PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 23751811-1 2013 Dehydroepiandrosterone (DHEA) and its sulfate, DHEAS, are the most abundant steroid hormones in primates, providing a large reservoir of precursors for the production of androgens. Steroids 76-92 sulfotransferase family 2A member 1 Homo sapiens 47-52 23988737-1 2013 Dehydroepiandrosterone sulfate (DHEAS) is a circulating steroid produced in the adrenal cortex, brain, and gonads. Steroids 56-63 sulfotransferase family 2A member 1 Homo sapiens 32-37 23988737-5 2013 The fact, however, that steroid sulfatase mRNA was not detected in the GC-2 cells and the clear demonstration of DHEAS-induced activation of Erk1/2, ATF-1 and CREB after silencing the androgen receptor by small interfering RNA (siRNA) clearly contradict this assumption and make it appear unlikely that DHEAS has to be converted in the cytosol into a different steroid in order to activate the kinases and transcription factors mentioned. Steroids 24-31 sulfotransferase family 2A member 1 Homo sapiens 113-118 23988737-6 2013 Instead, it is likely that the DHEAS-induced signaling is mediated through the interaction of the steroid with a membrane-bound G-protein-coupled receptor, since silencing of Guanine nucleotide-binding protein subunit alpha-11 (Gnalpha11) leads to the abolition of the DHEAS-induced stimulation of Erk1/2, ATF-1, and CREB. Steroids 98-105 sulfotransferase family 2A member 1 Homo sapiens 31-36 23988737-6 2013 Instead, it is likely that the DHEAS-induced signaling is mediated through the interaction of the steroid with a membrane-bound G-protein-coupled receptor, since silencing of Guanine nucleotide-binding protein subunit alpha-11 (Gnalpha11) leads to the abolition of the DHEAS-induced stimulation of Erk1/2, ATF-1, and CREB. Steroids 98-105 sulfotransferase family 2A member 1 Homo sapiens 269-274 23386646-9 2013 RESULTS: AV levels of DHEA-S were the highest among the steroids measured. Steroids 56-64 sulfotransferase family 2A member 1 Homo sapiens 22-28 23704104-1 2013 BACKGROUND AND PURPOSE: Previous research suggests greater risk of coronary heart disease with lower levels of the adrenal steroid dehydroepiandrosterone sulfate (DHEAS). Steroids 123-130 sulfotransferase family 2A member 1 Homo sapiens 163-168 23314986-1 2013 INTRODUCTION: Dehydroepiandrosterone sulfate (DHEA(S)) is a multi-functional steroid implicated in a broad range of biological effects, including obesity, diabetes, bone metabolism, neuroprotection, and anti-tumorigenesis. Steroids 77-84 sulfotransferase family 2A member 1 Homo sapiens 46-53 22182832-1 2012 Dehydroepiandrosterone (DHEA) and its sulfated form, DHEA-S, are the most abundant steroids circulating in human blood. Steroids 83-91 sulfotransferase family 2A member 1 Homo sapiens 53-59 22982504-1 2012 Previously, the steroid hormone progesterone has been demonstrated to stimulate OATP2B1-mediated transport of estrone-3-sulphate (E(1)S), dehydroepiandrosterone sulphate (DHEAS) and pregnenolone sulphate (PS), which may influence the uptake of precursor molecules for steroid hormone synthesis. Steroids 16-23 sulfotransferase family 2A member 1 Homo sapiens 171-176 22982504-1 2012 Previously, the steroid hormone progesterone has been demonstrated to stimulate OATP2B1-mediated transport of estrone-3-sulphate (E(1)S), dehydroepiandrosterone sulphate (DHEAS) and pregnenolone sulphate (PS), which may influence the uptake of precursor molecules for steroid hormone synthesis. Steroids 16-31 sulfotransferase family 2A member 1 Homo sapiens 171-176 22415563-1 2012 OBJECTIVE: The perimenopausal increase in circulating dehydroepiandrosterone sulfate (DHEAS) levels during the menopausal transition (MT) is accompanied by other adrenal steroids that have the potential to alter estrogen/androgen balance and explain the wide interwoman range of estrogen-related symptoms experienced during the MT. Steroids 170-178 sulfotransferase family 2A member 1 Homo sapiens 86-91 22415570-4 2012 This study was designed to test the hypothesis that the menopausal stage-specific change in circulating DHEAS is associated with concomitant changes in the circulating pattern of adrenal steroids and that some of these adrenal androgens could influence the circulating estrogen/androgen balance. Steroids 187-195 sulfotransferase family 2A member 1 Homo sapiens 104-109 22715193-1 2012 Adrenarche is an endocrine developmental process whereby humans and select nonhuman primates increase adrenal output of a series of steroids, especially DHEA and DHEAS. Steroids 132-140 sulfotransferase family 2A member 1 Homo sapiens 162-167 22703301-4 2012 Raloxifene, a synthetic steroid used in the prevention of osteoporosis, and dehydroepiandrosterone (DHEA), a ubiquitous steroid precusor, are reported to be sulfated efficiently by SULT2A1 in vitro, yet unlike DHEA, raloxifene is not sulfated in vivo. Steroids 24-31 sulfotransferase family 2A member 1 Homo sapiens 181-188 22703301-4 2012 Raloxifene, a synthetic steroid used in the prevention of osteoporosis, and dehydroepiandrosterone (DHEA), a ubiquitous steroid precusor, are reported to be sulfated efficiently by SULT2A1 in vitro, yet unlike DHEA, raloxifene is not sulfated in vivo. Steroids 120-127 sulfotransferase family 2A member 1 Homo sapiens 181-188 19594690-3 2009 However, it has been reported that levels of the steroid dehydroepiandrosterone sulphate (DHEAS) are reduced in plasma of patients with PBC, and substitutive therapy has been suggested to improve fatigue symptoms experienced during the course of this disease. Steroids 49-56 sulfotransferase family 2A member 1 Homo sapiens 90-95 21913674-4 2011 OHPCBs also interact with a human hydroxysteroid sulfotransferase that plays a role in the sulfation of endogenous alcohol-containing steroid hormones and bile acids (i.e., hSULT2A1). Steroids 134-150 sulfotransferase family 2A member 1 Homo sapiens 173-181 24683427-2 2011 The major sulfotransferase (SULT) isoforms that conjugate steroids in humans are SULT1E1, SULT2A1, and SULT2B1b. Steroids 58-66 sulfotransferase family 2A member 1 Homo sapiens 90-97 21533175-1 2011 Dehydroepiandrosterone sulphate (DHEAS) is the most abundant circulating steroid secreted by adrenal glands--yet its function is unknown. Steroids 73-80 sulfotransferase family 2A member 1 Homo sapiens 33-38 21187059-3 2011 One of these substrates for hSULT2A1 is dehydroepiandrosterone (DHEA), a major circulating steroid hormone in humans that serves as precursor to both androgens and estrogens. Steroids 91-106 sulfotransferase family 2A member 1 Homo sapiens 28-36 20739385-1 2010 CONTEXT: Dehydroepiandrosterone sulfate (DHEA-S), a major circulating sex steroid prohormone, declines with age. Steroids 74-81 sulfotransferase family 2A member 1 Homo sapiens 41-47 21112864-1 2010 OBJECTIVE: Dehydroepiandrosterone (DHEA) and Dehydroepiandrosterone-sulfate (DHEA-S) are the most abundant steroid hormones in the body. Steroids 107-123 sulfotransferase family 2A member 1 Homo sapiens 77-83 21206198-8 2010 Among sex steroids analyzed, only serum DHEA-S level was significantly different among the groups (p=0.026), showing a decreasing trend with age. Steroids 10-18 sulfotransferase family 2A member 1 Homo sapiens 40-46 21206198-12 2010 Among serum sex steroids, DHEA-S was the most correlated parameter with autonomic functions. Steroids 16-24 sulfotransferase family 2A member 1 Homo sapiens 26-32 20172962-1 2010 Dehydroepiandrosterone sulfate (DHEAS) is the most abundant steroid in the human circulation and is secreted by the adrenals in an age-dependent fashion, with maximum levels during the third decade and very low levels in old age. Steroids 60-67 sulfotransferase family 2A member 1 Homo sapiens 32-37 21394787-3 2011 RESULTS: While we found plasma cortisol concentrations to be unchanged, a decline in plasma