PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34053485-15 2021 Functional annotation and enrichment analysis demonstrated that there might be a crosstalk mechanism on functionally related genes such as nuclear receptor activity, ligand-activated transcription factor activity, and steroid hormone receptor activity, and played a role in the occurrence and development of diseases through forkhead box transcription factor O (FoxO) signaling pathway, Janus kinase/signal transducers and activators of transcription (JAK/STAT) signaling pathway, p53 signaling pathway, and phosphateidylinositol 3-kinase (PI3K)/Akt signaling pathway. Steroids 218-225 tumor protein p53 Homo sapiens 481-484 32233998-10 2020 GO analysis showed that DEGs were classified into three groups and DEGs mainly enriched in Steroid biosynthesis, Ubiquitin mediated proteolysis and p53 signaling pathway. Steroids 91-98 tumor protein p53 Homo sapiens 148-151 31959744-0 2020 P53 and Parkin co-regulate mitophagy in bone marrow mesenchymal stem cells to promote the repair of early steroid-induced osteonecrosis of the femoral head. Steroids 106-113 tumor protein p53 Homo sapiens 0-3 16352595-1 2006 Although protein phosphatase magnesium-dependent 1 delta (PPM1D) was initially characterized as a p53-regulated phosphatase responsible for inactivation of p38 MAPK and consequent inactivation of p53, its overexpression and amplification in human breast cancers led us to assess its role in steroid hormone action. Steroids 291-306 tumor protein p53 Homo sapiens 98-101 31244779-0 2019 Liver and Steroid Hormones-Can a Touch of p53 Make a Difference? Steroids 10-26 tumor protein p53 Homo sapiens 42-45 31244779-7 2019 Moreover, p53 was shown to be involved in steroid hormones regulation. Steroids 42-49 tumor protein p53 Homo sapiens 10-13 31244779-8 2019 In this review, we discuss the bi-directional regulation of the liver and the steroid hormones pointing to p53 as a novel regulator in this axis. Steroids 78-85 tumor protein p53 Homo sapiens 107-110 30615941-4 2019 Next, we generated IN for HepG2 cells, identified reporter transcription factors based on IN and found that the modulation of these genes affects key metabolic pathways associated with lipid metabolism (steroid biosynthesis, PPAR signalling pathway, fatty acid synthesis and oxidation) and cancer development (DNA replication, cell cycle and p53 signalling) involved in the progression of NAFLD and HCC. Steroids 203-210 tumor protein p53 Homo sapiens 342-345 28050764-1 2017 Cutaneous melanoma (CM) cells are resistant to apoptosis, and steroid hormones are involved in this process through regulation of TP53, MDM2, BAX, and BCL2 expression. Steroids 62-78 tumor protein p53 Homo sapiens 130-134 24648042-7 2014 High-dose steroids with anti-CD52 appeared to improve the response rate in 17p-/TP53 mutated cases and allogeneic transplantation achieved prolonged disease control irrespective of high-risk disease. Steroids 10-18 tumor protein p53 Homo sapiens 80-84 26358154-4 2016 In this study, we utilized our microarray data to identify and characterize novel p53 target genes expressed in human liver cells and associated with steroid hormones processing and transfer. Steroids 150-166 tumor protein p53 Homo sapiens 82-85 26358154-5 2016 We identified the steroid hormones binding factors, sex hormone-binding globulin (SHBG), corticosteroid-binding globulin (CBG) and cytochrome P450 family 21 subfamily A polypeptide 2, as novel p53 target genes. Steroids 18-25 tumor protein p53 Homo sapiens 193-196 26358154-8 2016 We demonstrated that the induction of the steroid hormones binding factors can be mediated by binding to specific p53 responsive elements within their promoters. Steroids 42-49 tumor protein p53 Homo sapiens 114-117 27185980-11 2016 CONCLUSION: Since p53 is known as an important inhibitory trigger for proliferative cycle of cells, in current study it was concluded that p53 inhibitory role decreases as malignancy potential increases, also tumors dependence on steroids via steroid receptors decreases as malignancy potential increases. Steroids 230-238 tumor protein p53 Homo sapiens 18-21 27185980-11 2016 CONCLUSION: Since p53 is known as an important inhibitory trigger for proliferative cycle of cells, in current study it was concluded that p53 inhibitory role decreases as malignancy potential increases, also tumors dependence on steroids via steroid receptors decreases as