PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 1379120-2 1992 By avoiding perchloric acid treatment, new fecal antigens related to CEA were identified. Perchloric Acid 12-27 CEA cell adhesion molecule 3 Homo sapiens 69-72 2616998-1 1989 Carcinoembryonic anti-antigen (CEA) polyclonal antibodies were obtained in ram and rabbit using as antigen source the extracts with perchloric acid from the human colon adenocarcinomas. Perchloric Acid 132-147 CEA cell adhesion molecule 3 Homo sapiens 31-34 1851320-2 1991 The yield of CEA was, in some cases, 20-30 times more than that obtained by the usual method with perchloric acid. Perchloric Acid 98-113 CEA cell adhesion molecule 3 Homo sapiens 13-16 2417110-1 1985 Antigens related to the carcinoembryonic antigen (CEA) were isolated from normal human plasma by perchloric acid extraction, gel permeation chromatography and immunoaffinity chromatography using a monoclonal antibody with broad specificity and high affinity. Perchloric Acid 97-112 CEA cell adhesion molecule 3 Homo sapiens 24-48 3632664-1 1987 Two antigens of 165 kD and 105 kD crossreacting with the carcinoembryonic antigen (CEA) were isolated from human meconium by perchloric acid extraction, differential immunoaffinity chromatography, and size exclusion HPLC. Perchloric Acid 125-140 CEA cell adhesion molecule 3 Homo sapiens 57-81 3632664-1 1987 Two antigens of 165 kD and 105 kD crossreacting with the carcinoembryonic antigen (CEA) were isolated from human meconium by perchloric acid extraction, differential immunoaffinity chromatography, and size exclusion HPLC. Perchloric Acid 125-140 CEA cell adhesion molecule 3 Homo sapiens 83-86 2417110-1 1985 Antigens related to the carcinoembryonic antigen (CEA) were isolated from normal human plasma by perchloric acid extraction, gel permeation chromatography and immunoaffinity chromatography using a monoclonal antibody with broad specificity and high affinity. Perchloric Acid 97-112 CEA cell adhesion molecule 3 Homo sapiens 50-53 3839768-1 1985 In perchloric acid extracts of normal lung and colonic tumors, 3 NCA molecules were identified by monoclonal antibodies that cross-reacted with CEA, which itself gave 2 bands in SDS-PAGE. Perchloric Acid 3-18 CEA cell adhesion molecule 3 Homo sapiens 144-147 6724739-1 1984 During the selection of monoclonal antibodies (MAb) raised against purified carcinoembryonic antigen (CEA), two MAbs were identified which immunoprecipitated a glycoprotein of 95 kD present both in perchloric acid extracts of normal lung and on the surface of normal granulocytes. Perchloric Acid 198-213 CEA cell adhesion molecule 3 Homo sapiens 76-100 2940803-1 1985 Carcinoembryonic antigen (CEA) was purified after perchloric acid extraction of glycoprotein from human normal and tumoral colon. Perchloric Acid 50-65 CEA cell adhesion molecule 3 Homo sapiens 0-30 6724739-1 1984 During the selection of monoclonal antibodies (MAb) raised against purified carcinoembryonic antigen (CEA), two MAbs were identified which immunoprecipitated a glycoprotein of 95 kD present both in perchloric acid extracts of normal lung and on the surface of normal granulocytes. Perchloric Acid 198-213 CEA cell adhesion molecule 3 Homo sapiens 102-105 6407507-1 1983 CEA was extracted by the perchloric acid method from primary adenocarcinomas of the colon and the ovary, from ascitic and pleural fluids from patients with pancreatic, lung and breast cancer, and from the cyst fluid of a benign ovarian cystadenoma. Perchloric Acid 25-40 CEA cell adhesion molecule 3 Homo sapiens 0-3 6311999-1 1983 Heat inactivation has been proposed as an alternative to perchloric acid (PCA) precipitation for the extraction of carcinoembryonic antigen (CEA) from human plasma. Perchloric Acid 57-72 CEA cell adhesion molecule 3 Homo sapiens 115-139 6311999-1 1983 Heat inactivation has been proposed