PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 10964798-5 2000 StAR protein mediates the rate-limiting and acutely regulated step in steroidogenesis, the transfer of cholesterol from the outer to the inner mitochondrial membrane where the cytochrome P450 side chain cleavage (P450scc) enzyme initiates the synthesis of all steroid hormones. Steroids 260-276 steroidogenic acute regulatory protein Mus musculus 0-4 10770490-8 2000 Consistent with the observed impairment in SF1 function, other SF1-dependent genes, including Cyp11b1 and steroidogenic acute regulatory protein (StAR), were poorly expressed and global steroidogenesis, as evidenced by the metabolism of 22(R)-hydroxycholesterol to steroid products, was impaired. Steroids 106-113 steroidogenic acute regulatory protein Mus musculus 146-150 10462417-2 1999 The steroidogenic acute regulatory (StAR) protein is an indispensable component in the acute regulatory phase and functions by rapidly mediating the transfer of the substrate for all steroid hormones, cholesterol, from the outer to the inner mitochondrial membrane where it is cleaved to pregnenolone, the first steroid formed. Steroids 183-199 steroidogenic acute regulatory protein Mus musculus 4-34 10462417-2 1999 The steroidogenic acute regulatory (StAR) protein is an indispensable component in the acute regulatory phase and functions by rapidly mediating the transfer of the substrate for all steroid hormones, cholesterol, from the outer to the inner mitochondrial membrane where it is cleaved to pregnenolone, the first steroid formed. Steroids 183-199 steroidogenic acute regulatory protein Mus musculus 36-40 10462417-2 1999 The steroidogenic acute regulatory (StAR) protein is an indispensable component in the acute regulatory phase and functions by rapidly mediating the transfer of the substrate for all steroid hormones, cholesterol, from the outer to the inner mitochondrial membrane where it is cleaved to pregnenolone, the first steroid formed. Steroids 4-11 steroidogenic acute regulatory protein Mus musculus 36-40 10462417-4 1999 To underscore its importance, mutations in the StAR gene have been shown to be the only cause of the potentially fatal disease lipoid congenital adrenal hyperplasia, in which affected individuals synthesize virtually no steroids. Steroids 220-228 steroidogenic acute regulatory protein Mus musculus 47-51 10221765-1 1999 The steroidogenic acute regulatory (StAR) protein plays essential roles in the delivery of cytosolic cholesterol into the mitochondrial inner membrane, which is an acute regulated and rate-limiting step for the steroid hormone synthesis. Steroids 211-226 steroidogenic acute regulatory protein Mus musculus 36-40 10750024-5 2000 These results suggest that inhibition of PP1 and PP2A inhibits steroid production by preventing the expression of the StAR protein, implicating PP1/2A dephosphorylation reactions as important regulators of stimulus-dependent StAR protein expression, and thus of steroidogenesis. Steroids 63-70 steroidogenic acute regulatory protein Mus musculus 118-122 10750024-5 2000 These results suggest that inhibition of PP1 and PP2A inhibits steroid production by preventing the expression of the StAR protein, implicating PP1/2A dephosphorylation reactions as important regulators of stimulus-dependent StAR protein expression, and thus of steroidogenesis. Steroids 63-70 steroidogenic acute regulatory protein Mus musculus 225-229 10098511-1 1999 The steroidogenic acute regulatory (StAR) protein, a 30-kDa mitochondrial factor, is a key regulator of steroid hormone biosynthesis, facilitating the transfer of cholesterol from the outer to the inner mitochondrial membrane. Steroids 104-119 steroidogenic acute regulatory protein Mus musculus 36-40 9013761-1 1997 Steroidogenic acute regulatory protein (StAR) delivers cholesterol to the inner mitochondrial membrane, where the cholesterol side-chain cleavage enzyme carries out the first committed