DHEA-S concentrations indicated effective steroid-synthesis inhibition. Steroids 134-141 sulfotransferase family 2A member 1 Homo sapiens 92-98 19595697-1 2009 The steroid dehydroepiandrosterone sulfate (DHEA-S) is associated with longevity and adaptation against external stress in humans. Steroids 4-11 sulfotransferase family 2A member 1 Homo sapiens 44-50 19627466-2 2009 Together with its sulfate version, DHEA-sulfate (DHEAS), it is the most abundant steroid in humans. Steroids 81-88 sulfotransferase family 2A member 1 Homo sapiens 49-54 19619146-1 2009 INTRODUCTION: Dehydroepiandrosterone (DHEA) and its sulfate DHEAS, which are the most abundant steroids in women, decline with age. Steroids 95-103 sulfotransferase family 2A member 1 Homo sapiens 60-65 18706658-1 2009 BACKGROUND: Among the neuroactive steroids, dehydroepiandrosterone sulfate (DHEA-S) is at least in part produced in the adrenal gland and is therefore under the control of the hypothalamic-pituitary-adrenocortical (HPA)-system. Steroids 34-42 sulfotransferase family 2A member 1 Homo sapiens 76-82 19063914-1 2009 DHEA and DHEAS are steroids synthesized in human adrenals, but their function is unclear. Steroids 19-27 sulfotransferase family 2A member 1 Homo sapiens 9-14 18727654-2 2008 In this study, we examined the association between levels of the stress-related steroid hormones cortisol and dehydroepiandrosterone-sulphate (DHEAS) and periodontitis in elderly subjects. Steroids 80-96 sulfotransferase family 2A member 1 Homo sapiens 143-148 17470679-3 2007 STS hydrolyzes steroid sulfates, such as estrone sulfate and dehydroepiandrosterone sulfate (DHEAS), to estrone and DHEA, which can be converted to steroids with potent estrogenic properties, that is, estradiol and androstenediol, respectively. Steroids 148-156 sulfotransferase family 2A member 1 Homo sapiens 93-98 18473744-4 2008 SULT 2A1 mainly sulfonates DHEA and some steroids, with hydroxy derivatives of polycyclic aromatic hydrocarbons. Steroids 41-49 sulfotransferase family 2A member 1 Homo sapiens 0-8 17548088-1 2007 OBJECTIVE: To examine the effect of a low concentration of DHEAS on the expression of the androgen receptor, estrogen receptor alpha and beta, progesterone receptor, aromatase, 3-beta-hydroxysteroid dehydrogenase, and cyclooxygenase-2 in human preovulatory granulosa cells, and to measure their production of steroid hormones (estrone, estradiol, progesterone, androstenedione, and testosterone). Steroids 191-198 sulfotransferase family 2A member 1 Homo sapiens 59-64 17595319-2 2007 Steroid- and bile acid-sulfotransferase (SULT2A1) promotes phase II metabolism through its sulfonating action on certain endobiotics, including steroids and bile acids, and on diverse xenobiotics, including therapeutic drugs. Steroids 144-152 sulfotransferase family 2A member 1 Homo sapiens 41-48 18280022-3 2008 This review summarizes studies showing the effect of DHEA and DHEAS on neurotransmitter systems at different levels (metabolism, release, reuptake, receptor activation), as well as the activation of voltage-gated ion channels and calcium homeostasis, showing the variety of effects that these steroids exert on those systems, allowing the discussion of its mechanisms of action and its relevance to psychiatric disorders. Steroids 293-301 sulfotransferase family 2A member 1 Homo sapiens 62-67 18073302-1 2008 CONTEXT: It has been proposed that dehydroepiandrosterone and dehydroepiandrosterone sulfate (DHEAS) exert neuroprotective effects in the brain, yet evidence of associations between the endogenous levels of these steroids and measures of cognitive function is lacking. Steroids 213-221 sulfotransferase family 2A member 1 Homo sapiens 94-99 17715402-6 2007 DHEAS is identical to PS except that it contains a carbonyl oxygen instead of an acetyl group at C17 on the steroid D ring. Steroids 108-115 sulfotransferase family 2A member 1 Homo sapiens 0-5 17715402-9 2007 Considering that first, the D ring contains the only structural difference between PS and DHEAS, and second, the strongest chemical and steric effects of a mutation are likely to be felt in the local environment of the altered residues, this result implies that the steroid D ring may contact M1 near the mutated residues. Steroids 266-273 sulfotransferase family 2A member 1 Homo sapiens 90-95 17470679-8 2007 Unexpectedly, serum androstenedione concentrations also decreased by up to 86%, showing that this steroid, which is the main substrate for the aromatase in postmenopausal women, is derived mainly from the peripheral conversion of DHEAS. Steroids 98-105 sulfotransferase family 2A member 1 Homo sapiens 230-235 16835396-0 2006 Regulation of steroid hormone biosynthesis enzymes and organic anion transporters by forskolin and DHEA-S treatment in adrenocortical cells. Steroids 14-29 sulfotransferase family 2A member 1 Homo sapiens 99-105 17334880-1 2007 The CYP3A7 enzyme metabolizes some steroid hormones, including dehydroepiandrosterone sulfate (DHEAS). Steroids 35-51 sulfotransferase family 2A member 1 Homo sapiens 95-100 16835396-4 2006 Additionally, we examined the impact of forskolin and DHEA-S on the expression of key enzymes in steroid biosynthesis and expression of hOAT3 and -4 in NCI-H295R cells. Steroids 97-104 sulfotransferase family 2A member 1 Homo sapiens 54-60 16835396-9 2006 We conclude that the increased cortisol release of adrenocortical cells by DHEA-S and forskolin stimulation is probably due to high expression of the key enzymes of steroid biosynthesis and hOAT3. Steroids 165-172 sulfotransferase family 2A member 1 Homo sapiens 75-81 16622721-1 2006 To assess adrenal function with respect to the presence or absence of steroid therapy, we investigated differences in the blood levels of adrenocorticotropic hormone (ACTH) and dehydroepiandrosterone sulfate (DHEAS) in relation to steroid (prednisolone) administration in 123 patients with rheumatoid arthritis (RA). Steroids 231-238 sulfotransferase family 2A member 1 Homo sapiens 209-214 16718630-8 2006 Accordingly, using multivariate regression analyses, the best steroid predictor of progesterone level was plasma DHEA-S. Steroids 62-69 sulfotransferase family 2A member 1 Homo sapiens 113-119 16718630-11 2006 Circulating DHEA-S level was the best steroid correlate of plasma progesterone. Steroids 38-45 sulfotransferase family 2A member 1 Homo sapiens 12-18 16508124-1 2006 Dehydroepiandrosterone-sulfate (DHEA-S), the sulfated form of dehydroepiandrosterone, is the most abundant steroids in human, although its biological activities are seemingly weak. Steroids 107-115 sulfotransferase family 2A member 1 Homo sapiens 32-38 16889589-1 2006 OBJECTIVE: Increased plasma dehydroepiandrosterone (DHEA) and dehydroepiandrosterone-sulfate (DHEAS) have been demonstrated in post-traumatic stress disorder (PTSD), but the documented beneficial effects of these steroids in enhancing mood and cognition, as well as neuroprotection, suggest their presence in PTSD may be associated with defensive rather than maladaptive effects. Steroids 213-221 sulfotransferase family 2A member 1 Homo sapiens 94-99 16960027-1 2006 BACKGROUND: Dehydroepiandrosterone sulfate (DHEAS) is an endogenously produced sex steroid that has been hypothesized to have anti-aging effects. Steroids 83-90 sulfotransferase family 2A member 1 Homo sapiens 44-49 16357103-2 2006 SULT2A1 is a liver- and intestine-expressed sulfo-conjugating enzyme that converts the alcohol-OH of neutral steroids, bile acids, and drugs to water-soluble sulfated metabolites. Steroids 109-117 sulfotransferase family 2A member 1 Homo sapiens 0-7 16622721-2 2006 Levels of ACTH and DHEAS were significantly lower in the steroid-treated group than in the non-treated group (ACTH: 11.79 pg/ml vs 27.92 pg/ml) (DHEAS: 418.12 ng/ml vs 883.91 ng/ml) (P<0.0001). Steroids 57-64 