PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 23085536-0 2012 Knockdown of NYGGF4 (PID1) rescues insulin resistance and mitochondrial dysfunction induced by FCCP in 3T3-L1 adipocytes. Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone 95-99 phosphotyrosine interaction domain containing 1 Homo sapiens 13-19 23085536-0 2012 Knockdown of NYGGF4 (PID1) rescues insulin resistance and mitochondrial dysfunction induced by FCCP in 3T3-L1 adipocytes. Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone 95-99 phosphotyrosine interaction domain containing 1 Homo sapiens 21-25 23085536-4 2012 We designed this study to determine whether silencing of NYGGF4 in 3T3-L1 adipocytes could rescue the effect of insulin sensitivity and mitochondrial function induced by the cyanide p-trifluoromethoxyphenyl-hydrazone (FCCP), a mitochondrion uncoupler, to ascertain further the mechanism of NYGGF4 involvement in obesity-associated insulin resistance. Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone 218-222 phosphotyrosine interaction domain containing 1 Homo sapiens 57-63 23085536-8 2012 We next analyzed the mitochondrial function in NYGGF4-silenced adipocytes incubated with FCCP. Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone 89-93 phosphotyrosine interaction domain containing 1 Homo sapiens 47-53 23085536-9 2012 NYGGF4 knockdown partly rescued the dissipation of mitochondrial mass, mitochondrial DNA, intracellular ATP synthesis, and intracellular reactive oxygen species (ROS) production occurred following the addition of FCCP, as well as inhibition of mitochondrial transmembrane potential (DeltaPsim) in 3T3-L1 adipocytes incubated with FCCP. Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone 213-217 phosphotyrosine interaction domain containing 1 Homo sapiens 0-6 23085536-9 2012 NYGGF4 knockdown partly rescued the dissipation of mitochondrial mass, mitochondrial DNA, intracellular ATP synthesis, and intracellular reactive oxygen species (ROS) production occurred following the addition of FCCP, as well as inhibition of mitochondrial transmembrane potential (DeltaPsim) in 3T3-L1 adipocytes incubated with FCCP. Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone 330-334 phosphotyrosine interaction domain containing 1 Homo sapiens 0-6