step in steroid hormone biosynthesis. Steroids 193-208 steroidogenic acute regulatory protein Mus musculus 40-44 9751505-2 1998 We have recently shown that DAX-1 can block the first and rate-limiting step in steroid biosynthesis by repressing StAR (steroidogenic acute regulatory protein) expression. Steroids 80-87 steroidogenic acute regulatory protein Mus musculus 115-119 9751505-2 1998 We have recently shown that DAX-1 can block the first and rate-limiting step in steroid biosynthesis by repressing StAR (steroidogenic acute regulatory protein) expression. Steroids 80-87 steroidogenic acute regulatory protein Mus musculus 121-159 9202209-3 1997 De novo synthesis of the steroidogenic acute regulatory (StAR) protein has been shown to be indispensable for acute steroid hormone biosynthesis; however, the effect of HSP induction on the synthesis of the StAR protein has not yet been studied. Steroids 116-131 steroidogenic acute regulatory protein Mus musculus 57-61 9348220-6 1997 Progesterone production was inhibited by actinomycin D in the hCG-pretreated cells, supporting the proposal that maintaining StAR protein synthesis is required for optimal steroid production in MA-10 mouse Leydig tumor cells. Steroids 172-179 steroidogenic acute regulatory protein Mus musculus 125-129 9282989-6 1997 These results indicate that the observed increase in steroid production in response to CRH in MA-10 Leydig tumor cells is similar to that previously seen with trophic hormone stimulation acting through the cAMP second messenger pathway, and that it occurs as a result of an increase in the synthesis of the StAR protein. Steroids 53-60 steroidogenic acute regulatory protein Mus musculus 307-311 9013761-1 1997 Steroidogenic acute regulatory protein (StAR) delivers cholesterol to the inner mitochondrial membrane, where the cholesterol side-chain cleavage enzyme carries out the first committed step in steroid hormone biosynthesis. Steroids 193-208 steroidogenic acute regulatory protein Mus musculus 0-38 8544843-4 1995 These data indicate that trophic hormones regulate StAR mRNA and protein within a time frame concomitant with the acute production of steroid hormones and provide the first evidence implicating changes in StAR transcription and/or mRNA stability in the functional response of steroidogenic cells to hormone action. Steroids 134-150 steroidogenic acute regulatory protein Mus musculus 51-55 7588255-0 1995 Steroid production after in vitro transcription, translation, and mitochondrial processing of protein products of complementary deoxyribonucleic acid for steroidogenic acute regulatory protein. Steroids 0-7 steroidogenic acute regulatory protein Mus musculus 154-192 7588255-7 1995 StAR was shown to induce steroid production in isolated mitochondria. Steroids 25-32 steroidogenic acute regulatory protein Mus musculus 0-4 7588255-9 1995 In these experiments, StAR increased steroid production by at least 4-fold over control mock-transfected lysate, and this increase was time and dose dependent. Steroids 37-44 steroidogenic acute regulatory protein Mus musculus 22-26 7588255-10 1995 Furthermore, the increase in steroid production induced by StAR-containing lysate was not observed when COS1 lysate containing high levels of another mitochondrially imported protein, adrenodoxin, was used. Steroids 29-36 steroidogenic acute regulatory protein Mus musculus 59-63 7588255-12 1995 During import and processing in vitro, StAR induces steroid production in isolated mitochondria in a specific manner. Steroids 52-59 steroidogenic acute regulatory protein Mus musculus 39-43 8544843-5 1995 In addition, in situ hybridization analyses of StAR expression in embryonic and adult mice demonstrated a precise spatial and temporal relationship in vivo between StAR expression and the capacity to produce steroid hormones. Steroids 208-224 steroidogenic acute regulatory protein Mus musculus 47-51 8544843-5 1995 In addition, in situ hybridization