation of ABCB1 were also noted in steroid-associated ONFH group. Steroids 40-47 ATP binding cassette subfamily B member 1 Homo sapiens 334-339 25104567-7 2014 The authors hypothesized that additional induction of the p-glycoprotein through steroids was synergistic. Steroids 81-89 ATP binding cassette subfamily B member 1 Homo sapiens 58-72 25145685-2 2014 P-gp is capable of regulating corticosteroid retention and thus P-gp upregulation has been implicated in steroid resistance in several inflammatory disorders. Steroids 37-44 ATP binding cassette subfamily B member 1 Homo sapiens 0-4 25145685-3 2014 The goal of this study is to determine whether P-gp regulates intracellular steroid retention in CRSwNP. Steroids 76-83 ATP binding cassette subfamily B member 1 Homo sapiens 47-51 25145685-12 2014 These findings, coupled with the known overexpression of P-gp in CRSwNP, may point to a possible mechanism for steroid resistance in this patient population. Steroids 111-118 ATP binding cassette subfamily B member 1 Homo sapiens 57-61 24395888-10 2014 Thus, MDR1(+) Th17 cells may be important mediators of chronic inflammation, particularly in clinical settings of steroid resistant inflammatory disease. Steroids 114-121 ATP binding cassette subfamily B member 1 Homo sapiens 6-10 24469730-0 2014 Genetic association of the P-glycoprotein gene ABCB1 polymorphisms with the risk for steroid-induced osteonecrosis of the femoral head in Chinese population. Steroids 85-92 ATP binding cassette subfamily B member 1 Homo sapiens 47-52 24469730-2 2014 Single nucleotide polymorphisms (SNPs) of the adenosine triphosphate-binding cassette B1 (ABCB1) gene have been demonstrated to be related to steroid-induced ONFH in small sample sizes of Japanese kidney failure and Chinese systemic lupus erythematosus patients. Steroids 142-149 ATP binding cassette subfamily B member 1 Homo sapiens 46-88 24469730-2 2014 Single nucleotide polymorphisms (SNPs) of the adenosine triphosphate-binding cassette B1 (ABCB1) gene have been demonstrated to be related to steroid-induced ONFH in small sample sizes of Japanese kidney failure and Chinese systemic lupus erythematosus patients. Steroids 142-149 ATP binding cassette subfamily B member 1 Homo sapiens 90-95 24469730-3 2014 However, there are obvious controversial results in the relationship of ABCB1 gene polymorphisms with steroid-induced ONFH. Steroids 102-109 ATP binding cassette subfamily B member 1 Homo sapiens 72-77 24469730-4 2014 The aim of this study was to validate the genetic association of ABCB1 polymorphisms with the risk for steroid-induced ONFH in a large cohort of Chinese population. Steroids 103-110 ATP binding cassette subfamily B member 1 Homo sapiens 65-70 24469730-10 2014 These findings suggested that rs1045642 SNP of ABCB1 may be associated with the risk of steroid-induced ONFH. Steroids 88-95 ATP binding cassette subfamily B member 1 Homo sapiens 47-52 24374471-1 2014 "s multi-drug resistance-1 gene polymorphisms in nephrotic syndrome: impact on susceptibility and response to steroids". Steroids 110-118 ATP binding cassette subfamily B member 1 Homo sapiens 3-26 24037553-0 2013 Aberrant CpG islands" hypermethylation of ABCB1 in mesenchymal stem cells of patients with steroid-associated osteonecrosis. Steroids 91-98 ATP binding cassette subfamily B member 1 Homo sapiens 42-47 23994685-0 2013 Multi-drug resistance-1 gene polymorphisms in nephrotic syndrome: impact on susceptibility and response to steroids. Steroids 107-115 ATP binding cassette subfamily B member 1 Homo sapiens 0-23 23994685-7 2013 Moreover, steroid non-responder NS patients had significantly higher frequencies of MDR1 G2677T/A GT, GA, and TT+AA genotypes than steroid responsive NS patients. Steroids 10-17 ATP binding cassette subfamily B member 1 Homo sapiens 84-88 23994685-9 2013 Interestingly the frequency of the TGC haplotype of MDR1 was lower in the initial steroid responders than in non-responders NS patients. Steroids 82-89 ATP binding cassette subfamily B member 1 Homo sapiens 52-56 23994685-11 2013 CONCLUSION: Our data suggested that MDR1 C3435T or G2677T/A gene polymorphisms are risk factors of increased susceptibility, earlier onset of NS, and steroid resistance. Steroids 150-157 ATP binding cassette subfamily B member 1 Homo sapiens 36-40 24217071-0 2013 The relationship between renal P-glycoprotein expression and response to steroid therapy in childhood nephrotic syndrome. Steroids 73-80 ATP binding cassette subfamily B member 1 Homo sapiens 31-45 21460357-0 2011 MDR-1 gene polymorphisms in steroid-responsive versus steroid-resistant nephrotic syndrome in children. Steroids 54-61 ATP binding cassette subfamily B member 1 Homo sapiens 0-5 23104431-10 2013 Our results showed that a delta-lactone ring and a sugar moiety at 3beta of the steroid body are favorable for DLC binding to P-gp. Steroids 80-87 ATP binding cassette subfamily B member 1 Homo sapiens 126-130 24617050-0 2013 P-glycoprotein-1 functional activity in CD5+CD7+ and CD20+ lymphocytes in systemic lupus erythematosus children: relation to disease activity, complications and steroid response. Steroids 161-168 ATP binding cassette subfamily B member 1 Homo sapiens 0-16 24617050-2 2013 Increased P-gp1 expression in lymphocytes of patients with systemic lupus erythematosus (SLE) may influence steroid requirements for disease control. Steroids 108-115 ATP binding cassette subfamily B member 1 Homo sapiens 10-15 24617050-10 2013 Steroids low responders whose SLEDAI were > or = 11 while receiving 1 mg/Kg/day of prednisolone demonstrated higher P-gp1 functions in CD 5+ and CD 7+ lymphocytes compared to high responders whose SLEDAI were < 11 while receiving < 1 mg/Kg/day of prednisolone. Steroids 0-8 ATP binding cassette subfamily B member 1 Homo sapiens 119-124 24617050-11 2013 CD5+ lymphocyte"s P-gp1 function was found to be lower in the patients receiving cyclophosphamide in addition to steroids compared to those on steroids only. Steroids 113-121 ATP binding cassette subfamily B member 1 Homo sapiens 18-23 24617050-11 2013 CD5+ lymphocyte"s P-gp1 function was found to be lower in the patients receiving cyclophosphamide in addition to steroids compared to those on steroids only. Steroids 143-151 ATP binding cassette subfamily B member 1 Homo sapiens 18-23 23170130-1 2012 Active