as an alternative to perchloric acid (PCA) precipitation for the extraction of carcinoembryonic antigen (CEA) from human plasma. Perchloric Acid 74-77 CEA cell adhesion molecule 3 Homo sapiens 115-139 7459230-2 1981 A mouse monoclonal antibody binds weakly to CEA in perchloric acid extracts of tumour but strongly to CEA similarly isolated from serum, and its spectrum of cancer detection differs from conventional antisera. Perchloric Acid 51-66 CEA cell adhesion molecule 3 Homo sapiens 44-47 7151270-8 1982 Exposure of CEA to perchloric acid seems to play a critical role in recovery of CEA material when assayed by the Roche method. Perchloric Acid 19-34 CEA cell adhesion molecule 3 Homo sapiens 12-15 7151270-8 1982 Exposure of CEA to perchloric acid seems to play a critical role in recovery of CEA material when assayed by the Roche method. Perchloric Acid 19-34 CEA cell adhesion molecule 3 Homo sapiens 80-83 7150474-4 1982 CEA was extracted from resected tumours with perchloric acid. Perchloric Acid 45-60 CEA cell adhesion molecule 3 Homo sapiens 0-3 6286169-5 1982 The perchloric acid (PCA) extract of feces was subjected to affinity chromatography using anti-CEA bound to Sepharose, and the bound protein was labelled with 125I, and then fractionated on a Sephadex G-200 column. Perchloric Acid 4-19 CEA cell adhesion molecule 3 Homo sapiens 95-98 6286169-5 1982 The perchloric acid (PCA) extract of feces was subjected to affinity chromatography using anti-CEA bound to Sepharose, and the bound protein was labelled with 125I, and then fractionated on a Sephadex G-200 column. Perchloric Acid 21-24 CEA cell adhesion molecule 3 Homo sapiens 95-98 7034200-2 1981 During follow-up of more than 3 years the CEA level was always found to be higher than 300 ng/ml as determined on 12 different blood samples using 3 different assays: the Hansen assay, our own inhibition radioimmunoassay performed on perchloric acid extract of serum, and a newly developed solid phase non-competitive enzyme immunoassay involving monoclonal anti-CEA antibody. Perchloric Acid 234-249 CEA cell adhesion molecule 3 Homo sapiens 42-45 1248140-2 1976 Perchloric acid extraction of serum was followed by counter-immunoelectrophoresis against monospecific antiserum to CEA. Perchloric Acid 0-15 CEA cell adhesion molecule 3 Homo sapiens 116-119 7204983-2 1980 The competitive protein binding (CPB) assay for CEA can be performed directly on serum or plasma without perchloric acid extraction. Perchloric Acid 105-120 CEA cell adhesion molecule 3 Homo sapiens 48-51 204321-1 1978 The use of perchloric acid and water for the extraction of CEA from tumour and foetal tissues has been investigated. Perchloric Acid 11-26 CEA cell adhesion molecule 3 Homo sapiens 59-62 204321-2 1978 In the case of tumour, lower recoveries of CEA were obtained from perchloric acid extracts than from aqueous extracts of the same tissue. Perchloric Acid 66-81 CEA cell adhesion molecule 3 Homo sapiens 43-46 1268028-5 1976 A convenient method of isolating CEA with high specific activity directly from perchloric acid extracts of tumour tissue is also described. Perchloric Acid 79-94 CEA cell adhesion molecule 3 Homo sapiens 33-36 62711-3 1976 The substances responsible for the CEA-activity were isolated by perchloric acid-extraction followed by two successive Sephadex G-200 chromatography into two pools, Pool I (PI) and Pool II (PII). Perchloric Acid 65-80 CEA cell adhesion molecule 3 Homo sapiens 35-38 824719-4 1976 Immunodiffusion of perchloric acid extracts of CEA-like material from heterozygote carrier blood indicated that the CEA-like material, which was elevated in homozygotes and heterozygotes for CF, showed only partial identity with two separate CEA preparations obtained from colon carcinomas and was not identical to either A, B, or O(H) blood group substances. Perchloric