analyses of StAR expression in embryonic and adult mice demonstrated a precise spatial and temporal relationship in vivo between StAR expression and the capacity to produce steroid hormones. Steroids 208-224 steroidogenic acute regulatory protein Mus musculus 164-168 33670702-4 2021 Mutations in STAR cause lipoid congenital adrenal hyperplasia (lipoid CAH), a disorder characterized by severe defects in adrenal and gonadal steroid production; in Leydig cells, the defects are seen mainly after the onset of hormone-dependent androgen formation. Steroids 142-149 steroidogenic acute regulatory protein Mus musculus 13-17 35409357-4 2022 STAR is part of a complex that shuttles cholesterol, the precursor of all steroid hormones, through the mitochondrial membrane where steroidogenesis is initiated. Steroids 74-81 steroidogenic acute regulatory protein Mus musculus 0-4 34999258-1 2022 Steroid hormone synthesis in steroidogenic cells requires cholesterol (Ch) delivery to/into mitochondria via StAR family trafficking proteins. Steroids 0-7 steroidogenic acute regulatory protein Mus musculus 109-113 34627990-6 2021 Biochemical analysis data revealed that the levels of the mature steroidogenic acute regulatory protein (STAR), a protein that works at the outer mitochondrial membrane to facilitate the translocation of cholesterol for steroid formation, was significantly reduced in response to MEHP exposures. Steroids 220-227 steroidogenic acute regulatory protein Mus musculus 65-103 34627990-6 2021 Biochemical analysis data revealed that the levels of the mature steroidogenic acute regulatory protein (STAR), a protein that works at the outer mitochondrial membrane to facilitate the translocation of cholesterol for steroid formation, was significantly reduced in response to MEHP exposures. Steroids 220-227 steroidogenic acute regulatory protein Mus musculus 105-109 27597394-5 2017 Using qPCR, we found in steroid-untreated EAE mice decreased mRNAs for the steroidogenic acute regulatory protein (Star), voltage-dependent anion channel (VDAC), P450scc (cholesterol side-chain cleavage), 5alpha-reductase, 3alpha-hydroxysteroid dehydrogenase (3alpha-HSD) and aromatase, whereas levels of 3beta-hydroxysteroid dehydrogenase (3beta-HSD) showed a large intra-group variance. Steroids 24-31 steroidogenic acute regulatory protein Mus musculus 75-113 33072314-11 2020 Results showed that miR-101-3p regulated STAR, CYP19A1, CYP11A1 and 3beta-HSD steroid hormone synthesis-associated genes by STC1 depletion, thus promoted E2 and P4 secretions. Steroids 78-85 steroidogenic acute regulatory protein Mus musculus 41-45 30922932-5 2019 This work further strengthens the possibility that noncoding-RNA-mediated regulation of STAR may play an important role in the regulation of steroid hormone production, and contributes further to our understanding of the many ways in which this important gene is regulated. Steroids 141-156 steroidogenic acute regulatory protein Mus musculus 88-92 28455626-2 2018 The rate-limiting step in testosterone biosynthesis involves the transfer of cholesterol to the mitochondrial inner membrane by the steroidogenic acute regulatory (Star) protein, a critical factor in steroid hormone biosynthesis. Steroids 200-215 steroidogenic acute regulatory protein Mus musculus 164-168 31677567-12 2020 In line, the expression of key progesterone synthetases, including steroidogenic acute regulatory protein (StAR) and 3beta-hydroxyl steroid dehydrogenase (3beta-HSD), was obviously downregulated in placenta from mice was exposed Cd during late pregnancy. Steroids 67-74 steroidogenic acute regulatory protein Mus musculus 107-111 31678557-2 2020 Previous work has shown that many different types of xenoestrogens regulate expression of the Steroidogenic Acute Regulatory protein (StAR), a cholesterol-transporting protein vital to steroid hormone biosynthesis; however, the regulatory mechanisms of StAR are incompletely characterized in