P-glycoprotein (P-gp) molecules have been shown to transport steroids out of peripheral lymphocytes, resulting in poor responses to systemic steroid therapy in patients with systemic lupus erythematosus (SLE). Steroids 68-76 ATP binding cassette subfamily B member 1 Homo sapiens 7-21 23170130-1 2012 Active P-glycoprotein (P-gp) molecules have been shown to transport steroids out of peripheral lymphocytes, resulting in poor responses to systemic steroid therapy in patients with systemic lupus erythematosus (SLE). Steroids 68-76 ATP binding cassette subfamily B member 1 Homo sapiens 23-27 23170130-1 2012 Active P-glycoprotein (P-gp) molecules have been shown to transport steroids out of peripheral lymphocytes, resulting in poor responses to systemic steroid therapy in patients with systemic lupus erythematosus (SLE). Steroids 68-75 ATP binding cassette subfamily B member 1 Homo sapiens 7-21 23170130-1 2012 Active P-glycoprotein (P-gp) molecules have been shown to transport steroids out of peripheral lymphocytes, resulting in poor responses to systemic steroid therapy in patients with systemic lupus erythematosus (SLE). Steroids 68-75 ATP binding cassette subfamily B member 1 Homo sapiens 23-27 23170130-2 2012 This study was carried out to investigate the correlation between the expression or activity of P-gp in peripheral lymphocytes and disease control in SLE patients with a long history of systemic steroid treatment. Steroids 195-202 ATP binding cassette subfamily B member 1 Homo sapiens 96-100 23170130-10 2012 In conclusion, the high expression levels of P-gp in the peripheral lymphocytes of SLE patients leads to poor disease control by systemic steroids. Steroids 138-146 ATP binding cassette subfamily B member 1 Homo sapiens 45-49 22868178-1 2012 Bivalent ligands were designed on the basis of the described close proximity of the ATP-site and the putative steroid-binding site of P-glycoprotein (ABCB1). Steroids 110-117 ATP binding cassette subfamily B member 1 Homo sapiens 134-148 22868178-1 2012 Bivalent ligands were designed on the basis of the described close proximity of the ATP-site and the putative steroid-binding site of P-glycoprotein (ABCB1). Steroids 110-117 ATP binding cassette subfamily B member 1 Homo sapiens 150-155 22610055-6 2012 RESULTS: C1236T in ABCB1 was associated with steroid resistance in INS children [odds ratio (OR) 2.65, 95 % confidence interval (CI) 1.01-6.94; p = 0.042] The frequency of the T allele was significantly higher in SR subjects than in SS subjects (0.81 vs. 0.62, respectively). Steroids 45-52 ATP binding cassette subfamily B member 1 Homo sapiens 19-24 22610055-9 2012 CONCLUSIONS: Our results indicate that among our pediatric patients with INS the C1236T polymorphism in the ABCB1 gene was associated with steroid resistance, while the A6986G polymorphism in the CYP3A5 gene showed a trend of association, but did not reach statistical significance, requiring further analysis. Steroids 139-146 ATP binding cassette subfamily B member 1 Homo sapiens 108-113 22464980-1 2012 There is concern that P-glycoprotein mediated efflux contributes to steroid resistance. Steroids 68-75 ATP binding cassette subfamily B member 1 Homo sapiens 22-36 23170130-11 2012 Emodin, an active ingredient derived from Chinese herbs, possesses a promising effect for overcoming P-gp-mediated steroid resistance by inhibiting the P-gp efflux function. Steroids 115-122 ATP binding cassette subfamily B member 1 Homo sapiens 101-105 21460357-2 2011 We undertook this study to examine the distribution of three most frequent MDR-1 exonic polymorphisms G3435C, G2677T/A and C1236T in patients with NS and control children to investigate their usefulness as markers of responsiveness of the disease to steroids. Steroids 250-258 ATP binding cassette subfamily B member 1 Homo sapiens 75-80 21553324-7 2011 The frequencies of the MDR1 1236 CC (18.8 vs 7.2%) or TC (53.5 vs 43.5%) genotype and C allele (45.5 vs 29.0%) were significantly higher in the initial steroid responders than in the non-responders. Steroids 152-159 ATP binding cassette subfamily B member 1 Homo sapiens 23-27 21553324-8 2011 Analysis of MDR1 three-marker haplotypes revealed that the frequency of the TGC haplotype was significantly lower in the initial steroid responders than in the non-responders (15.8 vs 29.0%). Steroids 129-136 ATP binding cassette subfamily B member 1 Homo sapiens 12-16 21553324-10 2011 These data suggest that the initial steroid response in children with NS may be influenced by genetic variations in the MDR1 gene. Steroids 36-43 ATP binding cassette subfamily B member 1 Homo sapiens 120-124 19303670-0 2009 Identification of putative steroid-binding sites in human ABCB1 and ABCG2. Steroids 27-34 ATP binding cassette subfamily B member 1 Homo sapiens 58-63 21974705-1 2011 In two patients with steroid-resistant nephrotic syndrome (SRNS), we investigated the relationship between clinical findings during immunosuppressive therapy and multiple drug resistant gene-1 (MDR-1) expression. Steroids 21-28 ATP binding cassette subfamily B member 1 Homo sapiens 194-199 21525574-0 2011 Soluble interleukine-2 receptor and MDR1 gene expression levels as inflammatory biomarkers for prediction of steroid response in children with nephrotic syndrome. Steroids 109-116 ATP binding cassette subfamily B member 1 Homo sapiens 36-40 21525574-1 2011 INTRODUCTION: Upregulation of interleukin-2 may be involved, not only in the pathophysiology of nephrotic syndrome, but also in steroid resistance treatment, by increasing expression of multidrug resistant gene-1 (MDR1) gene on lymphocytes and its product P-glycoprotein effluxing corticosteroid. Steroids 128-135 ATP binding cassette subfamily B member 1 Homo sapiens 186-212 21525574-6 2011 Levels of sIL2R and MDR1 gene expression in different subgroups were higher in known cases with relapse than in new onsets, both in activity and remission, and relatively higher in steroid-resistant than in steroid-sensitive ones. Steroids 181-188 ATP binding cassette subfamily B member 1 Homo sapiens 20-24 21525574-6 2011 Levels of sIL2R and MDR1 gene expression in different subgroups were higher in known cases with relapse than in new onsets, both in activity and remission, and relatively higher in steroid-resistant than in steroid-sensitive