PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
24395140-5	2014	Weighted linear regression was used to estimate geometric means and 95 % confidence intervals for IGF-1 and IGFBP-3 concentrations by sex steroid hormones and SHBG after adjusting for age, race/ethnicity, body mass index, waist circumference, alcohol consumption, cigarette smoking, physical activity, diabetes, and mutually adjusting for other sex hormones and SHBG.	Steroids	138-154	insulin like growth factor binding protein 3	Homo sapiens	108-115	
16390864-2	2006	GH or sex steroid treatment increases IGFBP-3, but little is known regarding the effects of these hormones on other IGFBPs.	Steroids	10-17	insulin like growth factor binding protein 3	Homo sapiens	38-45	
9568807-17	1998	It is concluded that (1) the CNS maturational events which change the regulation of serum IGF-1 and IGFBP-3 are induced by the pubertal increase in sex steroids in a nonreversible way and (2) the high adrenal steroid levels present in CAH induce a nonreversible activation of the GH-IGF-1 axis and of the GnRH pulse generator.	Steroids	152-160	insulin like growth factor binding protein 3	Homo sapiens	100-107	
14678285-13	2004	The decrease in IGF-I and IGFBP-3 levels after GnRHa therapy, which was not reversed with DHT administration, suggests that sex steroids have, through oestradiol, a GH-independent action on IGF-I and IGFBP-3 levels.	Steroids	128-136	insulin like growth factor binding protein 3	Homo sapiens	26-33	
14678285-13	2004	The decrease in IGF-I and IGFBP-3 levels after GnRHa therapy, which was not reversed with DHT administration, suggests that sex steroids have, through oestradiol, a GH-independent action on IGF-I and IGFBP-3 levels.	Steroids	128-136	insulin like growth factor binding protein 3	Homo sapiens	200-207	
15641264-0	2004	Correlation of sex steroids with IGF-1 and IGFBP-3 during different pubertal stages.	Steroids	19-27	insulin like growth factor binding protein 3	Homo sapiens	43-50	
15641264-10	2004	Estradiol levels of girls and testosterone levels of boys differed significantly between stages, and in both sexes, serum IGF-1 levels and IGF-1/IGFBP-3 ratios were significantly correlated with sex steroid levels.	Steroids	199-206	insulin like growth factor binding protein 3	Homo sapiens	145-152	
15641264-12	2004	Furthermore, increasing sex steroids with pubertal development increase the IGF-1 levels and IGF-1/IGFBP-3 ratios that affect bone growth.	Steroids	28-36	insulin like growth factor binding protein 3	Homo sapiens	99-106	
14670990-3	2004	IGFBP-3 has been shown to be cleaved by members of the kallikrein family, some of which are expressed in human thyroid and are characterized by regulation by steroid hormones.	Steroids	158-174	insulin like growth factor binding protein 3	Homo sapiens	0-7	
12361468-5	2002	In contrast, IGFBP-3 reduced steroid production and increased bax gene expression and the percentage of apoptotic cells (P < 0.05).	Steroids	29-36	insulin like growth factor binding protein 3	Homo sapiens	13-20	
11158935-7	2001	Female sex steroid treatment increased WLB-IGFBP-3 (P = 0.0005), whereas immunoreactive IGFBP-3 and IGFBP-3 proteolysis were normalized (P = 0.004).	Steroids	11-18	insulin like growth factor binding protein 3	Homo sapiens	43-50	
11158935-10	2001	During sex steroid treatment, IGFBP-3 proteolysis normalized, without any change in free IGF-I.	Steroids	11-18	insulin like growth factor binding protein 3	Homo sapiens	30-37	
9876343-3	1998	The combined effects of GH and anabolic androgenic steroids on IGFBP-3 and IGF-I levels are not known under authentic substance-abusing conditions.	Steroids	51-59	insulin like growth factor binding protein 3	Homo sapiens	63-70	
9876343-11	1998	Concomitant use of growth hormone and anabolic steroids decreased the IGFBP-3 concentration in five out of six abuse periods in spite of the fact that the IGF-I concentration remained elevated in four of them.	Steroids	47-55	insulin like growth factor binding protein 3	Homo sapiens	70-77	
9876343-12	1998	However, in two men who were on low calorie diet both the IGF-I and IGFBP-3 concentrations decreased during combined GH/anabolic steroid abuse.	Steroids	129-136	insulin like growth factor binding protein 3	Homo sapiens	68-75	
9876343-14	1998	CONCLUSION: Massive abuse of anabolic steroids decreases both the basal and GH-stimulated IGFBP-3 concentrations, whereas its effects on serum IGF-I concentration are variable and affected by low calorie diet.	Steroids	38-46	insulin like growth factor binding protein 3	Homo sapiens	90-97	
9568807-17	1998	It is concluded that (1) the CNS maturational events which change the regulation of serum IGF-1 and IGFBP-3 are induced by the pubertal increase in sex steroids in a nonreversible way and (2) the high adrenal steroid levels present in CAH induce a nonreversible activation of the GH-IGF-1 axis and of the GnRH pulse generator.	Steroids	152-159	insulin like growth factor binding protein 3	Homo sapiens	100-107	
9394163-7	1997	Poor growth during steroid treatment is associated with lower IGF1 and IGFBP3 levels.	Steroids	19-26	insulin like growth factor binding protein 3	Homo sapiens	71-77	
1385468-9	1992	These data show that IGFBP-3, IGFBP-2, IGFBP-1, and presumably IGFBP-4 and its glycosylated form are differentially regulated by peptide and steroid hormones in endometrial stromal cells and that their regulation is a function of stromal differentiation.	Steroids	141-148	insulin like growth factor binding protein 3	Homo sapiens	21-28	
1706350-11	1991	These data thus show that mRNAs encoding IGFBP-2 and IGFBP-3 are expressed in human endometrium, that their expression is differentially regulated in secretory compared to proliferative phase endometrium (different steroidogenic environments), and that the synthesis of both IGFBP-2 and IGFBP-3 proteins is regulated by steroid hormones.	Steroids	320-336	insulin like growth factor binding protein 3	Homo sapiens	53-60	
7559897-2	1995	It is generally believed that gonadal sex steroids stimulate pulsatile GH secretion, which, in turn, stimulates insulin-like growth factor I (IGF-I) and IGF-binding protein 3 (IGFBP-3) production.	Steroids	42-50	insulin like growth factor binding protein 3	Homo sapiens	153-174	
7559897-2	1995	It is generally believed that gonadal sex steroids stimulate pulsatile GH secretion, which, in turn, stimulates insulin-like growth factor I (IGF-I) and IGF-binding protein 3 (IGFBP-3) production.	Steroids	42-50	insulin like growth factor binding protein 3	Homo sapiens	176-183	
7507320-3	1994	We show here that MCF7 cell proliferation in steroid-stripped, serum containing media is significantly attenuated by rhIGF-BP3 (p < 0.05), with a maximal 40% inhibition of serum stimulated growth achieved by 6.25nM IGF-BP3.	Steroids	45-52	insulin like growth factor binding protein 3	Homo sapiens	119-126	
7507320-5	1994	These results demonstrate antagonism of steroid stimulated proliferation by an IGF binding protein and are compatible with the hypothesis that antiestrogen-induced accumulation of IGF-BP3 in the conditioned media of MCF7 cells contributes to the cytostatic action of these drugs.	Steroids	40-47	insulin like growth factor binding protein 3	Homo sapiens	180-187