fish. Steroids 185-192 steroidogenic acute regulatory protein Mus musculus 134-138 31678557-2 2020 Previous work has shown that many different types of xenoestrogens regulate expression of the Steroidogenic Acute Regulatory protein (StAR), a cholesterol-transporting protein vital to steroid hormone biosynthesis; however, the regulatory mechanisms of StAR are incompletely characterized in fish. Steroids 185-192 steroidogenic acute regulatory protein Mus musculus 253-257 27597394-5 2017 Using qPCR, we found in steroid-untreated EAE mice decreased mRNAs for the steroidogenic acute regulatory protein (Star), voltage-dependent anion channel (VDAC), P450scc (cholesterol side-chain cleavage), 5alpha-reductase, 3alpha-hydroxysteroid dehydrogenase (3alpha-HSD) and aromatase, whereas levels of 3beta-hydroxysteroid dehydrogenase (3beta-HSD) showed a large intra-group variance. Steroids 24-31 steroidogenic acute regulatory protein Mus musculus 115-119 24899578-12 2014 These data identify an essential role for the nuclear receptor NR2F2 as a direct activator of Star gene expression in Leydig cells, and thus in the control of steroid hormone biosynthesis. Steroids 159-174 steroidogenic acute regulatory protein Mus musculus 94-98 26995740-5 2016 Of the two enzymes required for testosterone biosynthesis, STAR and P450 SCC (encoded by Cyp11a1) enzyme abundance was also reduced following Mcl1 siRNA treatment, possibly leading to the reduced production of sex steroid precursors, and testosterone in these knockdown cells. Steroids 214-221 steroidogenic acute regulatory protein Mus musculus 59-63 26581634-4 2016 Steroid hormone production was increased significantly when MLTC-1 and Y1 cells were exposed to MBP at 10(-7)M. Additionally, vimentin and steroidogenic acute regulatory protein (StAR) expressions were upregulated at the same dose. Steroids 0-15 steroidogenic acute regulatory protein Mus musculus 139-177 26581634-4 2016 Steroid hormone production was increased significantly when MLTC-1 and Y1 cells were exposed to MBP at 10(-7)M. Additionally, vimentin and steroidogenic acute regulatory protein (StAR) expressions were upregulated at the same dose. Steroids 0-15 steroidogenic acute regulatory protein Mus musculus 179-183 25786521-3 2015 In this study, we demonstrated that exposure of K28 mouse testicular Leydig tumor cells to cadmium led to a significant increase in the mRNA level, promoter activity and protein level of the steroidogenic acute regulatory protein (StAR), an essential factor for steroid biosynthesis. Steroids 191-198 steroidogenic acute regulatory protein Mus musculus 231-235 24174323-4 2014 Deletion of StAR in mice resulted in a critical failure of steroid hormone production, but deletion of TSPO in mice was found to be embryonic lethal. Steroids 59-74 steroidogenic acute regulatory protein Mus musculus 12-16 24265455-2 2014 Regulation of steroid biosynthesis is principally mediated by the steroidogenic acute regulatory protein (StAR); however, the modes of action of retinoids in the regulation of steroidogenesis remain obscure. Steroids 14-21 steroidogenic acute regulatory protein Mus musculus 66-104 24265455-2 2014 Regulation of steroid biosynthesis is principally mediated by the steroidogenic acute regulatory protein (StAR); however, the modes of action of retinoids in the regulation of steroidogenesis remain obscure. Steroids 14-21 steroidogenic acute regulatory protein Mus musculus 106-110 24850413-1 2014 The steroidogenic acute regulatory protein (StAR) facilitates the delivery of cholesterol to the inner mitochondrial membrane, where the cholesterol side-chain cleavage enzyme catalyzes the initial step of steroid hormone biosynthesis. Steroids 206-221 steroidogenic acute regulatory protein Mus musculus 4-42 24850413-1 2014 The steroidogenic acute regulatory protein (StAR) facilitates the delivery of cholesterol to the inner mitochondrial membrane, where the cholesterol side-chain cleavage enzyme