sulfotransferase family 2A member 1 Homo sapiens 19-24 16622721-2 2006 Levels of ACTH and DHEAS were significantly lower in the steroid-treated group than in the non-treated group (ACTH: 11.79 pg/ml vs 27.92 pg/ml) (DHEAS: 418.12 ng/ml vs 883.91 ng/ml) (P<0.0001). Steroids 57-64 sulfotransferase family 2A member 1 Homo sapiens 145-150 15816945-10 2005 CONCLUSIONS: Women with more frequent seizures had alterations of their adrenal steroids characterized by an increase of cortisol and a decrease of DHEAS levels. Steroids 80-88 sulfotransferase family 2A member 1 Homo sapiens 148-153 15755854-1 2005 Dehydroepiandrosterone (DHEA) sulfate (DHEAS) is the most abundant steroid in the human circulation and is thought to be the circulating hydrophilic storage form of DHEA. Steroids 67-74 sulfotransferase family 2A member 1 Homo sapiens 39-44 15755854-2 2005 It is generally accepted that DHEA and DHEAS inter-convert freely and continuously via hydroxysteroid sulfotransferases and steroid sulfatase and that only desulfated DHEA can be converted downstream to sex steroids. Steroids 207-215 sulfotransferase family 2A member 1 Homo sapiens 39-44 16259799-1 2005 BACKGROUND: Dehydroepiandrosterone sulphate (DHEAS) is a steroid that is increasingly being recognized as a potential drug of abuse in many countries. Steroids 57-64 sulfotransferase family 2A member 1 Homo sapiens 45-50 15900045-1 2005 BACKGROUND: Contrasting etiologic hypotheses about the role of endogenous sex steroids in breast cancer development among premenopausal women implicate ovarian androgen excess and progesterone deficiency, estrogen excess, estrogen and progesterone excess, and both an excess or lack of adrenal androgens (dehydroepiandrosterone [DHEA] or its sulfate [DHEAS]) as risk factors. Steroids 78-86 sulfotransferase family 2A member 1 Homo sapiens 351-356 15677432-6 2004 Neuroactive steroids, such as DHEAS, and other sex hormones, including their synthetic derivatives, may have an adjunctive role in reversing or slowing the progression of negative symptoms. Steroids 12-20 sulfotransferase family 2A member 1 Homo sapiens 30-35 15713538-1 2005 Differential display (DD) PCR cloning of differentially expressed genes in hepatocellular carcinoma (HCC) and adjacent unaffected tissue demonstrated preferential down-regulation of a vital sex steroid precursor (dehydroepiandrosterone sulfotransferase; DHEA-ST; SULT2A1) in HCC. Steroids 194-201 sulfotransferase family 2A member 1 Homo sapiens 254-261 15713538-1 2005 Differential display (DD) PCR cloning of differentially expressed genes in hepatocellular carcinoma (HCC) and adjacent unaffected tissue demonstrated preferential down-regulation of a vital sex steroid precursor (dehydroepiandrosterone sulfotransferase; DHEA-ST; SULT2A1) in HCC. Steroids 194-201 sulfotransferase family 2A member 1 Homo sapiens 263-270 15713538-4 2005 The lowered expression in tumor cells of SULT2A1 in HCC tissues involved in metabolism and/or inactivation of sex steroids is consistent with a regulatory role of the SULT2A1 gene product in the development and/or tumor cell differentiation and progression of human HCC. Steroids 114-122 sulfotransferase family 2A member 1 Homo sapiens 41-48 16042365-1 2005 DHEA and its sulfate prohormone DHEAS are the most abundant circulating adrenal steroid hormones in humans. Steroids 80-96 sulfotransferase family 2A member 1 Homo sapiens 32-37 15717807-1 2004 UNLABELLED: The aim of our study was to investigate if there is any significant relationship between adrenal steroid hormone dehydroepiandrosterone-sulphate (DHEAS) and insulin resistance, as there are some previous signs in the literature suggesting such relationship but the results are not conclusive. Steroids 109-124 sulfotransferase family 2A member 1 Homo sapiens 158-163 15666810-1 2004 Dehydroepiandrosterone sulphate (DHEAS) is a steroid product of the adrenal gland, which circulates in high concentrations, but whose functions are largely unknown. Steroids 45-52 sulfotransferase family 2A member 1 Homo sapiens 33-38 15666810-4 2004 It was found that DHEAS at physiological concentrations (10 microM) caused inhibition of cellular growth, which was reversible following removal of the steroid. Steroids 152-159 sulfotransferase family 2A member 1 Homo sapiens 18-23 15635500-5 2004 Much of the steroid released by the fetal zone is DHEA-S, which is used by the placenta to produce estrogens. Steroids 12-19 sulfotransferase family 2A member 1 Homo sapiens 50-56 15004017-4 2004 We determined that the nuclear receptor CAR is required to coordinately up-regulate hepatic expression of Mrp4 and an enzyme known to sulfate hydroxy-bile acids and steroids, Sult2a1. Steroids 165-173 sulfotransferase family 2A member 1 Homo sapiens 175-182 15163435-1 2004 Dehydroepiandrosterone (DHEA) and its sulfate derivative DHEA-S are neurosteroids, produced in the brain, and neuroactive steroids, produced in the adrenals and affecting the brain. Steroids 73-81 sulfotransferase family 2A member 1 Homo sapiens 57-63 15240630-1 2004 Dehydroepiandrosterone (DHEA) and DHEA-sulfate (DHEAS), the representative sex steroid precursors, are postulated to have antiinflammatory effects, although the molecular background remains unknown. Steroids 79-86 sulfotransferase family 2A member 1 Homo sapiens 48-53 15004017-7 2004 Based on the hydrophilic nature of sulfated bile acids and the Mrp4 capability to transport sulfated steroids, our findings suggest that Mrp4 and Sult2a1 participate in an integrated pathway mediating elimination of sulfated steroid and bile acid metabolites from the liver. Steroids 101-109 sulfotransferase family 2A member 1 Homo sapiens 146-153 15004017-7 2004 Based on the hydrophilic nature of sulfated bile acids and the Mrp4 capability to transport sulfated steroids, our findings suggest that Mrp4 and Sult2a1 participate in an integrated pathway mediating elimination of sulfated steroid and bile acid metabolites from the liver. Steroids 101-108 sulfotransferase family 2A member 1 Homo sapiens 146-153 12523936-6 2003 Furthermore, we found that MRP4 transports dehydroepiandrosterone 3-sulphate (DHEAS), the most abundant circulating steroid in humans, which is made in the adrenal gland. Steroids 116-123 sulfotransferase family 2A member 1 Homo sapiens 78-83 14967152-1 2004 Dehydroepiandrosterone sulfate (DHEAS) is a 19-carbon steroid, situated along the steroid metabolic pathway. Steroids 54-61 sulfotransferase family 2A member 1 Homo sapiens 32-37 14573603-0 2004 Identifying androsterone (ADT) as a cognate substrate for human dehydroepiandrosterone sulfotransferase (DHEA-ST) important for steroid homeostasis: structure of the enzyme-ADT complex. Steroids 128-135 sulfotransferase family 2A member 1 Homo sapiens 64-103 14573603-0 2004 Identifying androsterone (ADT) as a cognate substrate for human dehydroepiandrosterone sulfotransferase (DHEA-ST) important for steroid homeostasis: structure of the enzyme-ADT complex. Steroids 128-135 sulfotransferase family 2A member 1 Homo sapiens 105-112 14573603-1 2004 In steroid biosynthesis, human dehydroepiandrosterone sulfotransferase (DHEA-ST) in the adrenals has been reported to catalyze the transfer of the sulfonate group from 3"-phosphoadenosine-5"-phosphosulfate to dehydroepiandrosterone (DHEA). Steroids 3-10 sulfotransferase family 2A member 1 Homo sapiens 31-70 14573603-1 2004 In steroid biosynthesis, human dehydroepiandrosterone sulfotransferase (DHEA-ST) in the adrenals has been reported to catalyze the transfer of the sulfonate group from 3"-phosphoadenosine-5"-phosphosulfate to dehydroepiandrosterone (DHEA). Steroids 3-10 sulfotransferase family 2A member 1 Homo sapiens 72-79 14644820-28 2003 The major steroid produced by the fetal adrenal zone is sulfoconjugated dehydroepiandrosterone (DHEAS). Steroids 10-17 sulfotransferase family 2A member 