PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 27208893-0 2016 Drug interaction study of natural steroids from herbs specifically toward human UDP-glucuronosyltransferase (UGT) 1A4 and their quantitative structure activity relationship (QSAR) analysis for prediction. Steroids 34-42 UDP glucuronosyltransferase family 1 member A4 Homo sapiens 80-117 9622078-11 1998 The steroid form of the UDPGT transcript was expressed in LNCaP cells and was enhanced in biochanin A-treated LNCaP cells. Steroids 4-11 UDP glucuronosyltransferase family 1 member A4 Homo sapiens 24-29 27208893-4 2016 Some natural steroids such as gitogenin, tigogenin, and solasodine were found to be the novel selective inhibitors of UGT1A4, and did not inhibit the activities of major human CYP isoforms. Steroids 13-21 UDP glucuronosyltransferase family 1 member A4 Homo sapiens 118-124 27208893-7 2016 And this inhibition of steroids towards UGT1A4 was also verified in human primary hepatocytes. Steroids 23-31 UDP glucuronosyltransferase family 1 member A4 Homo sapiens 40-46 27208893-8 2016 Furthermore, a quantitative structure-activity relationship (QSAR) of steroids with inhibitory effects toward human UGT1A4 isoform was established using the computational methods. Steroids 70-78 UDP glucuronosyltransferase family 1 member A4 Homo sapiens 116-122 27208893-9 2016 Our findings elucidate the potential for in vivo HDI effects of steroids in herbal medicine and foods, with the clinical dr ugs eliminated by UGT1A4, and reveal the vital pharamcophoric requirement of natural steroids for UGT1A4 inhibition activity. Steroids 64-72 UDP glucuronosyltransferase family 1 member A4 Homo sapiens 142-148 27208893-9 2016 Our findings elucidate the potential for in vivo HDI effects of steroids in herbal medicine and foods, with the clinical dr ugs eliminated by UGT1A4, and reveal the vital pharamcophoric requirement of natural steroids for UGT1A4 inhibition activity. Steroids 64-72 UDP glucuronosyltransferase family 1 member A4 Homo sapiens 222-228 15057901-13 2004 Two polymorphisms of the hepatic UGT1A4 protein show a differential metabolic activity toward mutagenic amines and endogenous steroids, altering hepatic metabolism and detoxification. Steroids 126-134 UDP glucuronosyltransferase family 1 member A4 Homo sapiens 33-39 18497089-7 2008 MCF-7 cells cultured steroid-free additionally expressed CYP1A2 as well as UGT1A4, 1A8, and 1A9. Steroids 21-28 UDP glucuronosyltransferase family 1 member A4 Homo sapiens 75-81