catalyzes the initial step of steroid hormone biosynthesis. Steroids 206-221 steroidogenic acute regulatory protein Mus musculus 44-48 23707772-3 2013 The current study tests the hypothesis that BPA first decreases the expression levels of the steroidogenic enzyme cytochrome P450 side-chain cleavage (Cyp11a1) and steroidogenic acute regulatory protein (StAR) in mouse antral follicles, leading to a decrease in sex steroid hormone production in vitro. Steroids 266-281 steroidogenic acute regulatory protein Mus musculus 204-208 23467407-1 2013 Steroidogenic acute regulatory (StAR) proteins in steroidogenic cells are implicated in the delivery of cholesterol (Ch) from internal or external sources to mitochondria (Mito) for initiation of steroid hormone synthesis. Steroids 196-211 steroidogenic acute regulatory protein Mus musculus 32-36 23362264-2 2013 The steroidogenic acute regulatory protein (StAR) controls the rate-limiting step in steroid biosynthesis. Steroids 4-11 steroidogenic acute regulatory protein Mus musculus 44-48 19282384-1 2009 The protein kinase C (PKC) signaling pathway plays integral roles in the expression of the steroidogenic acute regulatory (StAR) protein that regulates steroid biosynthesis in steroidogenic cells. Steroids 91-98 steroidogenic acute regulatory protein Mus musculus 123-127 22427666-13 2012 Over time 14-3-3gamma homodimerizes and dissociates from STAR, allowing this protein to induce maximal mitochondrial steroid formation. Steroids 117-124 steroidogenic acute regulatory protein Mus musculus 57-61 22529212-2 2012 Mice lacking StAR (Star(-/-)) share phenotypes with human individuals having congenital lipoid adrenal hyperplasia including compromised production of steroid hormones and florid accumulation of cholesterol esters in adrenal glands and gonads. Steroids 151-167 steroidogenic acute regulatory protein Mus musculus 13-28 22529212-5 2012 In Star(-/-) mice, expression levels of genes involved in cholesterol efflux and the inflammatory response were significantly up-regulated, whereas those related to steroid hormone biosynthesis or cholesterol biosynthesis and influx were not significantly changed. Steroids 165-180 steroidogenic acute regulatory protein Mus musculus 3-7 21350237-1 2012 Steroid hormone biosynthesis requires the steroidogenic acute regulatory protein (STAR). Steroids 0-15 steroidogenic acute regulatory protein Mus musculus 42-81 21350237-1 2012 Steroid hormone biosynthesis requires the steroidogenic acute regulatory protein (STAR). Steroids 0-15 steroidogenic acute regulatory protein Mus musculus 83-87 19493163-4 2009 Ovariectomy (OVX; high serum gonadotropins, low serum sex steroids) had a differential effect on StAR protein levels in the extrahypothalamic brain; increasing the 30- and 32-kDa variants but decreasing the 37-kDa variant and is indicative of cholesterol transport into mitochondria for steroidogenesis. Steroids 58-66 steroidogenic acute regulatory protein Mus musculus 97-101 18787026-1 2009 Dosage-sensitive sex reversal, adrenal hypoplasia congenita, critical region on the X chromosome, gene 1 (DAX-1) is an orphan nuclear receptor that has been demonstrated to be instrumental to the expression of the steroidogenic acute regulatory (StAR) protein that regulates steroid biosynthesis in steroidogenic cells. Steroids 214-221 steroidogenic acute regulatory protein Mus musculus 246-250 19698295-2 2009 Although several of these enhance the expression of the steroidogenic acute regulatory protein (STAR) and steroid production, the role of PPARgamma in regulating STAR-mediated steroidogenesis remains unclear. Steroids 56-63 steroidogenic acute regulatory protein Mus musculus 96-100 18187601-1 2008 The steroidogenic acute regulatory protein (StAR) stimulates the regulated production of steroid hormones in the adrenal cortex and gonads by facilitating the delivery of cholesterol to the inner mitochondrial membrane. Steroids 89-105 steroidogenic acute