ones. Steroids 207-214 ATP binding cassette subfamily B member 1 Homo sapiens 20-24 21525574-7 2011 CONCLUSIONS: We propose sIL2R and MDR1gene expression levels as early predictors of steroid resistance in nephrotic syndrome for early control of disease by immediate introduction of cytotoxic drugs. Steroids 84-91 ATP binding cassette subfamily B member 1 Homo sapiens 34-38 21604677-1 2011 P-glycoprotein (P-gp) is one of the major ABC transporters and involved in many essential processes such as lipid and steroid transport across cell membranes but also in the uptake of drugs such as HIV protease and reverse transcriptase inhibitors. Steroids 118-125 ATP binding cassette subfamily B member 1 Homo sapiens 0-14 21604677-1 2011 P-glycoprotein (P-gp) is one of the major ABC transporters and involved in many essential processes such as lipid and steroid transport across cell membranes but also in the uptake of drugs such as HIV protease and reverse transcriptase inhibitors. Steroids 118-125 ATP binding cassette subfamily B member 1 Homo sapiens 16-20 20553861-0 2010 Novel steroid carbamates reverse multidrug-resistance in cancer therapy and show linkage among efficacy, loci of drug action and P-glycoprotein"s cellular localization. Steroids 6-13 ATP binding cassette subfamily B member 1 Homo sapiens 129-143 20399647-1 2010 Steroidal bivalent ligands were designed on the basis of the described closer proximity of the ATP-site and the putative steroid-binding site of P-glycoprotein (ABCB1). Steroids 121-128 ATP binding cassette subfamily B member 1 Homo sapiens 145-159 20399647-1 2010 Steroidal bivalent ligands were designed on the basis of the described closer proximity of the ATP-site and the putative steroid-binding site of P-glycoprotein (ABCB1). Steroids 121-128 ATP binding cassette subfamily B member 1 Homo sapiens 161-166 21460357-0 2011 MDR-1 gene polymorphisms in steroid-responsive versus steroid-resistant nephrotic syndrome in children. Steroids 28-35 ATP binding cassette subfamily B member 1 Homo sapiens 0-5 21317201-8 2011 These findings implicate a role of ESR2 in the risk for developing CRC in women and suggest that HSD17B1, ABCB1, and SHBG genes may contribute to sex steroid-mediated effects on CRC development. Steroids 150-157 ATP binding cassette subfamily B member 1 Homo sapiens 106-111 21289623-6 2011 We suggest that ABCB1, but not CYP3A5, may predict short-term remission of Tac in steroid-refractory UC. Steroids 82-89 ATP binding cassette subfamily B member 1 Homo sapiens 16-21 21229388-1 2011 P-glycoprotein (P-gp), as an ATP-binding cassette transporter, transports a wide variety of substrates varying from small molecules like steroids to large polypeptides across the cell membrane in human and animals, even in aquatic animals. Steroids 137-145 ATP binding cassette subfamily B member 1 Homo sapiens 0-14 21229388-1 2011 P-glycoprotein (P-gp), as an ATP-binding cassette transporter, transports a wide variety of substrates varying from small molecules like steroids to large polypeptides across the cell membrane in human and animals, even in aquatic animals. Steroids 137-145 ATP binding cassette subfamily B member 1 Homo sapiens 16-20 19303670-3 2009 C-terminal ABCB1 NBD (ABCB1 NBD2) was predicted to bind steroids within a cavity formed partly by the P-Loop, Tyr1044 and Ile1050. Steroids 56-64 ATP binding cassette subfamily B member 1 Homo sapiens 11-16 19303670-3 2009 C-terminal ABCB1 NBD (ABCB1 NBD2) was predicted to bind steroids within a cavity formed partly by the P-Loop, Tyr1044 and Ile1050. Steroids 56-64 ATP binding cassette subfamily B member 1 Homo sapiens 22-27 17043887-0 2007 MDR-1 gene polymorphisms and clinical course of steroid-responsive nephrotic syndrome in children. Steroids 48-55 ATP binding cassette subfamily B member 1 Homo sapiens 0-5 19564743-6 2009 P-gp activity plays a negative role, both for a remission achieved on day 33 and for susceptibility to steroid therapy. Steroids 103-110 ATP binding cassette subfamily B member 1 Homo sapiens 0-4 19409404-6 2009 Differentially expressed genes included the Phase I xenobiotic, fatty acid, sterol and steroid metabolism genes Cyp2b2 and CYP2B6, Cyp3a1 and CYP3A4, and Cyp4a22 and CYP4A11; Phase II conjugation enzyme genes Ugt1a1 and UGT1A1; and Phase III ABC transporter genes Abcb1 and ABCB1. Steroids 87-94 ATP binding cassette subfamily B member 1 Homo sapiens 264-269 19409404-6 2009 Differentially expressed genes included the Phase I xenobiotic, fatty acid, sterol and steroid metabolism genes Cyp2b2 and CYP2B6, Cyp3a1 and CYP3A4, and Cyp4a22 and CYP4A11; Phase II conjugation enzyme genes Ugt1a1 and UGT1A1; and Phase III ABC transporter genes Abcb1 and ABCB1. Steroids 87-94 ATP binding cassette subfamily B member 1 Homo sapiens 274-279 18288958-10 2008 Progesterone is not transported by P-gp, but blocks P-gp-mediated efflux of other drugs and P-gp can mediate the transport of a variety of steroids. Steroids 139-147 ATP binding cassette subfamily B member 1 Homo sapiens 52-56 18288958-10 2008 Progesterone is not transported by P-gp, but blocks P-gp-mediated efflux of other drugs and P-gp can mediate the transport of a variety of steroids. Steroids 139-147 ATP binding cassette subfamily B member 1 Homo sapiens 52-56 18214345-0 2007 MDR1(ABCB1) gene polymorphisms associated with steroid-induced osteonecrosis of femoral head in systemic lupus erythematosus. Steroids 47-54 ATP binding cassette subfamily B member 1 Homo sapiens 0-4 18214345-0 2007 MDR1(ABCB1) gene polymorphisms associated with steroid-induced osteonecrosis of femoral head in systemic lupus erythematosus. Steroids 47-54 ATP binding cassette subfamily B member 1 Homo sapiens 5-10 18214345-1 2007 This study investigated the relationship between genetic polymorphism in the MDR1 (C3435T, G2677T) and the development of steroid-induced osteonecrosis of femoral head (ONF) in Chinese systemic lupus erythematosus (SLE) patients. Steroids 122-129 ATP binding cassette subfamily B member 1 Homo sapiens 77-81 17206635-3 2007 PATIENTS AND METHODS: The distribution of the different genotypes of single nucleotide polymorphisms (SNP) G2677T/A and C3435T of MDR1 exons 21 and 26, respectively, was studied in 154 patients (mean age, 44 yr) who had received CsA to treat severe attacks of steroid resistant UC in 11 centers in