PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
10384817-9	1998	The growth regulatory factors such as epidermal growth factor (EGF), keratinocyte growth factors (KGF), fibroblast growth factors (FGFs) and insulin-like growth factors II and I are mitogenic and directly stimulate cell proliferation under the modulating influence of steroid hormones.	Steroids	268-284	insulin like growth factor 2	Homo sapiens	141-177	
8396578-3	1993	Our underlying hypothesis is that estrogen and insulin-like growth factor-II (IGF-II) modulate the steroidogenic response of fetal zone cells to ACTH, driving steroid production toward DHAS rather than cortisol.	Steroids	99-106	insulin like growth factor 2	Homo sapiens	47-84	
9543152-7	1998	Previously, IGF-II has been shown to enhance granulosa cell steroid production after insulin preincubation.	Steroids	60-67	insulin like growth factor 2	Homo sapiens	12-18	
8742121-10	1996	In the fetal adrenal gland, IGF-2 mRNA is localized to 3 beta-hydroxysteroid hydrogenase (3 beta-HSD) immunoreactive cells, suggesting a close relationship to steroid hormone biosynthesis.	Steroids	159-174	insulin like growth factor 2	Homo sapiens	28-33	
7649082-2	1995	By metabolic labeling of cells grown in steroid- and growth factor-stripped serum conditions, we show that insulin-like growth factors (IGF-I and IGF-II) increase by approximately 5-fold the release of several proteins including cathepsin D, alpha 1-antichymotrypsin, and soluble forms of the multifunctional IGF-II/mannose 6-phosphate (M6P) receptor.	Steroids	40-47	insulin like growth factor 2	Homo sapiens	146-152	
9357999-1	1997	Insulin-like growth factors (IGF-I and IGF-II) are believed to mediate and modulate steroid hormone actions in the endometrium.	Steroids	84-99	insulin like growth factor 2	Homo sapiens	39-45	
9141522-11	1997	The effects of IGF-II on ACTH-stimulated steroid production were dose-dependent (EC50, 0.5-1.0 nmol/L), and IGF-II markedly increased the steroidogenic responsiveness of fetal zone cells to ACTH.	Steroids	41-48	insulin like growth factor 2	Homo sapiens	15-21	
7689953-5	1993	In HFCM from cells treated with vehicle, GH, insulin, epidermal growth factor, steroid hormones, or forskolin, IGF-II induced the select loss of detectable IGFBP-4 during the assay.	Steroids	79-95	insulin like growth factor 2	Homo sapiens	111-117	
8396578-16	1993	These data indicate that IGF-II increases ACTH-stimulated steroid production in fetal zone cells by increasing the expression of key steroidogenic enzymes.	Steroids	58-65	insulin like growth factor 2	Homo sapiens	25-31	
2285587-12	1990	In MCF-7 cells, increased IGFII mRNA, following transfection, can result in an increased basal cell growth rate in the absence of steroid.	Steroids	130-137	insulin like growth factor 2	Homo sapiens	26-31	
8496300-3	1993	The insulin-like growth factors (IGF-I and IGF-II) promote cellular growth and differentiation and have been proposed to participate in these cyclic endometrial events, acting as mediators of steroid hormones.	Steroids	192-208	insulin like growth factor 2	Homo sapiens	43-49	
15130350-1	2004	OBJECTIVE: To investigate the expression of insulin-like growth factor II (IGF-II) and its type I receptor (IGF-IR) and type II receptor (IGF-IIR) in the endometrium of women with unexplained infertility and their relation to steroid levels.	Steroids	226-233	insulin like growth factor 2	Homo sapiens	44-81	
33348377-13	2021	These data demonstrate that IGF2 produced by antral follicles, in response to steroid hormone regulation, could act as a paracrine factor that positively impacts preantral follicle development and function in primates.	Steroids	78-85	insulin like growth factor 2	Homo sapiens	28-32	
23319492-7	2013	IGF2 treatment resulted in increased steady state steroid levels and increased de novo steroidogenesis resulting in AR activation as demonstrated by PSA mRNA induction.	Steroids	50-57	insulin like growth factor 2	Homo sapiens	0-4	
23319492-8	2013	Inhibition of the IGF1R/INSR signalling axis attenuated the effects of IGF2 on steroid hormone synthesis.	Steroids	79-94	insulin like growth factor 2	Homo sapiens	71-75