regulatory protein Mus musculus 4-42 18187601-1 2008 The steroidogenic acute regulatory protein (StAR) stimulates the regulated production of steroid hormones in the adrenal cortex and gonads by facilitating the delivery of cholesterol to the inner mitochondrial membrane. Steroids 89-105 steroidogenic acute regulatory protein Mus musculus 44-48 18006634-4 2008 The increase in StAR protein occurred concomitantly with a significant increase in steroid hormone production. Steroids 83-98 steroidogenic acute regulatory protein Mus musculus 16-20 17479410-11 2007 Data indicate that MBP interfered with steroid hormone production by affecting StAR expression in MLTC-1 cells. Steroids 39-54 steroidogenic acute regulatory protein Mus musculus 79-83 17601886-2 2007 The rate-limiting step in steroid hormone biosynthesis is the transport of substrate cholesterol from the outer to inner mitochondrial membrane by the steroidogenic acute regulatory protein (StAR). Steroids 26-41 steroidogenic acute regulatory protein Mus musculus 151-189 17601886-2 2007 The rate-limiting step in steroid hormone biosynthesis is the transport of substrate cholesterol from the outer to inner mitochondrial membrane by the steroidogenic acute regulatory protein (StAR). Steroids 26-41 steroidogenic acute regulatory protein Mus musculus 191-195 18197253-6 2008 By means of ex vivo experiments, we showed that mitochondrial maximal steroidogenesis occurred as a result of the mutual action of steroidogenic acute regulatory (StAR) protein -a key regulatory component in steroid biosynthesis-, active ERK1/2 and PKA. Steroids 70-77 steroidogenic acute regulatory protein Mus musculus 131-161 18197253-6 2008 By means of ex vivo experiments, we showed that mitochondrial maximal steroidogenesis occurred as a result of the mutual action of steroidogenic acute regulatory (StAR) protein -a key regulatory component in steroid biosynthesis-, active ERK1/2 and PKA. Steroids 70-77 steroidogenic acute regulatory protein Mus musculus 163-167 17050526-5 2006 Co-expression of Tspo, Pap7, PkarIalpha, and Star genes resulted in the stimulation of steroid formation in both steroidogenic MA-10 and non-steroidogenic COS-F2-130 cells that were engineered to metabolize cholesterol. Steroids 87-94 steroidogenic acute regulatory protein Mus musculus 45-49 17400803-1 2007 The steroidogenic acute regulatory (StAR) protein plays a central role in the regulation of steroid biosynthesis. Steroids 4-11 steroidogenic acute regulatory protein Mus musculus 36-40 16999944-14 2006 These data support that MBP promotes steroid hormone production by facilitating StAR expression in MLTC-1 cells. Steroids 37-52 steroidogenic acute regulatory protein Mus musculus 80-84 16690799-1 2006 The first and rate-limiting step in the biosynthesis of steroid hormones is the transfer of cholesterol into mitochondria, which is facilitated by the steroidogenic acute regulatory (StAR) protein. Steroids 56-72 steroidogenic acute regulatory protein Mus musculus 151-181 16690799-1 2006 The first and rate-limiting step in the biosynthesis of steroid hormones is the transfer of cholesterol into mitochondria, which is facilitated by the steroidogenic acute regulatory (StAR) protein. Steroids 56-72 steroidogenic acute regulatory protein Mus musculus 183-187 16469751-1 2005 The first and rate-limiting step in the biosynthesis of steroid hormones is the transfer of cholesterol into mitochondria, which is facilitated by the steroidogenic acute regulatory (StAR) protein. Steroids 56-72 steroidogenic acute regulatory protein Mus musculus 183-187 16901926-1 2006 In the regulation of steroid biosynthesis, a process mediated by the steroidogenic acute regulatory (StAR) protein, both cAMP-dependent and -independent pathways are involved. Steroids 21-28 steroidogenic acute regulatory protein Mus musculus 101-105 15072555-1 2004 The steroidogenic acute regulatory (StAR) protein promotes intramitochondrial delivery of