France and Belgium. Steroids 260-267 ATP binding cassette subfamily B member 1 Homo sapiens 130-134 17206635-9 2007 CONCLUSION: The TT genotype of exon 21 MDR1 polymorphisms is associated with a higher risk of CsA failure in patients with steroid resistant UC. Steroids 123-130 ATP binding cassette subfamily B member 1 Homo sapiens 39-43 19101657-8 2009 These results suggest that higher P-glycoprotein activity on CD3(+) or CD4(+) cells necessitated treatment with higher steroid doses in order to achieve a clinical response. Steroids 119-126 ATP binding cassette subfamily B member 1 Homo sapiens 34-48 17636047-2 2007 We demonstrated previously that steroid/xenobiotic metabolism by tumor tissue through the PXR-CYP3A pathway might play an important role in endometrial cancer and that PXR ligands enhance PXR-mediated transcription in a ligand- and promoter-dependent fashion, leading to differential regulation of individual PXR targets, especially CYP3A4 and MDR1. Steroids 32-39 ATP binding cassette subfamily B member 1 Homo sapiens 344-348 17043887-1 2007 The study was aimed at investigating the association between MDR-1 genetic polymorphisms [C1236T, G2677T(A), C3435T] and parameters describing the clinical course and treatment response of childhood steroid-responsive nephrotic syndrome (SRNS). Steroids 199-206 ATP binding cassette subfamily B member 1 Homo sapiens 61-66 17526937-1 2006 Cytochrome P450 monooxygenase 3A4 (CYP3A4) and P-glycoprotein, encoded by multidrug resistance 1 (MDR1) gene, are responsible for the metabolism of endogenous steroids, prescribed drugs, and xenobiotics. Steroids 159-167 ATP binding cassette subfamily B member 1 Homo sapiens 47-61 17526937-1 2006 Cytochrome P450 monooxygenase 3A4 (CYP3A4) and P-glycoprotein, encoded by multidrug resistance 1 (MDR1) gene, are responsible for the metabolism of endogenous steroids, prescribed drugs, and xenobiotics. Steroids 159-167 ATP binding cassette subfamily B member 1 Homo sapiens 74-96 16761159-0 2006 Expression of P-glycoprotein in lymphocytes from children with nephrotic syndrome, depending on their steroid response. Steroids 102-109 ATP binding cassette subfamily B member 1 Homo sapiens 14-28 16738866-3 2006 The aim of the present study was to determine the expression of P-gp in lymphocytes (CD3) in the peripheral blood of children with steroid-sensitive nephrotic syndrome in the dynamics of the disease. Steroids 131-138 ATP binding cassette subfamily B member 1 Homo sapiens 64-68 17526937-1 2006 Cytochrome P450 monooxygenase 3A4 (CYP3A4) and P-glycoprotein, encoded by multidrug resistance 1 (MDR1) gene, are responsible for the metabolism of endogenous steroids, prescribed drugs, and xenobiotics. Steroids 159-167 ATP binding cassette subfamily B member 1 Homo sapiens 98-102 16337358-1 2006 P-glycoprotein (P-gp) coded with the multidrug resistance type I (MDR1) is expressed in various normal tissues including ovaries and may function as detoxification and steroid transport. Steroids 168-175 ATP binding cassette subfamily B member 1 Homo sapiens 0-14 16337358-1 2006 P-glycoprotein (P-gp) coded with the multidrug resistance type I (MDR1) is expressed in various normal tissues including ovaries and may function as detoxification and steroid transport. Steroids 168-175 ATP binding cassette subfamily B member 1 Homo sapiens 16-20 16337358-1 2006 P-glycoprotein (P-gp) coded with the multidrug resistance type I (MDR1) is expressed in various normal tissues including ovaries and may function as detoxification and steroid transport. Steroids 168-175 ATP binding cassette subfamily B member 1 Homo sapiens 66-70 15934077-0 2005 Clinical relevance of the expression of P-glycoprotein on peripheral blood lymphocytes to steroid resistance in patients with systemic lupus erythematosus. Steroids 90-97 ATP binding cassette subfamily B member 1 Homo sapiens 40-54 16706074-4 2006 AIM: to compare P-gp immunostaining pattern in colonic epithelial cells of steroid-refractory versus steroid-responder UC patients. Steroids 75-82 ATP binding cassette subfamily B member 1 Homo sapiens 16-20 16706074-4 2006 AIM: to compare P-gp immunostaining pattern in colonic epithelial cells of steroid-refractory versus steroid-responder UC patients. Steroids 101-108 ATP binding cassette subfamily B member 1 Homo sapiens 16-20 16706074-11 2006 CONCLUSIONS: These results suggest a critical role of P-gp overexpression in steroid-refractory UC. Steroids 77-84 ATP binding cassette subfamily B member 1 Homo sapiens 54-58 16442095-1 2006 Efflux transporters, p-glycoprotein and breast cancer resistance protein (BCRP), located at barrier sites such as the blood-brain barrier may affect distribution of steroids used for treating chronic inflammatory conditions and thus the extent to which they may perturb the hypothalamic-pituitary-adrenal axis. Steroids 165-173 ATP binding cassette subfamily B member 1 Homo sapiens 21-35 16706074-3 2006 The role of P-gp and its intestinal expression in steroid-refractory ulcerative colitis (UC) are controversial. Steroids 50-57 ATP binding cassette subfamily B member 1 Homo sapiens 12-16 15934077-3 2005 The aim of this study was to elucidate the clinical relevance of P-gp expression on lymphocytes to steroid resistance in patients with active SLE. Steroids 99-106 ATP binding cassette subfamily B member 1 Homo sapiens 65-69 15934077-10 2005 CONCLUSION: The overexpression of P-gp on lymphocytes might lead to exclusion of corticosteroids from lymphocytes, resulting in steroid resistance in patients with highly active SLE. Steroids 88-95 ATP binding cassette subfamily B member 1 Homo sapiens 34-38 15934077-11 2005 Reduction of P-gp expression achieved by intensive immunosuppressive treatment overcame the steroid resistance. Steroids 92-99 ATP binding cassette subfamily B member 1 Homo sapiens 13-17 15934077-12 2005 We therefore propose that measurement of P-gp expression on lymphocytes is useful in the assessment of steroid resistance and is a good marker for indicating the need for intensive immunosuppressive treatment in patients with highly active SLE. Steroids 103-110 ATP binding cassette subfamily B member 1 Homo sapiens 41-45 15060513-6 2004 With high-dose steroid-pulse treatment, the enterocyte mRNA expression of CYP3A4, but not of MDR1, was markedly enhanced. Steroids 15-22 ATP