PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 23683514-3 2013 OBJECTIVE: We sought to investigate the production of the TH17-associated cytokines IL-17A and IL-22 in culture in patients with moderate-to-severe asthma defined on the basis of their clinical response to steroids and the susceptibility of this response to inhibition by steroids and the active form of vitamin D, 1alpha,25-dihydroxyvitamin D3 (1,25[OH]2D3). Steroids 206-214 interleukin 17A Homo sapiens 84-90 23683514-3 2013 OBJECTIVE: We sought to investigate the production of the TH17-associated cytokines IL-17A and IL-22 in culture in patients with moderate-to-severe asthma defined on the basis of their clinical response to steroids and the susceptibility of this response to inhibition by steroids and the active form of vitamin D, 1alpha,25-dihydroxyvitamin D3 (1,25[OH]2D3). Steroids 272-280 interleukin 17A Homo sapiens 84-90 22444300-7 2012 The proportions of steroid-resistant rejection, incomplete recovery and recurrent ATCMR were higher in the IL-17 high group than in the FOXP3 high group (all indicators, P < 0 05). Steroids 19-26 interleukin 17A Homo sapiens 107-112 23160983-10 2013 CONCLUSIONS: GR-beta up-regulation by IL-17/IL-23 cytokines is associated with induced steroid insensitivity in PBMCs, observed as diminished Dexamethasone"s effects on cell proliferation, apoptosis and gene regulation. Steroids 87-94 interleukin 17A Homo sapiens 38-43 23160983-0 2013 Glucocorticoid receptor-beta up-regulation and steroid resistance induction by IL-17 and IL-23 cytokine stimulation in peripheral mononuclear cells. Steroids 47-54 interleukin 17A Homo sapiens 79-84 10679127-9 2000 Thus, our results suggest for the first time that IL-15 may represent a physiological trigger that via cyclosporin A and steroid sensitive pathways leads to the overproduction of IL-17 in the joints of rheumatoid arthritis patients. Steroids 121-128 interleukin 17A Homo sapiens 179-184 21645256-9 2011 The use of steroids and monoclonal antibodies reduced IL-17 expression, JAK2 phosphorylation and C4d deposition in acute ABMR patients. Steroids 11-19 interleukin 17A Homo sapiens 54-59 20545708-14 2010 CONCLUSION: Evidence of an increased GR-beta expression in epithelial cells following IL-17 stimulation suggests a possible role for Th17-associated cytokines in the mechanism of steroid hypo-responsiveness in asthmatic subjects. Steroids 179-186 interleukin 17A Homo sapiens 86-91 10853869-5 2000 The IL-17-induced neutrophil recruitment is mediated via induced CXC chemokine release through steroid-sensitive mechanisms and is modulated by release of endogenous tachykinins. Steroids 95-102 interleukin 17A Homo sapiens 4-9 17083726-9 2006 High sputum IL-8 and IL-17A mRNA levels were also found in moderate-to-severe (persistent) asthmatics on inhaled steroid treatment. Steroids 113-120 interleukin 17A Homo sapiens 21-27 35475923-2 2022 IL-17 is considered to induce neutrophilic inflammation in the lung, which is often observed in severe, steroid-resistant asthma-phenotypes. Steroids 104-111 interleukin 17A Homo sapiens 0-5 28840844-7 2017 The IL-17A levels were significantly correlated with those of IL-4, IL-25, IL-10, and IFN-gamma in patients with uncontrolled asthma, and the patients with the highest levels of all the above cytokines were refractory to high-dose of inhaled corticosteroid therapy and have a history of acute exacerbation within 1 year, requiring systemic steroid therapy. Steroids 249-256 interleukin 17A Homo sapiens 4-10 31601712-3 2020 Pulmonary research has quickly incorporated this technology, from characterizing the IL-17 signature of steroid-unresponsive COPD patients [1] to discovering pathogen-host interactions of M. tuberculosis [2]. Steroids 104-111 interleukin 17A Homo sapiens 85-90 35346673-0 2022 IL-17A Mediates Pyroptosis via ERK Pathway and Contributes to Steroid Resistance in CRSwNP. Steroids 62-69 interleukin 17A Homo sapiens 0-6 35293350-7 2022 Patients carrying AG genotype (rs2275913, IL-17A) had a significantly higher risk of steroid-dependent response (69.1% of SD VS 46.4% of SS; OR=2.58, p=0.014). Steroids 85-92 interleukin 17A Homo sapiens 42-48 33226450-7 2021 IL-17+ T cells were also down-regulated in polyps from patients treated with glucocorticoid steroids, and exhibited poly-functionality patterns in polyp tissues. Steroids 92-100 interleukin 17A Homo sapiens 0-5 35346673-13 2022 Moreover, IL-17A-induced pyroptosis contributes to steroid resistance by affecting glucocorticoid receptor (GR)alpha and GRbeta expression, and the inhibition of pyroptotic proteins partially abolished IL-17A-induced steroid resistance in hNECs. Steroids 51-58 interleukin 17A Homo sapiens 10-16 35346673-13 2022 Moreover, IL-17A-induced pyroptosis contributes to steroid resistance by affecting glucocorticoid receptor (GR)alpha and GRbeta expression, and the inhibition of pyroptotic proteins partially abolished IL-17A-induced steroid resistance in hNECs. Steroids 217-224 interleukin 17A Homo sapiens 10-16 35346673-13 2022 Moreover, IL-17A-induced pyroptosis contributes to steroid resistance by affecting glucocorticoid receptor (GR)alpha and GRbeta expression, and the inhibition of pyroptotic proteins partially abolished IL-17A-induced