cholesterol to the cholesterol side-chain cleavage system, which catalyzes the first enzymatic step in all steroid synthesis. Steroids 4-11 steroidogenic acute regulatory protein Mus musculus 36-40 15205373-2 2004 Steroid production in peripheral tissues is acutely regulated by the steroidogenic acute regulatory (StAR) protein, which mediates the rate-limiting step in steroid biosynthesis: the intramitochondrial delivery of cholesterol to cytochrome P450scc for conversion to steroid. Steroids 0-7 steroidogenic acute regulatory protein Mus musculus 69-99 15205373-2 2004 Steroid production in peripheral tissues is acutely regulated by the steroidogenic acute regulatory (StAR) protein, which mediates the rate-limiting step in steroid biosynthesis: the intramitochondrial delivery of cholesterol to cytochrome P450scc for conversion to steroid. Steroids 0-7 steroidogenic acute regulatory protein Mus musculus 101-105 15205373-2 2004 Steroid production in peripheral tissues is acutely regulated by the steroidogenic acute regulatory (StAR) protein, which mediates the rate-limiting step in steroid biosynthesis: the intramitochondrial delivery of cholesterol to cytochrome P450scc for conversion to steroid. Steroids 69-76 steroidogenic acute regulatory protein Mus musculus 101-105 15205373-2 2004 Steroid production in peripheral tissues is acutely regulated by the steroidogenic acute regulatory (StAR) protein, which mediates the rate-limiting step in steroid biosynthesis: the intramitochondrial delivery of cholesterol to cytochrome P450scc for conversion to steroid. Steroids 157-164 steroidogenic acute regulatory protein Mus musculus 69-99 15205373-2 2004 Steroid production in peripheral tissues is acutely regulated by the steroidogenic acute regulatory (StAR) protein, which mediates the rate-limiting step in steroid biosynthesis: the intramitochondrial delivery of cholesterol to cytochrome P450scc for conversion to steroid. Steroids 157-164 steroidogenic acute regulatory protein Mus musculus 101-105 15072555-10 2004 Secondly, through direct conversion to steroid, oxysterols may account in part for StAR-independent steroid production in the body. Steroids 39-46 steroidogenic acute regulatory protein Mus musculus 83-87 15072555-10 2004 Secondly, through direct conversion to steroid, oxysterols may account in part for StAR-independent steroid production in the body. Steroids 100-107 steroidogenic acute regulatory protein Mus musculus 83-87 12604660-1 2003 The steroidogenic acute regulatory protein (StAR), by virtue of its ability to facilitate the intramitochondrial transport of cholesterol, plays an important role in regulating steroid hormone biosynthesis in steroidogenic cells. Steroids 177-192 steroidogenic acute regulatory protein Mus musculus 4-42 15181477-1 2004 The steroidogenic acute regulatory (StAR) protein, a novel mitochondrial protein, is involved in the regulation of steroid hormone biosynthesis through its mediation of the intramitochondrial transport of the steroid substrate, cholesterol, to the cytochrome P450 cholesterol side chain cleavage (P450scc) enzyme. Steroids 115-130 steroidogenic acute regulatory protein Mus musculus 4-49 12604660-1 2003 The steroidogenic acute regulatory protein (StAR), by virtue of its ability to facilitate the intramitochondrial transport of cholesterol, plays an important role in regulating steroid hormone biosynthesis in steroidogenic cells. Steroids 177-192 steroidogenic acute regulatory protein Mus musculus 44-48 12604660-11 2003 Thus, for the first time, a direct stimulatory effect of a steroid on StAR gene expression has been demonstrated. Steroids 59-66 steroidogenic acute regulatory protein Mus musculus 70-74 12475389-8 2002 In summary, these results demonstrate that inhibition of PTP activity affected both StAR protein and mRNA synthesis and suggest that the activity of hormone-regulated PTPs is a requirement in the LH signaling cascade that results in the up-regulation