binding cassette subfamily B member 1 Homo sapiens 93-97 15713537-9 2005 These findings demonstrated age-related differences in the body"s capacity to metabolize steroids and xenobiotic compounds and suggest an important role for SXR and its target genes, CYP3A4 and MDR1 in this process. Steroids 89-97 ATP binding cassette subfamily B member 1 Homo sapiens 194-198 15650019-4 2005 Some steroids/EDCs strongly activated PXR-mediated transcription through the CYP3A4-responsive element compared with the MDR1-responsive element, whereas these steroids/EDCs also enhanced the CYP3A4 expression compared with the MDR1 expression. Steroids 5-13 ATP binding cassette subfamily B member 1 Homo sapiens 228-232 15650019-4 2005 Some steroids/EDCs strongly activated PXR-mediated transcription through the CYP3A4-responsive element compared with the MDR1-responsive element, whereas these steroids/EDCs also enhanced the CYP3A4 expression compared with the MDR1 expression. Steroids 160-168 ATP binding cassette subfamily B member 1 Homo sapiens 121-125 15650019-4 2005 Some steroids/EDCs strongly activated PXR-mediated transcription through the CYP3A4-responsive element compared with the MDR1-responsive element, whereas these steroids/EDCs also enhanced the CYP3A4 expression compared with the MDR1 expression. Steroids 160-168 ATP binding cassette subfamily B member 1 Homo sapiens 228-232 15003146-8 2004 Physiological and synthetic steroids such as cortisol and Dex are substrates of p-gp, and so Dex resistance in depression may be related to dysfunction of this protein. Steroids 28-36 ATP binding cassette subfamily B member 1 Homo sapiens 80-84 14965247-4 2004 MDR1/P-glycoprotein extrudes a very wide array of structurally dissimilar compounds, all lipophilic and ranging in mass from approximately 300 to 2000 Da, including cytotoxic drugs that act on different intracellular targets, steroid hormones, peptide antibiotics, immunosuppressive agents, calcium channel blockers, and others. Steroids 226-242 ATP binding cassette subfamily B member 1 Homo sapiens 0-4 14991868-1 2004 BACKGROUND: P-glycoprotein (P-gp) is commonly associated with multi-drug resistance (MDR) in cancer cells and the efflux of a broad spectrum of chemicals from the cell, including many chemotherapeutics and certain steroid hormones. Steroids 214-230 ATP binding cassette subfamily B member 1 Homo sapiens 12-26 14991868-1 2004 BACKGROUND: P-glycoprotein (P-gp) is commonly associated with multi-drug resistance (MDR) in cancer cells and the efflux of a broad spectrum of chemicals from the cell, including many chemotherapeutics and certain steroid hormones. Steroids 214-230 ATP binding cassette subfamily B member 1 Homo sapiens 28-32 14965247-4 2004 MDR1/P-glycoprotein extrudes a very wide array of structurally dissimilar compounds, all lipophilic and ranging in mass from approximately 300 to 2000 Da, including cytotoxic drugs that act on different intracellular targets, steroid hormones, peptide antibiotics, immunosuppressive agents, calcium channel blockers, and others. Steroids 226-242 ATP binding cassette subfamily B member 1 Homo sapiens 5-19 12175731-0 2002 The MDR1 polymorphisms at exons 21 and 26 predict steroid weaning in pediatric heart transplant patients. Steroids 50-57 ATP binding cassette subfamily B member 1 Homo sapiens 4-8 15072439-7 2004 Many of these herbal constituents, in particular flavonoids, were reported to modulate Pgp by directly interacting with the vicinal ATP-binding site, the steroid-binding site, or the substrate-binding site. Steroids 154-161 ATP binding cassette subfamily B member 1 Homo sapiens 87-90 12451243-0 2002 Lowered blood concentration of tacrolimus and its recovery with changes in expression of CYP3A and P-glycoprotein after high-dose steroid therapy. Steroids 130-137 ATP binding cassette subfamily B member 1 Homo sapiens 99-113 12451243-10 2002 CONCLUSION: Our results indicate that the decrease in the blood FK506 concentration caused by high-dose steroid therapy is a consequence of the induction of P-glycoprotein and CYP3A in the liver and intestine, and these changes were reversed within 2 weeks after cessation of steroid therapy. Steroids 104-111 ATP binding cassette subfamily B member 1 Homo sapiens 157-171 12451243-10 2002 CONCLUSION: Our results indicate that the decrease in the blood FK506 concentration caused by high-dose steroid therapy is a consequence of the induction of P-glycoprotein and CYP3A in the liver and intestine, and these changes were reversed within 2 weeks after cessation of steroid therapy. Steroids 276-283 ATP binding cassette subfamily B member 1 Homo sapiens 157-171 15669633-4 2004 The outcome of therapy with drugs such as steroids may be influenced by a wide range of genetic factors including polymorphisms in the multi-drug resistance 1 gene (MDR1), polymorphisms in glucocorticoid receptor genes and potentially other as yet undefined polymorphisms regulating the inflammatory process. Steroids 42-50 ATP binding cassette subfamily B member 1 Homo sapiens 135-158 15669633-4 2004 The outcome of therapy with drugs such as steroids may be influenced by a wide range of genetic factors including polymorphisms in the multi-drug resistance 1 gene (MDR1), polymorphisms in glucocorticoid receptor genes and potentially other as yet undefined polymorphisms regulating the inflammatory process. Steroids 42-50 ATP binding cassette subfamily B member 1 Homo sapiens 165-169 14583680-0 2003 ABCB1 C3435T and G2677T/A polymorphism decreased the risk for steroid-induced osteonecrosis of the femoral head after kidney transplantation. Steroids 62-69 ATP binding cassette subfamily B member 1 Homo sapiens 0-5 12737312-0 2003 RU49953: a non-hormonal steroid derivative that potently inhibits P-glycoprotein and reverts cellular multidrug resistance. Steroids 24-31 ATP binding cassette subfamily B member 1 Homo sapiens 66-80 11912009-4 2002 The aim of this work was to assess the expression and activity of P-glycoprotein in the mononuclear cells (MNC) from pemphigus patients with good and poor response to steroid therapy. Steroids 167-174 ATP binding cassette subfamily B member 1 Homo sapiens 66-80 11912009-7 2002 We found that the expression of P-glycoprotein at both mRNA and protein levels was similar in pemphigus patients with good and poor response to