1 Homo sapiens 96-101 15120419-1 2004 BACKGROUND: Dehydroepiandrosterone (DHEA) and DHEA-sulfate (DHEAS) are the major steroid hormones secreted by the adrenal gland. Steroids 81-97 sulfotransferase family 2A member 1 Homo sapiens 60-65 12939667-2 2003 OBJECTIVE: Dehydroepiandrosterone (DHEA) and DHEA-sulfate (DHEA-S) are the most abundant steroids in human plasma. Steroids 89-97 sulfotransferase family 2A member 1 Homo sapiens 59-65 12790800-13 2003 Increasing the CYP17 to HSD3B2 ratio is likely to promote the use of steroid precursors for the production of DHEA(S) and not for cortisol. Steroids 69-76 sulfotransferase family 2A member 1 Homo sapiens 110-117 12642469-5 2003 On the other hand, expressed CYP3A7-mediated CBZ 10,11-epoxidation was activated by sulfate conjugate steroids, such as pregnenolone 3-sulfate, 17alpha-hydroxypregnenolone 3-sulfate, and dehydroepiandrosterone 3-sulfate (DHEA-S), whereas the unconjugated form corresponding to these three steroids did not activate the reaction. Steroids 102-110 sulfotransferase family 2A member 1 Homo sapiens 221-227 11988089-1 2002 Dehydroepiandrosterone sulphotransferase (DHEA-ST) is an enzyme that converts dehydroepiandrosterone (DHEA), and some other steroids, into their sulphonated forms. Steroids 124-132 sulfotransferase family 2A member 1 Homo sapiens 0-40 12642469-5 2003 On the other hand, expressed CYP3A7-mediated CBZ 10,11-epoxidation was activated by sulfate conjugate steroids, such as pregnenolone 3-sulfate, 17alpha-hydroxypregnenolone 3-sulfate, and dehydroepiandrosterone 3-sulfate (DHEA-S), whereas the unconjugated form corresponding to these three steroids did not activate the reaction. Steroids 289-297 sulfotransferase family 2A member 1 Homo sapiens 221-227 14586159-3 2003 Dehydroepiandrosterone (DHEA) and its sulfate ester (DHEA-S) are neuroactive steroids with effects on several neurophysiological and behavioral processes. Steroids 77-85 sulfotransferase family 2A member 1 Homo sapiens 53-59 12425955-9 2002 The present study showed an inverse correlation of lymphocyte changes with the plasma levels of steroids, especially DHEA and its metabolite, DHEAS. Steroids 96-104 sulfotransferase family 2A member 1 Homo sapiens 142-147 11988089-1 2002 Dehydroepiandrosterone sulphotransferase (DHEA-ST) is an enzyme that converts dehydroepiandrosterone (DHEA), and some other steroids, into their sulphonated forms. Steroids 124-132 sulfotransferase family 2A member 1 Homo sapiens 42-49 11990382-1 2002 SULT2A1 catalyzes the sulfate conjugation of dehydroepiandrosterone (DHEA) as well as other steroids. Steroids 92-100 sulfotransferase family 2A member 1 Homo sapiens 0-7 12055703-6 2001 CONCLUSIONS: The results suggest that the plasma levels of DHEA-S and ASD (adrenal C19 steroid hormones) correlate with the plasma lipid profiles of healthy men. Steroids 87-103 sulfotransferase family 2A member 1 Homo sapiens 59-65 11247320-9 2001 In 5 out of 11 patients of childbearing age taking steroids for their SSc (< 10 mg/daily) DHEAS levels were significantly lower than in patients not taking steroids (p = 0.01). Steroids 51-59 sulfotransferase family 2A member 1 Homo sapiens 93-98 11853283-1 2001 The most abundant human steroid, dehydroepiandrosterone sulfate (DHEAS), may have a multitude of beneficial effects, but declines with age. Steroids 24-31 sulfotransferase family 2A member 1 Homo sapiens 65-70 11476767-9 2001 RESULT(S): The levels of all of the steroids that derived from DHEA metabolism (E1, E2, A, T, DHEAS) and osteocalcin were increased in plasma under DHEA supplementation. Steroids 36-44 sulfotransferase family 2A member 1 Homo sapiens 94-99 11247320-10 2001 On the contrary, 16 out of 29 postmenopausal women using steroids had lower DHEAS concentrations than in patients not taking steroids, although the difference was not statistically significant. Steroids 57-65 sulfotransferase family 2A member 1 Homo sapiens 76-81 10726960-1 2000 AIMS/BACKGROUND: Dehydroepiandrosterone sulphotransferase (DHEA ST) is the enzyme responsible for sulphation of lithocholic acid and other potentially hepatotoxic steroids. Steroids 163-171 sulfotransferase family 2A member 1 Homo sapiens 17-57 11321667-1 2001 Cortisol and dehydroepiandrosterone (DHEA) and its sulphate (DHEAS) are the major steroid hormones produced by the human adrenal cortex. Steroids 82-98 sulfotransferase family 2A member 1 Homo sapiens 61-66 11115773-5 2000 Conversion of DHEAS to DHEA was assessed in luteinized granulosa cells by tritiated steroid assay following incubation with or without LH or insulin and steroid accumulation in the medium measured by RIA. Steroids 84-91 sulfotransferase family 2A member 1 Homo sapiens 14-19 11115773-5 2000 Conversion of DHEAS to DHEA was assessed in luteinized granulosa cells by tritiated steroid assay following incubation with or without LH or insulin and steroid accumulation in the medium measured by RIA. Steroids 153-160 sulfotransferase family 2A member 1 Homo sapiens 14-19 11082899-8 2000 CONCLUSIONS: DHEAS might play an important role during girls puberty although its exact role is very difficult to establish because this steroid works mainly as a precursor for both estrogen and androgen formation. Steroids 137-144 sulfotransferase family 2A member 1 Homo sapiens 13-18 10843161-1 2000 Dehydroepiandrosterone sulfate (DHEAS) is the major secretory steroid of the human adrenal glands. Steroids 62-69 sulfotransferase family 2A member 1 Homo sapiens 32-37 11134123-1 2000 Dehydroepiandrosterone (DHEA) and DHEA sulfate (DHEAS) are adrenal precursors of steroid biosynthesis and centrally acting neurosteroids. Steroids 81-88 sulfotransferase family 2A member 1 Homo sapiens 48-53 11032981-1 2000 BACKGROUND: Dehydroepiandrosterone (DHEA) and its sulfate derivative DHEAS are neuroactive steroids. Steroids 91-99 sulfotransferase family 2A member 1 Homo sapiens 69-74 10774266-1 2000 BACKGROUND: DHEAS, the most abundant steroid secreted by the adrenal cortex, is suggested to have an important role in the development of immune reaction by activating T cell function and increasing antibody response, and has been tried as a vaccine adjuvant in elderly people. Steroids 37-44 sulfotransferase family 2A member 1 Homo sapiens 12-17 10726960-1 2000 AIMS/BACKGROUND: Dehydroepiandrosterone sulphotransferase (DHEA ST) is the enzyme responsible for sulphation of lithocholic acid and other potentially hepatotoxic steroids. Steroids 163-171 sulfotransferase family 2A member 1 Homo sapiens 59-66 10664831-9 2000 CONCLUSIONS: The anomalous positive correlation between cognitive dysfunction and DHEA-S levels, and the inverse correlation between cortisol levels and depressive symptoms, suggests that the relationships between psychiatric symptomatology and levels of steroids that are part of the hypothalamic-pituitary adrenal axis are different in the frail elderly population from that of younger and heartier populations. Steroids 255-263 sulfotransferase family 2A member 1 Homo sapiens 82-88 11155790-13 2000 Since DHEAS is the pool for peripheral sex steroids, such as testosterone and 17 beta-estradiol, lack of this hormone leads to a significant sex hormone deficiency in the periphery. Steroids 43-51 sulfotransferase family 2A member 1 Homo sapiens 6-11 10668635-1 1999 Dehydroepiandrosterone (DHEA) and its sulfate ester, DHEAS, are the most abundant steroids in the human circulation, although their exact biological significance is not completely understood. Steroids 82-90 sulfotransferase family 2A member 1 Homo sapiens 53-58 10403489-1 1999 Dehydroepiandrosterone (DHEA) and its sulfate (DHEA-S) are the most abundant steroidal products and major circulating steroids in humans. Steroids 118-126 sulfotransferase family 2A member 1 Homo sapiens 47-53 9539798-1 1998 Dehydroepiandrosterone (DHEA) and its sulfate derivative (DHEAS) are the most abundant steroids produced by the human adrenal, but no receptors have been identified for these steroids, and no function for them has been established, other than as precursors for sex steroid synthesis. Steroids 87-95 sulfotransferase family 2A member 1 Homo sapiens 58-63 10079390-3 1998 Recently, another hormone, the adrenal steroid dehydroepiandrosterone-sulfate (DHEAS), has appeared to exert antitumor effects similar to those previously described for MLT. Steroids 39-46 sulfotransferase family 2A member 1 Homo sapiens 79-84 9951633-7 1998 Thus, DHEA-S may serve as a physiological modulator of liver fatty acid metabolism and peroxisomal enzyme expression, and thereby may contribute to the anticarcinogenic and chemoprotective properties of this intriguing class of endogenous steroids. Steroids 239-247 sulfotransferase family 2A member 1 Homo sapiens 6-12 9951633-10 1998 The cortisol/DHEA-S ratio during the life span follows a U-shape curve, which may be telling us to explore these two critical adrenal steroids in tandem. Steroids 134-142 sulfotransferase family 2A member 1 Homo sapiens 13-19 9824214-1 1998 Dehydroepiandrosterone (DHEA) and dehydroepiandrosterone sulfate (DHEAS) are endogenous steroids that have recently been widely publicized as potential treatments for many disorders. Steroids 88-96 sulfotransferase family 2A member 1 Homo sapiens 66-71 9539798-1 1998 Dehydroepiandrosterone (DHEA) and its sulfate derivative (DHEAS) are the most abundant steroids produced by the human adrenal, but no receptors have been identified for these steroids, and no function for them has been established, other than as precursors for sex steroid synthesis. Steroids 175-183 sulfotransferase family 2A member 1 Homo sapiens 58-63 9539798-1 1998 Dehydroepiandrosterone (DHEA) and its sulfate derivative (DHEAS) are the most abundant steroids produced by the human adrenal, but no receptors have been identified for these steroids, and no function for them has been established, other than as precursors for sex steroid synthesis. Steroids 87-94 sulfotransferase family 2A member 1 Homo sapiens 58-63 9539798-9 1998 These studies provide evidence of mechanisms by which DHEA and DHEAS exert biological actions, show that they have specific functions other than as sex steroid precursors, mediate their effects via non-classic steroid hormone receptors, and suggest that their developmentally regulated synthesis in vivo may play crucial and different roles in organizing the neocortex. Steroids 152-159 sulfotransferase family 2A member 1 Homo sapiens 63-68 7749143-2 1995 In humans, very high levels of DHEA and/or dehydroepiandrosterone sulfate (DHEAS) have been found in breast tissues and secretions, and epidemiological studies suggest a role of these steroids in the modulation of breast cancer growth. Steroids 184-192 sulfotransferase family 2A member 1 Homo sapiens 75-80 9444968-8 1998 In conclusion, this study shows that the effects of DHEA/DHEA-S on osteoblastic cell growth and differentiation are likely to be mediated via an effect on 1,25(OH)2D3-induced changes in bone cells, suggesting a distinctive role for these steroids in the regulation of bone metabolism. Steroids 238-246 sulfotransferase family 2A member 1 Homo sapiens 52-63 9024954-1 1997 Dehydroepiandrosterone (DHEA) and its sulfate, DHEA-S, are plentiful adrenal steroid hormones that decrease with aging and may have significant neuropsychiatric effects. Steroids 77-93 sulfotransferase family 2A member 1 Homo sapiens 47-53 8971138-3 1996 Both EST and DHEA ST can catalyze the sulfonation of steroid compounds, including exogenously administered steroids such as ethinyl estradiol. Steroids 53-60 sulfotransferase family 2A member 1 Homo sapiens 13-20 8971138-3 1996 Both EST and DHEA ST can catalyze the sulfonation of steroid compounds, including exogenously administered steroids such as ethinyl estradiol. Steroids 107-115 sulfotransferase family 2A member 1 Homo sapiens 13-20 8917605-1 1996 In human beings of both sexes, dehydroepiandrosterone sulfate (DHEAS) circulating in blood is mostly an adrenally secreted steroid whose serum concentration (in the micromolar range and 30-50% higher in men than in women) decreases with age, toward approximately 20-10% of its value in young adults during the 8th and 9th decades. Steroids 123-130 sulfotransferase family 2A member 1 Homo sapiens 63-68 8917605-2 1996 The mechanism of action of DHEA and DHEAS is poorly known and may include partial transformation into sex steroids, increase of bioavailable insulin-like growth factor 1, and effects on neurotransmitter receptors. Steroids 106-114 sulfotransferase family 2A member 1 Homo sapiens 36-41 8724298-5 1996 After adjustment for multiple comparisons, there was significant negative correlation between steroid dose and DHEAS (RRank = -0.426, p = 0.005), but with none of the soluble immune mediators. Steroids 94-101 sulfotransferase family 2A member 1 Homo sapiens 111-116 7589785-5 1995 This recombinant cell line allowed determination of the substrate specificity and kinetic properties of this enzyme towards various steroid hormones, and by comparison of these activities with human liver cytosol we have shown that HST is the major sulphotransferase responsible for the sulphation of DHEA, androsterone and pregnenolone in man and that, functionally, the hepatic and adrenal enzymes are very similar. Steroids 132-148 sulfotransferase family 2A member 1 Homo sapiens 232-235 7710689-1 1995 Dehydroepiandrosterone sulfotransferase (DHEA ST) catalyzes the sulfate conjugation of DHEA and other steroids. Steroids 102-110 sulfotransferase family 2A member 1 Homo sapiens 0-39 7710689-1 1995 Dehydroepiandrosterone sulfotransferase (DHEA ST) catalyzes the sulfate conjugation of DHEA and other steroids. Steroids 102-110 sulfotransferase family 2A member 1 Homo sapiens 41-48 9678543-6 1998 Serum DHEAS concentrations were 10-fold higher in the rats given the steroid by gavage or in the diet compared with levels in control rats. Steroids 69-76 sulfotransferase family 2A member 1 Homo sapiens 6-11 9539145-1 1998 Dehydroepiandrosterone sulfate (DHEAS) is the major circulating steroid in man. Steroids 64-71 sulfotransferase family 2A member 1 Homo sapiens 32-37 9545554-1 1998 Dehydroepiandrosterone (DHEA) and its sulfate (DHEA-S) are the most abundant steroids in humans, and their serum concentrations progressively decrease with age. Steroids 77-85 sulfotransferase family 2A member 1 Homo sapiens 47-53 9465106-1 1998 DHEA, together with DHEAS, is the most abundant steroid in the blood of young adult humans. Steroids 48-55 sulfotransferase family 2A member 1 Homo sapiens 20-25 9215277-1 1997 The adrenal steroids, dehydroepiandrosterone (DHEA) and its sulfate (DHEAS), have attracted attention for their possible antiaging effects. Steroids 12-20 sulfotransferase family 2A member 1 Homo sapiens 69-74 8956025-1 1996 Dehydroepiandrosterone sulfate (DHEAS) is an adrenal steroid which has been inversely associated with development of atherosclerosis. Steroids 53-60 sulfotransferase family 2A member 1 Homo sapiens 32-37 8772596-10 1996 Our data suggest that DHEAS levels may influence and/or be influenced by several endocrine and metabolic features of oldest-old people, depending on the sexual steroid milieu. Steroids 160-167 sulfotransferase family 2A member 1 Homo sapiens 22-27 8597466-1 1995 The hypothesis has been advanced that the adrenal steroids dehydroepiandrosterone (DHEA) and DHEA sulfate (DHEAS) exert antiatherogenic and cardioprotective actions. Steroids 50-58 sulfotransferase family 2A member 1 Homo sapiens 107-112 7955120-4 1994 Interestingly, significant inhibition was observed at concentrations of DHEAS which are comparable to peak serum levels of this steroid occurring in the second decade of life. Steroids 