malignancy potential increases. Steroids 230-238 tumor protein p53 Homo sapiens 139-142 25151759-1 2014 INTRODUCTION: Malignant transformation of sex-steroid dependent tissues is associated with the loss of expression of sex steroid receptors as well as of the tumor suppression gene p53. Steroids 46-53 tumor protein p53 Homo sapiens 180-183 24169561-9 2014 Furthermore, CRT knock-down suppressed the ovarian steroid-stimulated PRL and IGFBP1 expression and morphological differentiation, and silencing of EPAC2 or CRT significantly increased senescence-associated beta-galactosidase activity with enhanced p21 expression and decreased p53 expression. Steroids 51-58 tumor protein p53 Homo sapiens 278-281 22737085-5 2012 Foxa1-only sites are enriched for p53 binding sites and are frequently found near genes important to cell cycle regulation, while Foxa2-restricted sites show only a limited match to the forkhead consensus and are found in genes involved in steroid and lipid metabolism. Steroids 240-247 tumor protein p53 Homo sapiens 34-37 20309662-0 2010 R72P polymorphism of TP53 in ulcerative colitis patients is associated with the incidence of colectomy, use of steroids and the presence of a positive family history. Steroids 111-119 tumor protein p53 Homo sapiens 21-25 19360465-3 2010 Of the analyzed genes, ERCC2, XRCC1, XRCC2, XRCC3 and Lig4 participate in DNA repair, TP53 in cell cycle check point control, AIB1, AR, COMT, CYP11A1, CYP17A1, CYP19A1, HSD17 and PGR in steroid hormone biosynthesis/metabolism/signaling, TYMS in folate metabolism and HER2, IL6, LRP1, TGFB and TGFBR1 affect cell growth. Steroids 186-201 tumor protein p53 Homo sapiens 86-90 10601598-10 2000 Namely, untreated ovarian dysfunction such as PCOS with unopposed estrogenic action in the endometrium may be associated with development and growth of EC in younger women, yet abnormality of p53 gene may be more concerned with the development of the post-menopausal EC, independently of sex steroid influence. Steroids 292-299 tumor protein p53 Homo sapiens 192-195 12161533-3 2002 The present study was conducted to elucidate the p53 protein content in human leiomyomas and its regulation by sex steroid hormones. Steroids 115-131 tumor protein p53 Homo sapiens 49-52 11832064-7 2000 Intralesional injection of steroid could increase c-myc and p53 gene expression of hypertrophic scars in vivo, which induced apoptosis of cells. Steroids 27-34 tumor protein p53 Homo sapiens 60-63 15608028-3 2005 In addition, recent data provide evidence that p53 plays a critical role in mediating pregnancy by regulating steroid hormone activation. Steroids 110-117 tumor protein p53 Homo sapiens 47-50 14675321-2 2003 Studies have suggested that steroid hormones may enhance the expression of these genes leading to loss of p53 gene-mediated cell apoptosis. Steroids 28-44 tumor protein p53 Homo sapiens 106-109 11677114-0 2001 Steroid-mediated inhibition of radiation-induced apoptosis in C4-1 cervical carcinoma cells is p53-dependent. Steroids 0-7 tumor protein p53 Homo sapiens 95-98 11677114-1 2001 In human papillomavirus (HPV) infected cervical epithelial cells the synthetic steroid dexamethasone inhibits radiation-induced apoptosis and increases the transcription of HPV E6/E7, enhancing p53 degradation. Steroids 79-86 tumor protein p53 Homo sapiens 194-197 11677114-7 2001 Steroid-dependent inhibition of radiation-induced apoptosis in carcinoma of the cervix involves E6 modulation of p53 expression and may adversely affect treatment. Steroids 0-7 tumor protein p53 Homo sapiens 113-116 11825490-6 1998 Both p53 mutation protein and p53 gene mutations were prevalent in steroid and progesterone receptors negative tumors (P < 0.05). Steroids 67-74 tumor protein p53 Homo sapiens 5-8 11825490-6 1998 Both p53 mutation protein and p53 gene mutations were prevalent in steroid and progesterone receptors negative tumors (P < 0.05). Steroids 67-74 tumor protein p53 Homo sapiens 30-33 9656718-0 1998 [A case of Cronkhite-Canada syndrome with multiple adenomas and a carcinoma of rectum detected after improvement of polyposis due to steroid treatment--an analysis of expression of p53 protein in polyps]. Steroids 133-140 tumor protein p53 Homo sapiens 181-184 9285694-6 1997 When cells were cultured in medium containing serum depleted of endogenous steroids (charcoal stripped serum), cell number and p53 levels declined. Steroids 75-83 tumor protein p53 Homo sapiens 127-130