of StAR protein and, subsequently, increased steroid synthesis. Steroids 296-303 steroidogenic acute regulatory protein Mus musculus 254-258 12486153-0 2002 An essential component in steroid synthesis, the steroidogenic acute regulatory protein, is expressed in discrete regions of the brain. Steroids 26-33 steroidogenic acute regulatory protein Mus musculus 49-87 12486153-5 2002 These data support a role for StAR in the production of neurosteroids and identify potential sites of active de novo steroid synthesis in the brain. Steroids 61-68 steroidogenic acute regulatory protein Mus musculus 30-34 11374809-1 2001 The Steroidogenic Acute Regulatory (StAR) protein is assumed to enhance the rate-limiting step of the steroid biosynthesis. Steroids 102-109 steroidogenic acute regulatory protein Mus musculus 4-34 12390868-1 2002 Steroid hormone biosynthesis in the adrenals and gonads is regulated by the steroidogenic acute regulatory (StAR) protein through its action in mediating the intramitochondrial transport of cholesterol. Steroids 0-15 steroidogenic acute regulatory protein Mus musculus 76-106 12390868-1 2002 Steroid hormone biosynthesis in the adrenals and gonads is regulated by the steroidogenic acute regulatory (StAR) protein through its action in mediating the intramitochondrial transport of cholesterol. Steroids 0-15 steroidogenic acute regulatory protein Mus musculus 108-112 12351695-1 2002 The steroidogenic acute regulatory protein (StAR) is essential for the regulated production of steroid hormones, mediating the translocation of intracellular cholesterol to the inner mitochondrial membrane where steroidogenesis begins. Steroids 95-111 steroidogenic acute regulatory protein Mus musculus 4-42 12351695-1 2002 The steroidogenic acute regulatory protein (StAR) is essential for the regulated production of steroid hormones, mediating the translocation of intracellular cholesterol to the inner mitochondrial membrane where steroidogenesis begins. Steroids 95-111 steroidogenic acute regulatory protein Mus musculus 44-48 11988331-5 2002 The giant cells express another protein indispensable for steroid hormone synthesis in the adrenal and gonads, Steroidogenic Acute Regulatory (StAR) protein. Steroids 58-73 steroidogenic acute regulatory protein Mus musculus 111-156 11773448-1 2002 The mitochondrial phosphoprotein, the steroidogenic acute regulatory (StAR) protein, is an essential component in the regulation of steroid biosynthesis in adrenal and gonadal cells through cAMP-dependent pathways. Steroids 38-45 steroidogenic acute regulatory protein Mus musculus 70-74 11374809-1 2001 The Steroidogenic Acute Regulatory (StAR) protein is assumed to enhance the rate-limiting step of the steroid biosynthesis. Steroids 102-109 steroidogenic acute regulatory protein Mus musculus 36-40 11384875-11 2001 These findings demonstrate a key role of thyroid hormone in maintaining mouse Leydig cell function, where thyroid hormone and StAR protein coordinately regulate steroid hormone biosynthesis. Steroids 161-176 steroidogenic acute regulatory protein Mus musculus 126-130 11196444-0 2000 Post-translational regulation of steroidogenic acute regulatory protein by cAMP-dependent protein kinase A. Adrenal steroid production is stimulated by adrenocorticotropin hormone activation of the cAMP-dependent protein kinase A (PKA) signaling pathway and subsequent induction of Steroidogenic Acute Regulatory (StAR) protein expression. Steroids 33-40 steroidogenic acute regulatory protein Mus musculus 282-312 11196444-0 2000 Post-translational regulation of steroidogenic acute regulatory protein by cAMP-dependent protein kinase A. Adrenal steroid production is stimulated by adrenocorticotropin hormone activation of the cAMP-dependent protein kinase A (PKA) signaling pathway and subsequent induction of Steroidogenic Acute Regulatory (StAR) protein expression. Steroids 33-40 steroidogenic acute regulatory protein Mus musculus 314-318