PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 31164411-11 2019 Enhanced expression of UGT2B17 and the lack of miR-224 signaling may contribute to the responsiveness of EA to the male sex steroids. Steroids 124-132 UDP glucuronosyltransferase family 2 member B17 Homo sapiens 23-30 27805301-1 2017 BACKGROUND: UDP-glucuronosyltransferase 2 family, polypeptide B17 (UGT2B17) encodes for an enzyme that modifies carcinogens, C19 steroids, xenobiotics, and anticancer chemotherapeutic agents by glucuronidation. Steroids 129-137 UDP glucuronosyltransferase family 2 member B17 Homo sapiens 12-65 30503386-0 2019 Impact of the UGT2B17 polymorphism on the steroid profile. Steroids 42-49 UDP glucuronosyltransferase family 2 member B17 Homo sapiens 14-21 30503386-2 2019 This article studies the genetic influence of polymorphism of the UGT2B17 gen on the urinary steroid profile and its implications for the anti-doping field. Steroids 93-100 UDP glucuronosyltransferase family 2 member B17 Homo sapiens 66-73 29781039-8 2018 Reduced TFS was observed for women with CLL exhibiting high expression of the steroid-inactivating UGT2B17 enzyme. Steroids 78-85 UDP glucuronosyltransferase family 2 member B17 Homo sapiens 99-106 27805301-1 2017 BACKGROUND: UDP-glucuronosyltransferase 2 family, polypeptide B17 (UGT2B17) encodes for an enzyme that modifies carcinogens, C19 steroids, xenobiotics, and anticancer chemotherapeutic agents by glucuronidation. Steroids 129-137 UDP glucuronosyltransferase family 2 member B17 Homo sapiens 67-74 26385605-10 2016 This study reveals that the androgen-inactivating UGT2B15 and UGT2B17 genes are direct targets of miR-376c and thus may influence steroid metabolism during prostate cancer progression. Steroids 130-137 UDP glucuronosyltransferase family 2 member B17 Homo sapiens 62-69 21928278-11 2011 Nevertheless, the detection of the UGT2B17-gene deletion in urine samples would provide additional information important for gathering evidence in analysis of steroids in doping control. Steroids 159-167 UDP glucuronosyltransferase family 2 member B17 Homo sapiens 35-42 22958586-13 2012 CONCLUSION: This study reports that in an in vitro supersome-based assay, the key steroid-metabolizing enzyme UGT2B17 is inhibited by a number of phenolic dietary substances and therefore may reduce the rate of testosterone glucuronidation in vivo. Steroids 82-89 UDP glucuronosyltransferase family 2 member B17 Homo sapiens 110-117 26668303-0 2015 Impact of UGT2B17 gene deletion on the steroid profile of an athlete. Steroids 39-46 UDP glucuronosyltransferase family 2 member B17 Homo sapiens 10-17 26668303-12 2015 The genotyping of UGT2B17 is an important source of information for understanding steroid profiling in the doping control field; therefore it is suggested that it be included in the Athletes Biological Passport. Steroids 82-89 UDP glucuronosyltransferase family 2 member B17 Homo sapiens 18-25 25794161-7 2015 RESULTS: In Alaska Native people, UGT2B17 deletion was strongly associated with lower BMI in male individuals (P<0.001), but not in female individuals, consistent with testosterone being a male dominant steroid. Steroids 206-213 UDP glucuronosyltransferase family 2 member B17 Homo sapiens 34-41 23288867-9 2013 The combined results reveal the strong preference of UGT1A10 for the 3-OH of physiologic estrogens and the equivalently strong preference of UGT2B7 and UGT2B17 for the hydroxyls on ring D of such steroid hormones. Steroids 196-212 UDP glucuronosyltransferase family 2 member B17 Homo sapiens 152-159 19572376-0 2009 Copy-number variations (CNVs) of the human sex steroid metabolizing genes UGT2B17 and UGT2B28 and their associations with a UGT2B15 functional polymorphism. Steroids 47-54 UDP glucuronosyltransferase family 2 member B17 Homo sapiens 74-81 21365123-7 2011 The androgen receptor (AR) and enzymes (AKR1C3, HSD17B2, HSD17B3, UGT2B15 and UGT2B17 ) that are involved in the metabolism of adrenal steroids were upregulated in castration resistant prostate cancer (CRPC). Steroids 135-143 UDP glucuronosyltransferase family 2 member B17 Homo sapiens 78-85 20429943-5 2010 Excretion of steroids is affected in individuals with a deletion mutation in the UGT2B17 gene. Steroids 13-21 UDP glucuronosyltransferase family 2 member B17 Homo sapiens 81-88 20429943-6 2010 We hypothesize that UGT2B17 deficient individuals are more vulnerable to developing renal disorders with prolonged use of AAS owing to increases in body mass index and possible direct toxic effects of steroids on the kidneys. Steroids 201-209 UDP glucuronosyltransferase family 2 member B17 Homo sapiens 20-27 20429943-11 2010 In individuals with the UGT2B17 deletion polymorphism, blood tests, biofluid analyses, urinalysis, and hair analyses following the administration of an anabolic steroid can be used to determine the fate of the substance once in the body. Steroids 161-168 UDP glucuronosyltransferase family 2 member B17 Homo sapiens 24-31 20429943-12 2010 IMPLICATIONS OF THE HYPOTHESIS: If the hypothesis is upheld, anabolic steroid users with a deletion mutation in the UGT2B17 gene may be exposed to an increased risk of developing renal disorders. Steroids 