128-135 sulfotransferase family 2A member 1 Homo sapiens 72-77 8142314-1 1994 The human cytosolic sulfotransferases (STs), dehydroepiandrosterone sulfotransferase (DHEA-ST) and the phenol-sulfating form of phenol sulfotransferase, (P-PST), have been expressed in bacteria and used to investigate the ability of the cloned enzymes to conjugate steroids and related compounds. Steroids 265-273 sulfotransferase family 2A member 1 Homo sapiens 45-84 7955120-1 1994 Dehydroepiandrosterone sulfate (DHEAS) is the most abundant adrenal steroid with apparent anticarcinogenic properties. Steroids 68-75 sulfotransferase family 2A member 1 Homo sapiens 32-37 8195238-1 1994 A novel stereoselective hydroxysteroid sulfotransferase (HST) that acts on neutral steroids having the 3-hydroxyl group in the alpha orientation but not on steroids where the 3-hydroxyl group is oriented in the beta position has been cloned and expressed. Steroids 83-91 sulfotransferase family 2A member 1 Homo sapiens 57-60 8195238-1 1994 A novel stereoselective hydroxysteroid sulfotransferase (HST) that acts on neutral steroids having the 3-hydroxyl group in the alpha orientation but not on steroids where the 3-hydroxyl group is oriented in the beta position has been cloned and expressed. Steroids 156-164 sulfotransferase family 2A member 1 Homo sapiens 57-60 8195238-5 1994 The guinea pig HST cDNA transiently transfected into Chinese hamster ovary K1 cells expressed a protein identical in size to that of purified guinea pig HST specific for 3 alpha-hydroxylated neutral steroids that was recently reported (Driscoll, W. J., Martin, B. M., Chen, H.-C., and Strott, C. A. Steroids 199-207 sulfotransferase family 2A member 1 Homo sapiens 15-18 8195238-5 1994 The guinea pig HST cDNA transiently transfected into Chinese hamster ovary K1 cells expressed a protein identical in size to that of purified guinea pig HST specific for 3 alpha-hydroxylated neutral steroids that was recently reported (Driscoll, W. J., Martin, B. M., Chen, H.-C., and Strott, C. A. Steroids 199-207 sulfotransferase family 2A member 1 Homo sapiens 153-156 8195238-9 1994 The expressed HST likewise exhibited sulfotransferase activity that was directed specifically toward steroid substrates containing a 3-hydroxyl group in the alpha orientation; on the other hand, steroids with a 3 beta-hydroxyl group were not sulfonated by the expressed HST. Steroids 101-108 sulfotransferase family 2A member 1 Homo sapiens 14-17 8195238-9 1994 The expressed HST likewise exhibited sulfotransferase activity that was directed specifically toward steroid substrates containing a 3-hydroxyl group in the alpha orientation; on the other hand, steroids with a 3 beta-hydroxyl group were not sulfonated by the expressed HST. Steroids 195-203 sulfotransferase family 2A member 1 Homo sapiens 14-17 8195238-10 1994 Thus, the cloned HST cDNA clearly coded for a steroid sulfotransferase with chiral specificity for 3 alpha-hydroxylated neutral steroids and was, therefore, given the designation of guinea pig 3 alpha-hydroxysteroid sulfotransferase (gp3 alpha-HST). Steroids 128-136 sulfotransferase family 2A member 1 Homo sapiens 17-20 8033249-2 1994 DHEA ST catalyzes the sulfation of DHEA and other steroids. Steroids 50-58 sulfotransferase family 2A member 1 Homo sapiens 0-7 8299591-9 1994 In light of the broad substrate specificity of this enzyme toward other steroids, in particular bile acids and cholesterol, the information presented forms a strong basis for further studies into the role of DHEA ST in modulating the activity of a number of biologically active and potentially toxic steroids in the developing human. Steroids 72-80 sulfotransferase family 2A member 1 Homo sapiens 208-215 8299591-9 1994 In light of the broad substrate specificity of this enzyme toward other steroids, in particular bile acids and cholesterol, the information presented forms a strong basis for further studies into the role of DHEA ST in modulating the activity of a number of biologically active and potentially toxic steroids in the developing human. Steroids 300-308 sulfotransferase family 2A member 1 Homo sapiens 208-215 8484674-2 1993 Compared with 518 postmenopausal control women (aged 45-65 years), DHEAS levels were below normal in the 120 patients with RA who had never taken corticosteroids and levels were further depressed in 39 patients currently using steroids. Steroids 153-161 sulfotransferase family 2A member 1 Homo sapiens 67-72 8222492-1 1993 Dehydroepiandrosterone sulfotransferase (DHEA ST) catalyzes the sulfation of steroid hormones such as DHEA, estrone, and estradiol. Steroids 77-93 sulfotransferase family 2A member 1 Homo sapiens 0-39 8222492-1 1993 Dehydroepiandrosterone sulfotransferase (DHEA ST) catalyzes the sulfation of steroid hormones such as DHEA, estrone, and estradiol. Steroids 77-93 sulfotransferase family 2A member 1 Homo sapiens 41-48 8222492-8 1993 The existence of a subgroup of subjects with a high level of DHEA ST enzymatic activity in liver and a 4.6-fold range in this activity have implications for individual differences in the sulfate conjugation of endogenous and exogenously administered steroid hormones and raise the possibility of pharmacogenetic regulation of this important enzyme in humans. Steroids 250-266 sulfotransferase family 2A member 1 Homo sapiens 61-68 8140596-6 1994 Cross-reactivity data from related steroids suggested only a small contribution to the DHEAS titer by other steroids. Steroids 35-43 sulfotransferase family 2A member 1 Homo sapiens 87-92 8140596-6 1994 Cross-reactivity data from related steroids suggested only a small contribution to the DHEAS titer by other steroids. Steroids 108-116 sulfotransferase family 2A member 1 Homo sapiens 87-92 8484674-3 1993 Twenty six patients who had completed steroid treatment also had lower DHEAS levels, suggesting a delayed recovery of adrenal androgen secretion. Steroids 38-45 sulfotransferase family 2A member 1 Homo sapiens 71-76 2177625-4 1990 These studies show that in LOCAH, in addition to the unconjugated steroids AD and T, the sulphoconjugated steroids DHEA-S, 5-ADIOL-S and 3 alpha-DIOL-S are increased, as is the glucuronide conjugate 3 alpha-DIOL-G and the index of bioavailable testosterone (FAI), and that mean SHBG levels are depressed. Steroids 106-114 sulfotransferase family 2A member 1 Homo sapiens 115-121 7678732-1 1993 Dehydroepiandrosterone sulphotransferase (DHEA-ST) catalyses the 3"-phosphoadenosine 5"-phosphosulphate-dependent sulphation of a wide variety of steroids in human liver and adrenal tissue and is responsible for most, if not all, of the sulphation of bile acids in human liver. Steroids 146-154 sulfotransferase family 2A member 1 Homo sapiens 0-40 7678732-1 1993 Dehydroepiandrosterone sulphotransferase (DHEA-ST) catalyses the 3"-phosphoadenosine 5"-phosphosulphate-dependent sulphation of a wide variety of steroids in human liver and adrenal tissue and is responsible for most, if not all, of the sulphation of bile acids in human liver. Steroids 146-154 sulfotransferase family 2A member 1 Homo sapiens 42-49 1569919-2 1992 DHEA-ST has a subunit molecular mass of 35 kDa and is responsible for the majority of the sulfation of steroids and bile acids in the liver. Steroids 103-111 sulfotransferase family 2A member 1 Homo sapiens 0-7 1569919-11 1992 Adrenal DHEA-ST demonstrated the same pattern of reactivity towards different steroid substrates as did human liver DHEA-ST, and neither form of DHEA-ST was found to sulfate cortisol. Steroids 78-85 sulfotransferase family 2A member 1 Homo sapiens 8-15 1569919-12 1992 The results of this study suggest that DHEA-ST is the major steroid ST present in human liver and adrenal tissue and that the physical, biochemical, and kinetic properties of adrenal DHEA-ST are similar if not identical to those of the liver form