steroid therapy. Steroids 144-151 ATP binding cassette subfamily B member 1 Homo sapiens 32-46 12175731-3 2002 The objectives of this study were (a) to determine whether the MDR1 exon 21 and exon 26 polymorphisms were related to steroid weaning in a pediatric heart transplant (HTx) population, and (b) to determine whether an association exist between the MDR1 exon 21 and exon 26 polymorphisms in these patients. Steroids 118-125 ATP binding cassette subfamily B member 1 Homo sapiens 63-67 12175731-7 2002 For steroid weaning at one year post-HTx for MDR1 C3435T, 12 of 18 (67%) patients in the CC genotype were still on prednisone, whereas only 18 of 47 (38%) of the CT/TT group were still receiving prednisone (p = 0.04). Steroids 4-11 ATP binding cassette subfamily B member 1 Homo sapiens 45-49 12175731-10 2002 We conclude that (a) a significantly larger number of MDR1 3435 CC HTx patients remain on steroids at 1 year after transplantation, and (b) the MDR1 C3435T genotype is associated with the G2677 genotype in pediatric HTx patients. Steroids 90-98 ATP binding cassette subfamily B member 1 Homo sapiens 54-58 12175731-10 2002 We conclude that (a) a significantly larger number of MDR1 3435 CC HTx patients remain on steroids at 1 year after transplantation, and (b) the MDR1 C3435T genotype is associated with the G2677 genotype in pediatric HTx patients. Steroids 90-98 ATP binding cassette subfamily B member 1 Homo sapiens 144-148 11509123-9 2001 Blasts from two patients with ALL during the first week of monotherapy with steroids revealed combined induction of the MDR1, multidrug resistance-associated protein 1 (MRP1), lung cancer resistance-related protein (LRP) and most PKC isozymes, predominantly PKCzeta. Steroids 76-84 ATP binding cassette subfamily B member 1 Homo sapiens 120-124 12002483-0 2002 Transepithelial transport and cellular accumulation of steroid hormones and polychlorobiphenyl in porcine kidney cells expressed with human P-glycoprotein. Steroids 55-71 ATP binding cassette subfamily B member 1 Homo sapiens 140-154 11576779-0 2001 Modulation of P-glycoprotein activity in Calu-3 cells using steroids and beta-ligands. Steroids 60-68 ATP binding cassette subfamily B member 1 Homo sapiens 14-28 11576779-3 2001 Pgp inhibition was observed at > or =100 microM steroids and beta-ligand. Steroids 51-59 ATP binding cassette subfamily B member 1 Homo sapiens 0-3 10897619-2 2000 This study aimed at evaluating MDR1 expression in NS sensitive(S) and resistant(R) to therapy (steroids/S/, cyclophosphamide/C/, CsA) patients. Steroids 95-103 ATP binding cassette subfamily B member 1 Homo sapiens 31-35 11160617-5 2001 These steroids are poor and good substrates of pgp, respectively, and cortisol 6beta-hydroxylase has been frequently used as an in vivo probe for CYP3A4. Steroids 6-14 ATP binding cassette subfamily B member 1 Homo sapiens 47-50 11475537-4 2000 The substrates of Pgp may be endogenous (steroid hormones, cytokines) or exogenous (cytostatic drugs). Steroids 41-57 ATP binding cassette subfamily B member 1 Homo sapiens 18-21 10773967-1 2000 Part II: Increased P-glycoprotein activity in lymphocytes from systemic lupus erythematosus patients might affect steroid requirements for disease control. Steroids 114-121 ATP binding cassette subfamily B member 1 Homo sapiens 19-33 10773967-3 2000 P-glycoprotein is a pump molecule that transports hydrophobic drugs (including steroids) and toxins outside the cells, thus inhibiting their therapeutic or toxic effects. Steroids 79-87 ATP binding cassette subfamily B member 1 Homo sapiens 0-14 9044851-0 1997 Chemosensitizing steroids: glucocorticoid receptor agonists capable of inhibiting P-glycoprotein function. Steroids 17-25 ATP binding cassette subfamily B member 1 Homo sapiens 82-96 10726475-0 1999 [Cyclosporin A reverses steroid-resistance induced by P-glycoprotein in patients with SLE]. Steroids 24-31 ATP binding cassette subfamily B member 1 Homo sapiens 54-68 10652600-3 1999 Moreover, P-gp can also play a role in steroid secretion and cellular detoxification by transporting various other substrates. Steroids 39-46 ATP binding cassette subfamily B member 1 Homo sapiens 10-14 9551426-3 1998 MDR1 Pgp transports xenobiotics, peptides, steroids, and phospholipids, and is also a regulator of swelling-activated chloride channels. Steroids 43-51 ATP binding cassette subfamily B member 1 Homo sapiens 0-4 9567214-6 1998 A variety of substrates ranging from chemotherapeutics to steroid hormones, antibiotics, and calcium channel blockers can be transported by P-gp, suggesting the possible involvement of this protein in other unknown functions. Steroids 58-74 ATP binding cassette subfamily B member 1 Homo sapiens 140-144 9044851-3 1997 We have explored the possibility that modified steroids could serve a dual purpose, as glucocorticoid receptor agonists and P-glycoprotein inhibitors. Steroids 47-55 ATP binding cassette subfamily B member 1 Homo sapiens 124-138 9044851-6 1997 The two resulting steroids, SA47 and SA450, were potent glucocorticoid receptor agonists also capable of inhibiting the human P-glycoprotein with an efficiency equal to that of verapamil. Steroids 18-26 ATP binding cassette subfamily B member 1 Homo sapiens 126-140 8713080-6 1996 The effects of these steroids on verapamil-stimulated P-gp ATPase activity support a non-competitive mechanism, i.e. the binding sites for verapamil and steroids are mutually non-exclusive for P-gp ATPase modulation. Steroids 21-29 ATP binding cassette subfamily B member 1 Homo sapiens 54-58 8713080-6 1996 The effects of these steroids on verapamil-stimulated P-gp ATPase activity support a non-competitive mechanism, i.e. the binding sites for verapamil and steroids are mutually non-exclusive for P-gp ATPase modulation. Steroids 21-29 ATP binding cassette subfamily B member 1 Homo sapiens 193-197 8713080-0 1996 Effects of steroids and verapamil on P-glycoprotein ATPase activity: progesterone, desoxycorticosterone, corticosterone and verapamil are mutually non-exclusive modulators. Steroids 11-19 ATP binding cassette subfamily B member 1 Homo sapiens 37-51 8713080-6 1996 The effects of these steroids on verapamil-stimulated P-gp ATPase activity support a non-competitive mechanism, i.e. the binding sites for verapamil and steroids are mutually non-exclusive for P-gp