70-77 UDP glucuronosyltransferase family 2 member B17 Homo sapiens 116-123 20878390-5 2011 Previously, homozygous deletion of the UGT2B17 gene in CNV 4q13.2, which encodes an enzyme that mediates the glucuronidation of steroid hormones, has shown association with the risk of hip fracture. Steroids 128-144 UDP glucuronosyltransferase family 2 member B17 Homo sapiens 39-46 19022937-10 2009 Although UGT2B7 and UGT2B17 exhibited high, although converse, stereoselectivity in testosterone and epitestosterone glucuronidation, UGT2A1, an extrahepatic enzyme that is expressed mainly in the nasal epithelium, catalyzed the glucuronidation of both steroids at considerable rates and similar kinetics. Steroids 253-261 UDP glucuronosyltransferase family 2 member B17 Homo sapiens 20-27 19487245-10 2009 Because UGT2B15 and UGT2B17 inactivate steroid hormones by glucuronidation, the regulation of their genes by 17beta-estradiol may maintain steroid hormone homeostasis and prevent excessive estrogen signaling activity. Steroids 39-55 UDP glucuronosyltransferase family 2 member B17 Homo sapiens 20-27 19487245-10 2009 Because UGT2B15 and UGT2B17 inactivate steroid hormones by glucuronidation, the regulation of their genes by 17beta-estradiol may maintain steroid hormone homeostasis and prevent excessive estrogen signaling activity. Steroids 39-54 UDP glucuronosyltransferase family 2 member B17 Homo sapiens 20-27 19088161-2 2009 The ability to glucuronidate T and other steroids depends on a number of different glucuronidases (UGT) of which UGT2B17 is essential. Steroids 41-49 UDP glucuronosyltransferase family 2 member B17 Homo sapiens 113-120 18992858-10 2008 Because UGT2B17 encodes an enzyme catabolizing steroid hormones, we measured the concentrations of serum testosterone and estradiol for 236 young Chinese males and assessed their UGT2B17 copy number. Steroids 47-54 UDP glucuronosyltransferase family 2 member B17 Homo sapiens 8-15 10623541-2 2000 UGT2B15 and UGT2B17 are 95% identical in primary structure, and are expressed in steroid target tissues where they conjugate C19 steroids. Steroids 81-88 UDP glucuronosyltransferase family 2 member B17 Homo sapiens 12-19 17935910-2 2007 BACKGROUND: UDP-glucuronosyltransferase (UGT) 2B17 is a phase II metabolizing enzyme that mediates the glucuronidation of C(19) steroids. Steroids 128-136 UDP glucuronosyltransferase family 2 member B17 Homo sapiens 12-50 11159850-6 2001 To date, six UGT2B proteins have been isolated, namely UGT2B4, UGT2B7, UGT2B10, UGT2B11, UGT2B15, and UGT2B17, all of which have been demonstrated to be active on steroid molecules, except for UGT2B10 and UGT2B11, for which no substrate was found. Steroids 163-170 UDP glucuronosyltransferase family 2 member B17 Homo sapiens 102-109 10623541-2 2000 UGT2B15 and UGT2B17 are 95% identical in primary structure, and are expressed in steroid target tissues where they conjugate C19 steroids. Steroids 129-137 UDP glucuronosyltransferase family 2 member B17 Homo sapiens 12-19 9699884-6 1998 UGT2B17 is also widely distributed in several human steroid target tissues. Steroids 52-59 UDP glucuronosyltransferase family 2 member B17 Homo sapiens 0-7 9699884-14 1998 In addition, UGT2B17 was shown to be more labile than UGT2B15 indicating that regulation of UGT2B17 expression would lead to a more rapid change in the level of glucuronidated steroids. Steroids 176-184 UDP glucuronosyltransferase family 2 member B17 Homo sapiens 13-20 9699884-14 1998 In addition, UGT2B17 was shown to be more labile than UGT2B15 indicating that regulation of UGT2B17 expression would lead to a more rapid change in the level of glucuronidated steroids. Steroids 176-184 UDP glucuronosyltransferase family 2 member B17 Homo sapiens 92-99 9364925-0 1997 Chromosomal localization, structure, and regulation of the UGT2B17 gene, encoding a C19 steroid metabolizing enzyme. Steroids 88-95 UDP glucuronosyltransferase family 2 member B17 Homo sapiens 59-66 9364925-1 1997 UGT2B17 is a UDP-glucuronosyltransferase enzyme expressed in several extrahepatic steroid target tissues, including the human prostate, where it glucuronidates C19 steroids such as dihydrotestosterone (DHT), androsterone (ADT), and androstane-3alpha, 17beta-diol (3alpha-diol). Steroids 82-89 UDP glucuronosyltransferase family 2 member B17 Homo sapiens 0-7 9364925-10 1997 This study demonstrates regulation of the UGT2B17 gene by physiological effectors of the human prostate and supports the hypothesis that UGT enzymes are involved in steroid metabolism in extrahepatic tissues. Steroids 165-172 UDP glucuronosyltransferase family 2 member B17 Homo sapiens 42-49 9202245-10 1997 UGT2B17 was shown to be more labile than UGT2B15, indicating that regulation of UGT2B17 expression would lead to a more rapid change in the level of glucuronidated steroids. Steroids 164-172 UDP glucuronosyltransferase family 2 member B17 Homo sapiens 0-7 9202245-10 1997 UGT2B17 was shown to be more labile than UGT2B15, indicating that regulation of UGT2B17 expression would lead to a more rapid change in the level of glucuronidated steroids. Steroids 164-172 UDP glucuronosyltransferase family 2 member B17 Homo sapiens 80-87