of the enzyme. Steroids 60-67 sulfotransferase family 2A member 1 Homo sapiens 39-46 1532354-10 1992 Low blood and SF levels of sulpho-conjugated steroids, particularly DHEAS, are a permanent disorder in patients with RA and positive RF reactivity. Steroids 45-53 sulfotransferase family 2A member 1 Homo sapiens 68-73 2177625-5 1990 These data suggest that as well as AD, 5-ADIOL-S and DHEA-S may act as pro-hormones for more potent steroids (T and 5 alpha-dihydrotestosterone) in peripheral tissues, while 3 alpha-DIOL-S and 3 alpha-DIOL-G may both reflect peripheral androgen metabolism in patients with LOCAH. Steroids 100-108 sulfotransferase family 2A member 1 Homo sapiens 53-59 2146099-6 1990 The demonstration of a clear-cut circadian oscillation in serum DHEA-S prompts studies on possible chrono-abnormalities of the steroid production in women with hyperandrogenic diseases. Steroids 127-134 sulfotransferase family 2A member 1 Homo sapiens 64-70 34838827-2 2022 BACKGROUND: DHEA-S is among the main endogenous steroid hormones. Steroids 48-55 sulfotransferase family 2A member 1 Homo sapiens 12-18 2532426-2 1989 Measurement of serum levels of these steroids is of increasing epidemiologic interest, since low serum concentrations of DHEAS or DHEA have been associated with an increased risk of dying of cardiovascular disease or of developing cancer. Steroids 37-45 sulfotransferase family 2A member 1 Homo sapiens 121-126 2525654-11 1989 In summary, the plasma levels of DHEAS, DHEA, delta 4-dione are markedly different between men and both animal models used and furthermore, measurements of prostatic levels of androgens suggest that the high plasma levels of these steroids are likely responsible for the presence of important amounts of DHT in human prostate after castration. Steroids 231-239 sulfotransferase family 2A member 1 Homo sapiens 33-38 157390-2 1979 In order to evaluate the steroid metabolizing capacity of the placental enzymatic complex under load conditions, a test was devised based upon a rapid introduction of 200 mg of DHEAS into the amniotic compartment during the third trimester of gestation. Steroids 25-32 sulfotransferase family 2A member 1 Homo sapiens 177-182 2967419-5 1988 The heritability index for variability of the plasma content of steroids was 45.4% (p less than .05) for total cortisol, 50.6% (P less than .05) for unbound plasma cortisol, 57.8% (P less than .05) for DHEA-S, and 32.4% (P greater than .05) for CBG. Steroids 64-72 sulfotransferase family 2A member 1 Homo sapiens 202-208 2977418-2 1988 The present study was undertaken to determine whether desulphation of the C19 steroid DHEAS is also impaired. Steroids 78-85 sulfotransferase family 2A member 1 Homo sapiens 86-91 6281086-4 1982 Although no discrete enzyme block was unmasked by ACTH, marked differences in steroid production ratios were apparent between the low and high DHEAS PCOD groups. Steroids 78-85 sulfotransferase family 2A member 1 Homo sapiens 143-148 2965660-3 1988 Since there is evidence that 5-androstene-3 beta, 17 beta-diol (delta 5-diol), a metabolite of dehydroepiandrosterone (DHEA) and DHEA-sulfate (DHEA-S) can induce typical oestrogenic responses in target tissues, we have investigated the effect of C19 adrenal steroids and compared them to that of 17 beta-oestradiol (E2) on the above-indicated parameters. Steroids 258-266 sulfotransferase family 2A member 1 Homo sapiens 143-149 6322821-5 1983 T values resulted higher than Tc thus stressing the high degree of cross-reactivity among DHT, DHEAS, A and T in unchromatographed serum steroid RIA. Steroids 137-144 sulfotransferase family 2A member 1 Homo sapiens 95-100 6261197-8 1981 Thus, serum DHEAS is a clinically useful indication of adrenal C-19 steroid secretion. Steroids 68-75 sulfotransferase family 2A member 1 Homo sapiens 12-17 156321-0 1979 Placental steroid synthesis from DHEAS during dexamethasone therapy. Steroids 10-17 sulfotransferase family 2A member 1 Homo sapiens 33-38 31445882-3 2019 SULT2A1 is one of the most abundant hepatic sulfotransferases and it catalyzes the sulfate conjugation of many endogenous substrates, such as bile acids and steroids. Steroids 157-165 sulfotransferase family 2A member 1 Homo sapiens 0-7 4467-5 1976 Comparison by linear regression of paired UA and UV steroid concentrations of delta5P, delta5P-S, DHEA, and DHEA-S revealed a significant correlation (P less than 0.01) for each steroid. Steroids 52-59 sulfotransferase family 2A member 1 Homo sapiens 108-114 4467-5 1976 Comparison by linear regression of paired UA and UV steroid concentrations of delta5P, delta5P-S, DHEA, and DHEA-S revealed a significant correlation (P less than 0.01) for each steroid. Steroids 178-185 sulfotransferase family 2A member 1 Homo sapiens 108-114 31295971-2 2019 Measurement of testosterone is recommended in all of the current clinical guidelines but other steroids, such as androstenedione and dehydroepiandrosterone sulfate (DHEAS), have also been shown to be useful in diagnosing PCOS and may give additional information on metabolic risk. Steroids 95-103 sulfotransferase family 2A member 1 Homo sapiens 165-170 31620295-1 2019 Background: Dehydroepiandrosterone sulfate (DHEAS) is an endogenous steroid hormone produced by the adrenal gland. Steroids 68-75 sulfotransferase family 2A member 1 Homo sapiens 44-49 29796990-1 2019 Dehydroepiandrosterone sulfate (DHEAS), one of the most important neuroactive steroids, is produced in the adrenals and the brain. Steroids 78-86 sulfotransferase family 2A member 1 Homo sapiens 32-37 30557606-5 2019 Here, we draw attention to the possible modulating influence of DHEA/DHEAS in early brain development from fetal life to the remarkable increase of these steroids in early childhood - the adrenarche. Steroids 154-162 sulfotransferase family 2A member 1 Homo sapiens 69-74 29796990-4 2019 The decline of DHEAS level was associated with age-related neuronal dysfunction and degeneration, most probably because the steroids protect the central nervous system (CNS) neurons against neurotoxic challenges. Steroids 124-132 sulfotransferase family 2A member 1 Homo sapiens 15-20 28782626-5 2017 Results derived from this study suggested a potential role of SULT2A1 as a Delta4-3-ketosteroid sulfotransferase in steroid metabolism. Steroids 88-95 sulfotransferase family 2A member 1 Homo sapiens 62-69 29684479-1 2018 Although dehydroepiandrosterone sulfate (DHEAS) constitutes the most abundant steroid in humans, in-depth investigations of its effects are rather scarce. Steroids 78-85 sulfotransferase family 2A member 1 Homo sapiens 41-46 29684479-5 2018 Exposure of these cells for 24 h to 1 muM DHEAS also leads to a significant reduction of claudin-1 expression that cannot be prevented by high concentrations of the steroid sulfatase inhibitor STX64, indicating that desulfation and further conversion of DHEAS to some other steroid hormone is not required for this action. Steroids 274-289 sulfotransferase family 2A member 1 Homo sapiens 42-47 29408762-6 2018 Several congeners of lower chlorinated OH-PCBs relevant to airborne PCB exposures were potent inhibitors of SULT1E1 and SULT2A1 and thus have the potential to disrupt regulation of intracellular concentrations of the receptor-active steroid substrates for these enzymes. Steroids 233-240 sulfotransferase family 2A member 1 Homo sapiens 120-127 29334627-1 2018 Neuroactive steroids, including testosterone, dehydroepiandrosterone (DHEA) and its sulfate (DHEA-S) might play an important role in the pathophysiology of schizophrenia. Steroids 12-20 sulfotransferase family 2A member 1 Homo sapiens 93-99 26682953-1 2016 Dehydroepiandrosterone (DHEA) is an adrenal steroid that circulates in high concentrations in humans in its sulfated form, DHEAS. Steroids 44-51 sulfotransferase family 2A member 1 Homo sapiens 123-128 