ATPase modulation. Steroids 153-161 ATP binding cassette subfamily B member 1 Homo sapiens 54-58 8713080-6 1996 The effects of these steroids on verapamil-stimulated P-gp ATPase activity support a non-competitive mechanism, i.e. the binding sites for verapamil and steroids are mutually non-exclusive for P-gp ATPase modulation. Steroids 153-161 ATP binding cassette subfamily B member 1 Homo sapiens 193-197 8713080-7 1996 A similar non-competitive inhibition of progesterone-stimulated P-gp ATPase activity by desoxycorticosterone or by corticosterone leads to the conclusion that these steroids, although sharing related structures, have distinct modulating sites on P-gp. Steroids 165-173 ATP binding cassette subfamily B member 1 Homo sapiens 64-68 8713080-7 1996 A similar non-competitive inhibition of progesterone-stimulated P-gp ATPase activity by desoxycorticosterone or by corticosterone leads to the conclusion that these steroids, although sharing related structures, have distinct modulating sites on P-gp. Steroids 165-173 ATP binding cassette subfamily B member 1 Homo sapiens 246-250 8664272-0 1996 Steroid treatment, accumulation, and antagonism of P-glycoprotein in multidrug-resistant cells. Steroids 0-7 ATP binding cassette subfamily B member 1 Homo sapiens 51-65 8664272-5 1996 Progesterone and progesterone-like compounds, however were potent inhibitors of Pgp-mediated vinblastine efflux; increased antagonism correlated with increased steroid hydrophobicity. Steroids 160-167 ATP binding cassette subfamily B member 1 Homo sapiens 80-83 8664272-7 1996 These results extend previous observations that Pgp can mediate the transport of, and be antagonized by, a variety of steroids and that these properties vary with both steroid"s hydrophobicity and the phosphorylated state of Pgp. Steroids 118-126 ATP binding cassette subfamily B member 1 Homo sapiens 48-51 8664272-7 1996 These results extend previous observations that Pgp can mediate the transport of, and be antagonized by, a variety of steroids and that these properties vary with both steroid"s hydrophobicity and the phosphorylated state of Pgp. Steroids 118-126 ATP binding cassette subfamily B member 1 Homo sapiens 225-228 7914405-9 1994 These results suggest that the antiestrogens and steroid hormones that are known to reverse the multidrug-resistant phenotype do so by directly interacting with Pgp, thus interfering with its anticancer drug-extruding activity. Steroids 49-56 ATP binding cassette subfamily B member 1 Homo sapiens 161-164 8664272-7 1996 These results extend previous observations that Pgp can mediate the transport of, and be antagonized by, a variety of steroids and that these properties vary with both steroid"s hydrophobicity and the phosphorylated state of Pgp. Steroids 118-125 ATP binding cassette subfamily B member 1 Homo sapiens 48-51 8664272-7 1996 These results extend previous observations that Pgp can mediate the transport of, and be antagonized by, a variety of steroids and that these properties vary with both steroid"s hydrophobicity and the phosphorylated state of Pgp. Steroids 118-125 ATP binding cassette subfamily B member 1 Homo sapiens 225-228 8833164-0 1996 P-glycoprotein expression in circulating blood leukocytes of patients with steroid-resistant asthma. Steroids 75-82 ATP binding cassette subfamily B member 1 Homo sapiens 0-14 8833164-2 1996 Thus, upregulation of P-glycoprotein may provide a mechanism for reduced glucocorticosteroid responses as they occur in steroid-resistant asthma. Steroids 85-92 ATP binding cassette subfamily B member 1 Homo sapiens 22-36 8833164-7 1996 These results suggest that increased P-glycoprotein expression can be excluded as a mechanism for steroid resistance. Steroids 98-105 ATP binding cassette subfamily B member 1 Homo sapiens 37-51 7654329-9 1994 We have found that RU486 is an inhibitor of P-glycoprotein function, indicating that steroid analogs could be useful chemosensitizers in patients undergoing chemotherapy. Steroids 85-92 ATP binding cassette subfamily B member 1 Homo sapiens 44-58 7914405-0 1994 Antiestrogens and steroid hormones: substrates of the human P-glycoprotein. Steroids 18-34 ATP binding cassette subfamily B member 1 Homo sapiens 60-74 7914405-4 1994 In the present study, this system has been utilized to investigate the possibility that antiestrogens and steroid hormones are transported by the Pgp. Steroids 106-113 ATP binding cassette subfamily B member 1 Homo sapiens 146-149 7914405-7 1994 Different degrees of stimulation of the Pgp ATPase activity were also obtained in the presence of steroid hormones such as progesterone, beta-estradiol, hydrocortisone, and corticosterone. Steroids 98-105 ATP binding cassette subfamily B member 1 Homo sapiens 40-43 1348973-2 1992 At 100 microM, both steroids inhibited the binding of a Vinca alkaloid photoaffinity analog to P-glycoprotein (P-gp) in MDR human neuroblastic SH-SY5Y/VCR cells [which show greater than 1500-fold resistance to vincristine (VCR) in the tetrazolium dye (MTT) assay]. Steroids 20-28 ATP binding cassette subfamily B member 1 Homo sapiens 95-109 8094292-4 1993 Further we show that the steroid hormones cortisol, testosterone, and progesterone cause an immediate, dose-dependent increase of daunorubicin accumulation in Pgp overexpressing cells. Steroids 25-32 ATP binding cassette subfamily B member 1 Homo sapiens 159-162 8094292-6 1993 These results demonstrate that Pgp may function as a transporter for cortisol and suggest a physiological role of the protein in steroid handling by organs such as the adrenal. Steroids 129-136 ATP binding cassette subfamily B member 1 Homo sapiens 31-34 1356900-3 1992 Interestingly, recent experiments suggest that steroid hormones may be physiologic substrates for P-glycoprotein. Steroids 47-63 ATP binding cassette subfamily B member 1 Homo sapiens 98-112 1354202-0 1992 P-glycoprotein transports corticosterone and is photoaffinity-labeled by the steroid. Steroids 77-84 ATP binding cassette subfamily B member 1 Homo sapiens 0-14 1348973-2 1992 At 100 microM, both steroids inhibited the binding of a Vinca alkaloid photoaffinity analog to P-glycoprotein (P-gp) in MDR human neuroblastic SH-SY5Y/VCR cells [which show greater than 1500-fold resistance to vincristine (VCR) in the tetrazolium dye (MTT) assay]. Steroids 20-28 