Acid 19-34 CEA cell adhesion molecule 3 Homo sapiens 47-50 824719-4 1976 Immunodiffusion of perchloric acid extracts of CEA-like material from heterozygote carrier blood indicated that the CEA-like material, which was elevated in homozygotes and heterozygotes for CF, showed only partial identity with two separate CEA preparations obtained from colon carcinomas and was not identical to either A, B, or O(H) blood group substances. Perchloric Acid 19-34 CEA cell adhesion molecule 3 Homo sapiens 116-119 824719-4 1976 Immunodiffusion of perchloric acid extracts of CEA-like material from heterozygote carrier blood indicated that the CEA-like material, which was elevated in homozygotes and heterozygotes for CF, showed only partial identity with two separate CEA preparations obtained from colon carcinomas and was not identical to either A, B, or O(H) blood group substances. Perchloric Acid 19-34 CEA cell adhesion molecule 3 Homo sapiens 116-119 52402-1 1975 The carcinoembryonic antigen (CEA) active glycoproteins from perchloric acid extract of liver-metastasized primary colon tumor have been separated by concanavalin A Sepharose (Con A Sepharose) chromatography. Perchloric Acid 61-76 CEA cell adhesion molecule 3 Homo sapiens 4-28 52402-1 1975 The carcinoembryonic antigen (CEA) active glycoproteins from perchloric acid extract of liver-metastasized primary colon tumor have been separated by concanavalin A Sepharose (Con A Sepharose) chromatography. Perchloric Acid 61-76 CEA cell adhesion molecule 3 Homo sapiens 30-33 241482-5 1975 These two precipitin lines fused completely with the two respective lines produced by antibody to perchloric acid-treated CEA. Perchloric Acid 98-113 CEA cell adhesion molecule 3 Homo sapiens 122-125 163161-0 1975 Rapid radioimmunoassay of carcinoembryonic antigen (CEA) in ultrafiltered perchloric acid extracts: results of a clinical survey. Perchloric Acid 74-89 CEA cell adhesion molecule 3 Homo sapiens 26-50 163161-0 1975 Rapid radioimmunoassay of carcinoembryonic antigen (CEA) in ultrafiltered perchloric acid extracts: results of a clinical survey. Perchloric Acid 74-89 CEA cell adhesion molecule 3 Homo sapiens 52-55 163161-1 1975 Perchloric acid treatment of the carcinoembryonic antigen (CEA) results in subunits of approximate mol. Perchloric Acid 0-15 CEA cell adhesion molecule 3 Homo sapiens 33-57 163161-1 1975 Perchloric acid treatment of the carcinoembryonic antigen (CEA) results in subunits of approximate mol. Perchloric Acid 0-15 CEA cell adhesion molecule 3 Homo sapiens 59-62 163161-4 1975 The assay was designed to take into account the changes CEA undergoes during perchloric acid extraction. Perchloric Acid 77-92 CEA cell adhesion molecule 3 Homo sapiens 56-59 4727056-1 1973 Carcinoembryonic antigen (CEA) was measured in whole serum and in serum extracted with perchloric acid by microradioimmunoassay in patients with benign and malignant diseases of the liver and pancreas. Perchloric Acid 87-102 CEA cell adhesion molecule 3 Homo sapiens 0-24 4727056-1 1973 Carcinoembryonic antigen (CEA) was measured in whole serum and in serum extracted with perchloric acid by microradioimmunoassay in patients with benign and malignant diseases of the liver and pancreas. Perchloric Acid 87-102 CEA cell adhesion molecule 3 Homo sapiens 26-29 4299103-2 1968 Tumor tissue extraction in 0.6 M perchloric acid followed by paper block electrophoresis and column chromatography on Sephadex G-200 resulted in highly purified CEA preparations as determined by both immunological and physicochemical criteria. Perchloric Acid 33-48 CEA cell adhesion molecule 3 Homo sapiens 161-164 226300-3 1979 The amounts of free CEA corresponded fairly well to the fractions of CEA which could be extracted by perchloric acid. Perchloric Acid 101-116 CEA cell adhesion molecule 3 Homo sapiens 20-23 226300-3 1979 The amounts