28319688-1 2017 BACKGROUND: In recent years, a relationship between depression and basal dehydroepiandrosterone (DHEA) and dehydroepiandrosterone sulfate (DHEA-S) levels has frequently been suggested, but responses of these adrenal steroids to psychosocial stress have not been examined in individuals with depressive disorders. Steroids 216-224 sulfotransferase family 2A member 1 Homo sapiens 139-145 27623070-8 2016 RESULTS: Of the Delta5-steroid sulfates quantified, DHEA-S was most abundant. Steroids 23-30 sulfotransferase family 2A member 1 Homo sapiens 52-58 27623070-10 2016 Steroid ratios (17OHPreg-S/DHEA-S) suggested increases in 17,20-lyase activity during childhood. Steroids 0-7 sulfotransferase family 2A member 1 Homo sapiens 27-33 26666359-1 2016 Dehydroepiandrosterone sulfate (DHEAS) and estrone sulfate (E1S) are two of the most abundant steroids in the human circulation. Steroids 94-102 sulfotransferase family 2A member 1 Homo sapiens 32-37 26938869-1 2016 Dehydroepiandrosterone sulfate (DHEAS) is a circulating sulfated steroid considered to be a pro-androgen in mammalian physiology. Steroids 65-72 sulfotransferase family 2A member 1 Homo sapiens 32-37 26938869-10 2016 Taken together, these results are consistent with the effects of DHEAS being mediated through a membrane-bound G-protein-coupled receptor interacting with Gnalpha11 in a signaling pathway that resembles the non-classical signaling pathways of steroid hormones. Steroids 243-250 sulfotransferase family 2A member 1 Homo sapiens 65-70 26938869-11 2016 Considering the fact that DHEAS is produced in reproductive organs, these findings also suggest that DHEAS, by acting as an autonomous steroid hormone and influencing the formation and dynamics of the TJ at the blood-testis barrier, might play a crucial role for the regulation and maintenance of male fertility. Steroids 135-150 sulfotransferase family 2A member 1 Homo sapiens 26-31 26938869-11 2016 Considering the fact that DHEAS is produced in reproductive organs, these findings also suggest that DHEAS, by acting as an autonomous steroid hormone and influencing the formation and dynamics of the TJ at the blood-testis barrier, might play a crucial role for the regulation and maintenance of male fertility. Steroids 135-150 sulfotransferase family 2A member 1 Homo sapiens 101-106 26704533-5 2016 The steroid levels (47 steroids and steroid polar conjugates) and their ratios in AD female patients indicated increased CYP11A1 activity, weakened activity of the CYP17A1C17,20 lyase metabolic step and attenuated sulfotransferase SULT2A1 activity at higher activity of the CYP17A1 17-hydroxylase step. Steroids 4-11 sulfotransferase family 2A member 1 Homo sapiens 231-238 26356576-8 2015 For the global perfusion, DHEAS was the only significant predictor amongst the steroid hormones, showing a strong negative correlation with cerebral perfusion. Steroids 79-86 sulfotransferase family 2A member 1 Homo sapiens 26-31 25960318-2 2015 The effects of celecoxib on the sulfonation of selected steroids catalyzed by human SULT2A1 were assessed through in vitro and in silico studies. Steroids 56-64 sulfotransferase family 2A member 1 Homo sapiens 84-91 25706901-1 2015 Dehydroepiandrosterone (DHEA) and dehydroepiandrosterone-sulphate (DHEAS) are the most abundant circulating adrenal steroid hormones. Steroids 116-132 sulfotransferase family 2A member 1 Homo sapiens 67-72 25823708-7 2015 RESULTS: The functional sensitivity of our steroid analysis was <1 3, <9 3, 2 3, <1 3, <15 9, 1 87 pg/mg hair for cortisol, cortisone, testosterone, androstenedione, dehydroepiandrosterone sulphate (DHEAS), and 17OHP, respectively. Steroids 43-50 sulfotransferase family 2A member 1 Homo sapiens 211-216 25993987-1 2015 INTRODUCTION: The established neuroprotective property of the sex steroid precursor dehydroepiandrosterone-sulfate (DHEAS) has not yet been investigated in the context of aneurysmal subarachnoid hemorrhage (aSAH). Steroids 66-73 sulfotransferase family 2A member 1 Homo sapiens 116-121 25747464-10 2015 Such an effect might be caused by the influence of DHEAS on serotonin neurotransmission, as this steroid decreased serotonin concentration and turnover in the striatum. Steroids 97-104 sulfotransferase family 2A member 1 Homo sapiens 51-56 26680489-3 2015 In the present study we evaluate the role of steroid sulfotransferase SULT2A1 in the pathophysiology of AD on the basis of circulating steroids (measured by GC-MS), in which the sulfation catalyzed by SULT2A1 dominates over glucuronidation (pregnenolone/sulfate, DHEA/sulfate, androstenediol/sulfate and 5alpha-reduced pregnane and androstane catabolites). Steroids 45-52 sulfotransferase family 2A member 1 Homo sapiens 70-77 26680489-3 2015 In the present study we evaluate the role of steroid sulfotransferase SULT2A1 in the pathophysiology of AD on the basis of circulating steroids (measured by GC-MS), in which the sulfation catalyzed by SULT2A1 dominates over glucuronidation (pregnenolone/sulfate, DHEA/sulfate, androstenediol/sulfate and 5alpha-reduced pregnane and androstane catabolites). Steroids 45-52 sulfotransferase family 2A member 1 Homo sapiens 201-208 24882158-8 2014 Our study confirms in humans a preclinically suggested relation of the steroid hormones progesterone and DHEAS to 5-HT1A receptor binding. Steroids 71-87 sulfotransferase family 2A member 1 Homo sapiens 105-110 25157097-3 2014 Also, hSULT2A1 functions in the metabolism of steroid hormones such as dehydroepiandrosterone (DHEA) and pregnenolone (PREG). Steroids 46-62 sulfotransferase family 2A member 1 Homo sapiens 6-14 25157097-4 2014 These roles of hSULT2A1 in steroid hormone metabolism and in generating a reactive metabolite of tamoxifen led us to examine its interactions with tamoxifen and several of its major metabolites. Steroids 27-42 sulfotransferase family 2A member 1 Homo sapiens 15-23 24508592-3 2014 We have previously shown that OHPCBs interact with human hydroxysteroid sulfotransferase hSULT2A1, an enzyme that catalyzes the sulfation of dehydroepiandrosterone (DHEA), other alcohol-containing steroids, bile acids, and many xenobiotics. Steroids 197-205 sulfotransferase family 2A member 1 Homo sapiens 89-97 24492894-1 2014 Sulfotransferase (SULT) 2A1 catalyzes sulfonation of drugs and endogenous compounds and plays an important role in xenobiotic metabolism as well as in the maintenance of steroid and lipid homeostasis. Steroids 170-177 sulfotransferase family 2A member 1 Homo sapiens 0-27 25905237-0 2000 Adrenal Androgens and Aging Dehydroepiandrosterone (DHEA) and its active metabolite DHEA sulfate (DHEAS), are steroid hormones synthesized and excreted primarily by the zona reticularis of the adrenal cortex in response to adrenocorticotropic hormone (ACTH). Steroids 110-126 sulfotransferase family 2A member 1 Homo sapiens 98-103 24586990-0 2014 Dehydroepiandrosterone sulfate (DHEAS) stimulates the first step in the biosynthesis of steroid hormones. Steroids 88-104 sulfotransferase family 2A member 1 Homo sapiens 32-37 24586990-1 2014 Dehydroepiandrosterone sulfate (DHEAS) is the most abundant circulating steroid in human, with the highest concentrations between age 20 and 30, but displaying a significant decrease with age. Steroids 72-79 sulfotransferase family 2A member 1 Homo sapiens 32-37 24586990-4 2014 In this study, the role of DHEAS on the first and rate-limiting step of steroid hormone biosynthesis was analyzed in a reconstituted in vitro system, consisting of purified CYP11A1, adrenodoxin and adrenodoxin reductase. Steroids 72-87 sulfotransferase family 2A member 1 Homo sapiens 27-32 24586990-10 2014 These findings indicate that DHEAS affects steroid hormone biosynthesis on a molecular level resulting in an increased formation of pregnenolone. Steroids 43-58 sulfotransferase family 2A member 1 Homo sapiens 29-34