ATP binding cassette subfamily B member 1 Homo sapiens 111-115 33812052-2 2021 Aside from its toxic actions, CS may alter expression of the drug- and steroid-binding pregnane X receptor (PXR), which when activated upregulates expression of cytochrome P450 (CYP) enzymes, glutathione transferases (GSTs), and multidrug resistance protein 1 (MDR1), an adaptive metabolic array that mediates clearance of CS component toxins. Steroids 71-78 ATP binding cassette subfamily B member 1 Homo sapiens 229-259 1674429-3 1991 By applying the method of immunocytochemical assay, we have demonstrated the appearance of the multidrug-resistant phenotype (P-glycoprotein+ cells, multidrug-resistant cells) in mononuclear cells of the peripheral blood from 32/49 patients receiving triple-drug (azathioprine, steroids, cyclosporine) immunosuppressive therapy after heart transplantation. Steroids 278-286 ATP binding cassette subfamily B member 1 Homo sapiens 126-140 33812052-2 2021 Aside from its toxic actions, CS may alter expression of the drug- and steroid-binding pregnane X receptor (PXR), which when activated upregulates expression of cytochrome P450 (CYP) enzymes, glutathione transferases (GSTs), and multidrug resistance protein 1 (MDR1), an adaptive metabolic array that mediates clearance of CS component toxins. Steroids 71-78 ATP binding cassette subfamily B member 1 Homo sapiens 261-265 33252269-3 2020 The aim of this study was to investigate the relationship between polymorphisms of the drug-metabolizing enzyme gene, cytochrome P450 (CYP450), and the drug transporter gene, ATP-binding cassette subfamily B member 1 (ABCB1), as well as their DNA methylation status with the pathogenesis of steroid-induced ONFH. Steroids 291-298 ATP binding cassette subfamily B member 1 Homo sapiens 218-223 35346283-9 2022 The steroid-induced FHON genetic variants including rs693 and rs1042031 in apolipoprotein (Apo)B, rs1045642 in ABCB1, and rs1799889 in PAI-1 showed significance in each reference. Steroids 4-11 ATP binding cassette subfamily B member 1 Homo sapiens 111-116 2563940-0 1989 Steroid hormones inhibit binding of Vinca alkaloid to multidrug resistance related P-glycoprotein. Steroids 0-16 ATP binding cassette subfamily B member 1 Homo sapiens 83-97 2563940-6 1989 These results suggest that P-glycoprotein in the adrenal gland could have a role in the secretion of steroid hormones. Steroids 101-117 ATP binding cassette subfamily B member 1 Homo sapiens 27-41 34011975-0 2021 Overexpression of P-glycoprotein and MRP-1 are pharmacogenomic biomarkers to determine steroid resistant phenotype in childhood idiopathic nephrotic syndrome. Steroids 87-94 ATP binding cassette subfamily B member 1 Homo sapiens 18-32 34011975-3 2021 The upregulation of P-glycoprotein (P-gp) and Multidrug resistance-associated protein 1 (MRP-1) modulate the pharmacokinetics of steroids and may contribute to steroid resistance. Steroids 129-137 ATP binding cassette subfamily B member 1 Homo sapiens 20-34 34011975-3 2021 The upregulation of P-glycoprotein (P-gp) and Multidrug resistance-associated protein 1 (MRP-1) modulate the pharmacokinetics of steroids and may contribute to steroid resistance. Steroids 129-137 ATP binding cassette subfamily B member 1 Homo sapiens 36-40 34011975-3 2021 The upregulation of P-glycoprotein (P-gp) and Multidrug resistance-associated protein 1 (MRP-1) modulate the pharmacokinetics of steroids and may contribute to steroid resistance. Steroids 129-136 ATP binding cassette subfamily B member 1 Homo sapiens 20-34 34011975-3 2021 The upregulation of P-glycoprotein (P-gp) and Multidrug resistance-associated protein 1 (MRP-1) modulate the pharmacokinetics of steroids and may contribute to steroid resistance. Steroids 129-136 ATP binding cassette subfamily B member 1 Homo sapiens 36-40 34011975-11 2021 The increased expression and functionality of P-gp and MRP-1 contribute to steroid resistance, and MDR-1 homozygous mutant G2677T/A promotes steroid resistance by inducing P-gp expression in NS. Steroids 75-82 ATP binding cassette subfamily B member 1 Homo sapiens 46-50 34011975-11 2021 The increased expression and functionality of P-gp and MRP-1 contribute to steroid resistance, and MDR-1 homozygous mutant G2677T/A promotes steroid resistance by inducing P-gp expression in NS. Steroids 141-148 ATP binding cassette subfamily B member 1 Homo sapiens 46-50 34011975-11 2021 The increased expression and functionality of P-gp and MRP-1 contribute to steroid resistance, and MDR-1 homozygous mutant G2677T/A promotes steroid resistance by inducing P-gp expression in NS. Steroids 141-148 ATP binding cassette subfamily B member 1 Homo sapiens 99-104 34011975-11 2021 The increased expression and functionality of P-gp and MRP-1 contribute to steroid resistance, and MDR-1 homozygous mutant G2677T/A promotes steroid resistance by inducing P-gp expression in NS. Steroids 141-148 ATP binding cassette subfamily B member 1 Homo sapiens 172-176 32469696-3 2021 Overexpression of P glycoprotein (P-gp) and reduce expression of Histone deacetylase 2 (HDAC2) has been linked to regulating the steroid action in other diseases like Nephrotic Syndrome (NS). Steroids 129-136 ATP binding cassette subfamily B member 1 Homo sapiens 18-32 32469696-3 2021 Overexpression of P glycoprotein (P-gp) and reduce expression of Histone deacetylase 2 (HDAC2) has been linked to regulating the steroid action in other diseases like Nephrotic Syndrome (NS). Steroids 129-136 ATP binding cassette subfamily B member 1 Homo sapiens 34-38 33252269-0 2020 Association of ABCB1 and CYP450 Gene Polymorphisms and their DNA Methylation Status with Steroid-Induced Osteonecrosis of the Femoral Head in the Chinese Population. Steroids 89-96 ATP binding cassette subfamily B member 1 Homo sapiens 15-20 33252269-9 2020 In the genetic model analysis, the T allele of the rs2032582 locus in the ABCB1 gene was associated with a reduced risk of steroid-induced ONFH under the dominant model (OR = 0.465, 95% CI: 0.223-0.972, p = 0.042). Steroids 123-130 ATP binding cassette subfamily B member 1 Homo sapiens 74-79 33252269-12 2020 Conclusions: This study provides evidence for two steroid-induced ONFH susceptibility genes (ABCB1, CYP450) in the Han Chinese population. Steroids 50-57 ATP binding cassette subfamily B member 1 Homo sapiens 93-98