steroid resistance in hNECs. Steroids 217-224 interleukin 17A Homo sapiens 202-208 32051346-1 2020 IL-17A plays a critical role in the pathogenesis of steroid-resistant neutrophilic airway inflammation, which is a hallmark of severe asthma and chronic obstructive pulmonary disease (COPD). Steroids 52-59 interleukin 17A Homo sapiens 0-6 25162311-10 2014 We summarize and discuss the implications of IL-17 in the induction of neutrophilic airway inflammation, steroid insensitivity, the epithelial cell profile, and airway remodeling. Steroids 105-112 interleukin 17A Homo sapiens 45-50 30383540-0 2019 An airway epithelial IL-17A response signature identifies a steroid-unresponsive COPD patient subgroup. Steroids 60-67 interleukin 17A Homo sapiens 21-27 29499168-1 2018 IL-17A is implicated in many aspects of pathogenesis of severe asthma, including inducing neutrophilic inflammation, airway hyperresponsiveness, steroid insensitivity and airway remodeling. Steroids 145-152 interleukin 17A Homo sapiens 0-6 30701852-8 2018 The highest content of the Il-17 was registered at patients with bronchial asthma and obesity as in comparison with indicators of patients with normal BMI, and with almost healthy that, perhaps, is the reason of low effect of steroid therapy at these patients. Steroids 226-233 interleukin 17A Homo sapiens 27-32 27888992-3 2016 IL-17 is associated with neutrophilic inflammation, steroid resistance and severe asthma, but its importance in the association between asthma and obesity is unknown. Steroids 52-59 interleukin 17A Homo sapiens 0-5 26405064-0 2016 Effects of Fluticasone Furoate on Clinical and Immunological Outcomes (IL-17) for Patients With Nasal Polyposis Naive to Steroid Treatment. Steroids 121-128 interleukin 17A Homo sapiens 71-76 26405064-8 2016 The IL-17A/F expression was higher in nonallergics with high neutrophil counts and was inclined by steroids. Steroids 99-107 interleukin 17A Homo sapiens 4-10 26600259-5 2016 SUMMARY: Steroid resistant severe asthma with predominant bronchial neutrophilic inflammation could benefit from IL-17 targeted therapies. Steroids 9-16 interleukin 17A Homo sapiens 113-118 25772594-0 2015 Distinct endotypes of steroid-resistant asthma characterized by IL-17A(high) and IFN-gamma(high) immunophenotypes: Potential benefits of calcitriol. Steroids 22-29 interleukin 17A Homo sapiens 64-70 25427574-2 2014 The IL-17 superfamily, which mediates cross-talk between the adaptive and innate immune systems, has been associated with diminished responses to steroids. Steroids 146-154 interleukin 17A Homo sapiens 4-9 31902928-5 2020 Regarding neutrophilic airway inflammation in steroid-resistant asthma, IL-17 derived from Th17 cells and IL-8 and tumor necrosis factor-alpha derived mainly from macrophages were reported to be involved in the pathogenesis. Steroids 46-53 interleukin 17A Homo sapiens 72-77 31164437-7 2019 Systemic corticosteroids, but not maintenance inhaled steroids resulted in improved symptom control and exacerbations concomitant with a reduction in functional ILC2s despite persistently elevated IL-17+ lymphoid cells. Steroids 16-24 interleukin 17A Homo sapiens 197-202 31078066-6 2019 It has been revealed that pro-inflammatory cytokines such as IFN-gamma, TNF-alpha, TGF-beta, IL-17A, IL-27, IL-33 and thymic stromal lymphopoietin (TSLP) may contribute to steroid resistance in severe asthma and COPD. Steroids 172-179 interleukin 17A Homo sapiens 93-99 30616547-2 2019 A subset of asthma patients also exhibits elevated IL-17, which is associated with greater disease severity, neutrophilic inflammation, and steroid resistance. Steroids 140-147 interleukin 17A Homo sapiens 51-56 30291224-2 2018 IL-17A regulates airway inflammation, oxidative stress, and reduction of steroid sensitivity in chronic obstructive pulmonary disease (COPD). Steroids 73-80 interleukin 17A Homo sapiens 0-6 27264458-0 2016 A combination of dexamethasone and anti-IL-17A treatment can alleviate diesel exhaust particle-induced steroid insensitive asthma. Steroids 103-110 interleukin 17A Homo sapiens 40-46 27038884-1 2016 AIMS: IL-17A plays a key role in the persistence of airway inflammation, oxidative stress, and reduction of steroid-sensitivity in COPD. Steroids 108-115 interleukin 17A Homo sapiens 6-12 24347461-0 2014 Defective IL-10 expression and in vitro steroid-induced IL-17A in paediatric severe therapy-resistant asthma. Steroids 40-47 interleukin 17A Homo sapiens 56-62 24583150-7 2014 The levels of serum IL-17A and IFN-gamma in steroid group and serum TNF-alpha in alcoholic group were significantly higher than those in the HC. Steroids 44-51 interleukin 17A Homo sapiens 20-26 24347461-11 2014 Conversely, steroids enhanced IL-17A levels, and therefore any steroid-sparing properties of vitamin D may have additional benefit in STRA. Steroids 12-20 interleukin 17A Homo sapiens 30-36 24347461-11 2014 Conversely, steroids enhanced IL-17A levels, and therefore any steroid-sparing properties of vitamin D may have additional benefit in STRA. Steroids 12-19 interleukin 17A Homo sapiens 30-36 24482023-10 2014 IL-17 immunostaining correlated with proteinuria, requirement for pulse steroids, and SLEDAI renal score, and negatively with GFR. Steroids 72-80 interleukin 17A Homo sapiens 0-5