of free CEA corresponded fairly well to the fractions of CEA which could be extracted by perchloric acid. Perchloric Acid 101-116 CEA cell adhesion molecule 3 Homo sapiens 69-72 226300-5 1979 The presence of CEA immune complexes in the perchloric acid precipitates could be demonstrated by gel filtration under dissociating andnon-dissociating conditions and after pre-incubation with 125I-CEA by radioimmuno-double-diffusion using monospecific rabbit antisera against human IgM and IgG. Perchloric Acid 44-59 CEA cell adhesion molecule 3 Homo sapiens 16-19 226300-5 1979 The presence of CEA immune complexes in the perchloric acid precipitates could be demonstrated by gel filtration under dissociating andnon-dissociating conditions and after pre-incubation with 125I-CEA by radioimmuno-double-diffusion using monospecific rabbit antisera against human IgM and IgG. Perchloric Acid 44-59 CEA cell adhesion molecule 3 Homo sapiens 198-201 568524-2 1978 A radioimmunoassay for CEA using commercially available reagents (CEA-Roche), which avoids the perchloric acid and dialysis steps used in the CEA-Roche assay, has been devised. Perchloric Acid 95-110 CEA cell adhesion molecule 3 Homo sapiens 23-26 568524-2 1978 A radioimmunoassay for CEA using commercially available reagents (CEA-Roche), which avoids the perchloric acid and dialysis steps used in the CEA-Roche assay, has been devised. Perchloric Acid 95-110 CEA cell adhesion molecule 3 Homo sapiens 66-69 568524-2 1978 A radioimmunoassay for CEA using commercially available reagents (CEA-Roche), which avoids the perchloric acid and dialysis steps used in the CEA-Roche assay, has been devised. Perchloric Acid 95-110 CEA cell adhesion molecule 3 Homo sapiens 66-69 670899-1 1978 Human carcinoembryonic antigen (CEA) was measured in perchloric acid extracts from 9 malignant gastrointestinal tumours, using two different radioimmunological methods (Hoffmann-La Roche and CEA-IRE-SORIN). Perchloric Acid 53-68 CEA cell adhesion molecule 3 Homo sapiens 6-30 670899-1 1978 Human carcinoembryonic antigen (CEA) was measured in perchloric acid extracts from 9 malignant gastrointestinal tumours, using two different radioimmunological methods (Hoffmann-La Roche and CEA-IRE-SORIN). Perchloric Acid 53-68 CEA cell adhesion molecule 3 Homo sapiens 32-35 203387-1 1978 Carcinoembryonic antigen (CEA) was isolated from a human tumor with 0.02 M sodium phosphate containing 0.14 M NaCl (pH 7.0) (saline) and further studied after treatment with perchloric acid or 8 M urea. Perchloric Acid 174-189 CEA cell adhesion molecule 3 Homo sapiens 0-30 203387-3 1978 Perchloric acid treatment resulted in an approximate 10-fold decrease in protein and a significant loss of CEA as compared to the saline- and urea-treated material. Perchloric Acid 0-15 CEA cell adhesion molecule 3 Homo sapiens 107-110 204321-3 1978 CEA has also been extracted with 3M KCl solution from insoluble perchloric acid residues of tumour homogenates and cancer patients" serum. Perchloric Acid 64-79 CEA cell adhesion molecule 3 Homo sapiens 0-3 204321-4 1978 Whilst a large proportion of CEA activity recovered from tumour was associated with the perchloric acid residue, the corresponding amounts from serum were very small. Perchloric Acid 88-103 CEA cell adhesion molecule 3 Homo sapiens 29-32 204321-7 1978 It has been shown that perchloric acid modifies the carbohydrate in CEA, thus altering its Con A-binding properties. Perchloric Acid 23-38 CEA cell adhesion molecule 3 Homo sapiens 68-71 619627-6 1978 Further characterization of the perchloric acid-soluble material from colon washings by gel filtration indicated that the CEA-like substance from colon cancer patients was higher in molecular weight than standard radiolabeled CEA and CEA from normal colon washings. Perchloric Acid 32-47 CEA cell adhesion molecule 3 Homo sapiens 122-125